WORKLIST ENTRIES (1):
INTRLEUKIN24 View alignment Interleukin-24 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B
PRINTS; PR01929 INTRLEUKIN13; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16
PRINTS; PR01932 INTRLEUKIN17; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19
PRINTS; PR01935 INTRLEUKIN20; PR01936 INTRLEUKIN22; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
MIM; 604136
Creation date 05-NOV-2008
1. FICKENSCHER, H., HOR, S., KUPERS, H., KNAPPE, A., WITTMANN, S. AND
STICHT, H.
The interleukin-10 family of cytokines.
TRENDS IMMUNOL. 23 89-96 (2002).
2. WANG, M. AND LIANG, P.
Interleukin-24 and its receptors.
IMMUNOLOGY 114 166-170 (2005).
3. FISHER, P., GOPALKRISHAN, R., CHADA, S., RAMESH, R., GRIMM, E.,
ROSENFELD, M., CURIEL, D. AND DENT, P.
mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene:
from the laboratory into the clinic.
CANCER BIOL.THER. S23-S37 (2003).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-24 (IL-24, also known as melanoma differentiation-associated
gene-7) belongs to the family of IL-10-related cytokines, which includes
IL-10, -19, -20, -22, -24 and -26 [1]. It has been proposed, based on the
expression pattern of IL-24 and its receptors, that the cytokine may play
a role in epidermal functions, such as wound healing [2]. IL-24 has also
been shown to possess cancer-specific apoptosis-inducing activity, and has
therefore been suggested as a potential anti-cancer agent [3].
INTRLEUKIN24 is a 3-element fingerprint that provides a signature for
interleukin-24. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length. A single iteration on SPTR55_38f was required
to reach convergence, no further sequences being identified beyond the
starting set. A single partial match was also found, Q2YHE5_HUMAN, a human
interleukin-24 splice variant that fails to match motif 2.
SUMMARY INFORMATION
6 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 6 6 6
2| 1 0 1
--+----------------
| 1 2 3
True positives..
IL24_MOUSE Q9WVP8_RAT IL24_RAT IL24_HUMAN
Q53XZ7_HUMAN Q7SX82_TETNG
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q2YHE5_HUMAN
PROTEIN TITLES
IL24_MOUSE Interleukin-24 precursor (Melanoma differentiation-associate
Q9WVP8_RAT C49a - Rattus norvegicus (Rat).
IL24_RAT Interleukin-24 precursor (Cytokine-like protein Mob-5) - Rat
IL24_HUMAN Interleukin-24 precursor (Suppression of tumorigenicity 16 p
Q53XZ7_HUMAN Interleukin 24 - Homo sapiens (Human).
Q7SX82_TETNG Interleukin-24 (Chromosome undetermined SCAF13843, whole gen
Q2YHE5_HUMAN IL-24 splice variant delE5 - Homo sapiens (Human).
SCAN HISTORY
SPTR55_38f 1 200 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN241 Length of motif = 16 Motif number = 1
Interleukin-24 motif I - 1
PCODE ST INT
VKDTMQAQDNITSARL IL24_HUMAN 76 76
VKNTVQTQDDITSIRL IL24_MOUSE 51 51
VANQAQLEQDDPSVRL Q7SX82_TETNG 54 54
VKNTVKTQDELTSVRL IL24_RAT 53 53
VKNTVKTQDELTSARL Q9WVP8_RAT 53 53
VKDTMQAQDNITSARL Q53XZ7_HUMAN 77 77
INTRLEUKIN242 Length of motif = 18 Motif number = 2
Interleukin-24 motif II - 1
PCODE ST INT
AESCYLVHTLLEFYLKTV IL24_HUMAN 103 11
AESCYLAHSLLKFYLNTV IL24_MOUSE 78 11
LEICCLHANILDFYLLNV Q7SX82_TETNG 80 10
AESCYLAHSLLKFYLNTV IL24_RAT 80 11
AESCYLAHSLLKFYLNTV Q9WVP8_RAT 80 11
AESCYLVHTLLEFYLKTV Q53XZ7_HUMAN 104 11
INTRLEUKIN243 Length of motif = 14 Motif number = 3
Interleukin-24 motif III - 1
PCODE ST INT
KALGEVDILLTWMQ IL24_HUMAN 188 67
KAFGEVDILLTWMQ IL24_MOUSE 163 67
KALGEVDILFYYLQ Q7SX82_TETNG 155 57
KAFGEVDILLAWMQ IL24_RAT 165 67
KAFGEVDILLAWMQ Q9WVP8_RAT 165 67
KALGEVDILLTWMQ Q53XZ7_HUMAN 189 67
FINAL MOTIF SETS
INTRLEUKIN241 Length of motif = 16 Motif number = 1
Interleukin-24 motif I - 1
PCODE ST INT
VKNTVQTQDDITSIRL IL24_MOUSE 51 51
VKNTVKTQDELTSARL Q9WVP8_RAT 53 53
VKNTVKTQDELTSVRL IL24_RAT 53 53
VKDTMQAQDNITSARL IL24_HUMAN 76 76
VKDTMQAQDNITSARL Q53XZ7_HUMAN 77 77
VANQAQLEQDDPSVRL Q7SX82_TETNG 54 54
INTRLEUKIN242 Length of motif = 18 Motif number = 2
Interleukin-24 motif II - 1
PCODE ST INT
AESCYLAHSLLKFYLNTV IL24_MOUSE 78 11
AESCYLAHSLLKFYLNTV Q9WVP8_RAT 80 11
AESCYLAHSLLKFYLNTV IL24_RAT 80 11
AESCYLVHTLLEFYLKTV IL24_HUMAN 103 11
AESCYLVHTLLEFYLKTV Q53XZ7_HUMAN 104 11
LEICCLHANILDFYLLNV Q7SX82_TETNG 80 10
INTRLEUKIN243 Length of motif = 14 Motif number = 3
Interleukin-24 motif III - 1
PCODE ST INT
KAFGEVDILLTWMQ IL24_MOUSE 163 67
KAFGEVDILLAWMQ Q9WVP8_RAT 165 67
KAFGEVDILLAWMQ IL24_RAT 165 67
KALGEVDILLTWMQ IL24_HUMAN 188 67
KALGEVDILLTWMQ Q53XZ7_HUMAN 189 67
KALGEVDILFYYLQ Q7SX82_TETNG 155 57
User query: Display/Full Code "INTRLEUKIN24"