WORKLIST ENTRIES (1): INTRLEUKIN19 View alignment Interleukin-19 signature Type of fingerprint: COMPOUND with 3 elements Links: PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3 PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6 PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9 PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B PRINTS; PR01929 INTRLEUKIN13; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16 PRINTS; PR01932 INTRLEUKIN17; PR01933 INTRLEUKIN18; PR01935 INTRLEUKIN20 PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34 PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX PDB; 1N1F 3Dinfo SCOP; 1N1F CATH; 1N1F MIM; 605687 Creation date 30-JUL-2008 1. FICKENSCHER, H., HOR, S., KUPERS, H., KNAPPE, A., WITTMANN, S. AND STICHT, H. The interleukin-10 family of cytokines. TRENDS IMMUNOL. 23 89-96 (2002). 2. CHANG, C., MAGRACHEVA, E., KOZLOV, S., FONG, S., TOBIN, G., KOTENKO, S., WLODAWER, A. AND ZDANOV, A. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J.BIOL.CHEM. 278 3308-3313 (2003). Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-19 (IL-19) belongs to the family of Il-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26 . IL-19 shares a receptor complex with IL-20, indicating that their biological activities may overlap . Both cytokines may play an important role in regulating the development and proper functioning of skin . INTRLEUKIN19 is a 3-element fingerprint that provides a signature for interleukin-19. The fingerprint was derived from an initial alignment of 2 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length, each encompassing a short region of beta strand. Two iterations on SPTR55_38f were required to reach convergence, at which point a true set comprising 3 sequences was identified. SUMMARY INFORMATION 3 codes involving 3 elements 0 codes involving 2 elements COMPOSITE FINGERPRINT INDEX 3| 3 3 3 2| 0 0 0 --+---------------- | 1 2 3 True positives.. IL19_MOUSE Q14BK1_MOUSE IL19_HUMAN PROTEIN TITLES IL19_MOUSE Interleukin-19 precursor (IL-19) - Mus musculus (Mouse). Q14BK1_MOUSE Interleukin 19 - Mus musculus (Mouse). IL19_HUMAN Interleukin-19 precursor (IL-19) (Melanoma differentiation-a
SCAN HISTORY SPTR55_38f 2 300 NSINGLE INITIAL MOTIF SETS INTRLEUKIN191 Length of motif = 13 Motif number = 1 Interleukin-19 motif I - 1 PCODE ST INT ISTDMHHIEESFQ IL19_HUMAN 30 30 ISVDMRLIEKSFH IL19_MOUSE 30 30 INTRLEUKIN192 Length of motif = 12 Motif number = 2 Interleukin-19 motif II - 1 PCODE ST INT FKDHQEPNPKIL IL19_HUMAN 90 47 FQDHQERSLEVL IL19_MOUSE 89 46 INTRLEUKIN193 Length of motif = 14 Motif number = 3 Interleukin-19 motif III - 1 PCODE ST INT QEATNATRVIHDNY IL19_HUMAN 131 29 QEATNATRIIHDNY IL19_MOUSE 130 29 FINAL MOTIF SETS INTRLEUKIN191 Length of motif = 13 Motif number = 1 Interleukin-19 motif I - 2 PCODE ST INT ISVDMRLIEKSFH IL19_MOUSE 30 30 ISVDMRLIEKSFH Q14BK1_MOUSE 30 30 ISTDMHHIEESFQ IL19_HUMAN 30 30 INTRLEUKIN192 Length of motif = 12 Motif number = 2 Interleukin-19 motif II - 2 PCODE ST INT FQDHQERSLEVL IL19_MOUSE 89 46 FQDHQERSLEVL Q14BK1_MOUSE 89 46 FKDHQEPNPKIL IL19_HUMAN 90 47 INTRLEUKIN193 Length of motif = 14 Motif number = 3 Interleukin-19 motif III - 2 PCODE ST INT QEATNATRIIHDNY IL19_MOUSE 130 29 QEATNATRIIHDNY Q14BK1_MOUSE 130 29 QEATNATRVIHDNY IL19_HUMAN 131 29
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