WORKLIST ENTRIES (1):
INTRLEUKIN17 View alignment Interleukin-17 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B
PRINTS; PR01929 INTRLEUKIN13; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
PFAM; PF0608 IL17
INTERPRO; IPR010345
PDB; 1JPY 3Dinfo
SCOP; 1JPY
CATH; 1JPY
Creation date 06-AUG-2008
1. AGGARWAL, S. AND GURNEY, A.
IL-17: prototype member of an emerging cytokine family.
J.LEUKOC.BIOL. 71 1-8 (2002).
2. KOLLS, K. AND LINDEN, A
Interleukin-17 family members and inflammation.
IMMUNITY 21 467-476 (2004).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-17 (IL-17) is a potent proinflammatory cytokine produced by
activated memory T cells [1]. The IL-17 family (of which there are 6 known
members, termed IL-17A to IL-17F) is thought to represent a distinct
signalling system that appears to have been highly conserved across
vertebrate evolution [1]. Family members play an active role in
inflammatory diseases, autoimmune diseases and cancer [2].
INTRLEUKIN17 is a 3-element fingerprint that provides a signature for
interleukin-17. The fingerprint was derived from an initial alignment of 8
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length. Four iterations on SPTR55_38f were required to
reach convergence, at which point a true set comprising 38 sequences was
identified. Three partial matches were also found: A8JYG6_CHICK and
Q6L5M6_CIOIN are translated chicken and sea squirt mRNAs, respectively,
that fail to match motif 1; and Q6L5M4_CIOIN is a translated sea squirt
mRNA that fails to match motif 3.
SUMMARY INFORMATION
38 codes involving 3 elements
3 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 38 38 38
2| 1 3 2
--+----------------
| 1 2 3
True positives..
A5HJM0_CALJA IL17_HUMAN Q5T2P0_HUMAN IL17_BOVIN
Q5BJ95_RAT IL17_SHV21 Q6NZ94_HUMAN IL17_SHV2C
Q778B0_9GAMA Q7TNI7_MOUSE Q8K4C3_MOUSE IL17_PIG
IL17_MOUSE Q544E6_MOUSE IL17_RAT A6N6I9_CALJA
IL17F_HUMAN Q6NSI0_HUMAN Q8K4C4_MOUSE IL17B_MOUSE
IL17D_HUMAN IL17B_HUMAN Q6IAG3_HUMAN Q70I20_ONCMY
Q5TKT1_DANRE B0BML6_XENTR B0FYQ2_ANAPL A6H6F0_MOUSE
Q8K4C5_MOUSE Q5XP68_CHICK Q7T1P7_CHICK Q6DIY0_XENTR
IL17C_HUMAN Q5TKT0_DANRE Q8K599_MOUSE Q5TKT4_DANRE
A9ECT5_LAMJA Q6L5M5_CIOIN
Subfamily: Codes involving 2 elements
Subfamily True positives..
A8JYG6_CHICK Q6L5M6_CIOIN Q6L5M4_CIOIN
PROTEIN TITLES
A5HJM0_CALJA Interleukin 17 A - Callithrix jacchus (Common marmoset).
IL17_HUMAN Interleukin-17A precursor (IL-17A) (IL-17) (Cytotoxic T-lymp
Q5T2P0_HUMAN Interleukin 17A (Interleukin 17) (Cytotoxic T-lymphocyte-ass
IL17_BOVIN Interleukin-17A precursor (IL-17A) (IL-17) - Bos taurus (Bov
Q5BJ95_RAT Interleukin 17F - Rattus norvegicus (Rat).
IL17_SHV21 Viral interleukin-17 precursor (vIL-17) (Immediate early gen
Q6NZ94_HUMAN Interleukin 17A - Homo sapiens (Human).
IL17_SHV2C Viral interleukin-17 precursor (vIL-17) (Immediate early gen
Q778B0_9GAMA Viral interleukin-13 - Saimiriine herpesvirus 2 (Herpesvirus
Q7TNI7_MOUSE Interleukin 17F, transcript variant (Interleukin 17F) - Mus
Q8K4C3_MOUSE IL-17F - Mus musculus (Mouse).
IL17_PIG Interleukin-17A precursor (IL-17A) (IL-17) - Sus scrofa (Pig
IL17_MOUSE Interleukin-17A precursor (IL-17A) (IL-17) (Cytotoxic T-lymp
Q544E6_MOUSE 0 day neonate thymus cDNA, RIKEN full-length enriched librar
IL17_RAT Interleukin-17A precursor (IL-17A) (IL-17) (Cytotoxic T-lymp
A6N6I9_CALJA IL-17F protein - Callithrix jacchus (Common marmoset).
IL17F_HUMAN Interleukin-17F precursor (IL-17F) (Interleukin-24) (IL-24)
Q6NSI0_HUMAN Interleukin 17F - Homo sapiens (Human).
Q8K4C4_MOUSE IL-17D - Mus musculus (Mouse).
IL17B_MOUSE Interleukin-17B precursor (IL-17B) (Cytokine-like protein ZC
IL17D_HUMAN Interleukin-17D precursor (IL-17D) (Interleukin-27) (IL-27)
IL17B_HUMAN Interleukin-17B precursor (IL-17B) (Cytokine-like protein Zc
Q6IAG3_HUMAN IL17B protein - Homo sapiens (Human).
Q70I20_ONCMY Interleukin 17 isoform D - Oncorhynchus mykiss (Rainbow trou
Q5TKT1_DANRE Interleukin 17_4 - Danio rerio (Zebrafish) (Brachydanio reri
B0BML6_XENTR Putative uncharacterized protein - Xenopus tropicalis (Weste
B0FYQ2_ANAPL Interleukin 17 - Anas platyrhynchos (Domestic duck).
A6H6F0_MOUSE Il17c protein - Mus musculus (Mouse).
Q8K4C5_MOUSE IL-17C - Mus musculus (Mouse).
Q5XP68_CHICK IL-17 - Gallus gallus (Chicken).
Q7T1P7_CHICK Interleukin 17 - Gallus gallus (Chicken).
Q6DIY0_XENTR Interleukin 17B - Xenopus tropicalis (Western clawed frog) (
IL17C_HUMAN Interleukin-17C precursor (IL-17C) (Cytokine CX2) - Homo sap
Q5TKT0_DANRE Interleukin 17_5 (Interleukin 17a/f3) (Novel protein similar
Q8K599_MOUSE Interleukin 27A precursor - Mus musculus (Mouse).
Q5TKT4_DANRE Interleukin 17_1 - Danio rerio (Zebrafish) (Brachydanio reri
A9ECT5_LAMJA Interleukin-17 - Lampetra japonica (Japanese lamprey) (Entos
Q6L5M5_CIOIN Interleukin 17-2 - Ciona intestinalis (Transparent sea squir
A8JYG6_CHICK Interleukin-17D - Gallus gallus (Chicken).
Q6L5M6_CIOIN Interleukin 17-1 - Ciona intestinalis (Transparent sea squir
Q6L5M4_CIOIN Interleukin 17-3 - Ciona intestinalis (Transparent sea squir
SCAN HISTORY
SPTR55_38f 4 300 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN171 Length of motif = 13 Motif number = 1
Interleukin-17 motif I - 1
PCODE ST INT
SPWTLQRNEDPER IL17_PIG 70 70
SPWTLHRNEDPDR IL17_MOUSE 75 75
SPWSFTVNQDSSR A9ECT5_LAMJA 94 94
SPWAYRISHDPAR Q70I20_ONCMY 95 95
SPYVTELVYDNKR Q6L5M5_CIOIN 95 95
SPWAYSINHDENR Q6DIY0_XENTR 114 114
SPWTYMFTHNESL Q5TKT4_DANRE 71 71
SPWTLHRNEDPER IL17_BOVIN 70 70
INTRLEUKIN172 Length of motif = 10 Motif number = 2
Interleukin-17 motif II - 1
PCODE ST INT
EAKCSHSGCI IL17_PIG 89 6
EAQCRHQRCV IL17_MOUSE 94 6
EAYCLCDGCL A9ECT5_LAMJA 113 6
EAYCLCKGCL Q70I20_ONCMY 114 6
QSKCLCSGCI Q6L5M5_CIOIN 114 6
EARCLCTGCV Q6DIY0_XENTR 133 6
EAKCSLTGCL Q5TKT4_DANRE 90 6
EAKCSHSGCI IL17_BOVIN 89 6
INTRLEUKIN173 Length of motif = 15 Motif number = 3
Interleukin-17 motif III - 1
PCODE ST INT
FRLEKVMVTVGCTCV IL17_PIG 131 32
FRVEKMLVGVGCTCV IL17_MOUSE 136 32
YKPDLETIALFCTCS A9ECT5_LAMJA 158 35
YTESYVSVAVGCTCV Q70I20_ONCMY 159 35
YSVVTEDVTIGCTCV Q6L5M5_CIOIN 154 30
YMAVMENIAVGCTCI Q6DIY0_XENTR 188 45
FKLEYKTIAVGCTCV Q5TKT4_DANRE 132 32
FRLEKMLVAVGCTCV IL17_BOVIN 131 32
FINAL MOTIF SETS
INTRLEUKIN171 Length of motif = 13 Motif number = 1
Interleukin-17 motif I - 4
PCODE ST INT
SPWNLHRNEDPER A5HJM0_CALJA 70 70
SPWNLHRNEDPER IL17_HUMAN 72 72
SPWNLHRNEDPER Q5T2P0_HUMAN 72 72
SPWTLHRNEDPER IL17_BOVIN 70 70
SPWDYNITRDPDR Q5BJ95_RAT 70 70
SPWTLHRNEDQDR IL17_SHV21 68 68
SPWNLHRNEDPER Q6NZ94_HUMAN 72 72
SPWTLYRNEDQDR IL17_SHV2C 68 68
SPWTLYRNEDQDR Q778B0_9GAMA 68 68
SPWDYNITRDPHR Q7TNI7_MOUSE 78 78
SPWDYNITRDPHR Q8K4C3_MOUSE 70 70
SPWTLQRNEDPER IL17_PIG 70 70
SPWTLHRNEDPDR IL17_MOUSE 75 75
SPWTLHRNEDPDR Q544E6_MOUSE 75 75
SPWTLSRNEDPDR IL17_RAT 67 67
SPWNYTVTWDPNR A6N6I9_CALJA 80 80
SPWNYTVTWDPNR IL17F_HUMAN 70 70
SPWNYTVTWDPNR Q6NSI0_HUMAN 80 80
SPWAYRISYDPAR Q8K4C4_MOUSE 99 99
SPWGYSINHDPSR IL17B_MOUSE 99 99
SPWAYRISYDPAR IL17D_HUMAN 92 92
SPWGYSINHDPSR IL17B_HUMAN 99 99
SPWGYSINHDPSR Q6IAG3_HUMAN 99 99
SPWAYRISHDPAR Q70I20_ONCMY 95 95
SPWAYRISHDPAR Q5TKT1_DANRE 98 98
SPWAYRISYNPTR B0BML6_XENTR 91 91
SPWDYRIDEDHNR B0FYQ2_ANAPL 86 86
SPWRYRIDTDENR A6H6F0_MOUSE 91 91
SPWRYRIDTDENR Q8K4C5_MOUSE 103 103
APWDYRIDEDHNR Q5XP68_CHICK 86 86
APWDYRIDEDHNR Q7T1P7_CHICK 86 86
SPWAYSINHDENR Q6DIY0_XENTR 114 114
SPWRYRVDTDEDR IL17C_HUMAN 107 107
SPWTYTTSVDESR Q5TKT0_DANRE 77 77
VPEAYSISYDPAR Q8K599_MOUSE 90 90
SPWTYMFTHNESL Q5TKT4_DANRE 71 71
SPWSFTVNQDSSR A9ECT5_LAMJA 94 94
SPYVTELVYDNKR Q6L5M5_CIOIN 95 95
INTRLEUKIN172 Length of motif = 10 Motif number = 2
Interleukin-17 motif II - 4
PCODE ST INT
EAKCRHLGCV A5HJM0_CALJA 89 6
EAKCRHLGCI IL17_HUMAN 91 6
EAKCRHLGCI Q5T2P0_HUMAN 91 6
EAKCSHSGCI IL17_BOVIN 89 6
EAQCRHSGCI Q5BJ95_RAT 89 6
EAKCRYLGCV IL17_SHV21 87 6
EAKCRHLGCI Q6NZ94_HUMAN 91 6
EAKCRYLGCV IL17_SHV2C 87 6
EAKCRYLGCV Q778B0_9GAMA 87 6
EAQCRHSGCI Q7TNI7_MOUSE 97 6
EAQCRHSGCI Q8K4C3_MOUSE 89 6
EAKCSHSGCI IL17_PIG 89 6
EAQCRHQRCV IL17_MOUSE 94 6
EAQCRHQRCV Q544E6_MOUSE 94 6
EAQCRHQRCV IL17_RAT 86 6
QAQCRHLGCV A6N6I9_CALJA 99 6
QAQCRNLGCI IL17F_HUMAN 89 6
QAQCRNLGCI Q6NSI0_HUMAN 99 6
EAYCLCRGCL Q8K4C4_MOUSE 118 6
EARCLCLGCV IL17B_MOUSE 118 6
EAYCLCRGCL IL17D_HUMAN 111 6
EARCLCLGCV IL17B_HUMAN 118 6
EARCLCLGCV Q6IAG3_HUMAN 118 6
EAYCLCKGCL Q70I20_ONCMY 114 6
EAYCLCKGCL Q5TKT1_DANRE 117 6
EAYCLCKGCL B0BML6_XENTR 110 6
DAECRYSRCV B0FYQ2_ANAPL 105 6
VAECLCRGCI A6H6F0_MOUSE 110 6
VAECLCRGCI Q8K4C5_MOUSE 122 6
DAQCRHSRCV Q5XP68_CHICK 105 6
DAQCRHSRCV Q7T1P7_CHICK 105 6
EARCLCTGCV Q6DIY0_XENTR 133 6
FAECLCRGCI IL17C_HUMAN 126 6
EAKCEKRGCL Q5TKT0_DANRE 96 6
EAYCLCRGCL Q8K599_MOUSE 109 6
EAKCSLTGCL Q5TKT4_DANRE 90 6
EAYCLCDGCL A9ECT5_LAMJA 113 6
QSKCLCSGCI Q6L5M5_CIOIN 114 6
INTRLEUKIN173 Length of motif = 15 Motif number = 3
Interleukin-17 motif III - 4
PCODE ST INT
FRLEKMLVSVGCTCV A5HJM0_CALJA 131 32
FRLEKILVSVGCTCV IL17_HUMAN 133 32
FRLEKILVSVGCTCV Q5T2P0_HUMAN 133 32
FRLEKMLVAVGCTCV IL17_BOVIN 131 32
FRLEKMLIKVGCTCV Q5BJ95_RAT 131 32
FRLEKMLVTVGCTCV IL17_SHV21 129 32
FRLEKILVSVDCTCV Q6NZ94_HUMAN 133 32
FRLEKMLVTVGCTCV IL17_SHV2C 129 32
FRLEKMLVTVGCTCV Q778B0_9GAMA 129 32
FRLEKMLLKVGCTCV Q7TNI7_MOUSE 139 32
FRLEKMLLKVGCTCV Q8K4C3_MOUSE 131 32
FRLEKVMVTVGCTCV IL17_PIG 131 32
FRVEKMLVGVGCTCV IL17_MOUSE 136 32
FRVEKMLVGVGCTCV Q544E6_MOUSE 136 32
FRVEKMLVGVGCTCV IL17_RAT 128 32
FQLEKLLVTVGCTCV A6N6I9_CALJA 141 32
FQLEKVLVTVGCTCV IL17F_HUMAN 131 32
FQLEKVLVTVGCTCV Q6NSI0_HUMAN 141 32
YAEHYITIPVGCTCV Q8K4C4_MOUSE 163 35
QRVVMETIAVGCTCI IL17B_MOUSE 165 37
YTEAYVTIPVGCTCV IL17D_HUMAN 156 35
QRAVMETIAVGCTCI IL17B_HUMAN 165 37
QRAVMETIAVGCTCI Q6IAG3_HUMAN 165 37
YTESYVSVAVGCTCV Q70I20_ONCMY 159 35
YTESYVSIAVGCTCV Q5TKT1_DANRE 163 36
YEEEYITIPVGCTCV B0BML6_XENTR 155 35
YRLEKKIITVGCTCV B0FYQ2_ANAPL 147 32
FHTEFIRVPVGCTCV A6H6F0_MOUSE 162 42
FHTEFIRVPVGCTCV Q8K4C5_MOUSE 174 42
YRLEKKMITVGCTCV Q5XP68_CHICK 147 32
YRLEKKMITVGCTCV Q7T1P7_CHICK 147 32
YMAVMENIAVGCTCI Q6DIY0_XENTR 188 45
FHTEFIHVPVGCTCV IL17C_HUMAN 178 42
LKLETKKVSVGCTCV Q5TKT0_DANRE 140 34
YAEHYITIPVGCTCV Q8K599_MOUSE 154 35
FKLEYKTIAVGCTCV Q5TKT4_DANRE 132 32
YKPDLETIALFCTCS A9ECT5_LAMJA 158 35
YSVVTEDVTIGCTCV Q6L5M5_CIOIN 154 30
User query: Display/Full Code "INTRLEUKIN17"