WORKLIST ENTRIES (1):
INTRLEUKIN15 View alignment Interleukin-15 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B
PRINTS; PR01929 INTRLEUKIN13; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR01947 INTLKN15MAML; PR01948 INTLKN15BIRD; PR01949 INTLKN15FISH
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
PFAM; PF02372 IL15
INTERPRO; IPR003443
MIM; 600554
Creation date 30-OCT-2008
1. LIU, C., PERUSSIA, B. AND YOUNG, J.
The emerging role of IL-15 in NK-cell development.
IMMUNOL.TODAY 21 113-116 (2000).
2. KU, C., MURAKAMI, M., SAKAMOTO, A., KAPPLER, J. AND MARRACK, P.
Control of homeostasis of CD8+ memory T cells by opposing cytokines.
SCIENCE 288 675-678 (2000).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-15 (IL-15) has a variety of biological functions, including
stimulation and maintenance of cellular immune responses [1]. It is
required for division of CD8+ T cells of memory phenotype, a process that
is increased by inhibition of IL-2 [2]. The numbers of CD8+ memory T cells
in animals may, therefore, be controlled by a balance between IL-15 and -2.
INTRLEUKIN15 is a 3-element fingerprint that provides a signature for
interleukin-15. The fingerprint was derived from an initial alignment of 31
sequences: the motifs were drawn from conserved regions spanning the
C-terminal two thirds of the alignment. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 32
sequences was identified. Two partial matches were also found, Q1AHQ7_MOUSE
and Q1AHQ6_MOUSE, mouse interleukin-15 isoforms that fail to match motifs 1
and 2 respectively.
SUMMARY INFORMATION
32 codes involving 3 elements
2 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 32 32 32
2| 1 1 2
--+----------------
| 1 2 3
True positives..
IL15_RABIT Q2PUG6_RABIT IL15_CERAE IL15_MACTH
IL15_MACMU IL15_HUMAN Q6FGX7_HUMAN IL15_PIG
Q06F26_PIG IL15_FELCA A8WE60_PIG Q5EEK6_MARMO
Q5WQV8_MARMO IL15_BOVIN Q75SZ9_CAVPO IL15_BUBBU
IL15_SHEEP IL15_RAT IL15_MOUSE Q3U1Z6_MOUSE
A7LLW4_CHICK Q9W756_CHICK Q9DEV5_CHICK B0FLP3_CHICK
Q1HFY0_ANAPL Q3SCC8_FUGRU Q3SCC9_FUGRU Q1AN27_FUGRU
Q1AN26_TETNG Q575Z3_ONCMY Q3SCC6_DANRE Q15KG7_DANRE
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q1AHQ7_MOUSE Q1AHQ6_MOUSE
PROTEIN TITLES
IL15_RABIT Interleukin-15 precursor (IL-15) - Oryctolagus cuniculus (Ra
Q2PUG6_RABIT Interleukin-15 - Oryctolagus cuniculus (Rabbit).
IL15_CERAE Interleukin-15 precursor (IL-15) - Cercopithecus aethiops (G
IL15_MACTH Interleukin-15 precursor (IL-15) - Macaca thibetana (Pere Da
IL15_MACMU Interleukin-15 precursor (IL-15) - Macaca mulatta (Rhesus ma
IL15_HUMAN Interleukin-15 precursor (IL-15) - Homo sapiens (Human).
Q6FGX7_HUMAN IL15 protein (Interleukin 15, isoform CRA_a) (cDNA FLJ77069,
IL15_PIG Interleukin-15 precursor (IL-15) - Sus scrofa (Pig).
Q06F26_PIG Interleukin-15 - Sus scrofa (Pig).
IL15_FELCA Interleukin-15 precursor (IL-15) - Felis silvestris catus (C
A8WE60_PIG Interleukin 15 - Sus scrofa (Pig).
Q5EEK6_MARMO Interleukin-15 - Marmota monax (Woodchuck).
Q5WQV8_MARMO Interleukin 15 precursor - Marmota monax (Woodchuck).
IL15_BOVIN Interleukin-15 precursor (IL-15) - Bos taurus (Bovine).
Q75SZ9_CAVPO Interleukin-15 precursor - Cavia porcellus (Guinea pig).
IL15_BUBBU Interleukin-15 precursor (IL-15) - Bubalus bubalis (Domestic
IL15_SHEEP Interleukin-15 precursor (IL-15) - Ovis aries (Sheep).
IL15_RAT Interleukin-15 precursor (IL-15) - Rattus norvegicus (Rat).
IL15_MOUSE Interleukin-15 precursor (IL-15) - Mus musculus (Mouse).
Q3U1Z6_MOUSE Interleukin-15 - Mus musculus (Mouse).
A7LLW4_CHICK Interleukin-15 - Gallus gallus (Chicken).
Q9W756_CHICK Interleukin-15 - Gallus gallus (Chicken).
Q9DEV5_CHICK Interleukin-15 - Gallus gallus (Chicken).
B0FLP3_CHICK Interleukin 15 - Gallus gallus (Chicken).
Q1HFY0_ANAPL Interleukin-15 precursor - Anas platyrhynchos (Domestic duck
Q3SCC8_FUGRU Interleukin 15 variant - Fugu rubripes (Japanese pufferfish)
Q3SCC9_FUGRU Interleukin 15 - Fugu rubripes (Japanese pufferfish) (Takifu
Q1AN27_FUGRU IL-15-like - Fugu rubripes (Japanese pufferfish) (Takifugu r
Q1AN26_TETNG IL-15-like - Tetraodon nigroviridis (Green puffer).
Q575Z3_ONCMY Interleukin-15 precursor - Oncorhynchus mykiss (Rainbow trou
Q3SCC6_DANRE Interleukin-15 - Danio rerio (Zebrafish) (Brachydanio rerio)
Q15KG7_DANRE Interleukin-15 - Danio rerio (Zebrafish) (Brachydanio rerio)
Q1AHQ7_MOUSE Putative interleukin 15 isoform aE6 precursor - Mus musculus
Q1AHQ6_MOUSE Putative interleukin 15 isoform aE7 precursor - Mus musculus
SCAN HISTORY
SPTR55_38f 2 300 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN151 Length of motif = 12 Motif number = 1
Interleukin-15 motif I - 1
PCODE ST INT
DTTLYTDSDFHP IL15_MOUSE 70 70
DATLYTESDVHP IL15_HUMAN 70 70
DATLYTESDVHP Q5WQV8_MARMO 70 70
DATLYTESDAHP Q2PUG6_RABIT 70 70
DACLYAPTNDDI Q575Z3_ONCMY 94 94
DAMLYAPSANSV Q3SCC9_FUGRU 77 77
DAMLYAPSANSV Q1AN27_FUGRU 77 77
DAMLYTPSANYV Q1AN26_TETNG 76 76
TAHLYTPKTDDI Q3SCC6_DANRE 95 95
TAHLYTPKIDDI Q15KG7_DANRE 95 95
DAMLYAPSANSV Q3SCC8_FUGRU 66 66
DVSLYTANTYED Q9DEV5_CHICK 88 88
DVSLYTANTYED Q9W756_CHICK 88 88
DVSLYTANTYED A7LLW4_CHICK 88 88
DVSLYTANTYED B0FLP3_CHICK 88 88
DVSLYTANTDED Q1HFY0_ANAPL 88 88
DTTLYTDSDFHP Q3U1Z6_MOUSE 70 70
DATLYTESDAHP IL15_BOVIN 70 70
DATLYTESDVHP Q5EEK6_MARMO 70 70
DATLYTEGDAHP IL15_BUBBU 70 70
DATLYTESDVHP IL15_CERAE 70 70
DATLYTESDVHP IL15_MACTH 70 70
DATLYTESDVHP IL15_MACMU 70 70
DATLYTESDVHP Q75SZ9_CAVPO 70 70
DATLYTESDVHP IL15_FELCA 70 70
DATLYTESDAHP IL15_SHEEP 70 70
DATLYTESDAHP Q06F26_PIG 70 70
DATLYTESDAHP IL15_RABIT 70 70
DATLYTESDAHP A8WE60_PIG 70 70
DATLYTESDAHP IL15_PIG 70 70
DTTLYTDSDFHP IL15_RAT 70 70
INTRLEUKIN152 Length of motif = 19 Motif number = 2
Interleukin-15 motif II - 1
PCODE ST INT
CKVTAMNCFLLELQVILHE IL15_MOUSE 83 1
CKVTAMKCFLLELQVISLE IL15_HUMAN 83 1
CKVTAMNCFLLELEVISHE Q5WQV8_MARMO 83 1
CKVTAMKCFLLELRVISHE Q2PUG6_RABIT 83 1
CIFKFMHCYLLELEVVLFE Q575Z3_ONCMY 110 4
CKNMSLRCYMLELIMVINE Q3SCC9_FUGRU 92 3
CKNMSLRCYMLELIMVINE Q1AN27_FUGRU 92 3
CKNKSLKCYMLELLMVIDE Q1AN26_TETNG 97 9
CTFRFFDCFLLEMKVVLYE Q3SCC6_DANRE 109 2
CTFRFFDCFLLEMKVVLYE Q15KG7_DANRE 109 2
CKNMSLRCYMLELIMVINE Q3SCC8_FUGRU 81 3
CQEPVMRCFFLEMKVILHE Q9DEV5_CHICK 102 2
CQEPVMRCFFLEMKVILHE Q9W756_CHICK 102 2
CQEPVMRCFFLEMKVILHE A7LLW4_CHICK 102 2
CQEPVMRCFFLEMKVILHE B0FLP3_CHICK 102 2
CQEPIMRCFFLEMNVILHE Q1HFY0_ANAPL 102 2
CKVTAMNCFLLELQVILHE Q3U1Z6_MOUSE 83 1
CKVTAMQCFLLELRVILHE IL15_BOVIN 83 1
CKVTAMNCFLLELEVISHE Q5EEK6_MARMO 83 1
CKVTAMQCFLLELRVILHE IL15_BUBBU 83 1
CKVTAMKCFLLELQVISHE IL15_CERAE 83 1
CKVTAMKCFLLELQVISHE IL15_MACTH 83 1
CKVTAMKCFLLELQVISHE IL15_MACMU 83 1
CKITAMKCFLLELRVILHE Q75SZ9_CAVPO 83 1
CKVTAMKCFLLELHVISLE IL15_FELCA 83 1
CKVTALQCFLLELRVILHE IL15_SHEEP 83 1
CKVTAMKCFLLELRVILQE Q06F26_PIG 83 1
CKVTAMKCFLLELRVISHE IL15_RABIT 83 1
CKVTAMKCFLLELHVILQE A8WE60_PIG 83 1
CKVTAMKCFLLELRVILQE IL15_PIG 83 1
CKVTAMNCFLLELQVILHE IL15_RAT 83 1
INTRLEUKIN153 Length of motif = 14 Motif number = 3
Interleukin-15 motif III - 1
PCODE ST INT
ECEELEEKTFTEFL IL15_MOUSE 135 33
ECEELEEKNIKEFL IL15_HUMAN 135 33
VCEELEEKNITEFL Q5WQV8_MARMO 135 33
ECEELEEKNITEFL Q2PUG6_RABIT 136 34
PCEAQRVANSTIFL Q575Z3_ONCMY 165 36
PCEEYAIRNITIFL Q3SCC9_FUGRU 138 27
PCEEYAIRNITMFL Q1AN27_FUGRU 138 27
PCEVYPQNNITIFL Q1AN26_TETNG 143 27
PCELQELTNSTLFF Q3SCC6_DANRE 157 29
PCELQELTNSTLFF Q15KG7_DANRE 157 29
PCEEYAIRNITIFL Q3SCC8_FUGRU 127 27
ECEEYEEKNFTEFI Q9DEV5_CHICK 158 37
ECEEYEEKNFTEFI Q9W756_CHICK 158 37
ECEEYEEKNFTEFI A7LLW4_CHICK 158 37
ECEEYEEKNFTEFI B0FLP3_CHICK 158 37
ECEEYEEKSFTEFI Q1HFY0_ANAPL 157 36
ECEELEEKTFTEFL Q3U1Z6_MOUSE 135 33
ECEELEEKSIKEFL IL15_BOVIN 135 33
VCEELEEKNITEFL Q5EEK6_MARMO 135 33
ECEELEEKSIKEFL IL15_BUBBU 135 33
ECEELEEKNIKEFL IL15_CERAE 135 33
ECEELEEKNIKEFL IL15_MACTH 135 33
ECEELEEKNIKEFL IL15_MACMU 135 33
ECEELEEKSIAEFL Q75SZ9_CAVPO 135 33
ECEELEEKNIKEFL IL15_FELCA 135 33
ECEELEKKSIKEFL IL15_SHEEP 135 33
ECEELEEKNINEFL Q06F26_PIG 135 33
ECEELEEKNITEFL IL15_RABIT 135 33
ECEELEEKNINEFL A8WE60_PIG 135 33
ECEELEEKNINEFL IL15_PIG 135 33
ECEELEERNFTEFL IL15_RAT 135 33
FINAL MOTIF SETS
INTRLEUKIN151 Length of motif = 12 Motif number = 1
Interleukin-15 motif I - 2
PCODE ST INT
DATLYTESDAHP IL15_RABIT 70 70
DATLYTESDAHP Q2PUG6_RABIT 70 70
DATLYTESDVHP IL15_CERAE 70 70
DATLYTESDVHP IL15_MACTH 70 70
DATLYTESDVHP IL15_MACMU 70 70
DATLYTESDVHP IL15_HUMAN 70 70
DATLYTESDVHP Q6FGX7_HUMAN 43 43
DATLYTESDAHP IL15_PIG 70 70
DATLYTESDAHP Q06F26_PIG 70 70
DATLYTESDVHP IL15_FELCA 70 70
DATLYTESDAHP A8WE60_PIG 70 70
DATLYTESDVHP Q5EEK6_MARMO 70 70
DATLYTESDVHP Q5WQV8_MARMO 70 70
DATLYTESDAHP IL15_BOVIN 70 70
DATLYTESDVHP Q75SZ9_CAVPO 70 70
DATLYTEGDAHP IL15_BUBBU 70 70
DATLYTESDAHP IL15_SHEEP 70 70
DTTLYTDSDFHP IL15_RAT 70 70
DTTLYTDSDFHP IL15_MOUSE 70 70
DTTLYTDSDFHP Q3U1Z6_MOUSE 70 70
DVSLYTANTYED A7LLW4_CHICK 88 88
DVSLYTANTYED Q9W756_CHICK 88 88
DVSLYTANTYED Q9DEV5_CHICK 88 88
DVSLYTANTYED B0FLP3_CHICK 88 88
DVSLYTANTDED Q1HFY0_ANAPL 88 88
DAMLYAPSANSV Q3SCC8_FUGRU 66 66
DAMLYAPSANSV Q3SCC9_FUGRU 77 77
DAMLYAPSANSV Q1AN27_FUGRU 77 77
DAMLYTPSANYV Q1AN26_TETNG 76 76
DACLYAPTNDDI Q575Z3_ONCMY 94 94
TAHLYTPKTDDI Q3SCC6_DANRE 95 95
TAHLYTPKIDDI Q15KG7_DANRE 95 95
INTRLEUKIN152 Length of motif = 19 Motif number = 2
Interleukin-15 motif II - 2
PCODE ST INT
CKVTAMKCFLLELRVISHE IL15_RABIT 83 1
CKVTAMKCFLLELRVISHE Q2PUG6_RABIT 83 1
CKVTAMKCFLLELQVISHE IL15_CERAE 83 1
CKVTAMKCFLLELQVISHE IL15_MACTH 83 1
CKVTAMKCFLLELQVISHE IL15_MACMU 83 1
CKVTAMKCFLLELQVISLE IL15_HUMAN 83 1
CKVTAMKCFLLELQVISLE Q6FGX7_HUMAN 56 1
CKVTAMKCFLLELRVILQE IL15_PIG 83 1
CKVTAMKCFLLELRVILQE Q06F26_PIG 83 1
CKVTAMKCFLLELHVISLE IL15_FELCA 83 1
CKVTAMKCFLLELHVILQE A8WE60_PIG 83 1
CKVTAMNCFLLELEVISHE Q5EEK6_MARMO 83 1
CKVTAMNCFLLELEVISHE Q5WQV8_MARMO 83 1
CKVTAMQCFLLELRVILHE IL15_BOVIN 83 1
CKITAMKCFLLELRVILHE Q75SZ9_CAVPO 83 1
CKVTAMQCFLLELRVILHE IL15_BUBBU 83 1
CKVTALQCFLLELRVILHE IL15_SHEEP 83 1
CKVTAMNCFLLELQVILHE IL15_RAT 83 1
CKVTAMNCFLLELQVILHE IL15_MOUSE 83 1
CKVTAMNCFLLELQVILHE Q3U1Z6_MOUSE 83 1
CQEPVMRCFFLEMKVILHE A7LLW4_CHICK 102 2
CQEPVMRCFFLEMKVILHE Q9W756_CHICK 102 2
CQEPVMRCFFLEMKVILHE Q9DEV5_CHICK 102 2
CQEPVMRCFFLEMKVILHE B0FLP3_CHICK 102 2
CQEPIMRCFFLEMNVILHE Q1HFY0_ANAPL 102 2
CKNMSLRCYMLELIMVINE Q3SCC8_FUGRU 81 3
CKNMSLRCYMLELIMVINE Q3SCC9_FUGRU 92 3
CKNMSLRCYMLELIMVINE Q1AN27_FUGRU 92 3
CKNKSLKCYMLELLMVIDE Q1AN26_TETNG 97 9
CIFKFMHCYLLELEVVLFE Q575Z3_ONCMY 110 4
CTFRFFDCFLLEMKVVLYE Q3SCC6_DANRE 109 2
CTFRFFDCFLLEMKVVLYE Q15KG7_DANRE 109 2
INTRLEUKIN153 Length of motif = 14 Motif number = 3
Interleukin-15 motif III - 2
PCODE ST INT
ECEELEEKNITEFL IL15_RABIT 135 33
ECEELEEKNITEFL Q2PUG6_RABIT 136 34
ECEELEEKNIKEFL IL15_CERAE 135 33
ECEELEEKNIKEFL IL15_MACTH 135 33
ECEELEEKNIKEFL IL15_MACMU 135 33
ECEELEEKNIKEFL IL15_HUMAN 135 33
ECEELEEKNIKEFL Q6FGX7_HUMAN 108 33
ECEELEEKNINEFL IL15_PIG 135 33
ECEELEEKNINEFL Q06F26_PIG 135 33
ECEELEEKNIKEFL IL15_FELCA 135 33
ECEELEEKNINEFL A8WE60_PIG 135 33
VCEELEEKNITEFL Q5EEK6_MARMO 135 33
VCEELEEKNITEFL Q5WQV8_MARMO 135 33
ECEELEEKSIKEFL IL15_BOVIN 135 33
ECEELEEKSIAEFL Q75SZ9_CAVPO 135 33
ECEELEEKSIKEFL IL15_BUBBU 135 33
ECEELEKKSIKEFL IL15_SHEEP 135 33
ECEELEERNFTEFL IL15_RAT 135 33
ECEELEEKTFTEFL IL15_MOUSE 135 33
ECEELEEKTFTEFL Q3U1Z6_MOUSE 135 33
ECEEYEEKNFTEFI A7LLW4_CHICK 158 37
ECEEYEEKNFTEFI Q9W756_CHICK 158 37
ECEEYEEKNFTEFI Q9DEV5_CHICK 158 37
ECEEYEEKNFTEFI B0FLP3_CHICK 158 37
ECEEYEEKSFTEFI Q1HFY0_ANAPL 157 36
PCEEYAIRNITIFL Q3SCC8_FUGRU 127 27
PCEEYAIRNITIFL Q3SCC9_FUGRU 138 27
PCEEYAIRNITMFL Q1AN27_FUGRU 138 27
PCEVYPQNNITIFL Q1AN26_TETNG 143 27
PCEAQRVANSTIFL Q575Z3_ONCMY 165 36
PCELQELTNSTLFF Q3SCC6_DANRE 157 29
PCELQELTNSTLFF Q15KG7_DANRE 157 29
User query: Display/Full Code "INTRLEUKIN15"