WORKLIST ENTRIES (1):
INTRLEUKIN13 View alignment Interleukin-13 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
PFAM; PF03487 IL13
INTERPRO; IPR003634
PDB; 1IJZ 3Dinfo; IGA3 3Dinfo; 1IK0 3Dinfo
SCOP; 1IJZ; IGA3; 1IK0
CATH; 1IJZ; IGA3; 1IK0
MIM; 147683
Creation date 24-JUL-2008
1. MINTY, A., CHALON, P., DEROCQ, J., DUMONT, X., GUILLEMOT, J.,
KAGHAD, M., LABIT, C., LEPLATOIS, P., LIAUZUN, P. AND MILOUX, B.
Interleukin-13 is a new human lymphokine regulating inflammatory and immune
responses.
NATURE 362 248-250 (1993).
2. WILLIS-KARP, M., LUYIMBAZI, J., XU, X., SCHOFIELD, B., NEBEN, T.,
KARP, C. AND DONALDSON, D.
Interleukin-13: central mediator of allergic asthma.
SCIENCE 282 2258-2261 (1998).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-13 (IL-13) inhibits inflammatory cytokine production and
synergises with IL-2 in regulating interferon-gamma synthesis [1]. It has
been identified as a central mediator of allergic asthma [2].
INTRLEUKIN13 is a 4-element fingerprint that provides a signature for
interleukin-13. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motifs 1, 3 and 4 encompassing short helical
regions. Two iterations on SPTR55_38f were required to reach convergence, at
which point a true set comprising 22 sequences was identified. Two partial
matches were also found, Q4VB51_HUMAN and Q4VB53_HUMAN, both of which are
translated human cDNA sequences that fail to match motif 1.
SUMMARY INFORMATION
22 codes involving 4 elements
2 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 22 22 22 22
3| 0 2 2 2
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
IL13_MACMU Q0ZB84_CERTO Q0ZB83_MACNE Q0PW92_MACFA
IL13_MACTH A9CB12_PAPAN IL13_HUMAN Q4VB52_HUMAN
Q4VB50_HUMAN IL13_PANTR IL13_CAMBA IL13_LAMGL
A9QWR5_BOVIN Q3I5F5_BUBBU Q0PW91_SHEEP IL13_BOVIN
IL13_PIG IL13_CANFA IL13_RAT Q7TNZ2_SIGHI
IL13_MOUSE Q5SUZ9_MOUSE
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q4VB51_HUMAN Q4VB53_HUMAN
PROTEIN TITLES
IL13_MACMU Interleukin-13 precursor (IL-13) - Macaca mulatta (Rhesus ma
Q0ZB84_CERTO Interleukin 13 - Cercocebus torquatus atys (Red-crowned mang
Q0ZB83_MACNE Interleukin 13 - Macaca nemestrina (Pig-tailed macaque).
Q0PW92_MACFA IL13 - Macaca fascicularis (Crab eating macaque) (Cynomolgus
IL13_MACTH Interleukin-13 precursor (IL-13) - Macaca thibetana (Pere Da
A9CB12_PAPAN Interleukin 13 (Predicted) - Papio anubis (Olive baboon).
IL13_HUMAN Interleukin-13 precursor (IL-13) - Homo sapiens (Human).
Q4VB52_HUMAN Interleukin 13 - Homo sapiens (Human).
Q4VB50_HUMAN Interleukin 13 - Homo sapiens (Human).
IL13_PANTR Interleukin-13 precursor (IL-13) - Pan troglodytes (Chimpanz
IL13_CAMBA Interleukin-13 precursor (IL-13) - Camelus bactrianus (Bactr
IL13_LAMGL Interleukin-13 precursor (IL-13) - Lama glama (Llama).
A9QWR5_BOVIN Interleukin 13 - Bos taurus (Bovine).
Q3I5F5_BUBBU Interleukin-13 - Bubalus bubalis (Domestic water buffalo).
Q0PW91_SHEEP IL13 - Ovis aries (Sheep).
IL13_BOVIN Interleukin-13 precursor (IL-13) - Bos taurus (Bovine).
IL13_PIG Interleukin-13 precursor (IL-13) - Sus scrofa (Pig).
IL13_CANFA Interleukin-13 precursor (IL-13) - Canis familiaris (Dog).
IL13_RAT Interleukin-13 precursor (IL-13) (T-cell activation protein
Q7TNZ2_SIGHI Interleukin 13 - Sigmodon hispidus (Hispid cotton rat).
IL13_MOUSE Interleukin-13 precursor (IL-13) (T-cell activation protein
Q5SUZ9_MOUSE Interleukin 13 - Mus musculus (Mouse).
Q4VB51_HUMAN IL13 protein - Homo sapiens (Human).
Q4VB53_HUMAN IL13 protein - Homo sapiens (Human).
SCAN HISTORY
SPTR55_38f 2 300 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN131 Length of motif = 19 Motif number = 1
Interleukin-13 motif I - 1
PCODE ST INT
RELIEELSNITQDQKTSLC IL13_RAT 34 34
RELIEELVNITQNQKAPLC IL13_HUMAN 30 30
KELIEELVNITQNQKVPLC IL13_BOVIN 30 30
KELIEELVNITQNQKAPLC IL13_CAMBA 30 30
INTRLEUKIN132 Length of motif = 22 Motif number = 2
Interleukin-13 motif II - 1
PCODE ST INT
MVWSVDLTAGGFCAALESLTNI IL13_RAT 56 3
MVWSINLTAGMYCAALESLINV IL13_HUMAN 52 3
MVWSLNLTSSMYCAALDSLISI IL13_BOVIN 52 3
MVWSINLTTSMYCAARESLINI IL13_CAMBA 52 3
INTRLEUKIN133 Length of motif = 13 Motif number = 3
Interleukin-13 motif III - 1
PCODE ST INT
CNAIHRTQRILNG IL13_RAT 80 2
CSAIEKTQRMLSG IL13_HUMAN 76 2
CSVIQRTKKMLNA IL13_BOVIN 76 2
CSVIQRTQRMLNA IL13_CAMBA 76 2
INTRLEUKIN134 Length of motif = 14 Motif number = 4
Interleukin-13 motif IV - 1
PCODE ST INT
DTKIEVAQFISKLL IL13_RAT 107 14
DTKIEVAQFVKDLL IL13_HUMAN 106 17
DTKIEVAQFLKDLL IL13_BOVIN 106 17
DTKIEVTQFIKTLL IL13_CAMBA 105 16
FINAL MOTIF SETS
INTRLEUKIN131 Length of motif = 19 Motif number = 1
Interleukin-13 motif I - 2
PCODE ST INT
KELIEELVNITQNQKAPLC IL13_MACMU 30 30
KELIEELVNITQNQKAPLC Q0ZB84_CERTO 30 30
KELIEELVNITQNQKAPLC Q0ZB83_MACNE 30 30
KELIEELVNITQNQKAPLC Q0PW92_MACFA 30 30
KELIEELVNITQNQKAPLC IL13_MACTH 30 30
RELIEELVNITQNQKAPLC A9CB12_PAPAN 30 30
RELIEELVNITQNQKAPLC IL13_HUMAN 30 30
RELIEELVNITQNQKAPLC Q4VB52_HUMAN 44 44
RELIEELVNITQNQKAPLC Q4VB50_HUMAN 30 30
RELIEELVNITQNQKAPLC IL13_PANTR 30 30
KELIEELVNITQNQKAPLC IL13_CAMBA 30 30
KELIEELVNITQNQKAPLC IL13_LAMGL 30 30
KELIEELVNITQNQKVPLC A9QWR5_BOVIN 30 30
KELIEELVNITQNQKVPLC Q3I5F5_BUBBU 30 30
KELIEELVNITQNQKVPLC Q0PW91_SHEEP 30 30
KELIEELVNITQNQKVPLC IL13_BOVIN 30 30
KELIEELVNITQNQKTPLC IL13_PIG 31 31
KELIEELVNITQNQASLCN IL13_CANFA 30 30
RELIEELSNITQDQKTSLC IL13_RAT 34 34
KELIEELSNITQDQRAPLC Q7TNZ2_SIGHI 34 34
KELIEELSNITQDQTPLCN IL13_MOUSE 34 34
KELIEELSNITQDQTPLCN Q5SUZ9_MOUSE 34 34
INTRLEUKIN132 Length of motif = 22 Motif number = 2
Interleukin-13 motif II - 2
PCODE ST INT
MVWSINLTAGVYCAALESLINV IL13_MACMU 52 3
MVWSINLTAGVYCAALESLINV Q0ZB84_CERTO 52 3
MVWSINLTAGVYCAALESLINV Q0ZB83_MACNE 52 3
MVWSINLTAGVYCAALESLINV Q0PW92_MACFA 52 3
MVWSINLTAGVYCAALESLINV IL13_MACTH 52 3
MVWSINLTAGVYCAALESLINV A9CB12_PAPAN 52 3
MVWSINLTAGMYCAALESLINV IL13_HUMAN 52 3
MVWSINLTAGMYCAALESLINV Q4VB52_HUMAN 66 3
MVWSINLTAGMYCAALESLINV Q4VB50_HUMAN 52 3
MVWSINLTAGVYCAALESLINV IL13_PANTR 52 3
MVWSINLTTSMYCAARESLINI IL13_CAMBA 52 3
MVWSINLTTSMYCAARESLINI IL13_LAMGL 52 3
MVWSLNLTSSMYCAALDSLISI A9QWR5_BOVIN 52 3
MVWSLNLTSSMYCAALDSLISI Q3I5F5_BUBBU 52 3
MVWSLNLTSSMYCAALDSLISI Q0PW91_SHEEP 52 3
MVWSLNLTSSMYCAALDSLISI IL13_BOVIN 52 3
VWSVNLTTSMQYCAALESLINI IL13_PIG 54 4
MVWSVNLTAGMYCAALESLINV IL13_CANFA 51 2
MVWSVDLTAGGFCAALESLTNI IL13_RAT 56 3
MVWSVDLTAGGFCGALDSLTNI Q7TNZ2_SIGHI 56 3
MVWSVDLAAGGFCVALDSLTNI IL13_MOUSE 55 2
MVWSVDLAAGGFCVALDSLTNI Q5SUZ9_MOUSE 55 2
INTRLEUKIN133 Length of motif = 13 Motif number = 3
Interleukin-13 motif III - 2
PCODE ST INT
CSAIEKTQRMLNG IL13_MACMU 76 2
CSAIEKTQRMLNG Q0ZB84_CERTO 76 2
CSAIEKTQRMLNG Q0ZB83_MACNE 76 2
CSAIEKTQRMLNG Q0PW92_MACFA 76 2
CSAIEKTQRMLNG IL13_MACTH 76 2
CSAIEKTQRMLNG A9CB12_PAPAN 76 2
CSAIEKTQRMLSG IL13_HUMAN 76 2
CSAIEKTQRMLSG Q4VB52_HUMAN 90 2
CSAIEKTQRMLSG Q4VB50_HUMAN 76 2
CSAIEKTQRMLSG IL13_PANTR 76 2
CSVIQRTQRMLNA IL13_CAMBA 76 2
CSVIQRTQRMLNA IL13_LAMGL 76 2
CSVIQRTKRMLNA A9QWR5_BOVIN 76 2
CSVIQRTKRMLNA Q3I5F5_BUBBU 76 2
CSVIHRTKRMLSA Q0PW91_SHEEP 76 2
CSVIQRTKKMLNA IL13_BOVIN 76 2
CSAIQKTQRMLSA IL13_PIG 78 2
CSAIQRTQRMLKA IL13_CANFA 75 2
CNAIHRTQRILNG IL13_RAT 80 2
CKPIYKTQRLLNA Q7TNZ2_SIGHI 80 2
CNAIYRTQRILHG IL13_MOUSE 79 2
CNAIYRTQRILHG Q5SUZ9_MOUSE 79 2
INTRLEUKIN134 Length of motif = 14 Motif number = 4
Interleukin-13 motif IV - 2
PCODE ST INT
DTKIEVAQFVKDLL IL13_MACMU 106 17
DTKIEVAQFVKDLL Q0ZB84_CERTO 106 17
DTKIEVAQFVKDLL Q0ZB83_MACNE 106 17
DTKIEVAQFVKDLL Q0PW92_MACFA 106 17
DTKIEVAQFVKDLL IL13_MACTH 106 17
DTKIEVAQFVKDLL A9CB12_PAPAN 106 17
DTKIEVAQFVKDLL IL13_HUMAN 106 17
DTKIEVAQFVKDLL Q4VB52_HUMAN 120 17
DTKIEVAQFVKDLL Q4VB50_HUMAN 106 17
DTKIEVAQFVKDLL IL13_PANTR 106 17
DTKIEVTQFIKTLL IL13_CAMBA 105 16
DTKIEVTQFIKTLL IL13_LAMGL 105 16
DTKIEVAQFLKDLL A9QWR5_BOVIN 106 17
DTKIEVAQFLKDLL Q3I5F5_BUBBU 106 17
DTKIEVAQFLKDLL Q0PW91_SHEEP 106 17
DTKIEVAQFLKDLL IL13_BOVIN 106 17
DTKIEVAQFVKDLL IL13_PIG 108 17
DTKIEVIQLVKNLL IL13_CANFA 105 17
DTKIEVAQFISKLL IL13_RAT 107 14
DTKIEVVQFITTLL Q7TNZ2_SIGHI 107 14
DTKIEVAHFITKLL IL13_MOUSE 106 14
DTKIEVAHFITKLL Q5SUZ9_MOUSE 106 14
User query: Display/Full Code "INTRLEUKIN13"