WORKLIST ENTRIES (1):
INTRLEUKIN11 View alignment Interleukin-11 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR01943 INTLKN11MAML; PR01944 INTLKN11FISH
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
PFAM; PF07400 IL11
INTERPRO; IPR010873
MIM; 147681
Creation date 23-JUL-2008
1. LENG, S. AND ELIAS, J.
Interleukin-11.
INT.J.BIOCHEM.CELL BIOL. 29 1059-1062 (1997).
2. TREPICCHIO, W. AND DORNER, A.
The therapeutic utility of Interleukin-11 in the treatment of inflammatory
disease.
EXPERT OPIN.INVESTIG.DRUGS 7 1501-1504 (1998).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates
megakaryocytopoiesis, resulting in increased production of platelets, as
well as activating osteoclasts, inhibiting epithelial cell proliferation
and apoptosis, and inhibiting macrophage mediator production. These
functions may be particularly important in mediating the hematopoietic,
osseous and mucosal protective effects of IL-11 [1]. The cytokine also
possesses anti-inflammatory activity, and has been proposed as a therapeutic
agent in the treatment of chronic inflammatory diseases, such as Crohn's
disease and rheumatoid arthritis [2].
INTRLEUKIN11 is a 3-element fingerprint that provides a signature for
interleukin-11. The fingerprint was derived from an initial alignment of 15
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length. A single iteration on SPTR55_38f was required to
reach convergence, no further sequences being identified beyond the
starting set.
SUMMARY INFORMATION
15 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 15 15 15
2| 0 0 0
--+----------------
| 1 2 3
True positives..
A3KPB8_MOUSE IL11_MOUSE IL11_MACFA IL11_HUMAN
A8K3F7_HUMAN IL11_RAT Q6UAM0_TETNG Q4H133_CYPCA
Q494Q7_TETNG Q5NKG1_ONCMY Q494Q9_FUGRU Q494Q5_DANRE
Q494Q8_FUGRU A8CEL7_PAROL Q494Q4_DANRE
PROTEIN TITLES
A3KPB8_MOUSE Interleukin 11 - Mus musculus (Mouse).
IL11_MOUSE Interleukin-11 precursor (IL-11) - Mus musculus (Mouse).
IL11_MACFA Interleukin-11 precursor (IL-11) - Macaca fascicularis (Crab
IL11_HUMAN Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory fa
A8K3F7_HUMAN cDNA FLJ78117, highly similar to Homo sapiens interleukin 11
IL11_RAT Interleukin-11 precursor (IL-11) - Rattus norvegicus (Rat).
Q6UAM0_TETNG Interleukin-11 - Tetraodon nigroviridis (Green puffer).
Q4H133_CYPCA Interleukin-11 - Cyprinus carpio (Common carp).
Q494Q7_TETNG Interleukin-11a - Tetraodon nigroviridis (Green puffer).
Q5NKG1_ONCMY Interleukin-11 (Interleukin-11 precursor) - Oncorhynchus myk
Q494Q9_FUGRU Interleukin-11a - Fugu rubripes (Japanese pufferfish) (Takif
Q494Q5_DANRE Interleukin-11a - Danio rerio (Zebrafish) (Brachydanio rerio
Q494Q8_FUGRU Interleukin-11b - Fugu rubripes (Japanese pufferfish) (Takif
A8CEL7_PAROL Interleukin 11 type b - Paralichthys olivaceus (Japanese flo
Q494Q4_DANRE Interleukin-11b - Danio rerio (Zebrafish) (Brachydanio rerio
SCAN HISTORY
SPTR55_38f 1 300 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN111 Length of motif = 11 Motif number = 1
Interleukin-11 motif I - 1
PCODE ST INT
LDSLPTLAMSA IL11_RAT 72 72
LDSLPTLAMSA IL11_MOUSE 72 72
LDSLPTLAMSA A3KPB8_MOUSE 72 72
LDSLPTLAMSA IL11_MACFA 72 72
LDSLPTLAMSA IL11_HUMAN 72 72
LDSLPTLAMSA A8K3F7_HUMAN 72 72
FPSLPEMSNRS Q494Q7_TETNG 69 69
FTSLPEMSNRS Q494Q9_FUGRU 69 69
FKSLPLMNNRA Q5NKG1_ONCMY 72 72
FKSLPAISSRA Q494Q5_DANRE 70 70
FKSLPAISSRV Q4H133_CYPCA 70 70
LDSLPHLQHSA Q6UAM0_TETNG 73 73
LDTLPHLPHSA Q494Q8_FUGRU 73 73
LSSLPSLNYSV Q494Q4_DANRE 68 68
LPDLPHMQHSA A8CEL7_PAROL 72 72
INTRLEUKIN112 Length of motif = 10 Motif number = 2
Interleukin-11 motif II - 1
PCODE ST INT
YFRHVQWLRR IL11_RAT 104 21
YLRHVQWLRR IL11_MOUSE 104 21
YLRHVQWLRR A3KPB8_MOUSE 104 21
YLRHVQWLRR IL11_MACFA 104 21
YLRHVQWLRR IL11_HUMAN 104 21
YLRHVQWLRR A8K3F7_HUMAN 104 21
YEHHFEWLNR Q494Q7_TETNG 102 22
YEHHFEWLNR Q494Q9_FUGRU 102 22
FEHHFAWLSR Q5NKG1_ONCMY 104 21
FQHHFEWLNN Q494Q5_DANRE 102 21
FEHHFEWLNR Q4H133_CYPCA 102 21
FRQHVDWLKR Q6UAM0_TETNG 105 21
FRQHIDWLKL Q494Q8_FUGRU 105 21
FKFHLDWVQR Q494Q4_DANRE 100 21
FRLHVDWLKT A8CEL7_PAROL 105 22
INTRLEUKIN113 Length of motif = 11 Motif number = 3
Interleukin-11 motif III - 1
PCODE ST INT
HLTLDWAVRGL IL11_RAT 182 68
HLTLDWAVRGL IL11_MOUSE 182 68
HLTLDWAVRGL A3KPB8_MOUSE 182 68
HLTLDWAVRGL IL11_MACFA 182 68
HLTLDWAVRGL IL11_HUMAN 182 68
HLTLDWAVRGL A8K3F7_HUMAN 182 68
KLFCDWAYRAF Q494Q7_TETNG 179 67
KLFCDWAYRAF Q494Q9_FUGRU 179 67
RLFCDWAQRVF Q5NKG1_ONCMY 181 67
SLFCDWAARVL Q494Q5_DANRE 178 66
RLFCDWASRVF Q4H133_CYPCA 179 67
TVFCDWTKRVL Q6UAM0_TETNG 180 65
KIFCHWSKRVL Q494Q8_FUGRU 180 65
LIFCDYYTRAL Q494Q4_DANRE 172 62
KVFCNWSKRVL A8CEL7_PAROL 180 65
FINAL MOTIF SETS
INTRLEUKIN111 Length of motif = 11 Motif number = 1
Interleukin-11 motif I - 1
PCODE ST INT
LDSLPTLAMSA A3KPB8_MOUSE 72 72
LDSLPTLAMSA IL11_MOUSE 72 72
LDSLPTLAMSA IL11_MACFA 72 72
LDSLPTLAMSA IL11_HUMAN 72 72
LDSLPTLAMSA A8K3F7_HUMAN 72 72
LDSLPTLAMSA IL11_RAT 72 72
LDSLPHLQHSA Q6UAM0_TETNG 73 73
FKSLPAISSRV Q4H133_CYPCA 70 70
FPSLPEMSNRS Q494Q7_TETNG 69 69
FKSLPLMNNRA Q5NKG1_ONCMY 72 72
FTSLPEMSNRS Q494Q9_FUGRU 69 69
FKSLPAISSRA Q494Q5_DANRE 70 70
LDTLPHLPHSA Q494Q8_FUGRU 73 73
LPDLPHMQHSA A8CEL7_PAROL 72 72
LSSLPSLNYSV Q494Q4_DANRE 68 68
INTRLEUKIN112 Length of motif = 10 Motif number = 2
Interleukin-11 motif II - 1
PCODE ST INT
YLRHVQWLRR A3KPB8_MOUSE 104 21
YLRHVQWLRR IL11_MOUSE 104 21
YLRHVQWLRR IL11_MACFA 104 21
YLRHVQWLRR IL11_HUMAN 104 21
YLRHVQWLRR A8K3F7_HUMAN 104 21
YFRHVQWLRR IL11_RAT 104 21
FRQHVDWLKR Q6UAM0_TETNG 105 21
FEHHFEWLNR Q4H133_CYPCA 102 21
YEHHFEWLNR Q494Q7_TETNG 102 22
FEHHFAWLSR Q5NKG1_ONCMY 104 21
YEHHFEWLNR Q494Q9_FUGRU 102 22
FQHHFEWLNN Q494Q5_DANRE 102 21
FRQHIDWLKL Q494Q8_FUGRU 105 21
FRLHVDWLKT A8CEL7_PAROL 105 22
FKFHLDWVQR Q494Q4_DANRE 100 21
INTRLEUKIN113 Length of motif = 11 Motif number = 3
Interleukin-11 motif III - 1
PCODE ST INT
HLTLDWAVRGL A3KPB8_MOUSE 182 68
HLTLDWAVRGL IL11_MOUSE 182 68
HLTLDWAVRGL IL11_MACFA 182 68
HLTLDWAVRGL IL11_HUMAN 182 68
HLTLDWAVRGL A8K3F7_HUMAN 182 68
HLTLDWAVRGL IL11_RAT 182 68
TVFCDWTKRVL Q6UAM0_TETNG 180 65
RLFCDWASRVF Q4H133_CYPCA 179 67
KLFCDWAYRAF Q494Q7_TETNG 179 67
RLFCDWAQRVF Q5NKG1_ONCMY 181 67
KLFCDWAYRAF Q494Q9_FUGRU 179 67
SLFCDWAARVL Q494Q5_DANRE 178 66
KIFCHWSKRVL Q494Q8_FUGRU 180 65
KVFCNWSKRVL A8CEL7_PAROL 180 65
LIFCDYYTRAL Q494Q4_DANRE 172 62
User query: Display/Full Code "INTRLEUKIN11"