WORKLIST ENTRIES (1):
INTRLEUKIN10 View alignment View Structure Interleukin-10 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCXC
PROSITE; PS00520 INTERLEUKIN_10
PFAM; PF00726 IL10
PDB; 1ILK 3Dinfo
SCOP; 1ILK
CATH; 1ILK
Creation date 08-MAR-2000
1. NICOLA N.A.
Interleukin-10 (IL-10).
IN GUIDEBOOK TO CYTOKINES AND THEIR RECEPTORS, NEW YORK, 1994, PP.83-85.
2. ZDANOV A., SCHALK-HIHI C., GUSTCHINA A., TSANG M., WEATHERBEE J.
AND WLODAWER, A.
Crystal structure of interleukin-10 reveals the functional dimer with an
unexpected topological similarity to interferon gamma.
STRUCTURE 3 591-601 (1995).
Interleukin 10 (IL-10) is a secreted 17-21kDa protein that is non-
glycosylated in humans but exists as a non-covalent homodimer. IL-10 is
secreted by some types of T-lymphocyte, B-lymphocytes and macrophages late
after antigen activation.
Generally, IL-10 inhibits T-cell and natural killer cell synthesis of other
cytokines at the transcriptional level, indirectly, by affecting
macrophages. These cytokines include interferon-gamma, IL-2, IL-3, tumour
necrosis factor and granulocyte-macrophage colony-stimulating factor
(GM-CSF). The mechanism of IL-10 induced inhibition appears to involve a
reduction in the abundance of the macrophage surface molecules that directly
stimulate T-cells and natural killer cells [1].
Proteins encoded by viruses such as Epstein-Barr virus and equine herpes
virus show a high degree of sequence identity to IL-10. These proteins are
thought to be involved in evasion of host immune responses. The IL-10
molecule is a tight dimer of 2 interpenetrating subunits that form a
V-shaped structure. Each half of the structure consists of 6 alpha-helices
(4 from 1 subunit and 2 from the other). Four of the helices form an
up-up-down-down bundle, which is observed in all other helical cytokines.
The overall topology resembles interferon-gamma [2].
INTRLEUKIN10 is a 4-element fingerprint that provides a signature for
interleukin-10. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning the full
alignment length - motif 1 spans alpha-helix 1; motif 2 contains helix 3 and
the preceding loop; motif 3 contains helix 7 and the preceding loop; and
motif 4 spans helix 9 and the N-terminal portion of helix 10. Two iterations
on SPTR37_10f were required to reach convergence, at which point a true set
comprising 21 sequences was identified.
SUMMARY INFORMATION
21 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 21 21 21 21
3| 0 0 0 0
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
IL10_MACFA IL10_MACNE IL10_MACMU I10H_HSVE2
IL10_HORSE IL10_MERUN O11386 O11387
BCRF_EBV IL10_HUMAN IL10_CERTO IL10_CEREL
Q9Z1Y5 IL10_CANFA IL10_FELCA IL10_BOVIN
IL10_SHEEP IL10_RAT IL10_PIG IL10_MOUSE
O97798
PROTEIN TITLES
IL10_MACFA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_MACNE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_MACMU INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
I10H_HSVE2 INTERLEUKIN-10 HOMOLOG PRECURSOR - EQUINE HERPESVIRUS TYPE 2
IL10_HORSE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_MERUN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
O11386 INTERLEUKIN-10 - ORF VIRUS.
O11387 PUTATIVE INTERLEUKIN-10 - ORF VIRUS.
BCRF_EBV BCRF1 PROTEIN PRECURSOR (20 KD PROTEIN) - EPSTEIN-BARR VIRUS
IL10_HUMAN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_CERTO INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_CEREL INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
Q9Z1Y5 INTERLEUKIN 10 - CAVIA PORCELLUS (GUINEA PIG).
IL10_CANFA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_FELCA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_BOVIN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_SHEEP INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_RAT INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_PIG INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
IL10_MOUSE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBIT
O97798 INTERLEUKIN-10 - TRICHOSURUS VULPECULA (BRUSH-TAILED POSSUM)
SCAN HISTORY
SPTR37_10f 2 200 NSINGLE
INITIAL MOTIF SETS
INTRLEUKIN101 Length of motif = 17 Motif number = 1
Interleukin-10 motif I - 1
PCODE ST INT
MLRDLRDAFSRVKTFFQ IL10_HUMAN 40 40
MLRDLRDAFSRVKTFFQ IL10_MACNE 40 40
MLRELRAAFGRVKIFFQ IL10_CANFA 41 41
MLLELRTAFSQVKTFFQ IL10_MOUSE 40 40
MLRDLRDAFSRVKTFFQ BCRF_EBV 33 33
MLRELRAAFSSVKTYFQ O97798 36 36
INTRLEUKIN102 Length of motif = 17 Motif number = 2
Interleukin-10 motif II - 1
PCODE ST INT
KGYLGCQALSEMIQFYL IL10_HUMAN 75 18
KGYLGCQALSEMIQFYL IL10_MACNE 75 18
KSYLGCQALSEMIQFYL IL10_CANFA 76 18
KGYLGCQALSEMIQFYL IL10_MOUSE 75 18
KGYLGCQALSEMIQFYL BCRF_EBV 68 18
KSYLGCQALSEMIKFYL O97798 71 18
INTRLEUKIN103 Length of motif = 10 Motif number = 3
Interleukin-10 motif III - 1
PCODE ST INT
RRCHRFLPCE IL10_HUMAN 124 32
RRCHRFLPCE IL10_MACNE 124 32
RRCHRFLPCE IL10_CANFA 127 34
RRCHRFLKCE IL10_MOUSE 124 32
RRCHRFLPCE BCRF_EBV 117 32
KRCHRFLPCE O97798 120 32
INTRLEUKIN104 Length of motif = 17 Motif number = 4
Interleukin-10 motif IV - 1
PCODE ST INT
LQEKGIYKAMSEFDIFI IL10_HUMAN 149 15
LQEKGVYKAMSEFDIFI IL10_MACNE 149 15
LQEKGVYKAMSEFDIFI IL10_CANFA 152 15
LEDQGVYKAMNEFDIFI IL10_MOUSE 149 15
LQEKGIYKAMSEFDIFI BCRF_EBV 142 15
LQEQGVYKAMGDFDIFI O97798 145 15
FINAL MOTIF SETS
INTRLEUKIN101 Length of motif = 17 Motif number = 1
Interleukin-10 motif I - 2
PCODE ST INT
MLRDLRDAFSRVKTFFQ IL10_MACFA 40 40
MLRDLRDAFSRVKTFFQ IL10_MACNE 40 40
MLRDLRDAFSRVKTFFQ IL10_MACMU 40 40
MLHELRAAFSRVKTFFQ I10H_HSVE2 40 40
MLHELRAAFSRVKTFFQ IL10_HORSE 40 40
MLRELRAAFSQVKTFFQ IL10_MERUN 40 40
MLRELRAAFGKVKTFFQ O11386 50 50
MLRELRAAFGKVKTFFQ O11387 50 50
MLRDLRDAFSRVKTFFQ BCRF_EBV 33 33
MLRDLRDAFSRVKTFFQ IL10_HUMAN 40 40
MLRDLRDVFSRVKTFFQ IL10_CERTO 40 40
MLRELRTAFSRVKNFFQ IL10_CEREL 41 41
MLRELRAAFGRVKTFFQ Q9Z1Y5 40 40
MLRELRAAFGRVKIFFQ IL10_CANFA 41 41
MLXELRAAFGKVKTFFQ IL10_FELCA 40 40
MLRELRAAFGEAKTFFQ IL10_BOVIN 40 40
MLRDVRAAFGKVKTFFQ IL10_SHEEP 41 41
MLRELRAAFSQVKTFFQ IL10_RAT 40 40
MLRELRAAFGPVKSFFQ IL10_PIG 36 36
MLLELRTAFSQVKTFFQ IL10_MOUSE 40 40
MLRELRAAFSSVKTYFQ O97798 36 36
INTRLEUKIN102 Length of motif = 17 Motif number = 2
Interleukin-10 motif II - 2
PCODE ST INT
KGYLGCQALSEMIQFYL IL10_MACFA 75 18
KGYLGCQALSEMIQFYL IL10_MACNE 75 18
KGYLGCQALSEMIQFYL IL10_MACMU 75 18
KGYLGCQALSEMIQFYL I10H_HSVE2 75 18
KGYLGCQALSEMIQFYL IL10_HORSE 75 18
KGYLGCQALSEMIQFYL IL10_MERUN 75 18
KGYLGCQALSEMIQFYL O11386 85 18
KGYLGCQALSEMIQFYL O11387 85 18
KGYLGCQALSEMIQFYL BCRF_EBV 68 18
KGYLGCQALSEMIQFYL IL10_HUMAN 75 18
KGYLGCQALSEMIQFYL IL10_CERTO 75 18
KGYLGCQALSEMIQFYL IL10_CEREL 76 18
KGYLGCQALSEMIQFYL Q9Z1Y5 75 18
KSYLGCQALSEMIQFYL IL10_CANFA 76 18
KGYLGCQALSEMIQFYL IL10_FELCA 75 18
KGYLGCQALSEMIQFYL IL10_BOVIN 75 18
KGYLGCQALSEMIQFYL IL10_SHEEP 76 18
KGYLGCQALSEMIKFYL IL10_RAT 75 18
KGYLGCQALSEMIQFYL IL10_PIG 71 18
KGYLGCQALSEMIQFYL IL10_MOUSE 75 18
KSYLGCQALSEMIKFYL O97798 71 18
INTRLEUKIN103 Length of motif = 10 Motif number = 3
Interleukin-10 motif III - 2
PCODE ST INT
RRCHRFLPCE IL10_MACFA 124 32
RRCHRFLPCE IL10_MACNE 124 32
RRCHRFLPCE IL10_MACMU 124 32
RRCHRFLPCE I10H_HSVE2 125 33
RRCHRFLPCE IL10_HORSE 124 32
RRCHRFLPCE IL10_MERUN 124 32
RRCHRFLPCE O11386 134 32
RRCHRFLPCE O11387 134 32
RRCHRFLPCE BCRF_EBV 117 32
RRCHRFLPCE IL10_HUMAN 124 32
RRCHRFLPCE IL10_CERTO 124 32
RRCHRFLPCE IL10_CEREL 125 32
RRCHRFLPCE Q9Z1Y5 124 32
RRCHRFLPCE IL10_CANFA 127 34
RRCHRFLPCE IL10_FELCA 124 32
RRCHRFLPCE IL10_BOVIN 124 32
RRCHRFLPCE IL10_SHEEP 125 32
RRCHRFLPCE IL10_RAT 124 32
RRCHQFLPCE IL10_PIG 120 32
RRCHRFLKCE IL10_MOUSE 124 32
KRCHRFLPCE O97798 120 32
INTRLEUKIN104 Length of motif = 17 Motif number = 4
Interleukin-10 motif IV - 2
PCODE ST INT
LQEKGVYKAMSEFDIFI IL10_MACFA 149 15
LQEKGVYKAMSEFDIFI IL10_MACNE 149 15
LQEKGVYKAMSEFDIFI IL10_MACMU 149 15
LQEKGVYKAMSEFDIFI I10H_HSVE2 150 15
LQEKGVYKAMSEFDIFI IL10_HORSE 149 15
LQEKGVYKAMNEFDIFI IL10_MERUN 149 15
LQERGVYKAMSEFDIFI O11386 159 15
LQERGVYKAMSEFDIFI O11387 159 15
LQEKGIYKAMSEFDIFI BCRF_EBV 142 15
LQEKGIYKAMSEFDIFI IL10_HUMAN 149 15
LQEKGVYKAMSEFDIFI IL10_CERTO 149 15
LQERGVYKAMSEFDIFI IL10_CEREL 150 15
LQDQGVYKAMNEFDIFI Q9Z1Y5 149 15
LQEKGVYKAMSEFDIFI IL10_CANFA 152 15
LQEKGVYKAMGEFDIFI IL10_FELCA 149 15
LQERGVYKAMSEFDIFI IL10_BOVIN 149 15
LQERGVYKAMSEFDIFI IL10_SHEEP 150 15
LQDKGVYKAMNEFDIFI IL10_RAT 149 15
LQERGVYKAMGEFDIFI IL10_PIG 145 15
LEDQGVYKAMNEFDIFI IL10_MOUSE 149 15
LQEQGVYKAMGDFDIFI O97798 145 15
User query: Display/Full Code "INTRLEUKIN10"