WORKLIST ENTRIES (1):
INTERLEUKIN9 View alignment Interleukin-9 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01294 INTRLEUKIN10
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCX
INTERPRO; IPR003630
MIM; 146931
Creation date 24-JUL-2008
1. LAUDER, A., JOLIN, H., SMITH, P., VAN DEN BERG, J., JONES, A.,
WISDEN, W., SMITH, K., DASVARMA, A., FALLON, P. AND MCKENZIE, A.
Lymphomagenesis, hydronephrosis, and autoantibodies result from
dysregulation of IL-9 and are differentially dependent on Th2 cytokines.
J.IMMUNOL. 173 113-122 (2004).
2. KNOOPS, L. AND RENAULD, J.
IL-9 and its Receptor: From Signal Transduction to Tumorigenesis.
GROWTH FACTORS 22 207-215 (2004).
3. TOWNSEND, M., FALLON, P., MATTHEWS, D., SMITH, P., JOLIN, H. AND
MCKENZIE, A.
IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary
mastocytosis and goblet cell hyperplasia but not T cell development.
IMMUNITY 13 573-583 (2000).
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-9 (IL-9) is expressed primarily by activated T cells [1]. The
growth factor and anti-apoptotic activities of IL-9 on multiple transformed
cells suggest a potential role for the cytokine in tumourigenesis [2]. IL-9
has also been proposed as a candidate gene for asthma [3].
INTERLEUKIN9 is a 3-element fingerprint that provides a signature for
interleukin-9. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning the
C-terminal two thirds of the alignment. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 7
sequences was identified.
SUMMARY INFORMATION
7 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 7 7 7
2| 0 0 0
--+----------------
| 1 2 3
True positives..
IL9_HUMAN Q6NZ75_HUMAN Q6NZ74_HUMAN Q7TNZ3_SIGHI
IL9_MOUSE Q38JW2_XENTR Q38JW3_XENTR
PROTEIN TITLES
IL9_HUMAN Interleukin-9 precursor (IL-9) (T-cell growth factor P40) (P
Q6NZ75_HUMAN Interleukin 9 - Homo sapiens (Human).
Q6NZ74_HUMAN Interleukin 9 - Homo sapiens (Human).
Q7TNZ3_SIGHI Interleukin 9 - Sigmodon hispidus (Hispid cotton rat).
IL9_MOUSE Interleukin-9 precursor (IL-9) (T-cell growth factor P40) (P
Q38JW2_XENTR Interleukin-9 - Xenopus tropicalis (Western clawed frog) (Si
Q38JW3_XENTR Interleukin-9 - Xenopus tropicalis (Western clawed frog) (Si
SCAN HISTORY
SPTR55_38f 2 300 NSINGLE
INITIAL MOTIF SETS
INTERLEUKIN91 Length of motif = 11 Motif number = 1
Interleukin-9 motif I - 1
PCODE ST INT
TSCLCLSVPTD IL9_MOUSE 52 52
TSCLCLGIPSD IL9_HUMAN 52 52
NMCGCLDIPQN Q38JW2_XENTR 51 51
NMCGCLDIPQN Q38JW3_XENTR 48 48
INTERLEUKIN92 Length of motif = 10 Motif number = 2
Interleukin-9 motif II - 1
PCODE ST INT
TTPCYREGLL IL9_MOUSE 65 2
TRPCFSERLS IL9_HUMAN 65 2
SLSCFNSGLQ Q38JW2_XENTR 64 2
SLSCFNSGLQ Q38JW3_XENTR 61 2
INTERLEUKIN93 Length of motif = 10 Motif number = 3
Interleukin-9 motif III - 1
PCODE ST INT
GNTLSFLKSL IL9_MOUSE 119 44
GNALTFLKSL IL9_HUMAN 119 44
GNWYSFLEEL Q38JW2_XENTR 116 42
GNWYSFLEEL Q38JW3_XENTR 113 42
FINAL MOTIF SETS
INTERLEUKIN91 Length of motif = 11 Motif number = 1
Interleukin-9 motif I - 2
PCODE ST INT
TSCLCLGIPSD IL9_HUMAN 52 52
TSCLCLGIPSD Q6NZ75_HUMAN 52 52
TSCPCLGIPSD Q6NZ74_HUMAN 52 52
TSCLCLPIPSD Q7TNZ3_SIGHI 55 55
TSCLCLSVPTD IL9_MOUSE 52 52
NMCGCLDIPQN Q38JW2_XENTR 51 51
NMCGCLDIPQN Q38JW3_XENTR 48 48
INTERLEUKIN92 Length of motif = 10 Motif number = 2
Interleukin-9 motif II - 2
PCODE ST INT
TRPCFSERLS IL9_HUMAN 65 2
TRPCFSERLS Q6NZ75_HUMAN 65 2
TRPCFSERLS Q6NZ74_HUMAN 65 2
TVPCFREGLS Q7TNZ3_SIGHI 68 2
TTPCYREGLL IL9_MOUSE 65 2
SLSCFNSGLQ Q38JW2_XENTR 64 2
SLSCFNSGLQ Q38JW3_XENTR 61 2
INTERLEUKIN93 Length of motif = 10 Motif number = 3
Interleukin-9 motif III - 2
PCODE ST INT
GNALTFLKSL IL9_HUMAN 119 44
GNALTFLKSL Q6NZ75_HUMAN 119 44
GNALTFLKSL Q6NZ74_HUMAN 119 44
GNTLSFLKNL Q7TNZ3_SIGHI 122 44
GNTLSFLKSL IL9_MOUSE 119 44
GNWYSFLEEL Q38JW2_XENTR 116 42
GNWYSFLEEL Q38JW3_XENTR 113 42
User query: Display/Full Code "INTERLEUKIN9"