WORKLIST ENTRIES (1):
INTERLEUKIN7 View alignment Interleukin-7 signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9; PR01294 INTRLEUKIN10
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCXC
INTERPRO; IPR001181
PROSITE; PS00255 INTERLEUKIN_7
Creation date 30-NOV-1995; UPDATE 07-JUN-1999
1. GOODWIN, R.G., LUPTON, S., SCHMIERER, A., HJERRILD, K.J., JERZY, R.,
CLEVENGER, W., GILLIS, S., COSMAN, D. AND NAMEN, A.E.
Human interleukin 7: molecular cloning and growth factor activity on human
and murine B-lineage cells.
PROC.NATL.ACAD.SCI.U.S.A. 86 302-306 (1989).
2. NAMEN, A.E., LUPTON, S., HJERRILD, K.J., WIGNALL, J., MOCHIZUKI, D.Y.,
SCHMIERER, A., MOSLEY, B., MARCH, C.J., URDAL, D. AND GILLIS, S.
Stimulation of B-cell progenitors by cloned murine interleukin-7.
NATURE 333 571-573 (1988).
Interleukins are soluble factors that stimulate growth-related activities
of leukocytes and other cell types [1]: they enhance cell proliferation and
differentiation, DNA synthesis, secretion of other biologically active
molecules, and responses to immune and inflammatory stimuli [1,2].
Interleukin-7 (IL7) is a hematopoietic growth factor produced by bone
marrow stromal cells [1,2]. It promotes growth of B-cell precursors, and
functions with IL2 in the activation of mature T-cells [1,2].
INTERLEUKIN7 is a 6-element fingerprint that provides a signature for
interleukin-7. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length - motif 7 spans the region encoded by PROSITE
pattern INTERLEUKIN_7 (PS00255), a conserved heptapeptide in the C-terminal
region of the protein. A single iteration on OWL26.3 was required to reach
convergence, no further sequences being identified behyond the starting set.
An update on SPTR37_9f identified a true set of 5 sequences.
SUMMARY INFORMATION
5 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 5 5 5 5 5 5
5| 0 0 0 0 0 0
4| 0 0 0 0 0 0
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
IL7_SHEEP IL7_BOVIN IL7_MOUSE IL7_RAT
IL7_HUMAN
PROTEIN TITLES
IL7_SHEEP INTERLEUKIN-7 PRECURSOR (IL-7) - OVIS ARIES (SHEEP).
IL7_BOVIN INTERLEUKIN-7 PRECURSOR (IL-7) - BOS TAURUS (BOVINE).
IL7_MOUSE INTERLEUKIN-7 PRECURSOR (IL-7) - MUS MUSCULUS (MOUSE).
IL7_RAT INTERLEUKIN-7 PRECURSOR (IL-7) - RATTUS NORVEGICUS (RAT).
IL7_HUMAN INTERLEUKIN-7 PRECURSOR (IL-7) - HOMO SAPIENS (HUMAN).
SCAN HISTORY
OWL26_3 1 100 NSINGLE
SPTR37_9f 2 6 NSINGLE
INITIAL MOTIF SETS
INTERLEUKIN71 Length of motif = 24 Motif number = 1
Interleukin-7 motif I - 1
PCODE ST INT
FHVSFRYIFGIPPLILVLLPVASS IL7_BOVIN 2 2
FHVSFRYIFGIPPLILVLLPVASS JC4035 2 2
FHVSFRYIFGLPPLILVLLPVASS IL7_HUMAN 2 2
FHVSFRYIFGIPPLILVLLPVTSS IL7_MOUSE 2 2
INTERLEUKIN72 Length of motif = 23 Motif number = 2
Interleukin-7 motif II - 1
PCODE ST INT
DCDISGKDGGAYQNVLMVNIDDL IL7_BOVIN 26 0
DCDFSGKDGGAYQNVLMVSIDDL JC4035 26 0
DCDIEGKDGKQYESVLMVSIDQL IL7_HUMAN 26 0
ECHIKDKEGKAYESVLMISIDEL IL7_MOUSE 26 0
INTERLEUKIN73 Length of motif = 21 Motif number = 3
Interleukin-7 motif III - 1
PCODE ST INT
SNCLNNEPNFFKKHSCDDNKE IL7_BOVIN 56 7
SNCLNNEPNFFKKHSCDDNKE JC4035 56 7
SNCLNNEFNFFKRHICDANKE IL7_HUMAN 57 8
SNCPNNEPNFFRKHVCDDTKE IL7_MOUSE 56 7
INTERLEUKIN74 Length of motif = 21 Motif number = 4
Interleukin-7 motif IV - 1
PCODE ST INT
ASFLNRASRKLRQFLKMNISD IL7_BOVIN 77 0
ASFLNRAARKLKQFLKMNISD JC4035 77 0
GMFLFRAARKLRQFLKMNSTG IL7_HUMAN 78 0
AAFLNRAARKLKQFLKMNISE IL7_MOUSE 77 0
INTERLEUKIN75 Length of motif = 20 Motif number = 5
Interleukin-7 motif V - 1
PCODE ST INT
DFKLHLSTVSQGTLTLLNCT IL7_BOVIN 98 0
DFKLHLSTVSQGTLTLLNCT JC4035 98 0
DFDLHLLKVSEGTTILLNCT IL7_HUMAN 99 0
EFNVHLLTVSQGTQTLVNCT IL7_MOUSE 98 0
INTERLEUKIN76 Length of motif = 23 Motif number = 6
Interleukin-7 motif VI - 1
PCODE ST INT
NDLCFLKILLQKIKTCWNKILRG IL7_BOVIN 150 32
NDLCFLKILLQKIKTCWNKILRG JC4035 150 32
NDLCFLKRLLQEIKTCWNKILMG IL7_HUMAN 151 32
NDACFLKRLLREIKTCWNKILKG IL7_MOUSE 130 12
FINAL MOTIF SETS
INTERLEUKIN71 Length of motif = 24 Motif number = 1
Interleukin-7 motif I - 2
PCODE ST INT
FHVSFRYIFGIPPLILVLLPVASS IL7_SHEEP 2 2
FHVSFRYIFGIPPLILVLLPVASS IL7_BOVIN 2 2
FHVSFRYIFGIPPLILVLLPVTSS IL7_MOUSE 2 2
FHVSFRYIFGIPPLILVLLPVTSS IL7_RAT 2 2
FHVSFRYIFGLPPLILVLLPVASS IL7_HUMAN 2 2
INTERLEUKIN72 Length of motif = 23 Motif number = 2
Interleukin-7 motif II - 2
PCODE ST INT
DCDFSGKDGGAYQNVLMVSIDDL IL7_SHEEP 26 0
DCDISGKDGGAYQNVLMVNIDDL IL7_BOVIN 26 0
ECHIKDKEGKAYESVLMISIDEL IL7_MOUSE 26 0
DCHIKDKDGKAFGSVLMISINQL IL7_RAT 26 0
DCDIEGKDGKQYESVLMVSIDQL IL7_HUMAN 26 0
INTERLEUKIN73 Length of motif = 21 Motif number = 3
Interleukin-7 motif III - 2
PCODE ST INT
SNCLNNEPNFFKKHSCDDNKE IL7_SHEEP 56 7
SNCLNNEPNFFKKHSCDDNKE IL7_BOVIN 56 7
SNCPNNEPNFFRKHVCDDTKE IL7_MOUSE 56 7
SDCPNNEPNFFKKHLCDDTKE IL7_RAT 56 7
SNCLNNEFNFFKRHICDANKE IL7_HUMAN 57 8
INTERLEUKIN74 Length of motif = 21 Motif number = 4
Interleukin-7 motif IV - 2
PCODE ST INT
ASFLNRAARKLKQFLKMNISD IL7_SHEEP 77 0
ASFLNRASRKLRQFLKMNISD IL7_BOVIN 77 0
AAFLNRAARKLKQFLKMNISE IL7_MOUSE 77 0
AAFLNRAARKLRQFLKMNISE IL7_RAT 77 0
GMFLFRAARKLRQFLKMNSTG IL7_HUMAN 78 0
INTERLEUKIN75 Length of motif = 20 Motif number = 5
Interleukin-7 motif V - 2
PCODE ST INT
DFKLHLSTVSQGTLTLLNCT IL7_SHEEP 98 0
DFKLHLSTVSQGTLTLLNCT IL7_BOVIN 98 0
EFNVHLLTVSQGTQTLVNCT IL7_MOUSE 98 0
EFNDHLLRVSDGTQTLVNCT IL7_RAT 98 0
DFDLHLLKVSEGTTILLNCT IL7_HUMAN 99 0
INTERLEUKIN76 Length of motif = 23 Motif number = 6
Interleukin-7 motif VI - 2
PCODE ST INT
NDLCFLKILLQKIKTCWNKILRG IL7_SHEEP 150 32
NDLCFLKILLQKIKTCWNKILRG IL7_BOVIN 150 32
NDACFLKRLLREIKTCWNKILKG IL7_MOUSE 130 12
NDPCFLKRLLREIKTCWNKILKG IL7_RAT 130 12
NDLCFLKRLLQEIKTCWNKILMG IL7_HUMAN 151 32
User query: Display/Full Code "INTERLEUKIN7"