WORKLIST ENTRIES (1):
INTERLEUKIN6 View alignment View Structure Interleukin-6 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00435 INTERLEUKIN7
PRINTS; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9; PR01294 INTRLEUKIN10
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCXC
INTERPRO; IPR001716
PDB; 1BGC 3Dinfo
SCOP; 1BGC
Creation date 29-NOV-1995; UPDATE 07-JUN-1999
1. HIRANO, T., YASUKAWA, K., HARADA, H., TAGA, T., WATANABE, Y., MATSUDA,
T., KASHIWAMURA, S., NAKAJIMA, K., KOYAMA, K., IWAMATSU, A., TSUNASAWA, S.,
SAKIYAMA, F., MATSUI, H., TAKAHARA, Y., TANIGUCHI, T. AND KISHIMOTO, T.
Complementary DNA for a novel human interleukin (BSF-2) that induces B
lymphocytes to produce immunoglobulins.
NATURE 324 73-76 (1986).
2. LUETTICKEN, C., KRUETTGEN, A., MOELLER, C., HEINRICH, P.C. AND
ROSE-JOHN, S.
Evidence for the importance of a positive charge and an alpha-helical
structure of the C-terminus for biological activity of human IL-6.
FEBS LETT. 282 265-267 (1991).
3. CLOGSTON, C.L., BOONE, T.C., CRANDALL, B.C., MENDIAZ, E.A. AND LU, H.S.
Disulfide structures of human interleukin-6 are similar to those of human
granulocyte colony stimulating factor.
ARCH.BIOCHEM.BIOPHYS. 272 144-151 (1989).
4. WALTER, M.R., COOK, W.J., ZHAO, B.G., CAMERON, R.P., EALICK, S.E.,
WALTER, R.L., REICHERT, P., NAGABHUSHAN, T.L., TROTTA, P.P. AND BUGG, C.E.
Crystal structure of recombinant human interleukin-4.
J.BIOL.CHEM. 267 20371-20376 (1992).
Interleukin-6 (IL6), also refered to as B-cell differentiation factor-2
(BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of
biological functions [1]: it induces the final maturation of B-cells into
immunoglobulin-producing cells [1]; and it induces nerve cell
differentiation, and myeloma and plasmacytoma growth [1,2].
IL6 has a compact, globular fold (similar to other cytokines), stablised by
2 disulphide bonds [3]. One half of the structure is dominated by a 4 alpha-
helix bundle with a left-handed twist [4]; the helices are anti-parallel,
with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-
sheet. The fourth alpha-helix is important to the biological activity of
the molecule [2].
INTERLEUKIN6 is a 4-element fingerprint that provides a signature for the
interleukin-6 cytokines. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 encodes the first
alpha helix; motif 2 encodes part of the first beta strand; motif 3 spans
part of the first beta strand and the second helix, and corresponds to
the region encoded by PROSITE pattern INTERLEUKIN_6 (PS00254), the 2 Cys
residues of which form a disulphide bond; and motif 4 spans the fourth
helix. Two iterations on OWL26.3 were required to reach convergence, at
which point a true set comprising 14 sequences was identified. A single
partial match (MGF_CHICK) was also found, a myelomonocytic growth factor
that matches motifs 3 and 4.
An update on SPTR37_9f identified a true set of 15 sequences.
SUMMARY INFORMATION
15 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 15 15 15 15
3| 0 0 0 0
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
IL6_PIG O46568 IL6_HORSE IL6_CANFA
IL6_MACFA IL6_HUMAN IL6_MACMU IL6_FELCA
IL6_CERTO IL6_CAPHI IL6_SHEEP IL6_BOVIN
O35736 IL6_RAT IL6_MOUSE
PROTEIN TITLES
IL6_PIG INTERLEUKIN-6 PRECURSOR (IL-6) - SUS SCROFA (PIG).
O46568 INTERLEUKIN-6 PRECURSOR (IL-6) - EQUUS CABALLUS (HORSE).
IL6_HORSE INTERLEUKIN-6 PRECURSOR (IL-6) - EQUUS CABALLUS (HORSE).
IL6_CANFA INTERLEUKIN-6 PRECURSOR (IL-6) - CANIS FAMILIARIS (DOG).
IL6_MACFA INTERLEUKIN-6 PRECURSOR (IL-6) - MACACA FASCICULARIS (CRAB E
IL6_HUMAN INTERLEUKIN-6 PRECURSOR (IL-6) (B-CELL STIMULATORY FACTOR 2)
IL6_MACMU INTERLEUKIN-6 PRECURSOR (IL-6) - MACACA MULATTA (RHESUS MACA
IL6_FELCA INTERLEUKIN-6 PRECURSOR (IL-6) - FELIS SILVESTRIS CATUS (CAT
IL6_CERTO INTERLEUKIN-6 PRECURSOR (IL-6) - CERCOCEBUS TORQUATUS ATYS (
IL6_CAPHI INTERLEUKIN-6 PRECURSOR (IL-6) - CAPRA HIRCUS (GOAT).
IL6_SHEEP INTERLEUKIN-6 PRECURSOR (IL-6) - OVIS ARIES (SHEEP).
IL6_BOVIN INTERLEUKIN-6 PRECURSOR (IL-6) - BOS TAURUS (BOVINE).
O35736 INTERLEUKIN-6 PRECURSOR (IL-6) - MARMOTA MONAX (WOODCHUCK).
IL6_RAT INTERLEUKIN-6 PRECURSOR (IL-6) - RATTUS NORVEGICUS (RAT).
IL6_MOUSE INTERLEUKIN-6 PRECURSOR (IL-6) (INTERLEUKIN HP-1) (B-CELL HY
SCAN HISTORY
OWL26_3 2 100 NSINGLE
SPTR37_9f 2 16 NSINGLE
INITIAL MOTIF SETS
INTERLEUKIN61 Length of motif = 17 Motif number = 1
IL6 motif I - 1
PCODE ST INT
LIKHIVDKISAIRKEIC IL6_SHEEP 56 56
LIKYILGKISALRKEMC IL6_CANFA 51 51
LIKRMVDKISAMRKEIC IL6_BOVIN 56 56
QIRYILDGISALRKETC IL6_HUMAN 56 56
LITHVLWEIVEMRKELC IL6_MOUSE 54 54
INTERLEUKIN62 Length of motif = 23 Motif number = 2
IL6 motif II - 1
PCODE ST INT
CENSKETLAENKLKLPKMEEKDG IL6_SHEEP 78 5
CEDSKEALAENNLHLPKLEGKDG IL6_CANFA 73 5
CESSKETLAENKLNLPKMEEKDG IL6_BOVIN 78 5
CESSKEALAENNLNLPKMAEKDG IL6_HUMAN 78 5
CMNNDDALAENNLKLPEIQRNDG IL6_MOUSE 76 5
INTERLEUKIN63 Length of motif = 22 Motif number = 3
IL6 motif III - 1
PCODE ST INT
CFQSGFNQAICLIKTTAGLLEY IL6_SHEEP 101 0
CFQSGFNQETCLTRITTGLVEF IL6_CANFA 96 0
CFQSGFNQAICLIRTTAGLLEY IL6_BOVIN 101 0
CFQSGFNEETCLVKIITGLLEF IL6_HUMAN 101 0
CYQTGYNQEICLLKISSGLLEY IL6_MOUSE 99 0
INTERLEUKIN64 Length of motif = 18 Motif number = 4
IL6 motif IV - 1
PCODE ST INT
IILRSLENFLQFSLRAIR IL6_SHEEP 189 66
LILRSLEDFLQFSLRAVR IL6_CANFA 188 70
LILRNLENFLQFSLRAIR IL6_BOVIN 189 66
LILRSFKEFLQSSLRALR IL6_HUMAN 193 70
FILKSLEEFLKVTLRSTR IL6_MOUSE 192 71
FINAL MOTIF SETS
INTERLEUKIN61 Length of motif = 17 Motif number = 1
IL6 motif I - 2
PCODE ST INT
LIKYILGKISAMRKEMC IL6_PIG 56 56
HIKYILGKISALKNEMC O46568 53 53
HIKYILGKISALKNEMC IL6_HORSE 53 53
LIKYILGKISALRKEMC IL6_CANFA 51 51
HIRYILDGISALRKETC IL6_MACFA 56 56
QIRYILDGISALRKETC IL6_HUMAN 56 56
HIRYILDGISALRKETC IL6_MACMU 56 56
LIKYILGKISALKKEMC IL6_FELCA 52 52
HIRYILDGISALRKETC IL6_CERTO 56 56
LIKHIVDKISAIRKEIC IL6_CAPHI 56 56
LIKHIVDKISAIRKEIC IL6_SHEEP 56 56
LIKRMVDKISAMRKEIC IL6_BOVIN 56 56
QISYLIKEVFEMRKELC O35736 49 49
LITYVLREILEMRKELC IL6_RAT 54 54
LITHVLWEIVEMRKELC IL6_MOUSE 54 54
INTERLEUKIN62 Length of motif = 23 Motif number = 2
IL6 motif II - 2
PCODE ST INT
CENSKEVLAENNLNLPKMAEKDG IL6_PIG 78 5
CENSKEVLAENNLNLPKMAEKDG O46568 75 5
CENSKEVLAENNLNLPKMAEKDG IL6_HORSE 75 5
CEDSKEALAENNLHLPKLEGKDG IL6_CANFA 73 5
CESSKEALAENNLNLPKMAEKDG IL6_MACFA 78 5
CESSKEALAENNLNLPKMAEKDG IL6_HUMAN 78 5
CESSKEALAENNLNLPKMAEKDG IL6_MACMU 78 5
CEDSKEALAENNLNLPKLAEKDG IL6_FELCA 74 5
CDSTKEALAENNLNLPKMAEKDG IL6_CERTO 78 5
CENSKETLAENKLKLPKMEEKDG IL6_CAPHI 78 5
CENSKETLAENKLKLPKMEEKDG IL6_SHEEP 78 5
CESSKETLAENKLNLPKMEEKDG IL6_BOVIN 78 5
CIKSHVAVSENNLNLPKMTEKDG O35736 71 5
CMNSDDALSENNLKLPEIQRNDG IL6_RAT 76 5
CMNNDDALAENNLKLPEIQRNDG IL6_MOUSE 76 5
INTERLEUKIN63 Length of motif = 22 Motif number = 3
IL6 motif III - 2
PCODE ST INT
CFQSGFNQETCLMRITTGLVEF IL6_PIG 101 0
CFQSGFNQETCLMKITTGLSEF O46568 98 0
CFQSGFNQETCLMKITTGLSEF IL6_HORSE 98 0
CFQSGFNQETCLTRITTGLVEF IL6_CANFA 96 0
CFQSGFNEDTCLVKIITGLLEF IL6_MACFA 101 0
CFQSGFNEETCLVKIITGLLEF IL6_HUMAN 101 0
CFQSGFNEDTCLVKIITGLLEF IL6_MACMU 101 0
CFQSGFNQETCLTRITTGLQEF IL6_FELCA 97 0
CFQSGFNEDTCLVKIITGLLEF IL6_CERTO 101 0
CFQSGFNQAICLIKTTAGLLEY IL6_CAPHI 101 0
CFQSGFNQAICLIKTTAGLLEY IL6_SHEEP 101 0
CFQSGFNQAICLIRTTAGLLEY IL6_BOVIN 101 0
CFQTGYNRDDCLVRITSGLLEF O35736 94 0
CFQTGYNQEICLLKICSGLLEF IL6_RAT 99 0
CYQTGYNQEICLLKISSGLLEY IL6_MOUSE 99 0
INTERLEUKIN64 Length of motif = 18 Motif number = 4
IL6 motif IV - 2
PCODE ST INT
LILRSLEDFLQFSLRAIR IL6_PIG 193 70
LILRSLEDFLQFSLRAIR O46568 189 69
LILRSLEDFLQFSLRAVR IL6_HORSE 189 69
LILRSLEDFLQFSLRAVR IL6_CANFA 188 70
LILRSFKEFLQSSLRALR IL6_MACFA 193 70
LILRSFKEFLQSSLRALR IL6_HUMAN 193 70
LILRSFKEFLQSNLRALR IL6_MACMU 193 70
LTLRRLEDFLQFSLRAVR IL6_FELCA 189 70
LILRSFKEFLQSSLRALR IL6_CERTO 193 70
IILRSLENFLQFSLRAIR IL6_CAPHI 189 66
IILRSLENFLQFSLRAIR IL6_SHEEP 189 66
LILRNLENFLQFSLRAIR IL6_BOVIN 189 66
LILSNFEDFLQFTLRAVR O35736 188 72
LILKALEEFLKVTMRSTR IL6_RAT 192 71
FILKSLEEFLKVTLRSTR IL6_MOUSE 192 71
User query: Display/Full Code "INTERLEUKIN6"