WORKLIST ENTRIES (1):
INTERLEUKIN5 View alignment View Structure Interleukin-5 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00434 INTERLEUKIN6; PR00435 INTERLEUKIN7
PRINTS; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9; PR01294 INTRLEUKIN10
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCXC
INTERPRO; IPR000186
PDB; 1BGC 3Dinfo
SCOP; 1BGC
Creation date 29-NOV-1995; UPDATE 12-FEB-2000
1. CAMPBELL, H.D., TUCKER, W.Q., HORT, Y., MARTINSON, M.E., MAYO, G.,
CLUTTERBUCK, E.J., SANDERSON, C.J. AND YOUNG, I.G.
Molecular cloning, nucleotide sequence and expression of the gene encoding
human eosinophil differentiation factor (interleukin 5).
PROC.NATL.ACAD.SCI.U.S.A. 84 6629-6633 (1987).
2. MILBURN, M.V., HASSELL, A.M., LAMBERT, M.H., JORDAN, S.R., PROUDFOOT,
A.E.I., GRABER, P. AND WELLS, T.N.
A novel dimer configuration revealed by the crystal structure at 2.4A
resolution of human interleukin-5.
NATURE 363 172-176 (1993).
3. PROUDFOOT, A.E.I., DAVIES, J.G., TURCATTI, G. AND WINGFIELD, P.T.
Human interleukin-5 expressed in Escherichia coli: assignment of the
disulfide bridges of the purified unglycosylated protein.
FEBS LETT. 283 61-64 (1991).
Interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF),
is a lineage-specific cytokine for eosinophilpoiesis [1,2]. It regulates
eosinophil growth and activation [1], and thus plays an important role in
diseases associated with increased levels of eosinophils, including asthma
[2].
IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF)
[2], but while these exist as monomeric structures, IL5 is a homodimer. The
fold contains an anti-parallel 4-alpha-helix bundle with a left handed twist,
connected by a 2-stranded anti-parallel beta-sheet [2,3]. The monomers are
held together by 2 interchain disulphide bonds [3].
INTERLEUKIN5 is a 4-element fingerprint that provides a signature for the
interleukin-5 cytokines. The fingerprint was derived from an initial
alignment of 3 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 encodes the first
helix; motif 2 spans the first beta-strand and the second helix; motif 3
encodes the third helix; and motif 4 spans the second beta-strand and the
fourth helix. Two iterations on OWL26.3 were required to reach convergence,
at which point a true set comprising 7 sequences was identified.
An update on SPTR37_10f identified a true set of 11 sequences.
SUMMARY INFORMATION
11 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 11 11 11 11
3| 0 0 0 0
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
IL5_HUMAN IL5_HORSE IL5_MACMU IL5_CERTO
IL5_MERUN IL5_BOVIN IL5_MOUSE IL5_SHEEP
IL5_RAT IL5_FELCA IL5_CAVPO
PROTEIN TITLES
IL5_HUMAN INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_HORSE INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_MACMU INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_CERTO INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_MERUN INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_BOVIN INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_MOUSE INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_SHEEP INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_RAT INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_FELCA INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
IL5_CAVPO INTERLEUKIN-5 PRECURSOR (IL-5) (T-CELL REPLACING FACTOR) (TR
SCAN HISTORY
OWL26_3 2 100 NSINGLE
SPTR37_9f 2 13 NSINGLE
SPTR37_10f 3 50 NSINGLE
INITIAL MOTIF SETS
INTERLEUKIN51 Length of motif = 29 Motif number = 1
IL5 motif I - 1
PCODE ST INT
VWAIAMEIPMSTVVKETLIQLSTHRALLT IL5_RAT 15 15
VWATAMEIPMSTVVKETLTQLSAHRALLT IL5_MOUSE 16 16
VYAIPTEIPTSALVKETLALLSTHRTLLI IL5_HUMAN 17 17
INTERLEUKIN52 Length of motif = 29 Motif number = 2
IL5 motif II - 1
PCODE ST INT
SNETMRLPVPTHKNHQLCIGEIFQGLDIL IL5_RAT 44 0
SNETMRLPVPTHKNHQLCIGEIFQGLDIL IL5_MOUSE 45 0
ANETLRIPVPVHKNHQLCTEEIFQGIGTL IL5_HUMAN 46 0
INTERLEUKIN53 Length of motif = 29 Motif number = 3
IL5 motif III - 1
PCODE ST INT
KNQTVRGGTVEILFQNLSLIKKYIDGQKE IL5_RAT 73 0
KNQTVRGGTVEMLFQNLSLIKKYIDRQKE IL5_MOUSE 74 0
ESQTVQGGTVERLFKNLSLIKKYIDGQKK IL5_HUMAN 75 0
INTERLEUKIN54 Length of motif = 30 Motif number = 4
IL5 motif IV - 1
PCODE ST INT
KCGEERRKTRHFLDYLQEFLGVMSTEWAME IL5_RAT 102 0
KCGEERRRTRQFLDYLQEFLGVMSTEWAME IL5_MOUSE 103 0
KCGEERRRVNQFLDYLQEFLGVMNTEWIIE IL5_HUMAN 104 0
FINAL MOTIF SETS
INTERLEUKIN51 Length of motif = 29 Motif number = 1
IL5 motif I - 2
PCODE ST INT
VYAIPTEIPTSALVKETLALLSTHRTLLI IL5_HUMAN 17 17
VCALAVESPMNRLVAETLTLLSTHRTLLI IL5_HORSE 17 17
VYAIPTEIPASALVKETLALLSTHRTLLI IL5_MACMU 17 17
MYAIPTEIPTSALVKETLTLLSTHRTLLI IL5_CERTO 17 17
VWAVALEIPMSAVVKETLIQLSTHRALLT IL5_MERUN 15 15
VCANAVESTMNRLVAETLTLLSSHRTLLI IL5_BOVIN 17 17
VWATAMEIPMSTVVKETLTQLSAHRALLT IL5_MOUSE 16 16
VCANAVESTMNRLVAETLTLLSTHQTLLI IL5_SHEEP 15 15
VWAIAMEIPMSTVVKETLIQLSTHRALLT IL5_RAT 15 15
VSAIAVQSPMNRLVAETLALLSTHRTLLI IL5_FELCA 17 17
CAIPKQSATLRALVRETLTLLSTHRTLLK IL5_CAVPO 18 18
INTERLEUKIN52 Length of motif = 29 Motif number = 2
IL5 motif II - 2
PCODE ST INT
ANETLRIPVPVHKNHQLCTEEIFQGIGTL IL5_HUMAN 46 0
GDGNLMIPTPEHKNHQLCIEEVFQGIDTL IL5_HORSE 46 0
ANETLRIPVPVHKNHQLCTEEIFQGIGTL IL5_MACMU 46 0
GNETLRIPVPVHKHHQLCTEEIFQGIGTL IL5_CERTO 46 0
SNETVRLPVPTHKNHQLCIGEIFQGLDIL IL5_MERUN 44 0
GDGNLMIPTPQHTNHQLCIEEVFQGIDTL IL5_BOVIN 46 0
SNETMRLPVPTHKNHQLCIGEIFQGLDIL IL5_MOUSE 45 0
GDGNLMIPTPQHTNHQLCIEEVFQGIDTL IL5_SHEEP 44 0
SNETMRLPVPTHKNHQLCIGEIFQGLDIL IL5_RAT 44 0
GDGNLMIPTPEHNNHQLCIEEVFQGIDTL IL5_FELCA 46 0
GNETLRISVPAHKNHQLCIEEIFQGIDTL IL5_CAVPO 47 0
INTERLEUKIN53 Length of motif = 29 Motif number = 3
IL5 motif III - 2
PCODE ST INT
ESQTVQGGTVERLFKNLSLIKKYIDGQKK IL5_HUMAN 75 0
KNQTVQGDAVAKLFQNLSLIKGYIDLQKK IL5_HORSE 75 0
ESQTVQGGTVERLFKNLSLIKKYIGGQKK IL5_MACMU 75 0
ESQTLQGGTVERLFKNLSLIKKYIDGQKK IL5_CERTO 75 0
KNQTARGGAVETLFQNLSLIKKYIDRQKE IL5_MERUN 73 0
KNQTAQGDAVKKIFQNLSLIKEYIDLQKR IL5_BOVIN 75 0
KNQTVRGGTVEMLFQNLSLIKKYIDRQKE IL5_MOUSE 74 0
KNQTAQGDAVKKIFRNLSLIKEYIDLQKR IL5_SHEEP 73 0
KNQTVRGGTVEILFQNLSLIKKYIDGQKE IL5_RAT 73 0
KNRTVPGDAVEKLFRNLSLIKEHIDRQKK IL5_FELCA 75 0
KNQTTQGEALATLFQNLSLIKKHIDLQKQ IL5_CAVPO 76 0
INTERLEUKIN54 Length of motif = 30 Motif number = 4
IL5 motif IV - 2
PCODE ST INT
KCGEERRRVNQFLDYLQEFLGVMNTEWIIE IL5_HUMAN 104 0
KCGGERWRVKQFLDYLQEFLGVINTEWTIE IL5_HORSE 104 0
KCGEERRRVNQFLDYLQEFLGVMNTEWIIE IL5_MACMU 104 0
KCGEERRRVNQFLDYLQEFLGVMNTEWIIE IL5_CERTO 104 0
KCGEERRRARQFLDYLQEFLGVMSTEWTME IL5_MERUN 102 0
KCGGERWRVKQFLDYLQVFLGVINTEWTME IL5_BOVIN 104 0
KCGEERRRTRQFLDYLQEFLGVMSTEWAME IL5_MOUSE 103 0
KCGGERWRVKQFLDYLQVFLGVINTEWTME IL5_SHEEP 102 0
KCGEERRKTRHFLDYLQEFLGVMSTEWAME IL5_RAT 102 0
KCGGERWRVKKFLDYLQVFLGVINTEWTME IL5_FELCA 104 0
KCGEERRRVKQFLDYLQEFLAVINTEWTIE IL5_CAVPO 105 0
User query: Display/Full Code "INTERLEUKIN5"