WORKLIST ENTRIES (1):
INTERLEUKIN2 View alignment Interleukin-2 signature
Type of fingerprint: COMPOUND with 5 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00430 INTERLEUKIN3; PR00431 INTERLEUKIN4
PRINTS; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6; PR00435 INTERLEUKIN7
PRINTS; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9; PR01294 INTRLEUKIN10
PRINTS; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B; PR01929 INTRLEUKIN13
PRINTS; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16; PR01932 INTRLEUKIN17
PRINTS; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19; PR01935 INTRLEUKIN20
PRINTS; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24; PR01938 INTRLEUKIN34
PRINTS; PR00433 IL6GCSFMGF; PR00437 SMALLCYTKCXC
INTERPRO; IPR000779
PROSITE; PS00424 INTERLEUKIN_2
PFAM; PF00715 IL2
PDB; 3INK 3Dinfo
SCOP; 3INK
CATH; 3INK
Creation date 01-FEB-1994; UPDATE 07-JUN-1999
1. YOKOTA, T., ARAI, N., LEE, F., RENNICK, D., MOSMANN, T. AND ARAI, K.
Use of a cDNA expression vector for isolation of mouse interleukin-2 cDNA
clones - expression of T-cell growth factor activity after transfection of
monkey cells.
PROC.NATL.ACAD.SCI.U.S.A. 82(1) 68-72 (1985).
2. CERRETTI, D.P., MCKEREGHAN, K., LARSEN, A., CANTRELL, M.A., ANDERSON, D.,
GILLIS, S., COSMAN, D. AND BAKER, P.E.
Cloning, sequence, and expression of bovine interleukin 2
PROC.NATL.ACAD.SCI.U.S.A. 83(10) 3223-3227 (1986).
3. MOTT, H.R., DRISCOLL, P.C., BOYD, J., COOKE, R.M., WEIR, M.P. AND
CAMPBELL, I.D.
Secondary structure of human interleukin 2 from 3D heteronuclear NMR
experiments.
BIOCHEMISTRY 31(33) 7741-7744 (1992).
T-Lymphocytes regulate the growth and differentiation of certain lympho-
poietic and haemopoietic cells through the release of various secreted
protein factors [1]. These factors, which include interleukin-2 (IL2), are
secreted by lectin- or antigen-stimulated T-cells, and have various
physiological effects. IL2 is a lymphokine that induces the proliferation
of responsive T-cells. In addition, it acts on some B-cells, via receptor-
specific binding [2], as a growth factor and antibody production stimulant
[3]. The protein is secreted as a single glycosylated polypeptide, cleavage
of a signal sequence being required for its activity, which is partially
species restricted [2].
Solution NMR suggests that IL2 is a mainly alpha-helical protein, its
structure comprising a bundle of 4 helices (termed A-D), flanked by 2
shorter helices and several poorly-defined loops. Residues in helix A, and
in the loop region between helices A and B, are important for receptor
binding [3]. Secondary structure analysis has suggested similarity to IL4
and granulocyte-macrophage colony stimulating factor (GMCSF) [3].
INTERLEUKIN2 is a 5-element fingerprint that provides a signature for the
IL2 cytokine family. The fingerprint was derived from an initial alignment
of 4 sequences: motif 1 spans the signal peptide and the highly-conserved
N-terminal PTSSST sequence; motif 3 includes the region encoded by PROSITE
pattern INTERLEUKIN_2 (PS00424); and motifs 3 and 4 each contain a Cys
residue required to form a disulphide bridge that stabilises the active
form of the peptide. Two iterations on OWL22.1 were required to reach
convergence, at which point a true set comprising 11 sequences was
identified. Five partial matches were also found: S34052, SYNDABILA,
SYNDABILB and SYNDABILC are IL2 sequences and fusion proteins that lack
the signal peptide; and S31209 is an IL2 fusion protein fragment.
An update on SPTR37_9f identified a true set of 19 sequences.
SUMMARY INFORMATION
19 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
5| 19 19 19 19 19
4| 0 0 0 0 0
3| 0 0 0 0 0
2| 0 0 0 0 0
--+--------------------------
| 1 2 3 4 5
True positives..
IL2_HUMAN IL2_MACMU Q13169 IL2_CERTO
IL2_MACFA IL2_FELCA IL2_PIG IL2_MIRAN
IL2_BOVIN IL2_SHEEP O77620 IL2_HORSE
IL2_CANFA IL2_CAPHI IL2_CEREL IL2_MERUN
IL2_RAT IL2_MOUSE O88210
PROTEIN TITLES
IL2_HUMAN INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_MACMU INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
Q13169 INTERLEUKIN 2 - HOMO SAPIENS (HUMAN).
IL2_CERTO INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_MACFA INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_FELCA INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_PIG INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_MIRAN INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_BOVIN INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_SHEEP INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
O77620 INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_HORSE INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_CANFA INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_CAPHI INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_CEREL INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_MERUN INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_RAT INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
IL2_MOUSE INTERLEUKIN-2 PRECURSOR (IL-2) (T-CELL GROWTH FACTOR) (TCGF)
O88210 INTERLEUKIN 2 PRECURSOR - CAVIA PORCELLUS (GUINEA PIG).
SCAN HISTORY
OWL22_1 2 100 NSINGLE
OWL26_0 1 100 NSINGLE
SPTR37_9f 2 20 NSINGLE
INITIAL MOTIF SETS
INTERLEUKIN21 Length of motif = 29 Motif number = 1
Interleukin-2 motif I - 1
PCODE ST INT
YKIQLLSCIALTLALVANGAPTSSSTGNT IL2_BOVIN 2 2
YKIQPLSCIALTLALVANGAPTSSSTGNT IL2_SHEEP 2 2
YKMQLLCCIALTLALMANGAPTSSSTKNT IL2_PIG 2 2
YRMQLLSCIALSLALVTNSAPTSSSTKKT IL2_HUMAN 2 2
INTERLEUKIN22 Length of motif = 16 Motif number = 2
Interleukin-2 motif II - 1
PCODE ST INT
NLKLSRMHTFDFYVPK IL2_BOVIN 53 22
NLKLSRMHTFNFYMPK IL2_SHEEP 53 22
NADLSRMLTFKFYMPK IL2_PIG 53 22
NPKLTRMLTFKFYMPK IL2_HUMAN 53 22
INTERLEUKIN23 Length of motif = 28 Motif number = 3
Interleukin-2 motif III - 1
PCODE ST INT
ATELKHLKCLLEELKLLEEVLNLAPSKN IL2_BOVIN 71 2
ATELKHLKCLLEELKLLEEVLDLAPSKN IL2_SHEEP 71 2
ATELKHLQCLVEELKALEGVLNLGQSKN IL2_PIG 70 1
ATELKHLQCLEEELKPLEEVLNLAQSKN IL2_HUMAN 70 1
INTERLEUKIN24 Length of motif = 22 Motif number = 4
Interleukin-2 motif IV - 1
PCODE ST INT
NIKRIVLELQGSETRFTCEYDD IL2_BOVIN 110 11
NIKRIVLELQGSETRFTCEYDD IL2_SHEEP 110 11
NINVTVLELKGSETSFKCEYDD IL2_PIG 109 11
NINVIVLELKGSETTFMCEYAD IL2_HUMAN 108 10
INTERLEUKIN25 Length of motif = 22 Motif number = 5
Interleukin-2 motif V - 1
PCODE ST INT
TVNAVEFLNKWITFCQSIYSTM IL2_BOVIN 133 1
TVKAVEFLNKWITFCQSIYSTM IL2_SHEEP 133 1
TVTAVEFLNKWITFCQSIYSTL IL2_PIG 132 1
TATIVEFLNRWITFCQSIISTL IL2_HUMAN 131 1
FINAL MOTIF SETS
INTERLEUKIN21 Length of motif = 29 Motif number = 1
Interleukin-2 motif I - 2
PCODE ST INT
YRMQLLSCIALSLALVTNSAPTSSSTKKT IL2_HUMAN 2 2
YRMQLLSCIALSLALVTNSAPTSSSTKKT IL2_MACMU 2 2
YRMQLLSCIALILALVTNSAPTSSSTKKT Q13169 2 2
YRMQLLSCIALSLALVTNSAPTSRSTKKT IL2_CERTO 2 2
YRMQLLSCIALSLALVTNSAPTSSSTKKT IL2_MACFA 2 2
YKIQLLSCIALTLILVTNSAPASSSTKET IL2_FELCA 2 2
YKMQLLCCIALTLALMANGAPTSSSTKNT IL2_PIG 2 2
CKMQLLSCIALSLVLVANSAPTTSSTKET IL2_MIRAN 2 2
YKIQLLSCIALTLALVANGAPTSSSTGNT IL2_BOVIN 2 2
YKIQPLSCIALTLALVANGAPTSSSTGNT IL2_SHEEP 2 2
YKVQLLSCIALTLALLTSSAPTSSSTKET O77620 2 2
YRMQLLSCIALTLAVLANSAPTSSSKRET IL2_HORSE 2 2
YKMQLLSCIALTLVLVANSAPITSSSTKE IL2_CANFA 2 2
YRMQLLSCIALTLALVANGAPTSSSTGNT IL2_CAPHI 2 2
YKIQLLSCIALTLALVANGAPTSSSTGNT IL2_CEREL 2 2
YSRQLASCVALALVLLANSAPTSSPAKEA IL2_MERUN 2 2
YSMQLASCVALTLVLLVNSAPTSSPAKET IL2_RAT 2 2
YSMQLASCVTLTLVLLVNSAPTSSSTSSS IL2_MOUSE 2 2
YKTLLLSCLALTLALLTSSAPTSSSPKQT O88210 2 2
INTERLEUKIN22 Length of motif = 16 Motif number = 2
Interleukin-2 motif II - 2
PCODE ST INT
NPKLTRMLTFKFYMPK IL2_HUMAN 53 22
NPKLTRMLTFKFYMPK IL2_MACMU 53 22
NPKLTRMLTFKFYMPK Q13169 56 25
NPKLTRMLTFKFYMPK IL2_CERTO 53 22
NPKLTRMLTFKFYMPK IL2_MACFA 53 22
NPKLSRMLTFKFYVPK IL2_FELCA 53 22
NADLSRMLTFKFYMPK IL2_PIG 53 22
DPKLSRMLTFKFYTPK IL2_MIRAN 53 22
NLKLSRMHTFDFYVPK IL2_BOVIN 53 22
NLKLSRMHTFNFYMPK IL2_SHEEP 53 22
NSKLSRMLTFKFYMPK O77620 53 22
NPKLSKILTFKINMPK IL2_HORSE 53 22
NPQLSRMLTFKFYTPK IL2_CANFA 54 23
NLKLSRMHTFNFYMPK IL2_CAPHI 53 22
NLKLSKMHTFNFFMPK IL2_CEREL 53 22
NPKLPMLLTFKFYMPR IL2_MERUN 53 22
NLKLPMMLTFKFYLPK IL2_RAT 53 22
NLKLPRMLTFKFYLPK IL2_MOUSE 67 36
NPRLPKMLKLKLYPPK O88210 51 20
INTERLEUKIN23 Length of motif = 28 Motif number = 3
Interleukin-2 motif III - 2
PCODE ST INT
ATELKHLQCLEEELKPLEEVLNLAQSKN IL2_HUMAN 70 1
ATELKHLQCLEEELKPLEEVLNLAQSKN IL2_MACMU 70 1
ATELKQLQCLEEELKPLEEVLNLAQSKN Q13169 73 1
ATELKHLQCLEEELKPLEEVLNLAQSKN IL2_CERTO 70 1
ATELRHLQCLEEELKPLEEVLNLAQSKS IL2_MACFA 70 1
ATELTHLQCLVEELKPLEEVLYLAQSKN IL2_FELCA 70 1
ATELKHLQCLVEELKALEGVLNLGQSKN IL2_PIG 70 1
ATELTHLQCLAEELKPLEEVLYLAQSKN IL2_MIRAN 70 1
ATELKHLKCLLEELKLLEEVLNLAPSKN IL2_BOVIN 71 2
ATELKHLKCLLEELKLLEEVLDLAPSKN IL2_SHEEP 71 2
VTELKHLQCLEEELKPLEEVLNLAQGKN O77620 70 1
ATELKHLQCLEEELKPLEEMLKNFLSKD IL2_HORSE 70 1
ATEFTHLQCLAEELKNLEEVLGLPQSKN IL2_CANFA 71 1
DTELKHLKCLLEELKLLEDVLDLAPSKN IL2_CAPHI 71 2
ATELKHLNCLLEELKLLEDVLSLSPSKN IL2_CEREL 71 2
ATELKHLQCLEEELGPLHDVLNLVQSKN IL2_MERUN 70 1
ATELKHLQCLENELGALQRVLDLTQSKS IL2_RAT 70 1
ATELKDLQCLEDELGPLRHVLDLTQSKS IL2_MOUSE 84 1
VSELQHLQCLEEELRAVEQVLNLAEHKN O88210 68 1
INTERLEUKIN24 Length of motif = 22 Motif number = 4
Interleukin-2 motif IV - 2
PCODE ST INT
NINVIVLELKGSETTFMCEYAD IL2_HUMAN 108 10
NINVIVLELKGSETTLMCEYAD IL2_MACMU 109 11
NINVIVLELKGSETTFMCEYAD Q13169 111 10
NINVIVLELKGSETTLMCEYAD IL2_CERTO 109 11
NINVIVLELKGSETTLMCEYAD IL2_MACFA 109 11
NINVTVLKLKGSETRFTCNYDD IL2_FELCA 109 11
NINVTVLELKGSETSFKCEYDD IL2_PIG 109 11
NINVTLLKLKGSETRFKCEYDD IL2_MIRAN 109 11
NIKRIVLELQGSETRFTCEYDD IL2_BOVIN 110 11
NIKRIVLELQGSETRFTCEYDD IL2_SHEEP 110 11
NINVTVLKLKGSETFMCEYDET O77620 109 11
NINVTVLGLKGSETRFTCEYDN IL2_HORSE 104 6
NMNVTLLKLKGSETSYNCEYDD IL2_CANFA 110 11
SLKGIVLELQGSETRFTCEYDD IL2_CAPHI 110 11
NIKRIVLELQGSETSFKCEYDA IL2_CEREL 117 18
NIRVTVMKLKGSENTLNCEFDD IL2_MERUN 109 11
NIRVTVVKLKGSENKFECQFDD IL2_RAT 109 11
NIRVTVVKLKGSDNTFECQFDD IL2_MOUSE 123 11
NINVTVLSLKGSETAFVCDLED O88210 107 11
INTERLEUKIN25 Length of motif = 22 Motif number = 5
Interleukin-2 motif V - 2
PCODE ST INT
TATIVEFLNRWITFCQSIISTL IL2_HUMAN 131 1
TATIVEFLNRWITFCQSIISTL IL2_MACMU 132 1
TATIVEFLNRWITFCQSIISTL Q13169 134 1
TATIVEFLNRWITFCQSIISTL IL2_CERTO 132 1
TATIVEFLNRWITFCQSIISTL IL2_MACFA 132 1
TATIVEFLNKWITFCQSIFSTL IL2_FELCA 132 1
TVTAVEFLNKWITFCQSIYSTL IL2_PIG 132 1
TATITEFLNKWITFCQSIFSTL IL2_MIRAN 132 1
TVNAVEFLNKWITFCQSIYSTM IL2_BOVIN 133 1
TVKAVEFLNKWITFCQSIYSTM IL2_SHEEP 133 1
TVTIVEFLNRWITFCQSIISAS O77620 130 -1
TETIVEFLNKWITFCQSIISTL IL2_HORSE 127 1
TATITEFLNKWITFCQSIFSTL IL2_CANFA 133 1
TVKAVEFQNKWTTFCQSIYSTL IL2_CAPHI 133 1
TVKAVEFLNKWITFCQRIYSTM IL2_CEREL 140 1
TVTVVEFLSRWITFCQSAISTM IL2_MERUN 132 1
PATVVEFLRRWIAICQSIISTM IL2_RAT 132 1
SATVVDFLRRWIAFCQSIISTS IL2_MOUSE 146 1
SVNIVEFLKRWTAFCQKIMSRL O88210 130 1
User query: Display/Full Code "INTERLEUKIN2"