WORKLIST ENTRIES (1):
IL6GCSFMGF View alignment View Structure Interleukin-6/G-CSF/MGF family signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00264 INTERLEUKIN1; PR00265 INTERLEUKIN2; PR00430 INTERLEUKIN3
PRINTS; PR00431 INTERLEUKIN4; PR00432 INTERLEUKIN5; PR00434 INTERLEUKIN6
PRINTS; PR00435 INTERLEUKIN7; PR00436 INTERLEUKIN8; PR01926 INTERLEUKIN9
PRINTS; PR01294 INTRLEUKIN10; PR01927 INTRLEUKIN11; PR01928 INTRLEUKN12B
PRINTS; PR01929 INTRLEUKIN13; PR01930 INTRLEUKIN15; PR01931 INTRLEUKIN16
PRINTS; PR01932 INTRLEUKIN17; PR01933 INTRLEUKIN18; PR01934 INTRLEUKIN19
PRINTS; PR01935 INTRLEUKIN20; PR01936 INTRLEUKIN22; PR01937 INTRLEUKIN24
PRINTS; PR01938 INTRLEUKIN34; PR00437 SMALLCYTKCXC
INTERPRO; IPR001716
PROSITE; PS00254 INTERLEUKIN_6
PFAM; PF00489 IL-6
PDB; 1BGC 3Dinfo
SCOP; 1BGC
Creation date 18-DEC-1995; UPDATE 07-JUN-1999
1. HIRANO, T., YASUKAWA, K., HARADA, H., TAGA, T., WATANABE, Y., MATSUDA,
T., KASHIWAMURA, S., NAKAJIMA, K., KOYAMA, K., IWAMATSU, A., TSUNASAWA, S.,
SAKIYAMA, F., MATSUI, H., TAKAHARA, Y., TANIGUCHI, T. AND KISHIMOTO, T.
Complementary DNA for a novel human interleukin (BSF-2) that induces B
lymphocytes to produce immunoglobulins.
NATURE 324 73-76 (1986).
2. LUETTICKEN, C., KRUETTGEN, A., MOELLER, C., HEINRICH, P.C. AND
ROSE-JOHN, S.
Evidence for the importance of a positive charge and an alpha-helical
structure of the C-terminus for biological activity of human IL-6.
FEBS LETT. 282 265-267 (1991).
3. CLOGSTON, C.L., BOONE, T.C., CRANDALL, B.C., MENDIAZ, E.A. AND LU, H.S.
Disulfide structures of human interleukin-6 are similar to those of human
granulocyte colony stimulating factor.
ARCH.BIOCHEM.BIOPHYS. 272 144-151 (1989).
4. WALTER, M.R., COOK, W.J., ZHAO, B.G., CAMERON, R.P., EALICK, S.E.,
WALTER, R.L., REICHERT, P., NAGABHUSHAN, T.L., TROTTA, P.P. AND BUGG, C.E.
Crystal structure of recombinant human interleukin-4.
J.BIOL.CHEM. 267 20371-20376 (1992).
Interleukin-6 (IL6) is a cytokine involved in a number of biological
functions: e.g., it induces the final maturation of B-cells into immuno-
globulin-producing cells, and induces nerve cell differentiation [1]. A
number of other cytokines may be grouped with IL6 on the basis of sequence
similarity [1-3]: these include granulocyte colony-stimulating factor (GCSF)
and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis by
affecting the production, differentiation and function of 2 related white
cell groups in the blood [3]. MGF also acts in hematopoiesis, stimulating
proliferation and colony formation of normal and transformed avian cells
of the myeloid lineage.
Proteins belonging to the IL6/GCSF/MGF family have a compact, globular
fold (similar to other interleukins), stabilised by 2 disulphide bonds [3].
One half of the structure is dominated by a 4 alpha-helix bundle with a
left-handed twist [4]: the helices are anti-parallel, with 2 overhand
connections, which fall into a 2-stranded anti-parallel beta-sheet [4]. The
fourth helix is important to the biological activity of the molecule [2].
IL6GCSFMGF is a 4-element fingerprint that provides a signature for the
IL6/GCSF/MGF cytokine family. The fingerprint was derived from an initial
alignment of 8 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 encodes the first
helix; motif 2 encodes part of the first strand; motif 3 spans part of the
first strand and the second helix, and corresponds to the region encoded by
PROSITE pattern INTERLEUKIN_6 (PS00254), the 2 Cys residues of which form a
disulphide bond; and motif 4 encodes the fourth helix. Two iterations on
OWL26.3 were required to reach convergence, at which point a true set
comprising 21 sequences was identified. Two partial matches (NRL_1RHGA1 and
NRL_1RHGB1) were also found, both of which are GCSF fragments lacking the
portion of sequence bearing motifs 3 and 4.
An update on SPTR37_9f identified a true set of 23 sequences.
SUMMARY INFORMATION
23 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 23 23 23 23
3| 0 0 0 0
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
IL6_PIG IL6_HUMAN O46568 IL6_HORSE
IL6_CANFA IL6_MACFA IL6_MACMU IL6_FELCA
IL6_CERTO IL6_SHEEP IL6_CAPHI IL6_BOVIN
O35736 IL6_MOUSE IL6_RAT CSF3_HUMAN
CSF3_PIG O19180 CSF3_CANFA CSF3_BOVIN
CSF3_MOUSE P97712 MGF_CHICK
PROTEIN TITLES
IL6_PIG INTERLEUKIN-6 PRECURSOR (IL-6) - SUS SCROFA (PIG).
IL6_HUMAN INTERLEUKIN-6 PRECURSOR (IL-6) (B-CELL STIMULATORY FACTOR 2)
O46568 INTERLEUKIN-6 PRECURSOR (IL-6) - EQUUS CABALLUS (HORSE).
IL6_HORSE INTERLEUKIN-6 PRECURSOR (IL-6) - EQUUS CABALLUS (HORSE).
IL6_CANFA INTERLEUKIN-6 PRECURSOR (IL-6) - CANIS FAMILIARIS (DOG).
IL6_MACFA INTERLEUKIN-6 PRECURSOR (IL-6) - MACACA FASCICULARIS (CRAB E
IL6_MACMU INTERLEUKIN-6 PRECURSOR (IL-6) - MACACA MULATTA (RHESUS MACA
IL6_FELCA INTERLEUKIN-6 PRECURSOR (IL-6) - FELIS SILVESTRIS CATUS (CAT
IL6_CERTO INTERLEUKIN-6 PRECURSOR (IL-6) - CERCOCEBUS TORQUATUS ATYS (
IL6_SHEEP INTERLEUKIN-6 PRECURSOR (IL-6) - OVIS ARIES (SHEEP).
IL6_CAPHI INTERLEUKIN-6 PRECURSOR (IL-6) - CAPRA HIRCUS (GOAT).
IL6_BOVIN INTERLEUKIN-6 PRECURSOR (IL-6) - BOS TAURUS (BOVINE).
O35736 INTERLEUKIN-6 PRECURSOR (IL-6) - MARMOTA MONAX (WOODCHUCK).
IL6_MOUSE INTERLEUKIN-6 PRECURSOR (IL-6) (INTERLEUKIN HP-1) (B-CELL HY
IL6_RAT INTERLEUKIN-6 PRECURSOR (IL-6) - RATTUS NORVEGICUS (RAT).
CSF3_HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR PRECURSOR (G-CSF) (PLU
CSF3_PIG GRANULOCYTE COLONY-STIMULATING FACTOR PRECURSOR (G-CSF) - SU
O19180 GRANULOCYTE-COLONY STIMULATING FACTOR - SUS SCROFA (PIG).
CSF3_CANFA GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) - CANIS FAMILI
CSF3_BOVIN GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) - BOS TAURUS (
CSF3_MOUSE GRANULOCYTE COLONY-STIMULATING FACTOR PRECURSOR (G-CSF) - MU
P97712 GRANULOCYTE COLONY STIMULATING FACTOR - RATTUS NORVEGICUS (R
MGF_CHICK MYELOMONOCYTIC GROWTH FACTOR PRECURSOR (MGF) - GALLUS GALLUS
SCAN HISTORY
OWL26_3 2 100 NSINGLE
SPTR37_9f 2 24 NSINGLE
INITIAL MOTIF SETS
IL6GCSFMGF1 Length of motif = 16 Motif number = 1
Interleukin-6 family motif I - 1
PCODE ST INT
LIKYILGKISALRKEM IL6_CANFA 51 51
QIRYILDGISALRKET IL6_HUMAN 56 56
LIKHIVDKISAIRKEI IL6_SHEEP 56 56
LIKRMVDKISAMRKEI IL6_BOVIN 56 56
QVRKIQGDGAALQEKL CSF3_HUMAN 50 50
QVRKIQGDGAALQEKL NRL_1GNC 21 21
LITHVLWEIVEMRKEL IL6_MOUSE 54 54
FTRKIRGDVAALQRAV MGF_CHICK 45 45
IL6GCSFMGF2 Length of motif = 24 Motif number = 2
Interleukin-6 family motif II - 1
PCODE ST INT
CDKFNKCEDSKEALAENNLHLPKL IL6_CANFA 67 0
CNKSNMCESSKEALAENNLNLPKM IL6_HUMAN 72 0
CEKNDECENSKETLAENKLKLPKM IL6_SHEEP 72 0
CEKNDECESSKETLAENKLNLPKM IL6_BOVIN 72 0
CATYKLCHPEELVLLGHSLGIPWA CSF3_HUMAN 69 3
CATYKLCHPEELVLLGHSLGIPWA NRL_1GNC 37 0
CNGNSDCMNNDDALAENNLKLPEI IL6_MOUSE 70 0
CDTFQLCTEEELQLVQPDPHLVQA MGF_CHICK 61 0
IL6GCSFMGF3 Length of motif = 26 Motif number = 3
Interleukin-6 family motif III - 1
PCODE ST INT
CFQSGFNQETCLTRITTGLVEFQLHL IL6_CANFA 96 5
CFQSGFNEETCLVKIITGLLEFEVYL IL6_HUMAN 101 5
CFQSGFNQAICLIKTTAGLLEYQIYL IL6_SHEEP 101 5
CFQSGFNQAICLIRTTAGLLEYQIYL IL6_BOVIN 101 5
CPSQALQLAGCLSQLHSGLFLYQGLL CSF3_HUMAN 97 4
CPSQALQLAGCLSQLHSGLFLYQGLL NRL_1GNC 65 4
CYQTGYNQEICLLKISSGLLEYHSYL IL6_MOUSE 99 5
CHKRGFQAEVCFTQIRAGLHAYHDSL MGF_CHICK 89 4
IL6GCSFMGF4 Length of motif = 17 Motif number = 4
Interleukin-6 family motif IV - 1
PCODE ST INT
ILRSLEDFLQFSLRAVR IL6_CANFA 189 67
ILRSFKEFLQSSLRALR IL6_HUMAN 194 67
ILRSLENFLQFSLRAIR IL6_SHEEP 190 63
ILRNLENFLQFSLRAIR IL6_BOVIN 190 63
VASHLQSFLEVSYRVLR CSF3_HUMAN 186 63
VASHLQSFLEVSYRVLR NRL_1GNC 154 63
ILKSLEEFLKVTLRSTR IL6_MOUSE 193 68
ILANFQRFLETAYRALR MGF_CHICK 180 65
FINAL MOTIF SETS
IL6GCSFMGF1 Length of motif = 16 Motif number = 1
Interleukin-6 family motif I - 2
PCODE ST INT
LIKYILGKISAMRKEM IL6_PIG 56 56
QIRYILDGISALRKET IL6_HUMAN 56 56
HIKYILGKISALKNEM O46568 53 53
HIKYILGKISALKNEM IL6_HORSE 53 53
LIKYILGKISALRKEM IL6_CANFA 51 51
HIRYILDGISALRKET IL6_MACFA 56 56
HIRYILDGISALRKET IL6_MACMU 56 56
LIKYILGKISALKKEM IL6_FELCA 52 52
HIRYILDGISALRKET IL6_CERTO 56 56
LIKHIVDKISAIRKEI IL6_CAPHI 56 56
LIKHIVDKISAIRKEI IL6_SHEEP 56 56
LIKRMVDKISAMRKEI IL6_BOVIN 56 56
QISYLIKEVFEMRKEL O35736 49 49
LITHVLWEIVEMRKEL IL6_MOUSE 54 54
LITYVLREILEMRKEL IL6_RAT 54 54
QVRKIQGDGAALQEKL CSF3_HUMAN 50 50
QVRKIQADGAELQERL CSF3_PIG 41 41
QVRKIQADGAELQERL O19180 41 41
QMRKVQADGTALQETL CSF3_CANFA 21 21
QVRKIQADGAELQERL CSF3_BOVIN 20 20
QVRKIQASGSVLLEQL CSF3_MOUSE 56 56
QVRKIQARNTELLEQL P97712 47 47
FTRKIRGDVAALQRAV MGF_CHICK 45 45
IL6GCSFMGF2 Length of motif = 24 Motif number = 2
Interleukin-6 family motif II - 2
PCODE ST INT
CEKYEKCENSKEVLAENNLNLPKM IL6_PIG 72 0
CNKSNMCESSKEALAENNLNLPKM IL6_HUMAN 72 0
CNNFSKCENSKEVLAENNLNLPKM O46568 69 0
CNNFSKCENSKEVLAENNLNLPKM IL6_HORSE 69 0
CDKFNKCEDSKEALAENNLHLPKL IL6_CANFA 67 0
CNRSNMCESSKEALAENNLNLPKM IL6_MACFA 72 0
CNRSNMCESSKEALAENNLNLPKM IL6_MACMU 72 0
CDNYNKCEDSKEALAENNLNLPKL IL6_FELCA 68 0
CNRSNMCDSTKEALAENNLNLPKM IL6_CERTO 72 0
CEKNDECENSKETLAENKLKLPKM IL6_CAPHI 72 0
CEKNDECENSKETLAENKLKLPKM IL6_SHEEP 72 0
CEKNDECESSKETLAENKLNLPKM IL6_BOVIN 72 0
CKNDETCIKSHVAVSENNLNLPKM O35736 65 0
CNGNSDCMNNDDALAENNLKLPEI IL6_MOUSE 70 0
CNGNSDCMNSDDALSENNLKLPEI IL6_RAT 70 0
CATYKLCHPEELVLLGHSLGIPWA CSF3_HUMAN 69 3
CATHKLCHPQELVLLGHSLGLPQA CSF3_PIG 57 0
CATHKLCHPQELVLLGHSLGLPQA O19180 57 0
CATHQLCHPEELVLLGHALGIPQP CSF3_CANFA 37 0
CAAHKLCHPEELMLLRHSLGIPQA CSF3_BOVIN 36 0
CATYKLCHPEELVLLGHSLGIPKA CSF3_MOUSE 72 0
CATYKLCHPEELVLFGHSLGIPKA P97712 63 0
CDTFQLCTEEELQLVQPDPHLVQA MGF_CHICK 61 0
IL6GCSFMGF3 Length of motif = 26 Motif number = 3
Interleukin-6 family motif III - 2
PCODE ST INT
CFQSGFNQETCLMRITTGLVEFQIYL IL6_PIG 101 5
CFQSGFNEETCLVKIITGLLEFEVYL IL6_HUMAN 101 5
CFQSGFNQETCLMKITTGLSEFQIYL O46568 98 5
CFQSGFNQETCLMKITTGLSEFQIYL IL6_HORSE 98 5
CFQSGFNQETCLTRITTGLVEFQLHL IL6_CANFA 96 5
CFQSGFNEDTCLVKIITGLLEFEVYL IL6_MACFA 101 5
CFQSGFNEDTCLVKIITGLLEFEVYL IL6_MACMU 101 5
CFQSGFNQETCLTRITTGLQEFQIYL IL6_FELCA 97 5
CFQSGFNEDTCLVKIITGLLEFEVYL IL6_CERTO 101 5
CFQSGFNQAICLIKTTAGLLEYQIYL IL6_CAPHI 101 5
CFQSGFNQAICLIKTTAGLLEYQIYL IL6_SHEEP 101 5
CFQSGFNQAICLIRTTAGLLEYQIYL IL6_BOVIN 101 5
CFQTGYNRDDCLVRITSGLLEFQVYL O35736 94 5
CYQTGYNQEICLLKISSGLLEYHSYL IL6_MOUSE 99 5
CFQTGYNQEICLLKICSGLLEFRFYL IL6_RAT 99 5
CPSQALQLAGCLSQLHSGLFLYQGLL CSF3_HUMAN 97 4
CSSQALQLTGCLNQLHGGLVLYQGLL CSF3_PIG 85 4
CSSQALQLTGCLNQLHGGLVLYQGLL O19180 85 4
CSSQALQLMGCLRQLHSGLFLYQGLL CSF3_CANFA 65 4
CSSQSLQLRGCLNQLHGGLFLYQGLL CSF3_BOVIN 64 4
CSSQALQQTQCLSQLHSGLCLYQGLL CSF3_MOUSE 100 4
CSSQALQQTKCLSQLHSGLFLYQGLL P97712 91 4
CHKRGFQAEVCFTQIRAGLHAYHDSL MGF_CHICK 89 4
IL6GCSFMGF4 Length of motif = 17 Motif number = 4
Interleukin-6 family motif IV - 2
PCODE ST INT
ILRSLEDFLQFSLRAIR IL6_PIG 194 67
ILRSFKEFLQSSLRALR IL6_HUMAN 194 67
ILRSLEDFLQFSLRAIR O46568 190 66
ILRSLEDFLQFSLRAVR IL6_HORSE 190 66
ILRSLEDFLQFSLRAVR IL6_CANFA 189 67
ILRSFKEFLQSSLRALR IL6_MACFA 194 67
ILRSFKEFLQSNLRALR IL6_MACMU 194 67
TLRRLEDFLQFSLRAVR IL6_FELCA 190 67
ILRSFKEFLQSSLRALR IL6_CERTO 194 67
ILRSLENFLQFSLRAIR IL6_CAPHI 190 63
ILRSLENFLQFSLRAIR IL6_SHEEP 190 63
ILRNLENFLQFSLRAIR IL6_BOVIN 190 63
ILSNFEDFLQFTLRAVR O35736 189 69
ILKSLEEFLKVTLRSTR IL6_MOUSE 193 68
ILKALEEFLKVTMRSTR IL6_RAT 193 68
VASHLQSFLEVSYRVLR CSF3_HUMAN 186 63
VVSQLQSFLELAYRVLR CSF3_PIG 174 63
VVSQLQSFLELAYRVLR O19180 174 63
VASNLQSFLELAYRALR CSF3_CANFA 154 63
VASQLHRFLELAYRGLR CSF3_BOVIN 153 63
AISYLQGFLETARLALH CSF3_MOUSE 189 63
VTSYLQSFLETAHHALH P97712 180 63
ILANFQRFLETAYRALR MGF_CHICK 180 65
User query: Display/Full Code "IL6GCSFMGF"