WORKLIST ENTRIES (1):

HTHREPRESSR View alignment View Structure     Lambda-repressor HTH signature
 Type of fingerprint: COMPOUND with 2  elements
Links:
   PRINTS; PR00030 HTHCRO; PR00024 HOMEOBOX; PR00025 ANTENNAPEDIA 
   PRINTS; PR00026 ENGRAILED; PR00027 PAIREDBOX; PR00028 POUDOMAIN 
   PRINTS; PR00029 OCTAMER
   INTERPRO; IPR000047
   PDB; 1PRA 3Dinfo
   SCOP; 1PRA
   CATH; 1PRA

 Creation date 23-MAR-1993; UPDATE 20-JUN-1999

   1. BRENNAN, R.G. AND  MATTHEWS, B.W.
   The helix-turn-helix DNA binding motif.
   J.BIOL.CHEM. 264 1903-1906 (1989).

   2. SAUER, R.T.,YOCUM, R.R., DOOLITTLE, R.F., LEWIS, M. AND PABO, C.O.
   Homology among DNA-binding proteins suggests use of a conserved super-
   secondary structure.
   NATURE 298 447-451 (1982)

   3. PABO, C.O. AND SAUER, R.T.
   Protein-DNA recognition.
   ANNU.REV.BIOCHEM. 53 293-321 (1984).

   Helix-turn-helix (HTH) motifs are found in all known DNA binding proteins
   that regulate gene expression. The motif consists of approximately 20 
   residues and is characterised by 2 alpha-helices, which make intimate 
   contacts with the DNA and are joined by a short turn. The second helix of 
   the HTH motif binds to DNA via a number of hydrogen bonds and hydrophobic 
   interactions, which occur between specific side chains and the exposed 
   bases and thymine methyl groups within the major groove of the DNA [1]. The
   first helix helps to stabilise the structure [2]. 
  
   The HTH motif is very similar in sequence and structure to the N-terminal 
   region of the lamda [3] and other repressor proteins, and has also been 
   identified in many other DNA-binding proteins on the basis of sequence and 
   structural similarity [1]. One of the principal differences between HTH 
   motifs in these different proteins arises from the stereochemical 
   requirement for glycine in the turn, which is needed to avoid steric 
   interference of the beta-carbon with the main chain: for cro and other 
   repressors the Gly appears to be mandatory, while for many of the homeotic
   and other DNA-binding proteins the requirement is relaxed. 
  
   HTHREPRESSR is a 2-element fingerprint that provides a signature for the HTH
   motif of lambda and other repressors, and various homeotic proteins. The
   fingerprint was derived from an initial alignment of 20 sequences (after
   Brennan and Matthews [1]): the motifs span the complete motif and hinge on
   the conserved glycine, differing from the equivalent cro motifs in terms of
   the number and distribution of charged and aromatic residues. Four
   iterations on OWL19.1 were required to reach convergence, at which point a
   true set comprising 102 sequences was identified. This set includes
   repressor proteins, an atypical cro sequence, RNA polymerase sigma factors,
   homeotic proteins, etc., all of which have Gly conserved in the turn. 
  
   An update on SPTR37_9f identified a true set of 103 sequences.

  SUMMARY INFORMATION
    103 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    2| 103  103  
   --+-----------
     |   1    2  

True positives..
 DLX2_BRARE     HMDL_DROME     DLX5_BRARE     DLX2_MOUSE     
 DLX2_HUMAN     DLX1_BRARE     HMD3_XENLA     DLX6_BRARE     
 DLX5_RAT       DLX5_MOUSE     DLX5_CHICK     DLX4_BRARE     
 DLX1_MOUSE     DLX3_AMBME     DLX3_BRARE     DLX3_HUMAN     
 DLX3_MOUSE     DLX3_NOTVI     DLX3_PLEWA     HMD2_XENLA     
 HMDL_BRAFL     HMD1_CHICK     Q91622         CDX2_HUMAN     
 CDX2_MESAU     HMD4_XENLA     HMD1_XENLA     CDX1_HUMAN     
 CDX1_MOUSE     Q17243         P79788         CDX2_MOUSE     
 DLX7_BRARE     DLX8_BRARE     Q21169         CDX4_HUMAN     
 Q90320         Q90262         CDX4_MOUSE     DLX7_MOUSE     
 HM16_CAEEL     Q04787         HMD1_CAEEL     HMED_XENLA     
 HME2_CHICK     HME2_BRARE     HMEN_BOMMO     HMIN_BOMMO     
 HME3_BRARE     HME1_BRARE     HM23_CAEEL     O17588         
 HLX1_MOUSE     HLX1_HUMAN     Q43428         DBX_MOUSE      
 HMEN_ARTSF     Q43427         ATH5_ARATH     Q06453         
 HAT1_ARATH     HAT5_ARATH     O08686         O43518         
 ATH6_ARATH     Q43425         O93236         Q43529         
 GSBD_DROME     HAT7_ARATH     PBX1_HUMAN     PBX1_MOUSE     
 PBX2_HUMAN     PBX2_MOUSE     Q39941         EXD_DROME      
 O46118         HAT4_ARATH     O54817         O88933         
 Q40782         Q39862         Q14333         O43812         
 SIX1_HUMAN     SIX2_MOUSE     O57407         O93534         
 Q90881         P91625         MTA1_YEAST     HX1A_MAIZE     
 Q41812         MTA0_YEAST     RPSF_BACME     RPSF_BACLI     
 O86069         Q52775         FX24_RHILV     HMCU_DROME     
 RPSF_BACSU     O32725         RPSG_CLOAB     


  PROTEIN TITLES
   DLX2_BRARE       HOMEOBOX PROTEIN DLX-2 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   HMDL_DROME       HOMEOTIC DISTAL-LESS PROTEIN (PROTEIN BRISTA) - DROSOPHILA M
   DLX5_BRARE       HOMEOBOX PROTEIN DLX-5 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   DLX2_MOUSE       HOMEOBOX PROTEIN DLX-2 (HOMEOBOX PROTEIN TES-1) - MUS MUSCUL
   DLX2_HUMAN       HOMEOBOX PROTEIN DLX-2 - HOMO SAPIENS (HUMAN).
   DLX1_BRARE       HOMEOBOX PROTEIN DLX-1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   HMD3_XENLA       HOMEOBOX PROTEIN DLL-3 (XDLL-3) - XENOPUS LAEVIS (AFRICAN CL
   DLX6_BRARE       HOMEOBOX PROTEIN DLX-6 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   DLX5_RAT         HOMEOBOX PROTEIN DLX-5 (DLX-3) (RDLX) - RATTUS NORVEGICUS (R
   DLX5_MOUSE       HOMEOBOX PROTEIN DLX-5 - MUS MUSCULUS (MOUSE).
   DLX5_CHICK       HOMEOBOX PROTEIN DLX-5 - GALLUS GALLUS (CHICKEN).
   DLX4_BRARE       HOMEOBOX PROTEIN DLX-4 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   DLX1_MOUSE       HOMEOBOX PROTEIN DLX-1 - MUS MUSCULUS (MOUSE).
   DLX3_AMBME       HOMEOBOX PROTEIN DLX-3 - AMBYSTOMA MEXICANUM (AXOLOTL).
   DLX3_BRARE       HOMEOBOX PROTEIN DLX-3 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   DLX3_HUMAN       HOMEOBOX PROTEIN DLX-3 - HOMO SAPIENS (HUMAN).
   DLX3_MOUSE       HOMEOBOX PROTEIN DLX-3 - MUS MUSCULUS (MOUSE).
   DLX3_NOTVI       HOMEOBOX PROTEIN DLX-3 (BOX-4) (NVHBOX-4) - NOTOPHTHALMUS VI
   DLX3_PLEWA       DISTAL-LESS LIKE PROTEIN DLX-3 - PLEURODELES WALTLII (IBERIA
   HMD2_XENLA       HOMEOBOX PROTEIN DLL-2 (XDLL-2) - XENOPUS LAEVIS (AFRICAN CL
   HMDL_BRAFL       HOMEOBOX PROTEIN DLL HOMOLOG - BRANCHIOSTOMA FLORIDAE (FLORI
   HMD1_CHICK       HOMEOBOX PROTEIN CHOX-CAD - GALLUS GALLUS (CHICKEN).
   Q91622           XCAD2 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   CDX2_HUMAN       HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) (CDX
   CDX2_MESAU       HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) - ME
   HMD4_XENLA       HOMEOBOX PROTEIN DLL-4 (XDLL-4) - XENOPUS LAEVIS (AFRICAN CL
   HMD1_XENLA       HOMEOBOX PROTEIN DLL-1 (DLL) (XDLL) - XENOPUS LAEVIS (AFRICA
   CDX1_HUMAN       HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - HO
   CDX1_MOUSE       HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - MU
   Q17243           CAD PROTEIN - BOMBYX MORI (SILK MOTH).
   P79788           HOMEOBOX PROTEIN - GALLUS GALLUS (CHICKEN).
   CDX2_MOUSE       HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) - MU
   DLX7_BRARE       HOMEOBOX PROTEIN DLX-7 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   DLX8_BRARE       HOMEOBOX PROTEIN DLX-8 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBR
   Q21169           K03A11.3 PROTEIN - CAENORHABDITIS ELEGANS.
   CDX4_HUMAN       HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - HO
   Q90320           CAUDAL HOMOLOG CDX1 - CYPRINUS CARPIO (COMMON CARP).
   Q90262           ZF-CAD1 PROTEIN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO
   CDX4_MOUSE       HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - MU
   DLX7_MOUSE       HOMEOBOX PROTEIN DLX-7 - MUS MUSCULUS (MOUSE).
   HM16_CAEEL       HOMEOBOX PROTEIN ENGRAILED-LIKE CEH-16 - CAENORHABDITIS ELEG
   Q04787           BRAIN-SPECIFIC HOMEOBOX PROTEIN - DROSOPHILA MELANOGASTER (F
   HMD1_CAEEL       PUTATIVE HOMEOBOX PROTEIN C28A5.4 - CAENORHABDITIS ELEGANS.
   HMED_XENLA       HOMEOBOX PROTEIN ENGRAILED-2B (EN-2B) (EN2 MABEN) - XENOPUS 
   HME2_CHICK       HOMEOBOX PROTEIN ENGRAILED-2 (GG-EN-2) - GALLUS GALLUS (CHIC
   HME2_BRARE       HOMEOBOX PROTEIN ENGRAILED-2 (ZF-EN-2) - BRACHYDANIO RERIO (
   HMEN_BOMMO       SEGMENTATION POLARITY HOMEOBOX PROTEIN ENGRAILED - BOMBYX MO
   HMIN_BOMMO       HOMEOBOX PROTEIN INVECTED - BOMBYX MORI (SILK MOTH).
   HME3_BRARE       HOMEOBOX PROTEIN ENGRAILED-3 (ZF-EN-1) - BRACHYDANIO RERIO (
   HME1_BRARE       HOMEOBOX PROTEIN ENGRAILED-1 - BRACHYDANIO RERIO (ZEBRAFISH)
   HM23_CAEEL       HOMEOBOX PROTEIN CEH-23 - CAENORHABDITIS ELEGANS.
   O17588           C16C2.1 PROTEIN - CAENORHABDITIS ELEGANS.
   HLX1_MOUSE       HOMEOBOX PROTEIN HLX1 - MUS MUSCULUS (MOUSE).
   HLX1_HUMAN       HOMEOBOX PROTEIN HLX1 (HOMEOBOX PROTEIN HB24) - HOMO SAPIENS
   Q43428           DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
   DBX_MOUSE        HOMEOBOX PROTEIN DBX - MUS MUSCULUS (MOUSE).
   HMEN_ARTSF       HOMEOBOX PROTEIN ENGRAILED - ARTEMIA SANFRANCISCANA (BRINE S
   Q43427           DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
   ATH5_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-5 (HD-ZIP PROTEIN ATHB-
   Q06453           HOMEOBOX PROTEIN ARISTALESS - DROSOPHILA MELANOGASTER (FRUIT
   HAT1_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT1 (HD-ZIP PROTEIN 1) - AR
   HAT5_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT5 (HD-ZIP PROTEIN 5) (HD-
   O08686           BARX2 - MUS MUSCULUS (MOUSE).
   O43518           BARX2 - HOMO SAPIENS (HUMAN).
   ATH6_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-6 (HD-ZIP PROTEIN ATHB-
   Q43425           DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
   O93236           DHARMA - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
   Q43529           HOMEOBOX - LYCOPERSICON ESCULENTUM (TOMATO).
   GSBD_DROME       GOOSEBERRY DISTAL PROTEIN (BSH9) - DROSOPHILA MELANOGASTER (
   HAT7_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT7 (HD-ZIP PROTEIN 7) (HD-
   PBX1_HUMAN       PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN
   PBX1_MOUSE       PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN
   PBX2_HUMAN       PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-2 (HOMEOBOX PROTEIN
   PBX2_MOUSE       PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-2 (HOMEOBOX PROTEIN
   Q39941           HOMEODOMAIN CONTAINING PROTEIN (HAHB-1) - HELIANTHUS ANNUUS 
   EXD_DROME        HOMEOBOX PROTEIN EXTRADENTICLE - DROSOPHILA MELANOGASTER (FR
   O46118           DNA-BINDING PROTEIN - DUGESIA TIGRINA (PLANARIAN).
   HAT4_ARATH       HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT4 (HD-ZIP PROTEIN 4) (HD-
   O54817           EXTRAEMBRYONIC, SPERMATOGENESIS, HOMEOBOX 1 (PAIRED-LIKE HOM
   O88933           HOMEOBOX PROTEIN SPX1 - MUS MUSCULUS (MOUSE).
   Q40782           HOMEOBOX-LEUCINE ZIPPER PROTEIN - PIMPINELLA BRACHYCARPA.
   Q39862           HOMEOBOX-LEUCINE ZIPPER PROTEIN - GLYCINE MAX (SOYBEAN).
   Q14333           FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD) GENE REGION, D
   O43812           DUX1 PROTEIN - HOMO SAPIENS (HUMAN).
   SIX1_HUMAN       HOMEOBOX PROTEIN SIX1 - HOMO SAPIENS (HUMAN).
   SIX2_MOUSE       HOMEOBOX PROTEIN SIX2 - MUS MUSCULUS (MOUSE).
   O57407           HOMEOBOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   O93534           HOMEOBOX PROTEIN BIX2 - XENOPUS LAEVIS (AFRICAN CLAWED FROG)
   Q90881           HOMEOBOX PROTEIN - GALLUS GALLUS (CHICKEN).
   P91625           LADYBIRD EARLY HOMEODOMAIN TRANSCRIPTION FACTOR - DROSOPHILA
   MTA1_YEAST       MATING-TYPE PROTEIN A-1 - SACCHAROMYCES CEREVISIAE (BAKER'S 
   HX1A_MAIZE       HOMEOBOX PROTEIN HOX1A - ZEA MAYS (MAIZE).
   Q41812           HOMEOBOX 2A PROTEIN - ZEA MAYS (MAIZE).
   MTA0_YEAST       MATING-TYPE PROTEIN A-1, INCOMPLETELY SPLICED - SACCHAROMYCE
   RPSF_BACME       RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN 
   RPSF_BACLI       RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN 
   O86069           FNR-TYPE TRANSCRIPTIONAL REGULATOR FNRND - RHIZOBIUM ETLI.
   Q52775           FNRN - RHIZOBIUM LEGUMINOSARUM.
   FX24_RHILV       PROBABLE TRANSCRIPTIONAL ACTIVATOR (ORF-240) - RHIZOBIUM LEG
   HMCU_DROME       HOMEOBOX PROTEIN CUT - DROSOPHILA MELANOGASTER (FRUIT FLY).
   RPSF_BACSU       RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN 
   O32725           RNA POLYMERASE SIGMA FACTOR - BACILLUS SPHAERICUS.
   RPSG_CLOAB       RNA POLYMERASE SIGMA-G FACTOR - CLOSTRIDIUM ACETOBUTYLICUM.

SCAN HISTORY OWL19_1 4 500 NSINGLE OWL26_0 1 900 NSINGLE SPTR37_9f 1 850 NSINGLE INITIAL MOTIF SETS HTHREPRESSR1 Length of motif = 10 Motif number = 1 Lambda-repressor HTH motif I - 1 PCODE ST INT TQTELATKAG RCRO_BP434 17 17 TQTELATKAG NRL_2CRO 17 17 TQRAVAKALG RCRO_BPP22 11 11 GQRKVADALG RPC1_BPP22 24 24 NQAELAQKVG RPC1_BP434 15 15 GQTKTAKDLG RCRO_LAMBD 14 14 SQESVADKMG RPC1_LAMBD 31 31 GQTKTAKDLG NRL_4CROE 12 12 EKEEVAKKCG MTA0_YEAST 98 98 LVAAVADKAG DBH_RHIME 5 5 TLYDVAEYAG LACI_ECOLI 4 4 GTEKTAEAVG RPC2_LAMBD 24 24 SRQQLADLTG RPC_BPP2 18 18 TIKDVARLAG GALR_ECOLI 2 2 NKKQLADIFG VNU1_LAMBD 3 3 SQRELKNELG TRPR_ECOLI 65 65 RQAALGKMVG RPC2_BPP22 19 19 SGEQLGETLG BIRA_ECOLI 20 20 HTHREPRESSR2 Length of motif = 17 Motif number = 2 Lambda-repressor HTH motif I - 2 PCODE ST INT GVKQQSIQLIEAGVTKR RCRO_BP434 26 -1 GVKQQSIQLIEAGVTKR NRL_2CRO 26 -1 GISDAAVSQWKEVIPEK RCRO_BPP22 20 -1 GINESQISRWKGDFIPK RPC1_BPP22 33 -1 GTTQQSIEQLENGKTKR RPC1_BP434 24 -1 GVYQSAINKAIHAGRKI RCRO_LAMBD 23 -1 GMGQSGVGALFNGINAL RPC1_LAMBD 40 -1 GVYQSAINKAIHAGRKI NRL_4CROE 21 -1 GITPLQVRVWVCNMRIK MTA0_YEAST 107 -1 GLSKADASSAVDAVFET DBH_RHIME 14 -1 GVSYQTVSRVVNQASHV LACI_ECOLI 13 -1 GVDKSQISRWKRDWIPK RPC2_LAMBD 33 -1 GVPYGTLSYYESGRSTP RPC_BPP2 27 -1 GVSVATVSRVINNSPKA GALR_ECOLI 11 -1 GASIRTIQNWQEQGMPV VNU1_LAMBD 12 -1 GAGIATITRGSNSLKAA TRPR_ECOLI 74 -1 GVSNVAISQWERSETEP RPC2_BPP22 28 -1 GMSRAAINKHIQTLRDW BIRA_ECOLI 29 -1 FINAL MOTIF SETS HTHREPRESSR1 Length of motif = 10 Motif number = 1 Lambda-repressor HTH motif I - 1 PCODE ST INT ERAELAASLG DLX2_BRARE 152 152 ERAELAASLG HMDL_DROME 153 153 ERAELAASLG DLX5_BRARE 154 154 ERAELAASLG DLX2_MOUSE 184 184 ERAELAASLG DLX2_HUMAN 181 181 ERAELAASLG DLX1_BRARE 157 157 ERAELAASLG HMD3_XENLA 166 166 ERAELAASLG DLX6_BRARE 154 154 ERAELAASLG DLX5_RAT 166 166 ERAELAASLG DLX5_MOUSE 166 166 ERAELAASLG DLX5_CHICK 165 165 ERAELAASLG DLX4_BRARE 166 166 ERAELAASLG DLX1_MOUSE 157 157 ERAELAAQLG DLX3_AMBME 155 155 ERAELAAQLG DLX3_BRARE 154 154 ERAELAAQLG DLX3_HUMAN 158 158 ERAELAAQLG DLX3_MOUSE 158 158 ERAELAAQLG DLX3_NOTVI 154 154 ERAELAAQLG DLX3_PLEWA 155 155 ERAELAAQLG HMD2_XENLA 159 159 ERAELAAQLG HMDL_BRAFL 145 145 RKAELAAALG HMD1_CHICK 166 166 RKAELAAALG Q91622 179 179 RKAELAATLG CDX2_HUMAN 213 213 RKAELAATLG CDX2_MESAU 214 214 ERAELAASLG HMD4_XENLA 156 156 ERAELAASLG HMD1_XENLA 154 154 RKSELAANLG CDX1_HUMAN 183 183 RKSELAANLG CDX1_MOUSE 183 183 RKAELAVSLG Q17243 149 149 RKAELASSLG P79788 207 207 RKSELAATLG CDX2_MOUSE 214 214 ERADLAAKLG DLX7_BRARE 158 158 ERADLAAKLG DLX8_BRARE 152 152 EREELAQCLG Q21169 154 154 RKSELAVNLG CDX4_HUMAN 202 202 RKSELAVNLG Q90320 180 180 RKSELAVNLG Q90262 180 180 RKSELAVNLG CDX4_MOUSE 200 200 ERAQLAAQLG DLX7_MOUSE 145 145 RRQELAHELG HM16_CAEEL 132 132 ERVELATALG Q04787 161 161 DRAALAHELG HMD1_CAEEL 131 131 RRQSLAQELG HMED_XENLA 205 205 RRQSLAQELG HME2_CHICK 228 228 RRQSLAQELG HME2_BRARE 205 205 RRQSLAAELG HMEN_BOMMO 309 309 RRQSLAAELG HMIN_BOMMO 401 401 RRQALAQELG HME3_BRARE 201 201 RRQALARELG HME1_BRARE 172 172 ERENLAQRLG HM23_CAEEL 240 240 TRAKLAESLG O17588 64 64 DRKQLAAMLG HLX1_MOUSE 302 302 DRKQLAAMLG HLX1_HUMAN 305 305 RKLELARALG Q43428 126 126 DRKKLASKLG DBX_MOUSE 210 210 RRQDLARELG HMEN_ARTSF 278 278 RKVQLAKELG Q43427 66 66 RKVKLAQELG ATH5_ARATH 98 98 TREELAMKIG Q06453 114 114 QKLALAKKLG HAT1_ARATH 161 161 RKTQLAKKLG HAT5_ARATH 94 94 DRLDLAQSLG O08686 141 141 DRLDLAQSLG O43518 137 137 RKVKLAQELG ATH6_ARATH 88 88 RKVQLAKDLG Q43425 115 115 TRAELAQNTG O93236 144 144 RKVQLAKELG Q43529 116 116 TREELAQSTG GSBD_DROME 214 214 RKMQLAKALG HAT7_ARATH 78 78 AKEELAKKCG PBX1_HUMAN 265 265 AKEELAKKCG PBX1_MOUSE 265 265 AKEELAKKCG PBX2_HUMAN 276 276 AKEELAKKCG PBX2_MOUSE 276 276 RKMQLARALG Q39941 118 118 AKEELARKCG EXD_DROME 270 270 SRESLARSLG O46118 186 186 QKQALAKQLG HAT4_ARATH 155 155 ARVELARRLG O54817 147 147 ARVELARRLG O88933 215 215 QKLALAKRLG Q40782 165 165 QKLALAKQLG Q39862 140 140 AREELARETG Q14333 585 585 AREELARETG O43812 123 123 EKRELAEATG SIX1_HUMAN 153 153 EKRELAEATG SIX2_MOUSE 153 153 QREELARQMG O57407 112 112 QREELARQMG O93534 112 112 SYTELAAKSG Q90881 181 181 DRDEIAASLG P91625 382 382 EKEEVAKKCG MTA1_YEAST 99 99 VKESLAEELG HX1A_MAIZE 588 588 TKESLAQELG Q41812 1063 1063 EKEEVAKKCG MTA0_YEAST 99 99 TQSEVAARLG RPSF_BACME 220 220 TQSEVADRLG RPSF_BACLI 220 220 SRAEIADFLG O86069 190 190 SRAEIADFLG Q52775 190 190 SRAEIADFLG FX24_RHILV 190 190 TIEFLANELG HMCU_DROME 1774 1774 TQSEVAERLG RPSF_BACSU 220 220 TIQELAQVLG O32725 134 134 TQMEVADEIG RPSG_CLOAB 227 227 HTHREPRESSR2 Length of motif = 17 Motif number = 2 Lambda-repressor HTH motif II - 1 PCODE ST INT GLTQTQVKIWFQNRRSK DLX2_BRARE 161 -1 GLTQTQVKIWFQNRRSK HMDL_DROME 162 -1 GLTQTQVKIWFQNRRSK DLX5_BRARE 163 -1 GLTQTQVKIWFQNRRSK DLX2_MOUSE 193 -1 GLTQTQVKIWFQNRRSK DLX2_HUMAN 190 -1 GLTQTQVKIWFQNKRSK DLX1_BRARE 166 -1 GLTQTQVKIWFQNKRSK HMD3_XENLA 175 -1 GLTQTQVKIWFQNKRSK DLX6_BRARE 163 -1 GLTQTQVKIWFQNKRSK DLX5_RAT 175 -1 GLTQTQVKIWFQNKRSK DLX5_MOUSE 175 -1 GLTQTQVKIWFQNKRSK DLX5_CHICK 174 -1 GLTQTQVKIWFQNKRSK DLX4_BRARE 175 -1 GLTQTQVKIWFQNKRSK DLX1_MOUSE 166 -1 GLTQTQVKIWFQNRRSK DLX3_AMBME 164 -1 GLTQTQVKIWFQNRRSK DLX3_BRARE 163 -1 GLTQTQVKIWFQNRRSK DLX3_HUMAN 167 -1 GLTQTQVKIWFQNRRSK DLX3_MOUSE 167 -1 GLTQTQVKIWFQNRRSK DLX3_NOTVI 163 -1 GLTQTQVKIWFQNRRSK DLX3_PLEWA 164 -1 GLTQTQVKIWFQNRRSK HMD2_XENLA 168 -1 GLTQTQVKIWFQNRRSK HMDL_BRAFL 154 -1 GLTERQVKIWFQNRRAK HMD1_CHICK 175 -1 GLTERQVKIWFQNRRAK Q91622 188 -1 GLSERQVKIWFQNRRAK CDX2_HUMAN 222 -1 GLSERQVKIWFQNRRAK CDX2_MESAU 223 -1 GVTQTQVKIWFQNRRSK HMD4_XENLA 165 -1 GVTQTQVKIWFQNKRSK HMD1_XENLA 163 -1 GLTERQVKIWFQNRRAK CDX1_HUMAN 192 -1 GLTERQVKIWFQNRRAK CDX1_MOUSE 192 -1 GLSERQVKIWFQNRRAK Q17243 158 -1 GLSERQVKIWFQNRRAK P79788 216 -1 GLSERQVKIWFQNRRAK CDX2_MOUSE 223 -1 GLTQTQVKIWFQNKRSK DLX7_BRARE 167 -1 GLTQTQVKIWFQNKRSK DLX8_BRARE 161 -1 GLTATQVKIWFQNRRYK Q21169 163 -1 GLSERQVKIWFQNRRAK CDX4_HUMAN 211 -1 GLSERQVKIWFQNRRAK Q90320 189 -1 GLSERQVKIWFQNRRAK Q90262 189 -1 GLSERQVKIWFQNRRAK CDX4_MOUSE 209 -1 GLTQTQVKIWFQNKRSK DLX7_MOUSE 154 -1 GLNESQIKIWFQNKRAK HM16_CAEEL 141 -1 GLSETQVKTWFQNRRMK Q04787 170 -1 GLSQTQVKIWFQNRRSK HMD1_CAEEL 140 -1 GLNESQIKIWFQNKRAK HMED_XENLA 214 -1 GLNESQIKIWFQNKRAK HME2_CHICK 237 -1 GLNESQIKIWFQNKRAK HME2_BRARE 214 -1 GLAEAQIKIWFQNKRAK HMEN_BOMMO 318 -1 GLAEAQIKIWFQNKRAK HMIN_BOMMO 410 -1 GLNESQIKIWFQNKRAK HME3_BRARE 210 -1 GLNESQIKIWFQNKRAK HME1_BRARE 181 -1 GLSPSQVRIWFQNRRSK HM23_CAEEL 249 -1 GLSDNQVKVWFQNRRTK O17588 73 -1 GLTDAQVKVWFQNRRMK HLX1_MOUSE 311 -1 GLTDAQVKVWFQNRRMK HLX1_HUMAN 314 -1 GLQPRQIAIWFQNRRAR Q43428 135 -1 GLKDSQVKIWFQNRRMK DBX_MOUSE 219 -1 GLHENQIKIWFQNNRAK HMEN_ARTSF 287 -1 GLQPRQVAIWFQNRRAR Q43427 75 -1 GLQPRQVAIWFQNRRAR ATH5_ARATH 107 -1 GLTEARIQVWFQNRRAK Q06453 123 -1 GLTARQVEVWFQNRRAR HAT1_ARATH 170 -1 GLQPRQVAVWFQNRRAR HAT5_ARATH 103 -1 GLTQLQVKTWYQNRRMK O08686 150 -1 GLTQLQVKTWYQNRRMK O43518 146 -1 GLQPRQVAVWFQNRRAR ATH6_ARATH 97 -1 GLQPRQVAIWFQNRRAR Q43425 124 -1 GLSEETVRVWFKNRRAR O93236 153 -1 GLQPRQIAIWFQNRRAR Q43529 125 -1 GLTEARVQVWFSNRRAR GSBD_DROME 223 -1 GLQPRQIAIWFQNRRAR HAT7_ARATH 87 -1 GITVSQVSNWFGNKRIR PBX1_HUMAN 274 -1 GITVSQVSNWFGNKRIR PBX1_MOUSE 274 -1 GITVSQVSNWFGNKRIR PBX2_HUMAN 285 -1 GITVSQVSNWFGNKRIR PBX2_MOUSE 285 -1 GLQPRQIAIWFQNRRAR Q39941 127 -1 GITVSQVSNWFGNKRIR EXD_DROME 279 -1 GLPESRVQVWFQNRRAK O46118 195 -1 GLRARQVEVWFQNRRAR HAT4_ARATH 164 -1 GLPEPRVQVWFQNRRAK O54817 156 -1 GLPEPRVQVWFQNRRAK O88933 224 -1 GLRPRQVEVWFQNRRAR Q40782 174 -1 GLRARQVEVWFQNRRAR Q39862 149 -1 GLPESRIQIWFQNRRAR Q14333 594 -1 GLPESRIQIWFQNRRAR O43812 132 -1 GLTTTQVSNWFKNRRQR SIX1_HUMAN 162 -1 GLTTTQVSNWFKNRRQR SIX2_MOUSE 162 -1 GLPESRIQVWFQNRRSK O57407 121 -1 GLPESRIQVWFQNRRSK O93534 121 -1 GLTKRVLQVWFQNARAK Q90881 286 95 GLSNAQVITWFQNRRAK P91625 391 -1 GITPLQVRVWFINKRMR MTA1_YEAST 108 -1 GLTFRQVNKWFETRRHS HX1A_MAIZE 597 -1 GLTFNQISKWFSGTRHY Q41812 1072 -1 GITPLQVRVWVCNMRIK MTA0_YEAST 108 -1 GISQVQVSRLEKKILKQ RPSF_BACME 229 -1 GISQVQVSRLEKKILKQ RPSF_BACLI 229 -1 GLTIETVSRQLTRLRKE O86069 199 -1 GLTIETVSRQMTRLRKS Q52775 199 -1 GLTIETVSRQMTRLRKI FX24_RHILV 199 -1 GLATRTITNWFHNHRMR HMCU_DROME 1783 -1 GISQVQVSRLEKKILKQ RPSF_BACSU 229 -1 GISQVQVSRLEKKILAQ O32725 227 83 GISQAQVSRLEKTALKH RPSG_CLOAB 236 -1

User query: Display/Full Code "HTHREPRESSR"