WORKLIST ENTRIES (1):
GLHYDRLASE39 View alignment Glycosyl hydrolase family 39 signature
Type of fingerprint: COMPOUND with 7 elements
Links:
PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
PRINTS; PR00732 GLHYDRLASE4; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7
PRINTS; PR00735 GLHYDRLASE8; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11
PRINTS; PR00736 GLHYDRLASE15; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20
PRINTS; PR00739 GLHYDRLASE26; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29
PRINTS; PR00843 GLHYDRLASE30; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36
PRINTS; PR00744 GLHYDRLASE37; PR00746 GLHYDRLASE41; PR00747 GLHYDRLASE47
PRINTS; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52; PR00846 GLHYDRLASE56
PRINTS; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59; PR00748 MELIBIASE
PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
INTERPRO; IPR000514
PROSITE; PS01027 GLYCOSYL_HYDROL_F39
PFAM; PF01229 Glycosyl_hydr19
Creation date 11-JUN-1997; UPDATE 07-JUN-1999
1. HENRISSAT, B. AND BAIROCH, A.
New families in the classification of glycosyl hydrolases based on amino
acid sequence similarities.
BIOCHEM.J. 293 781-788 (1993).
2. HENRISSAT, B.
A classification of glycosyl hydrolases based on amino acid sequence
similarities.
BIOCHEM.J. 280 309-316 (1991).
3. DAVIES, G. AND HENRISSAT, B.
Structures and mechanisms of glycosyl hydrolases.
STRUCTURE 3 853-859 (1995).
4. HENRISSAT, B. AND BAIROCH, A.
Updating the sequence-based classification of glycosyl hydrolases.
BIOCHEM.J. 316 695-696 (1996).
5. STOLTZFUS, L.J., SOSA-PINEDA, B., MOSKOWITZ, S.M., MENON, K.P.,
DLOTT, B., HOOPER, L., TEPLOW, D.B., SHULL, R.M. AND NEUFELD, E.F.
Cloning and characterization of cDNA encoding canine alpha-L-iduronidase.
mRNA deficiency in mucopolysaccharidosis I dog.
J.BIOL.CHEM. 267(10) 6570-6575 (1992).
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
hydrolyse the glycosidic bond between two or more carbohydrates, or between
a carbohydrate and a non-carbohydrate moiety. A classification system for
glycosyl hydrolases, based on sequence similarity, has led to the definition
of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
glycosid.txt). Family 39 encompasses mammalian alpha-L-iduronidases and some
bacterial beta-xylosidases.
Alpha-L-iduronidase is a lysosomal enzyme, deficiency of which causes muco-
polysaccharidosis I (MPS I) [5]. The enzyme hydrolyses alpha-L-iduronosidic
linkages in desulphated dermatan.
GLHYDRLASE39 is a 7-element fingerprint that provides a signature for
family 39 glycosyl hydrolases. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from conserved regions
spanning the central portion of the alignment - motif 3 includes the
region encoded by PROSITE pattern GLYCOSYL_HYDROL_F39 (PS01027), which
contains a Glu residue that may act as the proton donor in the catalytic
mechanism. A single iteration on OWL29.3 was required to reach convergence,
no further sequences being identified beyond the starting set.
An update on SPTR37_9f identified a true set of 6 sequences, and 1
partial match.
SUMMARY INFORMATION
6 codes involving 7 elements
1 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
7| 6 6 6 6 6 6 6
6| 1 1 1 1 1 1 0
5| 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0
--+------------------------------------
| 1 2 3 4 5 6 7
True positives..
IDUA_HUMAN IDUA_CANFA IDUA_MOUSE XYNB_THESA
O30360 XYNB_CALSA
Subfamily: Codes involving 6 elements
Subfamily True positives..
O30428
PROTEIN TITLES
IDUA_HUMAN ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - HOMO SAPIENS (
IDUA_CANFA ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - CANIS FAMILIAR
IDUA_MOUSE ALPHA-L-IDURONIDASE PRECURSOR (EC 3.2.1.76) - MUS MUSCULUS (
XYNB_THESA BETA-XYLOSIDASE (EC 3.2.1.37) (1,4-BETA-D-XYLAN XYLOHYDROLAS
O30360 BETA-XYLOSIDASE - THERMOANAEROBACTERIUM SP. 'JW/SL YS485'.
XYNB_CALSA BETA-XYLOSIDASE (EC 3.2.1.37) (1,4-BETA-D-XYLAN XYLOHYDROLAS
O30428 XYLANASE - CALDOCELLUM SACCHAROLYTICUM (CALDICELLULOSIRUPTOR
SCAN HISTORY
OWL29_3 1 25 NSINGLE
SPTR37_9f 2 7 NSINGLE
INITIAL MOTIF SETS
GLHYDRLASE391 Length of motif = 17 Motif number = 1
Glycosyl hydrolase family 39 motif I - 1
PCODE ST INT
LDGYLDLLRENQLLPGF IDUA_CANFA 113 113
LDGYLDLLRENQLLPGF IDUA_HUMAN 114 114
LDAFLDLLMENQLLPGF IDUA_MOUSE 104 104
FDSFLEIGIRPFVEIGF XYNB_THESA 86 86
IDFLLEIGMKPFIELSF XYNB_CALSA 89 89
GLHYDRLASE392 Length of motif = 18 Motif number = 2
Glycosyl hydrolase family 39 motif II - 1
PCODE ST INT
LVSLLARRYIGRYGLSYV IDUA_CANFA 154 24
LVSSLARRYIGRYGLAHV IDUA_HUMAN 155 24
LVSLLARRYIGRYGLTHV IDUA_MOUSE 145 24
LVKAVLHHFISRYGIEEV XYNB_THESA 133 30
LIEELARHLISRYGKNEV XYNB_CALSA 136 30
GLHYDRLASE393 Length of motif = 17 Motif number = 3
Glycosyl hydrolase family 39 motif III - 1
PCODE ST INT
VSKWNFETWNEPDHHDF IDUA_CANFA 171 -1
VSKWNFETWNEPDHHDF IDUA_HUMAN 172 -1
VSKWNFETWNEPDHHDF IDUA_MOUSE 162 -1
VLKWPFEIWNEPNLKEF XYNB_THESA 150 -1
VREWFFEVWNEPNLKDF XYNB_CALSA 153 -1
GLHYDRLASE394 Length of motif = 15 Motif number = 4
Glycosyl hydrolase family 39 motif IV - 1
PCODE ST INT
FTGELGVRLDYISLH IDUA_CANFA 247 59
FTGEAGVRLDYISLH IDUA_HUMAN 248 59
FTGEVGVRLDYISLH IDUA_MOUSE 238 59
FCYEENVPVDFVSRH XYNB_THESA 214 47
FCTKNGVPIDFISTH XYNB_CALSA 215 45
GLHYDRLASE395 Length of motif = 18 Motif number = 5
Glycosyl hydrolase family 39 motif V - 1
PCODE ST INT
PWRADVTYAAMVVKVVAQ IDUA_CANFA 310 48
PWRADVTYAAMVVKVIAQ IDUA_HUMAN 311 48
PWRADVTYAALVVKVIAQ IDUA_MOUSE 301 48
PVHDTPFNAAYIARILSE XYNB_THESA 287 58
PYHDIPYDAAFIVKTIID XYNB_CALSA 285 55
GLHYDRLASE396 Length of motif = 12 Motif number = 6
Glycosyl hydrolase family 39 motif VI - 1
PCODE ST INT
LDNPRCSPHGEW IDUA_CANFA 475 147
LDNGLCSPDGEW IDUA_HUMAN 476 147
LDNQLSSPYSAW IDUA_MOUSE 466 147
IDEEHGNPWGTW XYNB_THESA 415 110
IDEYNANPKRVW XYNB_CALSA 420 117
GLHYDRLASE397 Length of motif = 15 Motif number = 7
Glycosyl hydrolase family 39 motif VII - 1
PCODE ST INT
WQRLGRPVFPTAEEF IDUA_CANFA 486 -1
WRRLGRPVFPTAEQF IDUA_HUMAN 487 -1
WQHMGQPVFPSAEQF IDUA_MOUSE 477 -1
WIHMGRPRYPSKEQV XYNB_THESA 426 -1
WLEMGSPAYLNREQI XYNB_CALSA 431 -1
FINAL MOTIF SETS
GLHYDRLASE391 Length of motif = 17 Motif number = 1
Glycosyl hydrolase family 39 motif I - 2
PCODE ST INT
LDGYLDLLRENQLLPGF IDUA_HUMAN 114 114
LDGYLDLLRENQLLPGF IDUA_CANFA 113 113
LDAFLDLLMENQLLPGF IDUA_MOUSE 104 104
FDSFLEIGIRPFVEIGF XYNB_THESA 86 86
FDSFLEIGIRPFVEIGF O30360 86 86
IDFLLEIGMKPFIELSF XYNB_CALSA 89 89
GLHYDRLASE392 Length of motif = 18 Motif number = 2
Glycosyl hydrolase family 39 motif II - 2
PCODE ST INT
LVSSLARRYIGRYGLAHV IDUA_HUMAN 155 24
LVSLLARRYIGRYGLSYV IDUA_CANFA 154 24
LVSLLARRYIGRYGLTHV IDUA_MOUSE 145 24
LVKAVLHHFISRYGIEEV XYNB_THESA 133 30
LIKAVVSHFISRYGIDEV O30360 133 30
LIEELARHLISRYGKNEV XYNB_CALSA 136 30
GLHYDRLASE393 Length of motif = 17 Motif number = 3
Glycosyl hydrolase family 39 motif III - 2
PCODE ST INT
VSKWNFETWNEPDHHDF IDUA_HUMAN 172 -1
VSKWNFETWNEPDHHDF IDUA_CANFA 171 -1
VSKWNFETWNEPDHHDF IDUA_MOUSE 162 -1
VLKWPFEIWNEPNLKEF XYNB_THESA 150 -1
VAKWPFEIWNEPNLKEF O30360 150 -1
VREWFFEVWNEPNLKDF XYNB_CALSA 153 -1
GLHYDRLASE394 Length of motif = 15 Motif number = 4
Glycosyl hydrolase family 39 motif IV - 2
PCODE ST INT
FTGEAGVRLDYISLH IDUA_HUMAN 248 59
FTGELGVRLDYISLH IDUA_CANFA 247 59
FTGEVGVRLDYISLH IDUA_MOUSE 238 59
FCYEENVPVDFVSRH XYNB_THESA 214 47
FCYEENVPVDFVSRH O30360 214 47
FCTKNGVPIDFISTH XYNB_CALSA 215 45
GLHYDRLASE395 Length of motif = 18 Motif number = 5
Glycosyl hydrolase family 39 motif V - 2
PCODE ST INT
PWRADVTYAAMVVKVIAQ IDUA_HUMAN 311 48
PWRADVTYAAMVVKVVAQ IDUA_CANFA 310 48
PWRADVTYAALVVKVIAQ IDUA_MOUSE 301 48
PVHDTPFNAAYIARILSE XYNB_THESA 287 58
PVHDTPFNAAYIARILSE O30360 287 58
PYHDIPYDAAFIVKTIID XYNB_CALSA 285 55
GLHYDRLASE396 Length of motif = 12 Motif number = 6
Glycosyl hydrolase family 39 motif VI - 2
PCODE ST INT
LDNGLCSPDGEW IDUA_HUMAN 476 147
LDNPRCSPHGEW IDUA_CANFA 475 147
LDNQLSSPYSAW IDUA_MOUSE 466 147
IDEEHGNPWGTW XYNB_THESA 415 110
IDEEHGNPWGTW O30360 415 110
IDEYNANPKRVW XYNB_CALSA 420 117
GLHYDRLASE397 Length of motif = 15 Motif number = 7
Glycosyl hydrolase family 39 motif VII - 2
PCODE ST INT
WRRLGRPVFPTAEQF IDUA_HUMAN 487 -1
WQRLGRPVFPTAEEF IDUA_CANFA 486 -1
WQHMGQPVFPSAEQF IDUA_MOUSE 477 -1
WIHMGRPRYPSKEQV XYNB_THESA 426 -1
WIHMGRPRYPSKKEI O30360 426 -1
WLEMGSPAYLNREQI XYNB_CALSA 431 -1
User query: Display/Full Code "GLHYDRLASE39"