WORKLIST ENTRIES (1):
GIPRECEPTOR View alignment Gastric inhibitory polypeptide receptor precursor signature
Type of fingerprint: COMPOUND with 11 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00249 GPCRSECRETIN; PR00250 GPCRSTE2; PR00899 GPCRSTE3
PRINTS; PR00251 BACTRLOPSIN
INTERPRO; IPR001749
Creation date 22-MAY-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ISHIHARA T., NAKAMURA S., KAZIRO, Y., TAKAHASHI, T., TAKAHASHI, K.
AND NAGATA, S.
Molecular cloning and expression of a cDNA encoding the secretin receptor
EMBO J. 10 1635-1641 (1991).
3. LIN, H.Y., HARRIS, T.L., FLANNERY, M.S., ARUFFO, A., KAJI, E.H.,
GORN, A., KOLAKOWSKI, L.F., LODISH, H.F. AND GOLDRING, S.R.
Expression cloning of adenylate cyclase-coupled calcitonin receptor
SCIENCE 254 1022-1024 (1991).
4. JUEPPNER, H., ABOU-SAMRA, A.-B., FREEMAN, M., KONG, X.F.,
SCHIPANI, E., RICHARDS, J., KOLALOWSKI, L.F., HOCK, J., POTTS, J.T.,
KRONENBERG, H.M. AND SEGRE, G.E.
A G protein linked receptor for parathyroid hormone and parathyroid
hormone-related peptide.
SCIENCE 254 1024-1026 (1991).
5. ISHIHARA, T., SHIGEMOTO, R., MORI, K., TAKAHASHI, K. AND NAGATA, S.
Functional expression and tissue distribution of a novel receptor for
vasoactive intestinal polypeptide.
NEURON 8(4) 811-819 (1992).
6. VOLZ, A., GOKE, R., LANKAT-BUTTGEREIT, B., FEHMANN, H.C., BODE, H.P.
AND GOKE, B.
Molecular cloning, functional expression, and signal transduction of the
GIP-receptor cloned from a human insulinoma.
FEBS LETT. 373(1) 23-9 (1995).
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The secretin-like GPCRs include secretin [2], calcitonin [3], parathyroid
hormone/parathyroid hormone-related peptides [4] and vasoactive intestinal
peptide [5], all of which activate adenylyl cyclase and the phosphatidyl-
inositol-calcium pathway. The amino acid sequences of the receptors contain
high proportions of hydrophobic residues grouped into 7 domains, in a
manner reminiscent of the rhodopsins and other receptors believed to inter-
act with G proteins. However, while a similar 3D framework has been
proposed to account for this, there is no significant sequence similarity
between these families: the secretin-like receptors thus bear their own
unique '7TM' signature.
Glucose-dependent insulinotropic polypeptide (GIP) plays an important role
in the regulation of postprandial insulin secretion and proinsulin gene
expression of pancreatic beta-cells [6]. The human GIP-receptor encodes a
7TM protein that is similar to the human glucagon-like peptide 1(GLP-1)
receptor. It is hoped that an understanding of GIP-receptor regulation and
signal transduction will shed light on the hormone's failure to exert its
biological action at the pancreatic B-cell in type II diabetes mellitus.
GIPRECEPTOR is an 11-element fingerprint that provides a signature for
gastric inhibitory polypeptide receptors. The fingerprint was derived from
an initial alignment of 3 sequences: the motifs were drawn from conserved
regions spanning the full alignment length, focusing on those sections
that characterise the gastric inhibitory polypeptide receptors but
distinguish them from the rest of the secretin-like superfamily - motifs 1-6
span the N-terminal domain; motif 7 resides in the loop between TM domains 2
and 3; motif 8 spans the loop between TM domains 3 and 4; motif 9 spans the C-terminal portion of TM domain 6 and
loop between TM domains 4 and 5; and motifs 10 and 11 reside at the
C-terminus. A single iteration on SPTR37_9f was required to reach convergence,
no further sequences being identified beyond the starting set. Two partial
matches were also found, secretin and glucagon receptors that match motifs
1, 8 and 9.
SUMMARY INFORMATION
3 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
2 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
11| 3 3 3 3 3 3 3 3 3 3 3
10| 0 0 0 0 0 0 0 0 0 0 0
9| 0 0 0 0 0 0 0 0 0 0 0
8| 0 0 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0 0 0
2| 1 0 0 0 0 0 0 1 2 0 0
--+--------------------------------------------------------
| 1 2 3 4 5 6 7 8 9 10 11
True positives..
GIPR_MESAU GIPR_RAT GIPR_HUMAN
Subfamily: Codes involving 2 elements
Subfamily True positives..
SCRC_RAT GLR_RAT
PROTEIN TITLES
GIPR_MESAU GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
GIPR_RAT GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
GIPR_HUMAN GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
SCRC_RAT SECRETIN RECEPTOR PRECURSOR (SCT-R) - RATTUS NORVEGICUS (RAT
GLR_RAT GLUCAGON RECEPTOR PRECURSOR (GL-R) - RATTUS NORVEGICUS (RAT)
SCAN HISTORY
SPTR37_9f 1 77 NSINGLE
INITIAL MOTIF SETS
GIPRECEPTOR1 Length of motif = 21 Motif number = 1
Gastric inhibitory polypeptide receptor precursor motif I - 1
PCODE ST INT
PILQLLLRLSLCGLLLQRAET GIPR_HUMAN 5 5
PLRPRLLLLCLWGLLLQQAET GIPR_MESAU 2 2
PLRLLLLLLWLWGLSLQRAET GIPR_RAT 2 2
GIPRECEPTOR2 Length of motif = 18 Motif number = 2
Gastric inhibitory polypeptide receptor precursor motif II - 1
PCODE ST INT
TGSKGQTAGELYQRWERY GIPR_HUMAN 25 -1
TDSEGQTTGELYQRWERY GIPR_MESAU 22 -1
TDSEGQTTGELYQRWERY GIPR_RAT 22 -1
GIPRECEPTOR3 Length of motif = 15 Motif number = 3
Gastric inhibitory polypeptide receptor precursor motif III - 1
PCODE ST INT
CQETLAAAEPPSGLA GIPR_HUMAN 46 3
CEETLTAADPPSGMV GIPR_MESAU 43 3
CQNTLEATEPPSGLA GIPR_RAT 43 3
GIPRECEPTOR4 Length of motif = 14 Motif number = 4
Gastric inhibitory polypeptide receptor precursor motif IV - 1
PCODE ST INT
HHVAAGFVLRQCGS GIPR_HUMAN 92 31
RHVAAGYVFRQCGS GIPR_MESAU 89 31
RQVAAGFVFRQCGS GIPR_RAT 89 31
GIPRECEPTOR5 Length of motif = 17 Motif number = 5
Gastric inhibitory polypeptide receptor precursor motif V - 1
PCODE ST INT
WGLWRDHTQCENPEKNE GIPR_HUMAN 109 3
WGPWRDHTQCENPEKNG GIPR_MESAU 106 3
WGSWRDHTQCENPEKNG GIPR_RAT 106 3
GIPRECEPTOR6 Length of motif = 14 Motif number = 6
Gastric inhibitory polypeptide receptor precursor motif VI - 1
PCODE ST INT
EAFLDQRLILERLQ GIPR_HUMAN 125 -1
GAFQDQRLILERLQ GIPR_MESAU 122 -1
GAFQDQKLILERLQ GIPR_RAT 122 -1
GIPRECEPTOR7 Length of motif = 21 Motif number = 7
Gastric inhibitory polypeptide receptor precursor motif VII - 1
PCODE ST INT
PRPGPYLGDQALALWNQALAA GIPR_HUMAN 195 56
PTLGPYPGDRTLTLRNQALAA GIPR_MESAU 192 56
PPLGPYTGNQTPTLWNQALAA GIPR_RAT 192 56
GIPRECEPTOR8 Length of motif = 18 Motif number = 8
Gastric inhibitory polypeptide receptor precursor motif VIII - 1
PCODE ST INT
HSLLVLVGGSEEGHFRYY GIPR_HUMAN 242 26
HHLLVIVGGSEKGHFRCY GIPR_MESAU 239 26
HHLLVVVRRSEKGHFRCY GIPR_RAT 239 26
GIPRECEPTOR9 Length of motif = 18 Motif number = 9
Gastric inhibitory polypeptide receptor precursor motif IX - 1
PCODE ST INT
YLYENTQCWERNEVKAIW GIPR_HUMAN 279 19
YLLENTQCWERNEVKAIW GIPR_MESAU 276 19
YLYENTQCWERNEVKAIW GIPR_RAT 276 19
GIPRECEPTOR10 Length of motif = 18 Motif number = 10
Gastric inhibitory polypeptide receptor precursor motif X - 1
PCODE ST INT
QLPERAFRALPSGSGPGE GIPR_HUMAN 422 125
PHAELGPQALPSRSAPRE GIPR_MESAU 420 126
PHLGQAPRAVPLSSAPQE GIPR_RAT 414 120
GIPRECEPTOR11 Length of motif = 17 Motif number = 11
Gastric inhibitory polypeptide receptor precursor motif XI - 1
PCODE ST INT
LSSGTLPGPGNEASREL GIPR_HUMAN 446 6
LPSGPLHGPGEEVLESY GIPR_MESAU 445 7
LPSGMLHVPGDEVLESY GIPR_RAT 438 6
FINAL MOTIF SETS
GIPRECEPTOR1 Length of motif = 21 Motif number = 1
Gastric inhibitory polypeptide receptor precursor motif I - 1
PCODE ST INT
PLRPRLLLLCLWGLLLQQAET GIPR_MESAU 2 2
PLRLLLLLLWLWGLSLQRAET GIPR_RAT 2 2
PILQLLLRLSLCGLLLQRAET GIPR_HUMAN 5 5
GIPRECEPTOR2 Length of motif = 18 Motif number = 2
Gastric inhibitory polypeptide receptor precursor motif II - 1
PCODE ST INT
TDSEGQTTGELYQRWERY GIPR_MESAU 22 -1
TDSEGQTTGELYQRWERY GIPR_RAT 22 -1
TGSKGQTAGELYQRWERY GIPR_HUMAN 25 -1
GIPRECEPTOR3 Length of motif = 15 Motif number = 3
Gastric inhibitory polypeptide receptor precursor motif III - 1
PCODE ST INT
CEETLTAADPPSGMV GIPR_MESAU 43 3
CQNTLEATEPPSGLA GIPR_RAT 43 3
CQETLAAAEPPSGLA GIPR_HUMAN 46 3
GIPRECEPTOR4 Length of motif = 14 Motif number = 4
Gastric inhibitory polypeptide receptor precursor motif IV - 1
PCODE ST INT
RHVAAGYVFRQCGS GIPR_MESAU 89 31
RQVAAGFVFRQCGS GIPR_RAT 89 31
HHVAAGFVLRQCGS GIPR_HUMAN 92 31
GIPRECEPTOR5 Length of motif = 17 Motif number = 5
Gastric inhibitory polypeptide receptor precursor motif V - 1
PCODE ST INT
WGPWRDHTQCENPEKNG GIPR_MESAU 106 3
WGSWRDHTQCENPEKNG GIPR_RAT 106 3
WGLWRDHTQCENPEKNE GIPR_HUMAN 109 3
GIPRECEPTOR6 Length of motif = 14 Motif number = 6
Gastric inhibitory polypeptide receptor precursor motif VI - 1
PCODE ST INT
GAFQDQRLILERLQ GIPR_MESAU 122 -1
GAFQDQKLILERLQ GIPR_RAT 122 -1
EAFLDQRLILERLQ GIPR_HUMAN 125 -1
GIPRECEPTOR7 Length of motif = 21 Motif number = 7
Gastric inhibitory polypeptide receptor precursor motif VII - 1
PCODE ST INT
PTLGPYPGDRTLTLRNQALAA GIPR_MESAU 192 56
PPLGPYTGNQTPTLWNQALAA GIPR_RAT 192 56
PRPGPYLGDQALALWNQALAA GIPR_HUMAN 195 56
GIPRECEPTOR8 Length of motif = 18 Motif number = 8
Gastric inhibitory polypeptide receptor precursor motif VIII - 1
PCODE ST INT
HHLLVIVGGSEKGHFRCY GIPR_MESAU 239 26
HHLLVVVRRSEKGHFRCY GIPR_RAT 239 26
HSLLVLVGGSEEGHFRYY GIPR_HUMAN 242 26
GIPRECEPTOR9 Length of motif = 18 Motif number = 9
Gastric inhibitory polypeptide receptor precursor motif IX - 1
PCODE ST INT
YLLENTQCWERNEVKAIW GIPR_MESAU 276 19
YLYENTQCWERNEVKAIW GIPR_RAT 276 19
YLYENTQCWERNEVKAIW GIPR_HUMAN 279 19
GIPRECEPTOR10 Length of motif = 18 Motif number = 10
Gastric inhibitory polypeptide receptor precursor motif X - 1
PCODE ST INT
PHAELGPQALPSRSAPRE GIPR_MESAU 420 126
PHLGQAPRAVPLSSAPQE GIPR_RAT 414 120
QLPERAFRALPSGSGPGE GIPR_HUMAN 422 125
GIPRECEPTOR11 Length of motif = 17 Motif number = 11
Gastric inhibitory polypeptide receptor precursor motif XI - 1
PCODE ST INT
LPSGPLHGPGEEVLESY GIPR_MESAU 445 7
LPSGMLHVPGDEVLESY GIPR_RAT 438 6
LSSGTLPGPGNEASREL GIPR_HUMAN 446 6
User query: Display/Full Code "GIPRECEPTOR"