WORKLIST ENTRIES (1):
EPMEMFAMILY View alignment Epithelial membrane protein (EMP/PMP22/LMIP) family signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR01454 EPMEMPROT1; PR01455 EPMEMPROT2; PR01456 EPMEMPROT3
PRINTS; PR01457 LENSMEMPROT; PR01458 PMYELIN22
PROSITE; PS01221 PMP22_1; PS01222 PMP22_2
PFAM; PF00822 PMP22
INTERPRO; IPR000729
Creation date 23-NOV-2000
1. TAYLOR, V., WELCHER, A.A., PROGRAM, A.E. AND SUTER, U.
Epithelial membrane protein-1, peripheral myelin protein 22, and lens
membrane protein 20 define a novel gene family.
J.BIOL.CHEM. 270 28824-28833 (1995).
2. LOBSIGER, C., MAGYAR, J., TAYLOR, V., WULF, P., WELCHER, A., PROGRAM A.E.
AND SUTER, U.
Identification and characterization of a cDNA and the structural gene
encoding the mouse epithelial membrane protein-1.
GENOMICS 36 379-387 (1996).
3. ZOIDL, G., BLASS-KAMPMANN, S., D'URSO, D., SCHMALENBACH, C. AND MULLER, H.
Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in
Schwann cells: modulation of cell growth.
EMBO J. 14 1122-1128 (1995).
4. BEN-PORATH, I. AND BENVENISTY, N.
Characterization of a tumor-associated gene, a member of a novel family
of genes encoding membrane glycoproteins.
GENE 183 69-75 (1996).
5. LOUIS, C., HUR, K., GALVAN, A., TENBROEK, E., JARVIS, I., ECCLESTON, E.
AND HOWARD, J.
Identification of an 18,000-dalton protein in mammalian lens fiber cell
proteins.
J.BIOL.CHEM. 264 19967-19973 (1989).
The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin
protein 22 (PMP22), and lens fiber membrane intrinsic protein (LMIP)
comprise a protein family on the basis of sequence and structural
similarities [1]. Each family member is a small hydrophobic membrane
glycoprotein, ~160-170 amino acids in length, and shares a common predicted
transmembrane (TM) topology of 4 TM domains, with intracellular N- and
C-termini [2].
Roles for the EMP/PMP22/LMIP family members in cell structure and growth
and have been proposed [1]. PMP22 is a structural component of compact
myelin in the peripheral nervous system. It has also been implicated in the
control of cell proliferation. PMP22 expression levels are up-regulated in
cultured cells undergoing growth arrest [1], and modulation of PMP22 levels
in cultured Schwann cells exerts a profound effect on the length of the G1
phase of the cell cycle [3]. In contrast, EMP-1, which is co-expressed with
PMP22 in a range of tissues, displays an inverse pattern of regulation.
EMP-1 expression levels are high in proliferating cells and can be
down-regulated by inducing growth arrest [4]. It has therefore been
proposed that these proteins may perform reciprocal roles in the control of
cell quiescence and proliferation. Although the function of LMIP has not
been elucidated, its extremely high expression level in the mammalian eye
lens suggests it may perform a tissue specific role [5].
EPMEMFAMILY is a 4-element fingerprint that provides a signature for the
epithelial membrane protein (EMP/PMP22/LMIP) family. The fingerprint was
derived from an initial alignment of 15 sequences: the motifs were drawn
from conserved loop and TM regions, focusing on those sections that
characterise the EMP/PMP22/LMIP family - motif 1 lies in TM domain 2; motif
2 spans part of the intracellular loop and part of TM domain 3; motif 3
resides within TM domain 3; and motif 4 lies in TM domain 4. Two iterations
on SPTR39_14f were required to reach convergence, at which point a true set
comprising 16 sequences was identified. A single partial match was also
found, Q9TQZ3, a preliminary partial bovine sequence that is highly similar
to PMP22.
SUMMARY INFORMATION
16 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 16 16 16 16
3| 0 0 0 0
2| 0 1 1 0
--+---------------------
| 1 2 3 4
True positives..
EMP1_RABIT PM22_HUMAN PM22_MOUSE PM22_RAT
O88662 EMP2_HUMAN EMP1_HUMAN EMP1_RAT
EMP1_MOUSE EMP3_MOUSE Q9QYW5 O88333
EMP3_HUMAN LMIP_RAT LMIP_HUMAN LMIP_BOVIN
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q9TQZ3
PROTEIN TITLES
EMP1_RABIT EPITHELIAL MEMBRANE PROTEIN-1 (EMP-1) (TUMOR-ASSOCIATED MEMB
PM22_HUMAN PERIPHERAL MYELIN PROTEIN 22 (PMP-22) - Homo sapiens (Human)
PM22_MOUSE PERIPHERAL MYELIN PROTEIN 22 (PMP-22) (GROWTH-ARREST-SPECIFI
PM22_RAT PERIPHERAL MYELIN PROTEIN 22 (PMP-22) (CD25 PROTEIN) (SR13 M
O88662 XMP - Mus musculus (Mouse).
EMP2_HUMAN EPITHELIAL MEMBRANE PROTEIN-2 (EMP-2) (XMP PROTEIN) - Homo s
EMP1_HUMAN EPITHELIAL MEMBRANE PROTEIN-1 (EMP-1) (TUMOR-ASSOCIATED MEMB
EMP1_RAT EPITHELIAL MEMBRANE PROTEIN-1 (EMP-1) (TUMOR-ASSOCIATED MEMB
EMP1_MOUSE EPITHELIAL MEMBRANE PROTEIN-1 (EMP-1) (TUMOR-ASSOCIATED MEMB
EMP3_MOUSE EPITHELIAL MEMBRANE PROTEIN-3 (EMP-3) (HEMATOPOIETIC NEURAL
Q9QYW5 EMP3 HOMOLOG - Rattus norvegicus (Rat).
O88333 YMP - Mus musculus (Mouse).
EMP3_HUMAN EPITHELIAL MEMBRANE PROTEIN-3 (EMP-3) (YMP PROTEIN) (HEMATOP
LMIP_RAT LENS FIBER MEMBRANE INTRINSIC PROTEIN (MP17) (MP18) (MP19) (
LMIP_HUMAN LENS FIBER MEMBRANE INTRINSIC PROTEIN (MP18) (MP19) (MP20) -
LMIP_BOVIN LENS FIBER MEMBRANE INTRINSIC PROTEIN (MP18) (MP19) (MP21) (
Q9TQZ3 PAS POSITIVE GLYCOPROTEIN, PASII - Bos taurus (Bovine).
SCAN HISTORY
SPTR39_14f 2 300 NSINGLE
INITIAL MOTIF SETS
EPMEMFAMILY1 Length of motif = 8 Motif number = 1
Epithelial membrane protein (EMP/PMP22/LMIP) family motif I - 1
PCODE ST INT
AFMILSII EMP1_RABIT 66 66
ATMILSII PM22_HUMAN 67 67
ATMILSVI PM22_MOUSE 67 67
ATMILSVI PM22_RAT 67 67
ATMILSTI EMP2_HUMAN 66 66
ATMILSTI O88662 71 71
AFMILSII EMP1_HUMAN 66 66
AFMILSII EMP1_RAT 66 66
AFMILSII EMP1_MOUSE 66 66
ALMVLSLI EMP3_MOUSE 68 68
ALMVLSLI Q9QYW5 68 68
ALMVLSLI O88333 68 68
AFMILSAL LMIP_RAT 66 66
AFMILSAL LMIP_HUMAN 66 66
VLMVLSLI EMP3_HUMAN 68 68
AFMILSSL LMIP_BOVIN 66 66
EPMEMFAMILY2 Length of motif = 9 Motif number = 2
Epithelial membrane protein (EMP/PMP22/LMIP) family motif II - 1
PCODE ST INT
KGNRFFLSG EMP1_RABIT 91 17
KGGRFYITG PM22_HUMAN 92 17
KGGRFYITG PM22_MOUSE 92 17
KGGRFYITG PM22_RAT 92 17
QGERFVLTS EMP2_HUMAN 91 17
QGERFVLTS O88662 96 17
KGNRFFLSG EMP1_HUMAN 91 17
KGNRFFLSG EMP1_RAT 91 17
KGNRFFLSG EMP1_MOUSE 91 17
RGGLFYATG EMP3_MOUSE 93 17
RGGLFYATG Q9QYW5 93 17
RGGIFYATG O88333 93 17
RLSRPFSAG LMIP_RAT 94 20
RISRPFSAG LMIP_HUMAN 94 20
RGGLFYATG EMP3_HUMAN 93 17
RLSRPFSAG LMIP_BOVIN 94 20
EPMEMFAMILY3 Length of motif = 10 Motif number = 3
Epithelial membrane protein (EMP/PMP22/LMIP) family motif III - 1
PCODE ST INT
LCVLIGASIY EMP1_RABIT 107 7
LCVMSAAAIY PM22_HUMAN 108 7
LCVMSAAAIY PM22_MOUSE 108 7
LCVMSAAAIY PM22_RAT 108 7
LCVMIAASIY EMP2_HUMAN 107 7
LCVMIGASIY O88662 112 7
LCILVGVSIY EMP1_HUMAN 107 7
LCILIGVSIY EMP1_RAT 107 7
LCILVGVSIY EMP1_MOUSE 107 7
AAVFSGALIY EMP3_MOUSE 109 7
AAVFSGALIY Q9QYW5 109 7
AAVFSGALIY O88333 109 7
LFVLLALAIY LMIP_RAT 110 7
LFVVLALAIY LMIP_HUMAN 110 7
VAVFTGALIY EMP3_HUMAN 109 7
FFVLLALAIY LMIP_BOVIN 110 7
EPMEMFAMILY4 Length of motif = 8 Motif number = 4
Epithelial membrane protein (EMP/PMP22/LMIP) family motif IV - 1
PCODE ST INT
YSFILAWI EMP1_RABIT 135 18
FAYILAWV PM22_HUMAN 134 16
FAYILAWV PM22_MOUSE 134 16
FAYILAWV PM22_RAT 134 16
YSYILAWV EMP2_HUMAN 141 24
YSFILAWV O88662 146 24
YSYILGWI EMP1_HUMAN 132 15
YCFILTWI EMP1_RAT 135 18
YCFILTWI EMP1_MOUSE 135 18
YCFALAWV EMP3_MOUSE 137 18
YCFALAWV Q9QYW5 137 18
YCFALAWV O88333 137 18
WSYILGWV LMIP_RAT 138 18
WSYILGWV LMIP_HUMAN 138 18
YCFALAWV EMP3_HUMAN 137 18
WSYILGWV LMIP_BOVIN 138 18
FINAL MOTIF SETS
EPMEMFAMILY1 Length of motif = 8 Motif number = 1
Epithelial membrane protein (EMP/PMP22/LMIP) family motif I - 2
PCODE ST INT
AFMILSII EMP1_RABIT 66 66
ATMILSII PM22_HUMAN 67 67
ATMILSVI PM22_MOUSE 67 67
ATMILSVI PM22_RAT 67 67
ATMILSTI O88662 71 71
ATMILSTI EMP2_HUMAN 66 66
AFMILSII EMP1_HUMAN 66 66
AFMILSII EMP1_RAT 66 66
AFMILSII EMP1_MOUSE 66 66
ALMVLSLI EMP3_MOUSE 68 68
ALMVLSLI Q9QYW5 68 68
ALMVLSLI O88333 68 68
VLMVLSLI EMP3_HUMAN 68 68
AFMILSAL LMIP_RAT 66 66
AFMILSAL LMIP_HUMAN 66 66
AFMILSSL LMIP_BOVIN 66 66
EPMEMFAMILY2 Length of motif = 9 Motif number = 2
Epithelial membrane protein (EMP/PMP22/LMIP) family motif II - 2
PCODE ST INT
KGNRFFLSG EMP1_RABIT 91 17
KGGRFYITG PM22_HUMAN 92 17
KGGRFYITG PM22_MOUSE 92 17
KGGRFYITG PM22_RAT 92 17
QGERFVLTS O88662 96 17
QGERFVLTS EMP2_HUMAN 91 17
KGNRFFLSG EMP1_HUMAN 91 17
KGNRFFLSG EMP1_RAT 91 17
KGNRFFLSG EMP1_MOUSE 91 17
RGGLFYATG EMP3_MOUSE 93 17
RGGLFYATG Q9QYW5 93 17
RGGIFYATG O88333 93 17
RGGLFYATG EMP3_HUMAN 93 17
RLSRPFSAG LMIP_RAT 94 20
RISRPFSAG LMIP_HUMAN 94 20
RLSRPFSAG LMIP_BOVIN 94 20
EPMEMFAMILY3 Length of motif = 10 Motif number = 3
Epithelial membrane protein (EMP/PMP22/LMIP) family motif III - 2
PCODE ST INT
LCVLIGASIY EMP1_RABIT 107 7
LCVMSAAAIY PM22_HUMAN 108 7
LCVMSAAAIY PM22_MOUSE 108 7
LCVMSAAAIY PM22_RAT 108 7
LCVMIGASIY O88662 112 7
LCVMIAASIY EMP2_HUMAN 107 7
LCILVGVSIY EMP1_HUMAN 107 7
LCILIGVSIY EMP1_RAT 107 7
LCILVGVSIY EMP1_MOUSE 107 7
AAVFSGALIY EMP3_MOUSE 109 7
AAVFSGALIY Q9QYW5 109 7
AAVFSGALIY O88333 109 7
VAVFTGALIY EMP3_HUMAN 109 7
LFVLLALAIY LMIP_RAT 110 7
LFVVLALAIY LMIP_HUMAN 110 7
FFVLLALAIY LMIP_BOVIN 110 7
EPMEMFAMILY4 Length of motif = 8 Motif number = 4
Epithelial membrane protein (EMP/PMP22/LMIP) family motif IV - 2
PCODE ST INT
YSFILAWI EMP1_RABIT 135 18
FAYILAWV PM22_HUMAN 134 16
FAYILAWV PM22_MOUSE 134 16
FAYILAWV PM22_RAT 134 16
YSFILAWV O88662 146 24
YSYILAWV EMP2_HUMAN 141 24
YSYILGWI EMP1_HUMAN 132 15
YCFILTWI EMP1_RAT 135 18
YCFILTWI EMP1_MOUSE 135 18
YCFALAWV EMP3_MOUSE 137 18
YCFALAWV Q9QYW5 137 18
YCFALAWV O88333 137 18
YCFALAWV EMP3_HUMAN 137 18
WSYILGWV LMIP_RAT 138 18
WSYILGWV LMIP_HUMAN 138 18
WSYILGWV LMIP_BOVIN 138 18
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