WORKLIST ENTRIES (1):

D21N6MTFRASE View alignment View Structure    D21 class N6 adenine-specific DNA methyltransferase signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   PRINTS; PR00105 C5METTRFRASE; PR00505 D12N6MTFRASE; PR00507 N12N6MTFRASE
   PRINTS; PR00508 S21N4MTFRASE
   INTERPRO; IPR002295
   PROSITE; PS00092 N6_MTASE
   PDB; 1ADM 3Dinfo
   SCOP; 1ADM

 Creation date 24-MAY-1995; UPDATE 14-JUN-1999

   1. CHENG, X.
   Structure and function of DNA methyltransferases.
   ANNU.REV.BIOPHYS.BIOMOL.STRUCT. 24 293-318 (1995).

   2. LABAHN, J., GRANZIN, J., SCHLUCKEBIER, G., ROBINSON, D.P., JACK, W.E.,
   SCHILDKRAUT, I. AND SAENGER, W.
   Three-dimensional structure of the adenine-specific DNA methyltransferase
   M.TaqI in complex with the cofactor S-adenosylmethionine.
   PROC.NATL.ACAD.SCI.U.S.A. 91 10957-10961 (1994).

   3. TIMINSKAS, A., BUTKUS, V. AND JANULAITIS, A.
   Sequence motifs characteristic for DNA [cytosine-N4] and DNA [adenine-N6]
   methyltransferases. Classification of all DNA methyltransferases.
   GENE 157 3-11 (1995).

   4. WILLCOCK, D.F., DRYDEN, D.T. AND MURRAY, N.E.
   A mutational analysis of the two motifs common to adenine
   methyltransferases.
   EMBO J. 13 3902-3908 (1994).

   In prokaryotes, the major role of DNA methylation is to protect host
   DNA against degradation by restriction enzymes. There are 2 major classes
   of DNA methyltransferase that differ in the nature of the modifications 
   they effect [1]. The members of one class (C-MTases) methylate a ring
   carbon and form C5-methylcytosine (see PRINTS signature C5METTRFRASE).
   Members of the second class (N-MTases) methylate exocyclic nitrogens and
   form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases).
   Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM)
   as the methyl donor and are active as monomeric enzymes [1].
  
   The structure of N6-MTase TaqI (M.TaqI) has been resolved to 2.4A [2].
   The molecule folds into 2 domains: an N-terminal catalytic domain, which
   contains the catalytic and cofactor binding sites, and comprises a central
   9-stranded beta-sheet, surrounded by 5 helices; and a C-terminal DNA
   recognition domain, which is formed by 4 small beta-sheets and 8 alpha-
   helices. The N- and C-terminal domains form a cleft that accommodates the
   DNA substrate.
  
   A classification of N-MTases has been proposed, based on conserved motif
   (CM) arrangements [3]. According to this classification, N6-MTases that
   have a DPPY motif (CM II) occuring before the FxGxG motif (CM I) are
   designated D21 class N6-adenine MTases.
  
   D21N6MTFRASE is a 4-element fingerprint that provides a signature for the
   D21 class N6-adenine MTases. The fingerprint was derived from an initial
   alignment of 13 sequences. The motifs were drawn from the conserved
   regions used by Timinskas et al. [3] in their DNA MTase classification:
   the motifs correspond to CM II, III, Is and I, respectively - motif 1,
   which contains the N-MTase-specific tetrapeptide DPPY (cf. PROSITE pattern
   N6_MTASE), is important for methylation; and motif 4, which contains the
   FxGxG pattern, forms part of the cofactor (SAM) binding site [4]. Three
   iterations on OWL27.1 were required to reach convergence, at which point a 
   true set comprising 22 sequences was identified. Several partial matches
   were also found: S53866 is a phage HP1 cytosine MTase (M.PhiHII) that fails
   to match motif 3; MTC9_CITFR (M.Cfr9I), MTC1_CITFR (M.CfrBI) and MTX1_XANCC
   (XcyI) fail to match motif 1 and belong to the S21 class N4-cytosine MTases;
   MTB2_BACAM (M.BamHII) and MTP2_PROVU (M.PvuII), which match motifs 3 and 4,
   and MTSM_SERMA (M.SmaI), which match motifs 2 and 4, also belong to the S21
   class N4-cytosine MTases; MTB3_BACAR, BAMBAN111 (M.BanIII), MTB1_BACST
   (M.BseCI), MTTA_THEAQ and TATAQI (M.TaqI), which match motifs 1 and 2, are
   N12 class N6-adenine MTases, with CM I occuring before the CM II. 
  
   An update on SPTR37_9f identified a true set of 54 sequences, and 12
   partial matches.

  SUMMARY INFORMATION
     54 codes involving  4 elements
      5 codes involving  3 elements
      7 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  54   54   54   54  
    3|   5    1    4    5  
    2|   4    3    3    4  
   --+---------------------
     |   1    2    3    4  

True positives..
 YHDJ_ECOLI     Q45971         MTH1_HAEPA     O30569         
 O30570         MT22_STRPN     ML22_LACLC     MTH1_HAEIN     
 O25907         MT1C_MORBO     MTC9_CITFR     P94454         
 Q45489         MTR1_RHOSH     MTX1_XANCC     P96424         
 O68565         MTM2_MORBO     T3MO_SALTY     O68568         
 O25921         O86267         MTB1_BACAM     O68789         
 P71366         O24918         O82897         MT42_METJA     
 O25920         MTSM_SERMA     Q56638         T3MO_BPP1      
 MTC1_CITFR     Q08802         O74074         O74053         
 Q46975         MTM1_METJA     O68556         MTB2_BACAM     
 MTH3_HAEIN     O25040         O25315         O03956         
 Q38206         O51937         MTEC_ENTCL     MTHZ_METTF     
 O28863         O52513         MTK1_KLEPN     T3MO_ECOLI     
 MTP2_PROVU     MTH2_HAEHA     
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 O24891         O58333         O52692         MTMW_METWO     
 O25043         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 O25922         Q58606         P70724         O64360         
 P70802         MTTA_THEAQ     O32491         


  PROTEIN TITLES
   YHDJ_ECOLI       HYPOTHETICAL ADENINE-SPECIFIC METHYLASE IN FIS-ENVR INTERGEN
   Q45971           ADENINE METHYLTRANSFERASE - CAULOBACTER CRESCENTUS.
   MTH1_HAEPA       MODIFICATION METHYLASE HPAI (EC 2.1.1.72) (ADENINE-SPECIFIC 
   O30569           ADENINE DNA METHYLTRANSFERASE - SINORHIZOBIUM MELILOTI.
   O30570           ADENINE DNA METHYLTRANSFERASE - BRUCELLA ABORTUS.
   MT22_STRPN       MODIFICATION METHYLASE DPNII 2 (EC 2.1.1.72) (ADENINE-SPECIF
   ML22_LACLC       MODIFICATION METHYLASE LLADCHI B (EC 2.1.1.72) (ADENINE-SPEC
   MTH1_HAEIN       MODIFICATION METHYLASE HINFI (EC 2.1.1.72) (ADENINE-SPECIFIC
   O25907           ADENINE SPECIFIC DNA METHYLTRANSFERASE (HINFIM) - HELICOBACT
   MT1C_MORBO       MODIFICATION METHYLASE MBOI C (EC 2.1.1.72) (ADENINE-SPECIFI
   MTC9_CITFR       MODIFICATION METHYLASE CFR9I (EC 2.1.1.113) (N-4 CYTOSINE-SP
   P94454           MODIFICATION METHYLASE F5I1 (EC 2.1.1.72) (ADENINE-SPECIFIC 
   Q45489           BGLII MODIFICATION METHYLASE - BACILLUS SUBTILIS.
   MTR1_RHOSH       MODIFICATION METHYLASE RSRI (EC 2.1.1.72) (ADENINE-SPECIFIC 
   MTX1_XANCC       MODIFICATION METHYLASE XCYI (EC 2.1.1.113) (N-4 CYTOSINE-SPE
   P96424           METHYLASE M.PAC25I - PSEUDOMONAS ALCALIGENES.
   O68565           DNA MODIFICATION METHYLTRANSFERASE M.XMAI - XANTHOMONAS CAMP
   MTM2_MORBO       MODIFICATION METHYLASE MBOII (EC 2.1.1.72) (ADENINE-SPECIFIC
   T3MO_SALTY       TYPE III RESTRICTION-MODIFICATION SYSTEM STYLTI ENZYME MOD (
   O68568           DNA MODIFICATION METHYLTRANSFERASE M.XBAI - XANTHOMONAS CAMP
   O25921           TYPE IIS RESTRICTION ENZYME M2 PROTEIN (MOD) - HELICOBACTER 
   O86267           METHYLASE - LACTOCOCCUS LACTIS.
   MTB1_BACAM       MODIFICATION METHYLASE BAMHI (EC 2.1.1.113) (N-4 CYTOSINE-SP
   O68789           ADENINE DNA METHYLTRANSFERASE HOMOLOG - YERSINIA PESTIS.
   P71366           TYPE III RESTRICTION-MODIFICATION ECOP15 ENZYME (MOD) - HAEM
   O24918           TYPE II RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER P
   O82897           HEMAGGLUTININ-ASSOCIATED PROTEIN - ESCHERICHIA COLI.
   MT42_METJA       PROBABLE MODIFICATION METHYLASE MJ1498 (EC 2.1.1.113) (N-4 C
   O25920           TYPE IIS RESTRICTION ENZYME M1 PROTEIN (MOD) - HELICOBACTER 
   MTSM_SERMA       MODIFICATION METHYLASE SMAI (EC 2.1.1.113) (N-4 CYTOSINE-SPE
   Q56638           HAEMAGGLUTININ ASSOCIATED PROTEIN - VIBRIO CHOLERAE.
   T3MO_BPP1        TYPE III RESTRICTION-MODIFICATION SYSTEM ECOPI ENZYME MOD (E
   MTC1_CITFR       MODIFICATION METHYLASE CFRBI (EC 2.1.1.113) (N-4 CYTOSINE-SP
   Q08802           HYPOTHETICAL 25.6 KD PROTEIN IN VLP 3'REGION - VIBRIO CHOLER
   O74074           SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
   O74053           SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
   Q46975           ECOVIII MODIFICATION METHYLASE - ESCHERICHIA COLI.
   MTM1_METJA       MODIFICATION METHYLASE MJAI (EC 2.1.1.113) (N-4 CYTOSINE-SPE
   O68556           BGLI MODIFICATION METHYLTRANSFERASE - BACILLUS SUBTILIS.
   MTB2_BACAM       MODIFICATION METHYLASE BAMHII (EC 2.1.1.113) (N-4 CYTOSINE- 
   MTH3_HAEIN       MODIFICATION METHYLASE HINDIII (EC 2.1.1.72) (ADENINE-SPECIF
   O25040           ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER 
   O25315           ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER 
   O03956           DNA ADENINE METHYLTRANSFERASE - BACTERIOPHAGE MX8.
   Q38206           CYTOSINE METHYLASE - BACTERIOPHAGE HP1.
   O51937           TSP45I METHYLTRANSFERASE - THERMUS SP.
   MTEC_ENTCL       MODIFICATION METHYLASE ECAI (EC 2.1.1.72) (ADENINE-SPECIFIC 
   MTHZ_METTF       MODIFICATION METHYLASE MTHZI (EC 2.1.1.113) (N-4 CYTOSINE-SP
   O28863           MODIFICATION METHYLASE, TYPE III R/M SYSTEM - ARCHAEOGLOBUS 
   O52513           SFII METHYLTRANSFERASE - STREPTOMYCES FIMBRIATUS.
   MTK1_KLEPN       MODIFICATION METHYLASE KPNI (EC 2.1.1.72) (ADENINE-SPECIFIC 
   T3MO_ECOLI       TYPE III RESTRICTION-MODIFICATION SYSTEM ECOP15I ENZYME MOD 
   MTP2_PROVU       MODIFICATION METHYLASE PVU II (EC 2.1.1.113) (N-4 CYTOSINE-S
   MTH2_HAEHA       MODIFICATION METHYLASE HHAII (EC 2.1.1.72) (ADENINE-SPECIFIC
 
   O24891           ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA) - HELICOBACTER
   O58333           309AA LONG HYPOTHETICAL MODIFICATION METHYLASE - PYROCOCCUS 
   O52692           SCAI METHYLTRANSFERASE - STREPTOMYCES CAESPITOSUS.
   MTMW_METWO       MODIFICATION METHYLASE MWOI (EC 2.1.1.113) (N-4 CYTOSINE-SPE
   O25043           ADENINE SPECIFIC DNA METHYLTRANSFERASE (HPAIM) - HELICOBACTE
 
   O25922           TYPE III RESTRICTION ENZYME M PROTEIN (MOD) - HELICOBACTER P
   Q58606           HYPOTHETICAL PROTEIN MJ1209 - METHANOCOCCUS JANNASCHII.
   P70724           AATII METHYLASE - ACETOBACTER ACETI.
   O64360           GP52 - BACTERIOPHAGE N15.
   P70802           METHYLASE - ANABAENA VARIABILIS.
   MTTA_THEAQ       MODIFICATION METHYLASE TAQI (EC 2.1.1.72) (ADENINE-SPECIFIC 
   O32491           PUTATIVE N6-ADEININE SPECIFIC METHYLTRANSFERASE - BACTEROIDE

SCAN HISTORY OWL27_1 3 200 NSINGLE SPTR37_9f 4 190 NSINGLE INITIAL MOTIF SETS D21N6MTFRASE1 Length of motif = 13 Motif number = 1 D21 class N6 adenine MTase motif I - 1 PCODE ST INT VDMIYIDPPYNTG T3MO_SALTY 128 128 VKMIYIDPPYNTG T3MO_ECOLI 117 117 VNMIYIDPPYNTG T3MO_BPP1 117 117 IDLIITDPPYNLG MTH1_HAEPA 22 22 IDFCYIDPPYNTG MTK1_KLEPN 61 61 IDMIFADPPYFLS MT1C_MORBO 33 33 VQLIICDPPYNIM MTR1_RHOSH 59 59 AKLIYLDPPYATG MTEC_ENTCL 93 93 IDLIFADPPYFMQ MTH1_HAEIN 30 30 VQLAVIDPPYNLS MTM2_MORBO 24 24 VDTIFADPPFNLD MTB1_BACAM 138 138 IHAIISDIPYGID MTH3_HAEIN 22 22 VKIAFFDPQYRGV MTH2_HAEHA 31 31 D21N6MTFRASE2 Length of motif = 20 Motif number = 2 D21 class N6 adenine MTase motif II - 1 PCODE ST INT RLFLARKLLKDTGFIFISID T3MO_SALTY 190 49 RLYIARELMREDGTIFISID T3MO_ECOLI 181 51 RLYIARELLKEDGVIFISID T3MO_BPP1 181 51 WLEECYRVLKPHGTIYIFMG MTH1_HAEPA 56 21 RLFHAHKMLKDTGIIAISID MTK1_KLEPN 103 29 WIAQARQLLKDNGTIWISGT MT1C_MORBO 80 34 WLAEAERVLSPTGSIAIFGG MTR1_RHOSH 88 16 RLILMREILDDDGTIYVHIG MTEC_ENTCL 133 27 WLKECKRILKSTGSIWVIGS MTH1_HAEIN 78 35 WIDKVLDKLDKDGSLYIFNT MTM2_MORBO 56 19 WIDECIRVLKPGGSLFIYNI MTB1_BACAM 173 22 WSNEWFRVLKSGSSVFVFAG MTH3_HAEIN 90 55 FINEFERVLLPNGYLFLWVD MTH2_HAEHA 74 30 D21N6MTFRASE3 Length of motif = 23 Motif number = 3 D21 class N6 adenine MTase motif III - 1 PCODE ST INT FDTPKPTALLKKIIKLAIDKDGV T3MO_SALTY 390 180 FTNAKTIKLVEDLISFACDGEGI T3MO_ECOLI 415 214 FEGPKPVPLITDLVKIGTKKDSL T3MO_BPP1 409 208 HPTQKPEALYERMILASSNEGDI MTH1_HAEPA 173 97 FDTPKALNYIMSIINCMAKPDAL MTK1_KLEPN 318 195 HPTQKPLGLLSRIILSSTQKDDL MT1C_MORBO 190 90 HPTQKPAAVIERLVRALSHPGST MTR1_RHOSH 223 115 YPTEKNFNMMKLIVGASSNPGDL MTEC_ENTCL 322 169 HSTQKPESLLYKVILSSSKPNDV MTH1_HAEIN 193 95 HITPKPRDLIERIIRASSNPNDL MTM2_MORBO 193 117 KFNELSVKLLDRIITMSTNEGDV MTB1_BACAM 299 106 HVAQKPLNLMKLLIDLVTKEEQI MTH3_HAEIN 234 124 HTHSKPIEMQKQLILATTQEGDL MTH2_HAEHA 169 75 D21N6MTFRASE4 Length of motif = 15 Motif number = 4 D21 class N6 adenine MTase motif IV - 1 PCODE ST INT VLDFFAGSGTTAHAV T3MO_SALTY 413 0 VLDFFAGSGTTAHTV T3MO_ECOLI 438 0 VLDFFAGSGTTAEAV T3MO_BPP1 432 0 VLDPFVGSGTLNFVC MTH1_HAEPA 196 0 ILDFFAGSGTTAHAA MTK1_KLEPN 341 0 ILDPFSGSGTTGIAG MT1C_MORBO 213 0 VLDFFAGSGVTARVA MTR1_RHOSH 246 0 VIDPFCGSGSTLHAA MTEC_ENTCL 345 0 VLDPFFGTGTTGAVA MTH1_HAEIN 216 0 VLDCFMGSGTTAIVA MTM2_MORBO 216 0 VLDPFGGSGTTFAVS MTB1_BACAM 322 0 VLDPFAGSGTTLLAA MTH3_HAEIN 257 0 ILDPASGGYSVFECC MTH2_HAEHA 192 0 FINAL MOTIF SETS D21N6MTFRASE1 Length of motif = 13 Motif number = 1 D21 class N6 adenine MTase motif I - 4 PCODE ST INT VDLIFADPPYNIG YHDJ_ECOLI 34 34 VDLIFADPPYNLQ Q45971 25 25 IDLIITDPPYNLG MTH1_HAEPA 22 22 VDVVFADPPYNLQ O30569 40 40 VDVIFADPPYNLQ O30570 40 40 MDMIFADPPYFLS MT22_STRPN 42 42 MDMIFADPPYFLS ML22_LACLC 42 42 IDLIFADPPYFMQ MTH1_HAEIN 30 30 VDFIFADPPYFMQ O25907 28 28 IDMIFADPPYFLS MT1C_MORBO 33 33 VRCIVTSPPYWGL MTC9_CITFR 45 45 IDLIIADPPYVVS P94454 45 45 VDLVVTSPPYNIN Q45489 55 55 VQLIICDPPYNIM MTR1_RHOSH 59 59 VRCVVTSPPYWGL MTX1_XANCC 45 45 VRCVVTSPPYWGL P96424 106 106 VRCVVTSPPYWGL O68565 45 45 VQLAVIDPPYNLS MTM2_MORBO 24 24 VDMIYIDPPYNTG T3MO_SALTY 128 128 ADLVYLDPPFFTN O68568 27 27 VDLIITSPPYFNI O25921 22 22 IHLILSDIPYGIS O86267 23 23 VDTIFADPPFNLD MTB1_BACAM 138 138 VDFILTDPPYLVG O68789 9 9 VKLIYIDPPYNTG P71366 143 143 FDLIFADPPYFLS O24918 39 39 VDFILTDPPYLVG O82897 21 21 VDVVVTSPPYNIG MT42_METJA 23 23 VDLAIIDPPYNLK O25920 23 23 FDCVVTSPPYWGL MTSM_SERMA 44 44 VDLFITDPPYESL Q56638 34 34 VNMIYIDPPYNTG T3MO_BPP1 117 117 VNLVFTSPPYYNA MTC1_CITFR 132 132 VDLFITDPPYESL Q08802 21 21 YRLAVTSPPYYGH O74074 35 35 YRLAVTSPPYYGH O74053 29 29 AHLILSDIPYGIG Q46975 33 33 VHLVVTSPPYPMI MTM1_METJA 28 28 IALSVWSPPYHVG O68556 29 29 IDLTVTSPPYDDL MTB2_BACAM 10 10 IHAIISDIPYGID MTH3_HAEIN 22 22 IQTIYIDPPYNTK O25040 21 21 IKMIYIDPPYNTG O25315 98 98 VDAIVTDPPYGET O03956 31 31 VHMVMTSPPYFGL Q38206 50 50 VQLVYIDPPYGTG O51937 94 94 AKLIYLDPPYATG MTEC_ENTCL 93 93 INLVVTSPPYPMV MTHZ_METTF 23 23 VQTIYIDPPFNKE O28863 448 448 INTVVTSPPYWAV O52513 48 48 IDFCYIDPPYNTG MTK1_KLEPN 61 61 VKMIYIDPPYNTG T3MO_ECOLI 117 117 ISLVMTSPPFALQ MTP2_PROVU 47 47 VKIAFFDPQYRGV MTH2_HAEHA 31 31 D21N6MTFRASE2 Length of motif = 20 Motif number = 2 D21 class N6 adenine MTase motif II - 4 PCODE ST INT VIAECHRVLKKQGSMYIMNS YHDJ_ECOLI 68 21 WLKAARRVLKDDGAIWVIGS Q45971 73 35 WLEECYRVLKPHGTIYIFMG MTH1_HAEPA 56 21 WLLACRRVLKPTGTLWVIGS O30569 88 35 WLLACRRVLKPNGTIWVIGS O30570 88 35 WIRLAKEVLKPNGTVWISGS MT22_STRPN 89 34 WIRLARLVLKPNGTIWVSGS ML22_LACLC 89 34 WLKECKRILKSTGSIWVIGS MTH1_HAEIN 78 35 WLKECQRILKDNGSICVIGS O25907 76 35 WIAQARQLLKDNGTIWISGT MT1C_MORBO 80 34 IFSEAKRVLTDDGTLWVNIG MTC9_CITFR 82 24 WISFAYKVLKPSGSLIVFND P94454 89 31 IIEQCHRVLKPSGSIFWQVG Q45489 86 18 WLAEAERVLSPTGSIAIFGG MTR1_RHOSH 88 16 IFAEVKRVLTDDGTLWLNIG MTX1_XANCC 82 24 IFAEVRRVLTDDGTLWLNIG P96424 143 24 IFAEVKRVLTDDGTLWLNIG O68565 82 24 WIDKVLDKLDKDGSLYIFNT MTM2_MORBO 56 19 RLFLARKLLKDTGFIFISID T3MO_SALTY 190 49 RLREAHRVLKHSGSIFVHCD O68568 72 32 VWLECYRALKPNGKLCINVP O25921 71 36 WAKEWFRVLKPGSSCFIFAG O86267 92 56 WIDECIRVLKPGGSLFIYNI MTB1_BACAM 173 22 ACHEMYRVLKKDALMVSFYG O68789 42 20 RLEIAKTLLADDGVIFVQCD P71366 177 21 WINNAKKALKDTGSLLISGT O24918 86 34 ACNEMYRVLKKDALMVSFYG O82897 54 20 VVKEIKRVLKDDGSFFINVG MT42_METJA 57 21 WIDKMLPKLKDTGSFYIFNT O25920 55 19 LFRDVRRTLKDDGTLWLNIG MTSM_SERMA 81 24 LFREVYRVLKKGSHFYLFCD Q56638 80 33 RLYIARELLKEDGVIFISID T3MO_BPP1 181 51 VIKECHRVLSEGRFFVINVS MTC1_CITFR 164 19 LFREVYRVLKKGSHFYLFCD Q08802 67 33 VFKSCMDLLTDDGSLFIVIG O74074 73 25 VFKSCMDLLTDDGSLFIVIG O74053 67 25 WATEWFRVLKPGASAIIFAG Q46975 102 56 VWEEVYRVLVPGGIACINIG MTM1_METJA 88 47 VIALHYPILKPGGFLVINID O68556 60 18 TAQELYRVTKEGGVVVWVVG MTB2_BACAM 35 12 WSNEWFRVLKSGSSVFVFAG MTH3_HAEIN 90 55 HLILAKAVLKQSGCLFISMD O25040 53 19 RLKLARDLLKEDGVIFISID O25315 170 59 WPGLVRPLLKRTGSMWCFGS O03956 54 10 VAEQLRRVLRPDGSWWLNLG Q38206 87 24 RLILLRELMADSGLIFVHID O51937 148 41 RLILMREILDDDGTIYVHIG MTEC_ENTCL 133 27 VWHEVDRVTAPGGVVIINIG MTHZ_METTF 73 37 RIRLGRELLNERGSIFVRCD O28863 483 22 IFREVYRVLATDGSAWLNIG O52513 85 24 RLFHAHKMLKDTGIIAISID MTK1_KLEPN 103 29 RLYIARELMREDGTIFISID T3MO_ECOLI 181 51 FAKVVNKKLKPDGSFVVDFG MTP2_PROVU 79 19 FINEFERVLLPNGYLFLWVD MTH2_HAEHA 74 30 D21N6MTFRASE3 Length of motif = 23 Motif number = 3 D21 class N6 adenine MTase motif III - 4 PCODE ST INT HPTQKPEALLKRIILASSNPGDI YHDJ_ECOLI 195 107 HPTQKPEALLYRVILSTTKPGDV Q45971 189 96 HPTQKPEALYERMILASSNEGDI MTH1_HAEPA 173 97 HPTQKPEALLARILMASTKPGDV O30569 204 96 HPTQKPEALLARIMMASSKPGDV O30570 204 96 HPTQKPEYLLERIILASTKEGDY MT22_STRPN 200 91 HPTQKPEYILERIILASTKENDY ML22_LACLC 200 91 HSTQKPESLLYKVILSSSKPNDV MTH1_HAEIN 193 95 HSTQKPEALLKKIILSATKPKDI O25907 191 95 HPTQKPLGLLSRIILSSTQKDDL MT1C_MORBO 190 90 HFATFPTELIRPCILASTKPGDY MTC9_CITFR 226 124 HPTQKPVKLIEYLIRIHSNENDI P94454 190 81 HPTQYPEDMIERIVLSTTEPNDI Q45489 221 115 HPTQKPAAVIERLVRALSHPGST MTR1_RHOSH 223 115 HFTTFPPELIRPCIHASTEPGDY MTX1_XANCC 226 124 HFATFPPDLIRPCIQASTEPGDY P96424 287 124 HFATFPPELIRPCIHASTEPGDY O68565 226 124 HITPKPRDLIERIIRASSNPNDL MTM2_MORBO 193 117 FDTPKPTALLKKIIKLAIDKDGV T3MO_SALTY 390 180 YPTQKPILLLERIIEISTDPGDF O68568 215 123 HAALMPAELARRLIRLYSCVGDV O25921 219 128 HPTQKPLVLMKALIELTTQENQI O86267 231 119 KFNELSVKLLDRIITMSTNEGDV MTB1_BACAM 299 106 HPTEKPVTSLQPLIESFTHPGAI O68789 132 70 KNGKKPEALLRRIIDMTTKEGDI P71366 432 235 HPTQKPLALLVRLLLMASDENSL O24918 196 90 HPTEKPVTSLQPLIESFTHPNAI O82897 144 70 HPATFPPKLPEMCIKLHGVKKTN MT42_METJA 204 127 HPSIKPKALIERMIKASSHKNDL O25920 193 118 HFAVFPRAMARLCVLAGSRPGGK MTSM_SERMA 227 126 YPTEKPVELLEVLIRQSSSENEI Q56638 169 69 FEGPKPVPLITDLVKIGTKKDSL T3MO_BPP1 409 208 HPATFPYGLAERVIKYYSFKNDV MTC1_CITFR 305 121 YPTEKPVELLEVLIRQSSSENEI Q08802 156 69 HFAVFPEDLVSRIVKFATKEGDY O74074 281 188 HFAVFPEDLVSRIVKFATREGDY O74053 275 188 HPTQKPVALMKTLIELTTQKGQL Q46975 241 119 RTASFPEEIPRRLIRMFSIIGDT MTM1_METJA 223 115 HEAKFPLLLPQRLIKLLTQKGDT O68556 245 165 HPAIFPEKLAEDHILSWSNEGDI MTB2_BACAM 182 127 HVAQKPLNLMKLLIDLVTKEEQI MTH3_HAEIN 234 124 FKTPKPVALIKYLLLCSTPKDSI O25040 285 212 FTYPKGVEFMKKIILHSTTPNEG O25315 377 187 NETQKPVALVEPLVRNACPPGGL O03956 187 113 HFAVYPPELCEVPIKSSCPPVVC Q38206 268 161 YPTEKNLDMLKLIVQTGSNEGDL O51937 335 167 YPTEKNFNMMKLIVGASSNPGDL MTEC_ENTCL 322 169 RAAAYPFELAYRLINMYSIMGDW MTHZ_METTF 213 120 FSTENSEILLKRVIESTSNEGDL O28863 708 205 HFAVMPRKLAHFALKATLPMNGS O52513 349 244 FDTPKALNYIMSIINCMAKPDAL MTK1_KLEPN 318 195 FTNAKTIKLVEDLISFACDGEGI T3MO_ECOLI 415 214 HPARFPAKLPEFFIRMLTEPDDL MTP2_PROVU 246 147 HTHSKPIEMQKQLILATTQEGDL MTH2_HAEHA 169 75 D21N6MTFRASE4 Length of motif = 15 Motif number = 4 D21 class N6 adenine MTase motif IV - 4 PCODE ST INT VLDPFAGSFTTGAVA YHDJ_ECOLI 218 0 ILDPFFGVGTTGAAA Q45971 212 0 VLDPFVGSGTLNFVC MTH1_HAEPA 196 0 VLDPFFGSGTTGAVA O30569 227 0 ILDPFFGSGTTGAVA O30570 227 0 ILDPFVGSGTTGVVA MT22_STRPN 223 0 ILDPFVGSGTTGVVA ML22_LACLC 223 0 VLDPFFGTGTTGAVA MTH1_HAEIN 216 0 ILDPFFGTGTTGAVA O25907 214 0 ILDPFSGSGTTGIAG MT1C_MORBO 213 0 VLDPFFGSGTVGVVC MTC9_CITFR 249 0 ILDPFMGSGTTGVAS P94454 213 0 VLDPFIGMGTTASVA Q45489 244 0 VLDFFAGSGVTARVA MTR1_RHOSH 246 0 VLDPFFGSGTVGLVC MTX1_XANCC 249 0 VLDPFFGSGTVGLVC P96424 310 0 VLDPFFGSGTVGLVC O68565 249 0 VLDCFMGSGTTAIVA MTM2_MORBO 216 0 VLDFFAGSGTTAHAV T3MO_SALTY 413 0 IVDPFCGSGTTLVAA O68568 238 0 VLDPFSGSGTTLREA O25921 242 0 VLDPFSGSGTTLVAA O86267 254 0 VLDPFGGSGTTFAVS MTB1_BACAM 322 0 VLDPFAGSGSTCVAA O68789 155 0 VLDYHLGSGTTAAVA P71366 455 0 IGDPFSGSSTTGIAA O24918 219 0 VLDPFAGSGSTCVAA O82897 167 0 VLDPFMGIGSTAIAC MT42_METJA 228 1 ILDLFSGSGMTSLVA O25920 216 0 VLDPFFGSGTTGVVC MTSM_SERMA 250 0 VADSFFGSGSTLIAA Q56638 192 0 VLDFFAGSGTTAEAV T3MO_BPP1 432 0 ILDPFAGSGTTAKAA MTC1_CITFR 328 0 VADSFFGSGATLIAA Q08802 179 0 VLDPFAGRGTTGIVS O74074 304 0 VLDPFAGRGTTGIVS O74053 298 0 VIDPFSGSGSTLVAA Q46975 264 0 VLDPFLGTGTTVKAA MTM1_METJA 246 0 VLDCFMGSGTTAVAA O68556 268 0 VFDPFMGSGTTAKMA MTB2_BACAM 205 0 VLDPFAGSGTTLLAA MTH3_HAEIN 257 0 ILDFFAGSGTTAQAV O25040 308 0 ILDFFAGSGTTVHAV O25315 402 2 VADFFAGSGSTALAC O03956 210 0 VLDPFAGAGTTCLSA Q38206 406 115 VLDPFAGSGTTLIAS O51937 358 0 VIDPFCGSGSTLHAA MTEC_ENTCL 345 0 VLDPFLGTGTTMIAA MTHZ_METTF 236 0 VLDFFLGSGTTTAVA O28863 731 0 CLDPFMGSGTTGRVV O52513 372 0 ILDFFAGSGTTAHAA MTK1_KLEPN 341 0 VLDFFAGSGTTAHTV T3MO_ECOLI 438 0 VVDIFGGSNTTGLVA MTP2_PROVU 269 0 ILDPASGGYSVFECC MTH2_HAEHA 192 0

User query: Display/Full Code "D21N6MTFRASE"