WORKLIST ENTRIES (1):

CPSASE View alignment View Structure          Carbamoyl-phosphate synthase protein CPSase domain signature
 Type of fingerprint: COMPOUND with 7  elements
Links:
   PRINTS; PR00099 CPSGATASE; PR00096 GATASE; PR00097 ANTSNTHASEII 
   PRINTS; PR00101 ATCASE; PR00102 OTCASE; PR00100 AOTCASE
   INTERPRO; IPR000901
   PROSITE; PS00866 CPSASE_1; PS00867 CPSASE_2

 Creation date 14-MAR-1992; UPDATE 26-JUN-1999

   1. MAKOFF, A.J. AND RADFORD A.
   Genetics and biochemistry of carbamoyl-phosphate biosynthesis and its
   utilisation in the pyrimidine biosynthetic pathway.
   MICROBIOL.REV. 42  307-328 (1978).

   2. PIETTE, J., NYUNOYA, H., LUSTY, C.J., CUNIN, R., WEYENS, G., CRABEEL,
   M., CHARLIER, D., GLANSDORFF, N. AND PIERARD, A.
   DNA sequence of the carA gene and the control region of carAB: Tandem
   promoters, respectively controlled by arginine and the pyrimidines,
   regulate the synthesis of carbamoyl-phosphate synthetase in E.coli K-12.
   PROC.NATL.ACAD.SCI.U.S.A. 81 4134-4138 (1984).

   3. SIMMER, J.P., KELLY, R.E., RINKER, A.G., SCULLY, J.L. AND EVANS, D.R.
   Mammalian carbamoyl phosphate synthetase.
   J.BIOL.CHEM. 265 10395-10402 (1990).

   Carbamoyl-phosphate synthetase (CPSase) is an enzyme of special interest,
   being common to both the arginine and pyrimidine biosynthetic pathways: it
   thus raises the problem of how to regulate pyrimidine and arginine 
   biosynthesis separately. CPSase catalyses the production of carbamoyl-
   phosphate from its precursors, the precursors depending on the pathway 
   involved: in pyrimidine biosynthesis the nitrogen donor is glutamate, the 
   other precursors being ATP and hydrogen carbonate; in arginine biosynthesis
   the precursors are carbon dioxide and an ammonium ion.
   
   E.coli and other bacteria possess only one CPSase enzyme, which produces
   carbamoyl-phosphate for both pathways and has 2 subunits coded for by the 
   genes carA and carB: carA codes for the small subunit, which has glutamine 
   amidotransferase (GATase) activity, and carB codes for the large subunit, 
   which has CPSase activity. These 2 genes are genetically linked as the 
   carAB operon, which is differentially regulated at 2 tandem promoters 
   during transcription by both arginine and UMP, while ornithine stimulates
   activity.
   
   Eukaryotes possess 2 different CPSase enzymes, one for each pathway, both
   of which are comparmentalised and regulated separately. Pyrimidine
   biosynthesis occurs in the cytosol where glutamine is the nitrogen donor,
   and arginine biosynthesis (the urea cycle) occurs in the mitochondria where
   ammonium ions are the nitrogen donors, with N-acetylglutamine acting as an 
   allosteric activator. The arginine-specific CPSase catalyses the same 
   overall reaction and has the same structure as the prokaryotic enzyme, yet
   in S.cerevisiae the 2 genes, CPA1 and CPA2, are unlinked. In this organism,
   the gene URA2 codes for the glutamine-dependent carbamoylphosphate
   synthetase and the ATCase for the pyrimidine biosynthetic pathway. 
   
   Two main CPSases have been identified in mammals: CPSase I is mitochondrial,
   it is found in high levels in the liver and is involved in arginine bio-
   synthesis; CPSase II is cytosolic, it is associated with aspartate
   carbamoyltransferase (ATCase) and dihydroorotase (DHOase) and is involved
   in pyrimidine biosynthesis. In the pyrimidine pathway in most eukaryotes, 
   CPSase is found as a domain in a multi-functional protein, which also has 
   GATase, ACTase and DHOase activity.
   
   CPSASE is a 7-element fingerprint that provides a signature for the 
   carbamoyl-phosphate synthase CPSase domain. The fingerprint was derived 
   from an initial alignment of 5 sequences: motifs 3 and 6 include regions
   encoded by PROSITE patterns CPSASE_1 (PS00866) and CPSASE_2 (PS00867).
   Two iterations on OWL18.0 were required to reach convergence, at which
   point a true set comprising 9 sequences was identified. Three partial
   matches were also found: PYR1_DICDI is a fusion protein containing
   glutamine-dependent CPsase-, ATCase- and DHOase-activity, but the CPSase
   region is incomplete; CARB_METBA is a fragment of the large chain of the
   CPSase protein from Methanosacina barkeri; SCURA2 is a fragment of a yeast
   protein that has been translated from the 5'-region of the URA2 gene for
   carbamoyl-phosphate synthetase and lacks the portion of sequence bearing
   the last 5 motifs.
  
   An update on SPTR37_9f identified a true set of 41 sequences, and 1
   partial match.

  SUMMARY INFORMATION
     41 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      1 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    7|  41   41   41   41   41   41   41  
    6|   0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0  
    4|   1    1    1    1    0    0    0  
    3|   0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0  
   --+------------------------------------
     |   1    2    3    4    5    6    7  

True positives..
 PYR1_SQUAC     PYR1_MESAU     PYR1_YEAST     PYR1_SCHPO     
 Q92115         PYR1_DICDI     PYR1_HUMAN     Q18990         
 CARB_TRICU     P70087         CPSM_HUMAN     CPSM_RANCA     
 O28994         CPSM_RAT       CARB_YEAST     O67869         
 O42433         Q42601         O15829         CARB_BACCL     
 Q51430         O15830         CARB_BACSU     P96495         
 Q55756         CARB_SALTY     CARB_ECOLI     O50236         
 O50302         CARB_LACPL     CARY_BACSU     Q27448         
 Q27732         PYR1_DROME     O25577         Q59599         
 O32771         CARB_SULSO     Q58776         O67233         
 O27077         
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 O27078         


  PROTEIN TITLES
   PYR1_SQUAC       CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHA
   PYR1_MESAU       CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHA
   PYR1_YEAST       URA2 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPH
   PYR1_SCHPO       URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPH
   Q92115           CARBAMOYL PHOSPHATE SYNTHETASE III [GLUTAMINE] MITOCHONDRIAL
   PYR1_DICDI       PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOS
   PYR1_HUMAN       CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHA
   Q18990           D2085.1 PROTEIN - CAENORHABDITIS ELEGANS.
   CARB_TRICU       CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE-SPECIFIC, LARGE CHAIN
   P70087           CARBAMOYL-PHOSPHATE SYNTHETASE III (EC 6.3.5.5) (CARBAMOYL-P
   CPSM_HUMAN       CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECUR
   CPSM_RANCA       CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECUR
   O28994           CARBAMOYL-PHOSPHATE SYNTHASE, LARGE (OR AMMONIA) SUBUNIT (CA
   CPSM_RAT         CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL PRECUR
   CARB_YEAST       CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE-SPECIFIC, LARGE CHAIN
   O67869           CARBAMOYL-PHOSPHATE SYNTHASE LARGE SUBUNIT - AQUIFEX AEOLICU
   O42433           CARBAMOYL-PHOSPHATE SYNTHETASE III (EC 6.3.5.5) - MICROPTERU
   Q42601           CARBAMOYL PHOSPHATE SYNTHETASE LARGE CHAIN (EC 6.3.4.16) (CA
   O15829           CARBAMYL PHOSPHATE SYNTHASE - LEISHMANIA MEXICANA.
   CARB_BACCL       CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHA
   Q51430           CARBAMOYLPHOSPHATE SYNTHETASE LARGE SUBUNIT - PSEUDOMONAS AE
   O15830           CARBAMYL PHOSPHATE SYNTHASE - TRYPANOSOMA CRUZI.
   CARB_BACSU       CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHA
   P96495           CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYSING) LARGE S
   Q55756           CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHA
   CARB_SALTY       CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) (CARBA
   CARB_ECOLI       CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) (CARBA
   O50236           CARBAMOYLPHOSPHATE SYNTHETASE LARGE SUBUNIT - ZYMOMONAS MOBI
   O50302           CARBOMYLPHOSPHATE SYNTHETASE LARGE SUBUNIT - BACILLUS STEARO
   CARB_LACPL       CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHA
   CARY_BACSU       CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE-SPECIFIC, LARGE CHAIN
   Q27448           GLUTAMINE-DEPENDENT CARBAMOYL PHOSPHATE SYNTHASE (EC 6.3.5.5
   Q27732           CARBAMOYL-PHOSPHATE SYNTHASE - PLASMODIUM FALCIPARUM.
   PYR1_DROME       CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES: GLUTAMINE-DEPEN
   O25577           CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYSING) (PYRAB)
   Q59599           CARBAMOYL PHOSPHATE SYNTHETASE (GLUTAMINE) LARGE SUBUNIT (EC
   O32771           CARBAMOYLPHOSPHATE SYNTHETASE - LACTOCOCCUS LACTIS.
   CARB_SULSO       CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5) (CARBA
   Q58776           HYPOTHETICAL PROTEIN MJ1381 - METHANOCOCCUS JANNASCHII.
   O67233           CARBAMOYL-PHOSPHATE SYNTHASE LARGE SUBUNIT - AQUIFEX AEOLICU
   O27077           CARBAMOYL-PHOSPHATE SYNTHASE, LARGE SUBUNIT - METHANOBACTERI
 
   O27078           CARBAMOYL-PHOSPHATE SYNTHASE, LARGE SUBUNIT - METHANOBACTERI

SCAN HISTORY OWL18_0 2 50 NSINGLE OWL19_1 1 50 NSINGLE OWL26_0 1 100 NSINGLE SPTR37_9f 4 75 NSINGLE INITIAL MOTIF SETS CPSASE1 Length of motif = 15 Motif number = 1 CPSase motif I - 1 PCODE ST INT SIGQAGEFDYSGSQA CARB_YEAST 40 40 SIGQAGEFDYSGSQA PYR1_DROME 420 420 SIGQAGEFDYSGSQA PYR1_MESAU 405 405 SIGQAGEFDYSGSQA PYR1_YEAST 449 449 VIGQACEFDYSGAQA CARB_ECOLI 18 18 CPSASE2 Length of motif = 11 Motif number = 2 CPSase motif II - 1 PCODE ST INT NPNIATNQTSH CARB_YEAST 69 14 NPNIATVQTSK PYR1_DROME 449 14 NPNIATVQTSQ PYR1_MESAU 434 14 NPNIATIQTSK PYR1_YEAST 478 14 NSNPATIMTDP CARB_ECOLI 47 14 CPSASE3 Length of motif = 13 Motif number = 3 CPSase motif III - 1 PCODE ST INT VRSAYALGGLGSG CARB_YEAST 189 109 ARAAFSLGGLGSG PYR1_DROME 568 108 VRAAFALGGLGSG PYR1_MESAU 554 109 VRAAYALGGLGSG PYR1_YEAST 596 107 IRPSFTMGGSGGG CARB_ECOLI 167 109 CPSASE4 Length of motif = 20 Motif number = 4 CPSase motif IV - 1 PCODE ST INT ILVEKSLKGWKEVEYEVVRD CARB_YEAST 223 21 LIVDKSLKGWKEVEYEVVRA PYR1_DROME 602 21 VLIDKSLKGWKEIEYEVVRD PYR1_MESAU 588 21 VLVEKSMKGWKEVEYEVVRD PYR1_YEAST 630 21 LLIDESLIGWKEYEMEVVRD CARB_ECOLI 203 23 CPSASE5 Length of motif = 18 Motif number = 5 CPSase motif V - 1 PCODE ST INT PLGVHTGDSMVFAPSQTL CARB_YEAST 258 15 PLGIHTGESIVVAPSQTL PYR1_DROME 638 16 PLGIHTGESIVVAPSQTL PYR1_MESAU 623 15 PLGIHTGDSIVVAPSQTL PYR1_YEAST 665 15 AMGIHTGDSITVAPAQTL CARB_ECOLI 238 15 CPSASE6 Length of motif = 30 Motif number = 6 CPSase motif VI - 1 PCODE ST INT VIEVNARLSRSSALASKATGYPLAYTAAKI CARB_YEAST 315 39 IIEVNERLSRTSALASKAPGYPLAYVAAKV PYR1_DROME 694 38 IIEVNARLSRSSALASKATGYPLAYVAAKL PYR1_MESAU 680 39 IIEVNARLSRSSALASKATGYPLAYTAAKL PYR1_YEAST 722 39 VIEMNPRVSRSSALASKATGFPIAKVAAKL CARB_ECOLI 296 40 CPSASE7 Length of motif = 19 Motif number = 7 CPSase motif VII - 1 PCODE ST INT SVGEVMAIGRNYEEAFQKA CARB_YEAST 397 49 SVGEVMAIGRQLRGSVPKS PYR1_DROME 776 49 SVGEVMGIGRSFEEAFQKA PYR1_MESAU 761 48 SVGEVMSIGRTFEEAIQKA PYR1_YEAST 804 49 SVGEVMAIGRTQQESLQKA CARB_ECOLI 379 50 FINAL MOTIF SETS CPSASE1 Length of motif = 15 Motif number = 1 CPSase motif I - 4 PCODE ST INT SIGQAGEFDYSGSQA PYR1_SQUAC 408 408 SIGQAGEFDYSGSQA PYR1_MESAU 405 405 SIGQAGEFDYSGSQA PYR1_YEAST 450 450 SIGQAGEFDYSGSQA PYR1_SCHPO 486 486 SIGQAGEFDYSGSQA Q92115 435 435 SIGQAGEFDYSGSQA PYR1_DICDI 377 377 SIGQAGEFDYSGSQA PYR1_HUMAN 405 405 TIGQAGEFDYSGAQA Q18990 402 402 SIGQAGEFDYSGSQA CARB_TRICU 87 87 SIGQAGEFDYSGSQA P70087 432 432 SIGQAGEFDYSGSQA CPSM_HUMAN 434 434 SIGQAGEFDYSGSQA CPSM_RANCA 431 431 VIGQAAEFDYSGSQA O28994 19 19 SIGQAGEFDYSGSQA CPSM_RAT 434 434 SIGQAGEFDYSGSQA CARB_YEAST 40 40 VIGQAAEFDYSGTQA O67869 19 19 SIGQAGEFDYSGSQA O42433 435 435 VIGQACEFDYSGTQA Q42601 110 110 VIAQAGEFDYSGSQC O15829 384 384 VIGQAAEFDYAGTQA CARB_BACCL 19 19 VIGQACEFDYSGAQA Q51430 19 19 VIAQAGEFDYSGSQC O15830 385 385 IIGQAAEFDYAGTQA CARB_BACSU 19 19 TIGQAAEFDYSGTQA P96495 19 19 VIGQACEFDYSGTQA Q55756 43 43 VIGQACEFDYSGAQA CARB_SALTY 18 18 VIGQACEFDYSGAQA CARB_ECOLI 18 18 VIGQACEFDYSGTQA O50236 19 19 VIGQAAEFDYAGTQA O50302 19 19 IIGQAAEFDYSGTQA CARB_LACPL 19 19 IIGQAAEFDYSGTQG CARY_BACSU 19 19 SIGQAGEFDYSGSQA Q27448 513 513 CIGQAGEFDYSGTQA Q27732 702 702 SIGQAGEFDYSGSQA PYR1_DROME 420 420 VIGQACEFDYSGTQS O25577 19 19 VIGQACEFDYSGAQA Q59599 19 19 IIGQAAEFDYAGTEA O32771 19 19 KIAEAAEFDYSGSQA CARB_SULSO 17 17 RIGQGIEFDYSSVHA Q58776 96 96 RIGQGIEFDYACVHA O67233 14 14 RIGQGIEFDYCCVHA O27077 324 324 CPSASE2 Length of motif = 11 Motif number = 2 CPSase motif II - 4 PCODE ST INT NPNIATVQTSK PYR1_SQUAC 437 14 NPNIATVQTSQ PYR1_MESAU 434 14 NPNIATIQTSK PYR1_YEAST 479 14 NPNIATIQTSK PYR1_SCHPO 515 14 NPNIASVQTNE Q92115 464 14 NPNIATVQTSP PYR1_DICDI 406 14 NPNIATVQTSQ PYR1_HUMAN 434 14 NPNIATVQTSK Q18990 431 14 NPNIATIQTSH CARB_TRICU 116 14 NPNIASVQTNE P70087 461 14 NPNIASVQTNE CPSM_HUMAN 463 14 NPNIASVQTNE CPSM_RANCA 460 14 NSNPATIMTDP O28994 48 14 NPNIASVQTNE CPSM_RAT 463 14 NPNIATNQTSH CARB_YEAST 69 14 NSNPATIMTDP O67869 48 14 NPNIASVQTNE O42433 464 14 NSNPATIMTDP Q42601 139 14 NPNIATVQTDD O15829 413 14 NSNPATIMTDT CARB_BACCL 48 14 NSNPATIMTDP Q51430 48 14 NPNIATVQTDD O15830 414 14 NSNPATIMTDT CARB_BACSU 48 14 NSNPATIMTDP P96495 48 14 NSNPASIMTDP Q55756 72 14 NSNPATIMTDP CARB_SALTY 47 14 NSNPATIMTDP CARB_ECOLI 47 14 NSNPATIMTDP O50236 48 14 NSNPATIMTDT O50302 48 14 NSNPATIMTDK CARB_LACPL 48 14 NSNPATIMTDE CARY_BACSU 48 14 NPNVATVQTNH Q27448 542 14 NPNIATVQTSK Q27732 731 14 NPNIATVQTSK PYR1_DROME 449 14 NSNPATVMTDP O25577 48 14 NSNPATIMTDP Q59599 48 14 NSNPATIMTDR O32771 48 14 NSNVATVQTSK CARB_SULSO 46 14 NNNPETVSTDY Q58776 125 14 NCNPETVSTDY O67233 43 14 NNNPETVSTDY O27077 353 14 CPSASE3 Length of motif = 13 Motif number = 3 CPSase motif III - 4 PCODE ST INT VRAAFALGGLGSG PYR1_SQUAC 557 109 VRAAFALGGLGSG PYR1_MESAU 554 109 VRAAYALGGLGSG PYR1_YEAST 597 107 VRAAYALGGLGSG PYR1_SCHPO 633 107 VRAAYALGGLGSG Q92115 587 112 VRAAYCLGGLGSG PYR1_DICDI 526 109 VRAAFAVGGLGSG PYR1_HUMAN 554 109 VRAAYALGGLGSG Q18990 551 109 LRSAFSLGGLGSF CARB_TRICU 236 109 LRSAYSLGGLGSG P70087 584 112 IRSAYALGGLGSG CPSM_HUMAN 586 112 IRSAYALGGLGSG CPSM_RANCA 583 112 VRPAFTLGGTGGG O28994 168 109 IRSAYALGGLGSG CPSM_RAT 586 112 VRSAYALGGLGSG CARB_YEAST 189 109 LRPAFTLGGTGSS O67869 168 109 LRSAYALGPLGSG O42433 587 112 IRPAFTLGGTGGG Q42601 260 110 VRAAYCLGGQGSG O15829 533 109 VRPAFTLGGTGGG CARB_BACCL 168 109 IRPSFTMGGTGGG Q51430 168 109 LRAAYCLGGQGSG O15830 534 109 VRPAYTLGGTGGG CARB_BACSU 168 109 VRPSFTLGGTGGG P96495 168 109 IRPAFTLAGTGGG Q55756 193 110 IRPSFTMGGTGGG CARB_SALTY 167 109 IRPSFTMGGSGGG CARB_ECOLI 167 109 IRPSFTMGGTGGG O50236 167 108 VRPAFTLGGTGGG O50302 168 109 VRPAFTMGGTGGG CARB_LACPL 168 109 IRPAYTLGGKGGG CARY_BACSU 168 109 VRTNYALGGFGSG Q27448 661 108 VRTTFSLGGLNSS Q27732 851 109 ARAAFSLGGLGSG PYR1_DROME 568 108 IRASFTLAGGGSG O25577 166 107 IRPSFTMGGSGGG Q59599 168 109 VGPAFTMGGTGGG O32771 168 109 VRVSFNLGGRGSM CARB_SULSO 166 109 VRPSYVLGGRAMQ Q58776 243 107 VRPSYVLGGRAMR O67233 157 103 VRPSYVLGGRAME O27077 467 103 CPSASE4 Length of motif = 20 Motif number = 4 CPSase motif IV - 4 PCODE ST INT ILVDKSLKGWKEIEYEVVRD PYR1_SQUAC 591 21 VLIDKSLKGWKEIEYEVVRD PYR1_MESAU 588 21 VLVEKSMKGWKEVEYEVVRD PYR1_YEAST 631 21 VLIERSMKGWKEIEYEVVRD PYR1_SCHPO 667 21 ILVEQSLLGWKEVEYEVVRD Q92115 621 21 VLVEKSLKGWKEIEYEVLRD PYR1_DICDI 560 21 VLVDKSLKGWKEIEYEVVRD PYR1_HUMAN 588 21 VLVDKSLKGWKEVEYEVVRD Q18990 585 21 VLIEKSLKGWKEVEYEVVRD CARB_TRICU 269 20 ILVEKSLMGWKEVEYEVVRD P70087 618 21 ILVEKSVTGWKEIEYEVVRD CPSM_HUMAN 620 21 ILVERSVVGWKEIEYEVVRD CPSM_RANCA 617 21 VLIEEGVLGWKEFELEVMRD O28994 204 23 ILVERSVTGWKEIEYEVVRD CPSM_RAT 620 21 ILVEKSLKGWKEVEYEVVRD CARB_YEAST 223 21 VLLDKSLIGWKEIEFEVVRD O67869 204 23 ILVEKSLMGWKEVEYEVVRD O42433 621 21 VLVEKSLLGWKEYELEVMRD Q42601 296 23 VLLEESVAGWKEIEYEVVRD O15829 567 21 CLLERSIAGYKEIEYEVMRD CARB_BACCL 204 23 LLIDESLIGWKEYEMEVVRD Q51430 204 23 VLLEESVAGWKEVEYEVVRD O15830 568 21 CLLEKSIAGYKEIEYEVMRD CARB_BACSU 204 23 ALVEESVLGWKEFELEVMRD P96495 204 23 ILVEKSLLGWKEYELEVMRD Q55756 229 23 LLIDESLIGWKEYEMEVVRD CARB_SALTY 203 23 LLIDESLIGWKEYEMEVVRD CARB_ECOLI 203 23 VLIEESVIGWKEYEMEVVRD O50236 203 23 CLLERSIAGYNQIEYEVMRD O50302 204 23 VLIEQSIAGYKEIEFEVMRD CARB_LACPL 204 23 CLVEKSIAGFKEIEYEVMRD CARY_BACSU 204 23 VYIDKALKGWKEIEFEIIRD Q27448 717 43 IFIDKSLQGWKEIEYELLRD Q27732 886 22 LIVDKSLKGWKEVEYEVVRA PYR1_DROME 602 21 ILIEESLLGWKEYEMEVIRD O25577 202 23 LLIEQSVLGWKEYEMEVVRD Q59599 204 23 CLIEESIAGYKEIEYEVMRD O32771 204 23 VLLEKYLYHWIELEYEVMRD CARB_SULSO 202 23 VLIDKFLEDAIELDVDAVCD Q58776 279 23 VLIDKFLDNSIELDVDAVSD O67233 193 23 ILVDKFLEDAIEVDVDALCD O27077 503 23 CPSASE5 Length of motif = 18 Motif number = 5 CPSase motif V - 4 PCODE ST INT PLGIHTGESIVVAPSQTL PYR1_SQUAC 626 15 PLGIHTGESIVVAPSQTL PYR1_MESAU 623 15 PLGIHTGDSIVVAPSQTL PYR1_YEAST 666 15 PLGIHTGDSIVVAPSQTL PYR1_SCHPO 702 15 PLGIHTGDSVVVAPSQTL Q92115 656 15 PLGIHTGESIVVAPSQTL PYR1_DICDI 595 15 PLGIHTGESIVVAPSQTL PYR1_HUMAN 623 15 PLGIHTGESVVVAPSQTL Q18990 620 15 PLGTHTGDSIVVAPSQTL CARB_TRICU 304 15 PLGIHTGDSIVVAPSQTL P70087 653 15 AMGVHTGDSVVVAPAQTL CPSM_HUMAN 655 15 AMGVHTGDSIVVAPCQTL CPSM_RANCA 652 15 PMGVHTGDSITVAPAQTL O28994 239 15 AMGVHTGDSVVVAPAQTL CPSM_RAT 655 15 PLGVHTGDSMVFAPSQTL CARB_YEAST 258 15 PMGVHTGDSITVAPTQTL O67869 239 15 PLGIHTGDSIVVAPSQTL O42433 656 15 PMGVHTGDSITVAPAQTL Q42601 331 15 PMGVHTGESIVVAPSQTL O15829 602 15 PVGIHTGDSIVVAPSQTL CARB_BACCL 239 15 PMGVHTGDSITVAPAQTL Q51430 239 15 PMGTHTGESIVVAPLQTL O15830 603 15 PVGIHTGDSIVVAPSQTL CARB_BACSU 239 15 PMGVHTGDSITVAPAQTL P96495 239 15 PMGVHTGDSITVAPAQTL Q55756 264 15 AMGIHTGDSITVAPAQTL CARB_SALTY 238 15 AMGIHTGDSITVAPAQTL CARB_ECOLI 238 15 PMGVHTGDSITVAPALTM O50236 238 15 PVGIHTGDSIVVAPSQTL O50302 239 15 PVGIHTGDSIVYAPVQTL CARB_LACPL 239 15 PVGVHTGDSIVVAPSQTL CARY_BACSU 239 15 PLGIHTGDSIVVAPAQTL Q27448 752 15 PLGIHTGDSIVVAPSQTL Q27732 921 15 PLGIHTGESIVVAPSQTL PYR1_DROME 638 16 PMGVHTGDSITIAPSLTL O25577 237 15 PMGVHTGDSITVAPAETL Q59599 239 15 PVGVHTGDSIVFAPSQTL O32771 239 15 PMGVHTGESTVVAPCQTL CARB_SULSO 237 15 EAGVHSGDSATVIPPQTL Q58776 313 14 EAGVHSGDSATSIPPYSL O67233 227 14 EAGVHSGDSACVIPPQSI O27077 537 14 CPSASE6 Length of motif = 30 Motif number = 6 CPSase motif VI - 4 PCODE ST INT IIEVNARLSRSSALASKATGYPLAYVAAKL PYR1_SQUAC 683 39 IIEVNARLSRSSALASKATGYPLAYVAAKL PYR1_MESAU 680 39 IIEVNARLSRSSALASKATGYPLAYTAAKL PYR1_YEAST 723 39 IIEVNARLSRSSALASKATGYPLAFTAAKL PYR1_SCHPO 759 39 IIEVNARLSRSSALASKATGYPLAFVAAKL Q92115 713 39 IIEVNARLSRSSALASKATGYPLAFISAKV PYR1_DICDI 652 39 IIEVNARLSRSSALASKATGYPLAYVAAKL PYR1_HUMAN 680 39 IIEVNARLSRSSALASKATGYPLAYVAAKL Q18990 677 39 VIEMNARLSRSSALASKATGYPLAYTAAKI CARB_TRICU 360 38 IIEVNARLSRSSALASKATGYPLAFVAAKL P70087 710 39 IIEVNARLSRSSALASKATGYPLAFIAAKI CPSM_HUMAN 712 39 IIEVNARLSRSSALASKATGYPLAFIAAKI CPSM_RANCA 709 39 AIEMNPRVSRSSALASKATGFPIAKIAAKL O28994 297 40 IIEVNARLSRSSALASKATGYPLAFIAAKI CPSM_RAT 712 39 VIEVNARLSRSSALASKATGYPLAYTAAKI CARB_YEAST 315 39 VIEMNPRVSRSSALASKATGFPIAKVAAKL O67869 297 40 IIEVNARLSRSSALASKATGYPLAFVAAKL O42433 713 39 IIEMNPRVSRSSALASKATGFPIAKMAAKL Q42601 389 40 VIEVNARLSRSSALASKATGYPLAHVATKI O15829 659 39 VIEVNPRVSRSSALASKATGYPIAKLAAKI CARB_BACCL 296 39 VIEMNPRVSRSSALASKATGFPIAKIAAKL Q51430 297 40 VIEVNARLSRSSALASKATGYPLALVAAKI O15830 660 39 IIEVNPRVSRSSALASKATGYPIAKLAAKI CARB_BACSU 296 39 VIEMNPRVSRSSALASKATGFPIAKIAALL P96495 297 40 VIEMNPRVSRSSALASKATGFPIAKFAAKL Q55756 322 40 VIEMNPRVSRSSALASKATGFPIAKVAAKL CARB_SALTY 296 40 VIEMNPRVSRSSALASKATGFPIAKVAAKL CARB_ECOLI 296 40 VIEMNPRVSRSSALASKATGFPIAKVATKL O50236 296 40 VIEVNPRVSRSSALASKATGYPIAKLAAKI O50302 296 39 IIEVNPRVSRSSALASKATGYPIAKMAAKI CARB_LACPL 296 39 VIEVNPRVSRSSALASKATGYPIAKMAAKL CARY_BACSU 296 39 IVELNARLSRSSALASKATGYPLAYFAARI Q27448 809 39 IIEVNARLSRSSALASKATGYPLAYISAKI Q27732 978 39 IIEVNERLSRTSALASKAPGYPLAYVAAKV PYR1_DROME 694 38 VIEMNPRVSRSSALASKATGFPIAKVATML O25577 295 40 DRDEPAAVSRSSALASKATGFPIAKVAANW Q59599 298 41 VIEVNPRVSRSSALASKATGYPIAKMSAKI O32771 296 39 IIETNPRMSRSSALASKATGYPLAYVSAKL CARB_SULSO 294 39 VLEANPRASRTVPYVSKSVGIPLAKLATKI Q58776 368 37 VLEVNPRASRTVPFVSKSIGYPLAKIATKV O67233 282 37 ILEANPRASRTVPFVSKATGVPLAKMAARL O27077 595 40 CPSASE7 Length of motif = 19 Motif number = 7 CPSase motif VII - 4 PCODE ST INT SVGEVMAIGRNFEEAFQKA PYR1_SQUAC 765 49 SVGEVMGIGRSFEEAFQKA PYR1_MESAU 761 48 SVGEVMSIGRTFEEAIQKA PYR1_YEAST 805 49 SVGEVMSIGRTFEEAIQKA PYR1_SCHPO 841 49 SVGEVMAIGRTFEESFQKA Q92115 795 49 SVGEVMSIGRKFEEAIQKA PYR1_DICDI 734 49 SVGEVMGIGRSFEEAFQKA PYR1_HUMAN 761 48 SVGEVMGIGRCFEEALQKA Q18990 759 49 SVGEVMAIGRTFEESLQKA CARB_TRICU 442 49 SVGEVMAVGRTFEESMQKA P70087 792 49 SVGEVMAIGRTFEESFQKA CPSM_HUMAN 794 49 SVGEVMAIGRTFEESFQKA CPSM_RANCA 791 49 SVGEVMAVGRTFEEALQKA O28994 379 49 SVGEVMAIGRTFEESFQKA CPSM_RAT 794 49 SVGEVMAIGRNYEEAFQKA CARB_YEAST 397 49 SVGEVMAIGRTFKEALLKA O67869 379 49 SVGEVMAVGRTFEESMQKA O42433 795 49 SVGESMALGRTFQESFQKA Q42601 471 49 SVGEVMSIGRTFEEAMQKA O15829 741 49 ATGEVMAIGRTFEESLLKA CARB_BACCL 378 49 SVGEVMAIGRTFQESVQKA Q51430 380 50 SVGEVMAIGRTFEEALQKA O15830 742 49 ATGEVMAIGRTLEESLLKA CARB_BACSU 378 49 SVGEVMAIGRTFKEALMKA P96495 386 56 SVGEAMAIGRTFQESFQKA Q55756 404 49 SVGEVMAIGRTQQESLQKA CARB_SALTY 379 50 SVGEVMAIGRTQQESLQKA CARB_ECOLI 379 50 SVGEVMAIGRSFPESLQKA O50236 378 49 ATGEVMSIGRTFEESLLKA O50302 378 49 ATGEVMAIGRNIEEATLKA CARB_LACPL 378 49 ATGEVMAIERNLEAAIQKA CARY_BACSU 378 49 SVGEVMSIGRTFEEAMQKA Q27448 891 49 SVGEVMSIGRTFEESIQKS Q27732 1060 49 SVGEVMAIGRQLRGSVPKS PYR1_DROME 776 49 SIGEVMAIGGNFLEALQKA O25577 376 48 SVGEVMAMGRTIQESFQKA Q59599 381 50 ATGEVMAIGRNIEESLLKA O32771 378 49 SVGEVMSIGRSFEESLQKA CARB_SULSO 376 49 STGEAIGIDKDFGRAYYKA Q58776 452 51 STGEVMGIDKEFGLAYYKA O67233 372 57 STGEAMGIDENFGIAYYKS O27077 669 41

User query: Display/Full Code "CPSASE"