WORKLIST ENTRIES (1):

CLOACNIMMNTY View alignment View Structure    Cloacin immunity protein signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   PRINTS; PR01295 CLOACIN; PR01297 LYSISCOLICIN; PR01298 MICROCIN
   PRINTS; PR01299 PYOCIN; PR01300 PYOCINKILLER

 Creation date 17-FEB-2000

   1. VAN DEN ELZEN, P.J., GAASTRA, W., SPELT, C.E., DE GRAAF, F.K.,
   VELTKAMP, E. AND NIJKAMP, H.J.
   Molecular structure of the immunity gene and immunity protein of the
   bacteriocinogenic plasmid Clo DF13.
   NUCLEIC ACIDS RES. 8 4349-4363 (1980). 

   The cloacin immunity protein complexes with cloacin in equimolar quantities
   and inhibits it by binding with high affinity to the cloacin C-terminal
   catalytic domain. The immunity protein is relatively small, containing 85
   amino acids. 
  
   An extra ribosome binding site has been found to precede the immunity gene
   on the polycistronic Clo DF13 mRNA [1], which perhaps accounts for the fact
   that, in cloacinogenic cells, more immunity protein than cloacin is 
   synthesised [1]. Comparison of the complete amino acid sequence of the Clo
   DF13 immunity protein with that of the Col E3 and Col E6 immunity proteins
   reveals extensive similarities in primary structure, although Col E3 and 
   Clo DF13 immunity proteins are exchangeable only to a low extent in vivo
   and in vitro [1]. 
  
   CLOACNIMMNTY is a 4-element fingerprint that provides a signature for
   cloacin immunity proteins. The fingerprint was derived from an initial 
   alignment of 3 sequences: the motifs were drawn from conserved regions 
   spanning the full alignment length. Two iterations on SPTR37_10f were
   required to reach convergence, at which point a true set comprising 4
   sequences was identified.

  SUMMARY INFORMATION
      4 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|   4    4    4    4  
    3|   0    0    0    0  
    2|   0    0    0    0  
   --+---------------------
     |   1    2    3    4  

True positives..
 IMM6_ECOLI     IMM3_ECOLI     IMMC_ECOLI     Q47110         


  PROTEIN TITLES
   IMM6_ECOLI       COLICIN E6 IMMUNITY PROTEIN (IMME6) (MICROCIN E6 IMMUNITY PR
   IMM3_ECOLI       COLICIN E3 IMMUNITY PROTEIN (IMME3) (MICROCIN E3 IMMUNITY PR
   IMMC_ECOLI       IMMUNITY PROTEIN FOR CLOACIN - ESCHERICHIA COLI.
   Q47110           IMMUNITY PROTEIN - ESCHERICHIA COLI.

SCAN HISTORY SPTR37_10f 1 100 NSINGLE INITIAL MOTIF SETS CLOACNIMMNTY1 Length of motif = 17 Motif number = 1 Cloacin immunity protein motif I - 1 PCODE ST INT GLKLDLTWFDKSTEDFK IMM3_ECOLI 2 2 GLKLHINWFDKRTEEFK IMM6_ECOLI 2 2 GLKLHIHWFDKKTEEFK IMMC_ECOLI 2 2 CLOACNIMMNTY2 Length of motif = 21 Motif number = 2 Cloacin immunity protein motif II - 1 PCODE ST INT GEEYSKDFGDDGSVMESLGVP IMM3_ECOLI 19 0 GGEYSKDFGDDGSVIERLGMP IMM6_ECOLI 19 0 GGEYSKDFGDDGSVIESLGMP IMMC_ECOLI 19 0 CLOACNIMMNTY3 Length of motif = 20 Motif number = 3 Cloacin immunity protein motif III - 1 PCODE ST INT KDNVNNGCFDVIAEWVPLLQ IMM3_ECOLI 41 1 KDNINNGWFDVIAEWVPLLQ IMM6_ECOLI 41 1 KDNINNGWFDVEKPWVSILQ IMMC_ECOLI 41 1 CLOACNIMMNTY4 Length of motif = 23 Motif number = 4 Cloacin immunity protein motif IV - 1 PCODE ST INT PYFNHQIDISDNEYFVSFDYRDG IMM3_ECOLI 61 0 PYFNHQIDISDNEYFVSFDYRDG IMM6_ECOLI 61 0 PHFKNVIDISKFDYFVSFVYRDG IMMC_ECOLI 61 0 FINAL MOTIF SETS CLOACNIMMNTY1 Length of motif = 17 Motif number = 1 Cloacin immunity protein motif I - 2 PCODE ST INT GLKLHINWFDKRTEEFK IMM6_ECOLI 2 2 GLKLDLTWFDKSTEDFK IMM3_ECOLI 2 2 GLKLHIHWFDKKTEEFK IMMC_ECOLI 2 2 GLKLNLTWFDKKTEDFK Q47110 2 2 CLOACNIMMNTY2 Length of motif = 21 Motif number = 2 Cloacin immunity protein motif II - 2 PCODE ST INT GGEYSKDFGDDGSVIERLGMP IMM6_ECOLI 19 0 GEEYSKDFGDDGSVMESLGVP IMM3_ECOLI 19 0 GGEYSKDFGDDGSVIESLGMP IMMC_ECOLI 19 0 GEEYSKDFGDDGSVIESLGMP Q47110 19 0 CLOACNIMMNTY3 Length of motif = 20 Motif number = 3 Cloacin immunity protein motif III - 2 PCODE ST INT KDNINNGWFDVIAEWVPLLQ IMM6_ECOLI 41 1 KDNVNNGCFDVIAEWVPLLQ IMM3_ECOLI 41 1 KDNINNGWFDVEKPWVSILQ IMMC_ECOLI 41 1 KDNINNGGFDVKKSWVPLLQ Q47110 41 1 CLOACNIMMNTY4 Length of motif = 23 Motif number = 4 Cloacin immunity protein motif IV - 2 PCODE ST INT PYFNHQIDISDNEYFVSFDYRDG IMM6_ECOLI 61 0 PYFNHQIDISDNEYFVSFDYRDG IMM3_ECOLI 61 0 PHFKNVIDISKFDYFVSFVYRDG IMMC_ECOLI 61 0 PYFKNKIEVDKYWYQISFDYRDG Q47110 61 0

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