WORKLIST ENTRIES (1):
BUTYPHLNCDUF View alignment Butyrophylin C-terminal DUF signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR01406 BBOXZNFINGER
PFAM; PF00622 SPRY
INTERPRO; IPR000107
Creation date 25-APR-2000
1. BORDEN, K.L.
RING fingers and B-boxes: zinc-binding protein-protein interaction domains.
BIOCHEM.CELL BIOL. 76 351-358 (1998).
2. BORDEN, K.L., LALLY, J.M., MARTIN, S.R., O'REILLY, N.J., ETKIN, L.D.
AND FREEMONT, P.S.
Novel topology of a zinc-binding domain from a protein involved in
regulating early Xenopus development.
EMBO J. 14(23) 5947-5956 (1995).
3. PONTING, C., SCHULTZ, J. AND BORK, P
SPRY domains in ryanodine receptors (Ca(2+)-release channels).
TRENDS BIOCHEM.SCI. 22 193-194 (1997).
Several proteins that contain RING fingers also contain a well-conserved
40-residue cysteine-rich domain termed a B-box zinc finger. Often, one or
two copies of the B-box are associated with a coiled coil domain in addition
to the ring finger, forming a tripartite motif. The tripartite motif is
found in transcription factors, ribonucleoproteins and proto-oncoproteins,
but no function has yet been ascribed to the domain [1].
The solution structure of the B-box motif has been determined by NMR [2].
The protein is a monomer, with 2 beta-strands, 2 helical turns and 3
extended loop regions packed in a novel topology [2]. Of 7 potential zinc
ligands, only 4 are used, binding a single zinc atom in a C2-H2 tetrahedral
arrangement [2]. The B-box structure differs in tertiary fold from all
other known zinc-binding motifs.
A group of proteins that contain the B-box motif also host a well conserved
domain of unknown function (DUF). Proteins that include this domain are,
e.g.: butyrophilin, the RET finger protein, the 52kDa Ro protein and the
Xenopus nuclear factor protein. The C-terminal portion of this region has
been termed the SPRY domain (after SPla and the RYanodine Receptor) [1].
BUTYPHLNCDUF is a 6-element fingerprint that provides a signature for the
butyrophilin C-terminal domain and related proteins. The fingerprint was
derived from an initial alignment of 7 proteins: the motifs were drawn from
short conserved regions spanning the C-terminal portion of the alignment -
motifs 1-3 lie N-terminal to the SPRY domain, and motifs 4-6 reside within
it. Five iterations on SPTR37_10f were required to reach convergence, at
which point a true set comprising 26 sequences was identified. Several
partial matches were also found, all of which are related DNA-binding
proteins that fail to match one or more motifs.
SUMMARY INFORMATION
26 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
2 codes involving 3 elements
7 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 26 26 26 26 26 26
5| 0 0 0 0 0 0
4| 0 0 1 1 1 1
3| 1 0 2 1 2 0
2| 2 0 6 0 4 2
--+-------------------------------
| 1 2 3 4 5 6
True positives..
BUTY_HUMAN BUTY_MOUSE O00480 BUTY_BOVIN
O00475 O00478 RO52_HUMAN O00481
O75657 P78408 RFP_HUMAN RFP_MOUSE
P78409 O75658 O75656 O00635
O15553 O75677 RO52_MOUSE O75679
O75678 A33_PLEWA Q91431 Q92021
O95604 Q12899
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q91885
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q91884 O95361
Subfamily: Codes involving 2 elements
Subfamily True positives..
Y129_HUMAN Q14258 Q61510 O70583
O35418 O15344 Q91453
PROTEIN TITLES
BUTY_HUMAN BUTYROPHILIN PRECURSOR (BT) - HOMO SAPIENS (HUMAN).
BUTY_MOUSE BUTYROPHILIN PRECURSOR (BT) - MUS MUSCULUS (MOUSE).
O00480 BUTYROPHILIN (BTF2) (BUTYROPHILIN) - HOMO SAPIENS (HUMAN).
BUTY_BOVIN BUTYROPHILIN PRECURSOR (BT) - BOS TAURUS (BOVINE).
O00475 BUTYROPHILIN - HOMO SAPIENS (HUMAN).
O00478 BUTYROPHILIN - HOMO SAPIENS (HUMAN).
RO52_HUMAN 52 KD RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (R
O00481 BUTYROPHILIN - HOMO SAPIENS (HUMAN).
O75657 BTF5 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN).
P78408 BUTYROPHILIN PROTEIN - HOMO SAPIENS (HUMAN).
RFP_HUMAN ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN) - HOMO SAPIENS
RFP_MOUSE ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN) - MUS MUSCULUS
P78409 BUTYROPHILIN - HOMO SAPIENS (HUMAN).
O75658 BTF4 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN).
O75656 DJ45P21.2 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN).
O00635 SIMILAR TO THE 52KD RO/SSA PROTEIN AND RFP - HOMO SAPIENS (H
O15553 PYRIN - HOMO SAPIENS (HUMAN).
O75677 RFPL1L - HOMO SAPIENS (HUMAN).
RO52_MOUSE 52 KD RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (R
O75679 RET FINGER PROTEIN-LIKE 3 - HOMO SAPIENS (HUMAN).
O75678 RET FINGER PROTEIN-LIKE 2 - HOMO SAPIENS (HUMAN).
A33_PLEWA ZINC-BINDING PROTEIN A33 - PLEURODELES WALTLII (IBERIAN RIBB
Q91431 NUCLEAR FACTOR 7 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q92021 XNF7=ZINC FINGER NUCLEAR PHOSPHOPROTEIN - XENOPUS LAEVIS (AF
O95604 ZINC FINGER PROTEIN - HOMO SAPIENS (HUMAN).
Q12899 ACID FINGER PROTEIN - HOMO SAPIENS (HUMAN).
Q91885 RING FINGER PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91884 RING FINGER PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O95361 ESTROGEN-RESPONSIVE B BOX PROTEIN - HOMO SAPIENS (HUMAN).
Y129_HUMAN HYPOTHETICAL PROTEIN KIAA0129 - HOMO SAPIENS (HUMAN).
Q14258 ESTROGEN RESPONSIVE FINGER PROTEIN (EFP) - HOMO SAPIENS (HUM
Q61510 ESTROGEN-RESPONSIVE FINGER PROTEIN - MUS MUSCULUS (MOUSE).
O70583 MIDLINE 1 (MIDLINE 1 PROTEIN) - MUS MUSCULUS (MOUSE).
O35418 MIDLINE 1 (RING FINGER PROTEIN) - MUS MUSCULUS (MOUSE).
O15344 PUTATIVE TRANSCRIPTION FACTOR XPRF (MIDLINE 1 FETAL KIDNEY I
Q91453 STONUSTOXIN BETA-SUBUNIT - SYNANCEIA HORRIDA.
SCAN HISTORY
SPTR37_10f 5 75 NSINGLE
INITIAL MOTIF SETS
BUTYPHLNCDUF1 Length of motif = 18 Motif number = 1
Butyrophylin C-terminal DUF motif I - 1
PCODE ST INT
GLAPLTLDPNTAHPNLVL A33_PLEWA 444 444
HEVDVTLDPDTAHPHLFL BUTY_MOUSE 302 302
HAVDVTLDPDTAHPHLFL BUTY_HUMAN 301 301
HAVDVTLDPDTAHPHLFL BUTY_BOVIN 301 301
CAVHITLDPDTANPWLIL RO52_HUMAN 285 285
YSVDVTLDPDTAYPSLIL RFP_HUMAN 314 314
YSVDVTLDPDTAYPSLIL RFP_MOUSE 323 323
BUTYPHLNCDUF2 Length of motif = 18 Motif number = 2
Butyrophylin C-terminal DUF motif II - 1
PCODE ST INT
LSEGLTSVKYTDTKQQLP A33_PLEWA 461 -1
LYEDSKSVRLEDSRQILP BUTY_MOUSE 319 -1
LYEDSKSVRLEDSRQKLP BUTY_HUMAN 318 -1
LYEDSKSVRLEDSRQKLP BUTY_BOVIN 318 -1
LSEDRRQVRLGDTQQSIP RO52_HUMAN 302 -1
LSDNLRQVRYSYLQQDLP RFP_HUMAN 331 -1
LSDNLRQVRYSYLQQDLP RFP_MOUSE 340 -1
BUTYPHLNCDUF3 Length of motif = 25 Motif number = 3
Butyrophylin C-terminal DUF motif III - 1
PCODE ST INT
RFSQCILVLGAEGFDSGKHYWEVEV A33_PLEWA 483 4
RFDSWPCVLGRETFTSGRHYWEVEV BUTY_MOUSE 341 4
RFDSWPCVLGRETFTSGRHYWEVEV BUTY_HUMAN 340 4
RFDSWPCVMGREAFTSGRHYWEVEV BUTY_BOVIN 340 4
RFDSYPMVLGAQHFHSGKHYWEVDV RO52_HUMAN 324 4
RFNLFPCVLGSPCFIAGRHYWEVEV RFP_HUMAN 353 4
RFNLFPCVLGSPCFIAGRHYWEVEV RFP_MOUSE 362 4
BUTYPHLNCDUF4 Length of motif = 14 Motif number = 4
Butyrophylin C-terminal DUF motif IV - 1
PCODE ST INT
WDVGMASESSNRKG A33_PLEWA 513 5
WAIGVCRENVVKKG BUTY_MOUSE 371 5
WAIGVCRENVMKKG BUTY_HUMAN 370 5
WAIGVCRENVMKKG BUTY_BOVIN 370 5
WDLGVCRDSVRRKG RO52_HUMAN 354 5
WTIGVCEDSVCRKG RFP_HUMAN 383 5
WTIGVCEDSVCRKG RFP_MOUSE 392 5
BUTYPHLNCDUF5 Length of motif = 25 Motif number = 5
Butyrophylin C-terminal DUF motif V - 1
PCODE ST INT
LNLTSKPSKIGVYLDYEGGQVSFYN A33_PLEWA 557 30
LRLAGPPRRVGVFLDYDAGDISFYN BUTY_MOUSE 414 29
LPLAGPPRRVGIFLDYESGDISFYN BUTY_HUMAN 413 29
LPLAGPPRRVGVFLDYESGDIFFYN BUTY_BOVIN 413 29
LHLQVPPCQVGIFLDYEAGMVSFYN RO52_HUMAN 398 30
LPLRTPLQRVGIFLDYDAGEVSFYN RFP_HUMAN 427 30
LPLRTPLQRVGIFLDYDAGEVSFYN RFP_MOUSE 436 30
BUTYPHLNCDUF6 Length of motif = 19 Motif number = 6
Butyrophylin C-terminal DUF motif VI - 1
PCODE ST INT
PIYTFNGSFTEKLYPYLSP A33_PLEWA 587 5
IYTFPSISFSGPLRPFFCL BUTY_MOUSE 445 6
IYTFSNVTFSGPLRPFFCL BUTY_HUMAN 444 6
IYTFSKASFSGPLRPFFCL BUTY_BOVIN 444 6
IYSFSECAFTGPLRPFFSP RO52_HUMAN 430 7
TFTFSHATFCGPVRPYFSL RFP_HUMAN 458 6
TFTFSHATFCGPVRPYFSL RFP_MOUSE 467 6
FINAL MOTIF SETS
BUTYPHLNCDUF1 Length of motif = 18 Motif number = 1
Butyrophylin C-terminal DUF motif I - 5
PCODE ST INT
HAVDVTLDPDTAHPHLFL BUTY_HUMAN 301 301
HEVDVTLDPDTAHPHLFL BUTY_MOUSE 302 302
HAADVVLDPDTAHPELFL O00480 325 325
HAVDVTLDPDTAHPHLFL BUTY_BOVIN 301 301
HAVDVVLDPDTAHPDLFL O00475 326 326
KPADVILDPDTANAILLV O00478 338 338
CAVHITLDPDTANPWLIL RO52_HUMAN 285 285
KPADVILDPKTANPILLV O00481 338 338
KPADVILDPKTANPILLV O75657 320 320
HAVDVVLDPDTAHPDLFL P78408 312 312
YSVDVTLDPDTAYPSLIL RFP_HUMAN 314 314
YSVDVTLDPDTAYPSLIL RFP_MOUSE 323 323
SAADVILYPDMANAILLV P78409 496 496
LTPDVILYPDMANAILLV O75658 311 311
HAANVVLDQDTGHPYLFV O75656 243 243
HQVSVTLDPDTAHHELIL O00635 290 290
HAVNVILDAETAYPNLIF O15553 596 596
FQVDMTLDADTANNFLLI O75677 94 94
CWVHITLDRNTANSWLII RO52_MOUSE 289 289
FQVDMTLDADTANNFLLI O75679 94 94
FQVDMTLDANTANNFLLI O75678 94 94
GLAPLTLDPNTAHPNLVL A33_PLEWA 444 444
SLTPMLLDPNSAHPNLHL Q91431 431 431
SLTPMLLDPTSAHPNLHL Q92021 430 430
DSGVITLDPQTASRSLVL O95604 292 292
KTVSVTLDPQSASGYLQL Q12899 311 311
BUTYPHLNCDUF2 Length of motif = 18 Motif number = 2
Butyrophylin C-terminal DUF motif II - 5
PCODE ST INT
LYEDSKSVRLEDSRQKLP BUTY_HUMAN 318 -1
LYEDSKSVRLEDSRQILP BUTY_MOUSE 319 -1
LSEDRRSVRRGPYRQRVP O00480 342 -1
LYEDSKSVRLEDSRQKLP BUTY_BOVIN 318 -1
LSEDRRSVRRCPFRHLGE O00475 343 -1
VSEDQRSVQRAEEPRDLP O00478 355 -1
LSEDRRQVRLGDTQQSIP RO52_HUMAN 302 -1
VSEDQRSVQRAKEPQDLP O00481 355 -1
VSEDQRSVQRAKEPQDLP O75657 337 -1
LSEDRRSVRRCPFRHLGE P78408 329 -1
LSDNLRQVRYSYLQQDLP RFP_HUMAN 331 -1
LSDNLRQVRYSYLQQDLP RFP_MOUSE 340 -1
VSEDQRSVQRAEEPHDLP P78409 513 -1
VSEDQRSVQRAEEPHDLP O75658 328 -1
VSEDKRSVTLDPSRESIP O75656 260 -1
LSEDRRQVTRGYTQENQD O00635 307 -1
FSDDLKSVRLGNKWERLP O15553 613 -1
ISDDLRSVRSGCITQNRQ O75677 111 -1
ISKDRRQVRMGDTHQNVS RO52_MOUSE 306 -1
ISDDLRSVRSGLITQNRQ O75679 111 -1
ISDDLRSVRSGRIRQNRQ O75678 111 -1
LSEGLTSVKYTDTKQQLP A33_PLEWA 461 -1
LSDGLTSVRYGENKLSLP Q91431 448 -1
LSDGLTSVRYGENKLSLP Q92021 447 -1
LSEDRKSVRYTRQKKSLP O95604 309 -1
LSEDWKCVTYTSLYKSAY Q12899 328 -1
BUTYPHLNCDUF3 Length of motif = 25 Motif number = 3
Butyrophylin C-terminal DUF motif III - 5
PCODE ST INT
RFDSWPCVLGRETFTSGRHYWEVEV BUTY_HUMAN 340 4
RFDSWPCVLGRETFTSGRHYWEVEV BUTY_MOUSE 341 4
RFDSQPCVLGWESFASGKHYWEVEV O00480 364 4
RFDSWPCVMGREAFTSGRHYWEVEV BUTY_BOVIN 340 4
RFDSQPCVLGRESFASGKHYWEVEV O00475 368 7
RFEWRYCVLGCENFTSGRHYWEVEV O00478 377 4
RFDSYPMVLGAQHFHSGKHYWEVDV RO52_HUMAN 324 4
RFNWHYCVLGCESFISGRHYWEVEV O00481 377 4
RFNWHYCVLGCESFISGRHYWEVEV O75657 359 4
RFDSQPCVLGRESFASGKHYWEVEV P78408 354 7
RFNLFPCVLGSPCFIAGRHYWEVEV RFP_HUMAN 353 4
RFNLFPCVLGSPCFIAGRHYWEVEV RFP_MOUSE 362 4
RFEWRYCVLGCESFMSERHYWEVEV P78409 535 4
RFEWRYCVLGCESFMSERHYWEVEV O75658 350 4
RFDSQLCVLGQESFASGKHYLEVDV O75656 282 4
RFTAFPCVLGCEGFTSGRRYFEVDV O00635 329 4
RFDSCIIVLGSPSFLSGRRYWEVEV O15553 635 4
RFDVSICILGSPRFTCGRHYWEVDV O75677 133 4
RFSNYPMVLGAQRFSSGKMYWEVDV RO52_MOUSE 328 4
RFDVSVCILGSPRFTCGRHYWEVDV O75679 133 4
RFDVSVCILGSPRFTCGRHCWEVDV O75678 133 4
RFSQCILVLGAEGFDSGKHYWEVEV A33_PLEWA 483 4
RFSQCILVLGSQGFDSGRHYWEVEV Q91431 470 4
RFSQCILVLGSQGFDSGRHYWEVEV Q92021 469 4
RFDGLPAVLGFPGFSSGRHRWQVDL O95604 331 4
QFDCEPGVLGSKGFTWGKVYWEVEV Q12899 350 4
BUTYPHLNCDUF4 Length of motif = 14 Motif number = 4
Butyrophylin C-terminal DUF motif IV - 5
PCODE ST INT
WAIGVCRENVMKKG BUTY_HUMAN 370 5
WAIGVCRENVVKKG BUTY_MOUSE 371 5
WTVGVCRHSVERKG O00480 394 5
WAIGVCRENVMKKG BUTY_BOVIN 370 5
WTVGVCRDSVERKG O00475 398 5
WHIGVCSKNVERKK O00478 407 5
WDLGVCRDSVRRKG RO52_HUMAN 354 5
WHIGVCSKNVQRKG O00481 407 5
WHIGVCSKNVQRKG O75657 389 5
WTVGVCRDSVERKG P78408 384 5
WTIGVCEDSVCRKG RFP_HUMAN 383 5
WTIGVCEDSVCRKG RFP_MOUSE 392 5
WHIGVCSKNVERKK P78409 565 5
WHIGVCSKNVERKK O75658 380 5
WTVGICRDNVERKW O75656 312 5
WDLGVCMENVQRGT O00635 359 5
WILGACKTSISRKG O15553 665 5
WDLGVCRESVHRKG O75677 163 5
WDLGVCRDSVQRKG RO52_MOUSE 358 5
WDLGVCRESVHCKG O75679 163 5
WDLGVCRESVHRKG O75678 163 5
WDVGMASESSNRKG A33_PLEWA 513 5
WDVGMASESSNRKG Q91431 500 5
WDVGMASESSNRKG Q92021 499 5
CTVGVAGEGVRRKG O95604 363 7
CMVGVARDSVKRKG Q12899 437 62
BUTYPHLNCDUF5 Length of motif = 25 Motif number = 5
Butyrophylin C-terminal DUF motif V - 5
PCODE ST INT
LPLAGPPRRVGIFLDYESGDISFYN BUTY_HUMAN 413 29
LRLAGPPRRVGVFLDYDAGDISFYN BUTY_MOUSE 414 29
LPLKESLCRVGVFLDYEAGDVSFYN O00480 437 29
LPLAGPPRRVGVFLDYESGDIFFYN BUTY_BOVIN 413 29
LPLKESLCRVGVFLDYEAGDVSFYN O00475 441 29
LKLPEPPRKVGIFLDYETGEISFYN O00478 452 31
LHLQVPPCQVGIFLDYEAGMVSFYN RO52_HUMAN 398 30
LKLPKPPKKVGVFLDYETGDISFYN O00481 451 30
LKLPKPPKKVGVFLDYETGDISFYN O75657 433 30
LPLKESLCRVGVFLDYEAGDVSFYN P78408 427 29
LPLRTPLQRVGIFLDYDAGEVSFYN RFP_HUMAN 427 30
LPLRTPLQRVGIFLDYDAGEVSFYN RFP_MOUSE 436 30
LKLPEPPRKVGVILDYETGHISFYN P78409 610 31
LKLPEPPRKVGVILDYETGHISFYN O75658 425 31
LSLEEPLCQVGIFLDYEAGDVSFYN O75656 355 29
LHLHEQPLLVGIFLDYEAGVVSFYN O00635 403 30
LLIKEPPKRVGIFVDYRVGSISFYN O15553 709 30
LFVDRKLQRVGIFLDMGMQNVSFFD O75677 207 30
LHIQVPPCQIGIFVDYEAGVVSFYN RO52_MOUSE 401 29
LLVDRKLQRVGIFLDMGMQNVSFFD O75679 207 30
LFVDRKLQRVGIFLDMGMQNVSFFD O75678 207 30
LNLTSKPSKIGVYLDYEGGQVSFYN A33_PLEWA 557 30
LSLTSHPRKIGVYVDYEGGQISFYN Q91431 544 30
LSLSSHPRKIGVYVDYEGGQISFYN Q92021 543 30
LPLSEIPRGVRVALDYEAGQVTLHN O95604 406 29
LFPALRPRRVGIALDYEGGTVTFTN Q12899 480 29
BUTYPHLNCDUF6 Length of motif = 19 Motif number = 6
Butyrophylin C-terminal DUF motif VI - 5
PCODE ST INT
IYTFSNVTFSGPLRPFFCL BUTY_HUMAN 444 6
IYTFPSISFSGPLRPFFCL BUTY_MOUSE 445 6
IYTCPRSAFTVPVRPFFRL O00480 468 6
IYTFSKASFSGPLRPFFCL BUTY_BOVIN 444 6
IYTCPRSAFSVPVRPFFRL O00475 472 6
IYTFPHASFSEPLYPVFRI O00478 483 6
IYSFSECAFTGPLRPFFSP RO52_HUMAN 430 7
IHTFLDVSFSEALYPVFRI O00481 482 6
IHTFLDVSFSEALYPVFRI O75657 464 6
IYTCPRSAFSGPDTSQSGD P78408 458 6
TFTFSHATFCGPVRPYFSL RFP_HUMAN 458 6
TFTFSHATFCGPVRPYFSL RFP_MOUSE 467 6
IYTFLHASSSEPLYPVFRI P78409 641 6
IYTFLHASSSEPLYPVFRI O75658 456 6
IYTFPHSAFSVPVRPFFSL O75656 386 6
IFTFPKASFSDTLRPYFQV O00635 434 6
IYTFASCSFSGPLQPIFSP O15553 740 6
VYTFRSVSAEEPLHLFFAP O75677 238 6
IYTFSECVFAGPLRPFFNV RO52_MOUSE 433 7
VYTFRSVSAEEPLRPFLAP O75679 238 6
VYTFRSVSAEEPLCPFLAP O75678 238 6
PIYTFNGSFTEKLYPYLSP A33_PLEWA 587 5
IIYTFSATFTEKLYPYLSP Q91431 574 5
IIYTFNATFTEKLYPYLSP Q92021 573 5
PIFTFTASFSGKVFPFFAV O95604 436 5
LIYTFTATFTRRLVPFLWL Q12899 510 5
User query: Display/Full Code "BUTYPHLNCDUF"