WORKLIST ENTRIES (1):

BP450 View alignment View Structure           B-class P450 signature
 Type of fingerprint: COMPOUND with 9  elements
Links:
   PRINTS; PR00385 P450
   INTERPRO; IPR002397
   PDB; 2CPP 3Dinfo; 1CPT 3Dinfo
   SCOP; 2CPP; 1CPT
   CATH; 2CPP; 1CPT

 Creation date 11-JUL-1995; UPDATE 13-JUN-1999

   1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY (NC-IUB).
   Nomenclature of electron-transfer proteins. Recommendations 1989.
   EUR.J.BIOCHEM. 200 599-611 (1991).
  
   2. NEBERT, D.W. AND GONZALEZ, F.J.
   P450 genes: structure, evolution, and regulation. 
   ANNU.REV.BIOCHEM. 56 945-993 (1987). 

   3. DEGTYARENKO, K.N. AND ARCHAKOV, A.I.
   Molecular evolution of P450 superfamily and P450-containing monooxygenase
   systems.
   FEBS LETT. 332 1-8 (1993).

   4. RUETTINGER, R.T., WEN, L.P. AND FULCO, A.J.
   Coding nucleotide, 5' regulatory, and deduced amino acid sequences of 
   P-450BM-3, a single peptide cytochrome P-450:NADPH-P-450 reductase from 
   Bacillus megaterium. 
   J.BIOL.CHEM. 264 10987-10995 (1989).

   5. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P., 
   ESTABROOK, R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J.,   
   GUNSALUS, I.C., GOTOH, O., OKUDA, K. AND NEBERT, D.W.          
   The P450 superfamily: update on new sequences, gene mapping, accession 
   numbers, early trivial names of enzymes, and nomenclature. 
   DNA CELL BIOL. 12 1-51 (1993). 

   6. KIZAWA, H., TOMURA, D., ODA, M., FUKAMIZU, A., HOSHINO, T., GOTOH, O.,
   YASUI, T. AND SHOUN, H.
   Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome 
   P-450 cDNA from Fusarium oxysporum. 
   J.BIOL.CHEM. 266 10632-10637 (1991). 

   7. POULOS, T.L., FINZEL, B.C. AND HOWARD, A.J.
   High-resolution crystal structure of cytochrome P450cam. 
   J.MOL.BIOL. 195 687-700 (1987). 

   8. HASEMANN, C.A., RAVICHANDRAN, K.G., PETERSON, J.A. AND DEISENHOFER, J.
   Crystal structure and refinement of cytochrome P450terp at 2.3A resolution. 
   J.MOL.BIOL. 236 1169-1185 (1994). 

   9. CUPP-VICKERY, J.R. AND POULOS, T.L. 
   Structure of cytochrome P450eryF involved in erythromycin biosynthesis. 
   NAT.STRUCT.BIOL. 2 144-153 (1995). 

   P450 enzymes constitute a superfamily of haem-thiolate proteins [1],
   widely distributed in bacteria, fungi, plants and animals. The enzymes
   are involved in metabolism of a plethora of both exogenous and endogenous
   compounds [2]. Usually, they act as terminal oxidases in multicomponent
   electron transfer chains, called P450-containing monooxygenase systems. 
   
   P450-containing monooxygenase systems primarily fall into 2 major classes:
   bacterial/mitochondrial (type I), and microsomal (type II). Alternatively,
   P450-containing systems can be classified according to the number of their
   protein components [3]: mitochondrial and most bacterial P450 systems have
   3 components - an FAD-containing flavoprotein (NADPH or NADH-dependent
   reductase), an iron-sulphur protein, and P450; the eukaryotic microsomal 
   P450 system contains 2 components - NADPH:P450 reductase (a flavoprotein
   containing both FAD and FMN) and P450; and a soluble monooxygenase P450BM-3
   from Bacillus megaterium exists as a single polypeptide chain with 2 
   functional parts (the haem and flavin domains), and represents a unique 
   bacterial one-component system - sequence and functional comparisons show
   that these domains are more similar to P450 and the flavoprotein of the
   microsomal 2-component P450 monooxygenase system than to the relevant
   proteins of the 3-component system [4].
   
   Current P450 nomenclature, based on divergent evolution of the P450 super-
   family, was proposed and developed by Nebert et al. [5]. But evolution of
   P450s is not restricted to phylogeny; phylogenetic analysis can only be
   applied to certain groups of orthologous genes (e.g. CYP1A1, 1A2, 2E1, 7,
   11A1, 11B1, 17, 19, 21A1, 27 and 51). Some P450 gene clusters (e.g. the
   mammalian CYP1A1 and CYP1A2, rat CYP2D cluster, house fly CYP6A and CYP6C 
   gene clusters, CYP13A cluster in Caenorhabditis elegans) have seemingly 
   appeared via gene duplication events and should be considered paralogous.
   In P450 gene subfamilies such as CYP2A, 2B, 2C, 2D, 3A, 4A and 52A, which,
   presumably, have arisen through numerous species-specific gene duplication
   and conversion events, orthologue assignments are impossible. This kind of
   evolution can be concerned with intraspecific specialisation. Gene fusion
   events can lead to the appearance of a one-component P450 system. It has
   been hypothesised that the Fusarium oxysporum P450nor (CYP55) gene is a
   xenologous gene of prokaryotic origin [6]. Another example of a much more
   ancient horizontal gene transfer event could be the integration of former
   mitochondrial genes (families CYP11 and CYP27) into the nuclear genome.
   Finally, convergent evolution cannot be ignored, such as witnessed in the
   membrane-binding anchors or in the substrate-binding sites of P450 enzymes
   from the different families, which have similar substrate specificity. 
   
   On the basis of sequence similarity, all P450s can be categorised into 2
   main groups, the so-called B- and E-classes: P450 proteins of prokaryotic
   3-component systems and fungal P450nor (CYP55) belong to the B-class; all
   other known P450s from distinct systems are of the E-class. The data
   suggest that divergence of the P450 superfamily into B- and E-classes, and
   further divergence into stable P450 groups within the E-class, must be very
   ancient and had occured before the appearance of eukaryotes. 
   
   By contrast with the E-class, which mainly consists of multigenic families,
   most families in the B-class are presented by the unique known sequence. 
   Exceptions are families CYP105 (5 subfamilies), CYP107 (6 subfamilies) 
   and CYP113 (2 subfamilies); only CYP105A and CYP106A subfamilies contain 
   2 different genes.  
   
   To date, the 3D structures of 4 P450s have been reported, 3 of which belong
   to the B-class: P450cam [7], P450terp [8] and P450eryF [9]. The P450
   molecule is an alpha/beta protein, shaped like a triangular prism; the
   overall structure can be roughly divided into alpha-rich ('right side') and
   beta-rich ('left side') domains [7-9]. However, this division appears to be
   artificial since the alpha- and beta-rich domains comprise discontinuous
   assemblies of secondary structure segments and do not constitute independent
   folding units. Although the sequence identity between any 2 P450s with known
   3D structure reaches only 20% or less, the overall topology of the proteins
   is similar, with some differences in the orientations of various helices.
   The most dramatic variations between P450 structures are found in regions 
   responsible for substrate binding and access. 
   
   BP450 is a 9-element fingerprint that provides a signature for B-class 
   P450s. The fingerprint was derived from an initial alignment of 20
   sequences: the motifs were drawn from the most conserved regions of the
   alignment - motif 1 includes the N-terminal part of the C helix; motifs 2
   and 3 are adjacent and span the E helix and the major part of the F helix;
   motif 4 includes the C-terminal half of the G helix and the entire H helix;
   motif 5 corresponds to the K helix (cf. motif 3 of signature P450); motifs
   6 and 7 span strands 3 and 4, the 3-10 helix of P450cam (the K' helix in
   P450 terp [8]) and the neighbouring loop region; motifs 8 and 9 are
   adjacent, spanning the invariant Cys residue, which provides the haem iron
   thiolate ligand (cf. PROSITE pattern CYTOCHROME_P450 (PS00086) and motifs
   4 and 5 of signature P450) - motif 9 spans the N-terminus of the L helix
   (nb. in the B-class P450s, the regions corresponding to motifs 1 and 2 of
   signature P450 are not sufficiently conserved to be used in the fingerprint,
   although at the structural level, the I and J helices are well conserved in
   all known crystal structures [7-9]). Two iterations on OWL26.0 were required
   to reach convergence, at which point a true set comprising 23 sequences was
   identified. Several partial matches were also found, several of which are
   P450 sequences matching 5 motifs; most of the sequences matching only 2
   motifs are noise. Among the partial matches, 2 bacterial P450 sequences
   were found: a hypothetical product of CYP117 gene from Bradyrhizobium
   japonicum (BJU126785), matching motifs 3, 6, 8 and 9; and nitrogen fixation-
   associated gene CYP110 from Anabaena sp., which matches only motifs 5 and 9.
  
   An update on SPTR37_9f identified a true set of 45 sequences, and 255
   partial matches.

  SUMMARY INFORMATION
     45 codes involving  9 elements
      9 codes involving  8 elements
      6 codes involving  7 elements
      5 codes involving  6 elements
      5 codes involving  5 elements
      8 codes involving  4 elements
     52 codes involving  3 elements
    170 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    9|  45   45   45   45   45   45   45   45   45  
    8|   7    9    8    5    9    9    8    9    8  
    7|   3    4    5    4    6    6    3    6    5  
    6|   5    1    2    4    3    5    3    5    2  
    5|   3    1    1    3    3    5    3    5    1  
    4|   0    0    1    1    2    7    8    7    6  
    3|   6    4    2    1   10   36   43   17   37  
    2|   8    4    2    6   27   86   77   32   98  
   --+----------------------------------------------
     |   1    2    3    4    5    6    7    8    9  

True positives..
 Q59523         O32460         O87605         CPXF_STRGO     
 CPXE_STRGO     Q59831         CPXK_SACER     Q59819         
 Q59910         O31785         CPXJ_SACER     O34374         
 O85697         CPXY_BACSU     CPXM_BACSU     CPXQ_SACER     
 CPXH_STRGR     CPXR_BRAJA     O87674         YP22_MYCTU     
 O52544         BIOI_BACSU     CPXM_BACME     FAS1_RHOFA     
 Q54302         O52823         O53563         CPXR_RHISN     
 O08464         P77902         NOR2_CYLTO     CPXI_BACME     
 O87192         O52561         YU44_MYCTU     Q60005         
 NOR_FUSOX      O87675         CPXL_PSESP     CPXP_RHISN     
 NOR1_CYLTO     CPXP_BRAJA     P71856         Q59723         
 O33180         
Subfamily:  Codes involving 8 elements
 Subfamily True positives..
 CPXG_STRSQ     CPXW_SULSO     THCB_RHOSO     Y08Q_MYCTU     
 CPXC_AGRT6     Q59921         YU42_MYCTU     O24727         
 O52560         
Subfamily:  Codes involving 7 elements
 Subfamily True positives..
 O52802         O52572         P77977         O50242         
 CPXA_PSEPU     Q59971         
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 Q59079         O53936         O08362         O50243         
 Y4VG_RHISN     
Subfamily:  Codes involving 5 elements
 Subfamily True positives..
 O87673         CPXD_AGRT6     O52822         O34926         
 C883_ARATH     
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 YU34_MYCTU     Q54823         CPN2_MOUSE     C881_MAIZE     
 Q64539         Q64546         Q64586         CPN1_PIG       
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 CP2B_HUMAN     O13254         O54225         O33934         
 CP2B_MOUSE     CP2B_RAT       CPM1_RAT       O46515         
 Q27465         CPN1_RAT       CPN3_RAT       CPN2_RAT       
 CPXU_RHISN     CPM1_HUMAN     O13820         AVNA_ASPPA     
 O17655         O87829         O69653         O65624         
 THAS_RAT       O81077         CP09_MYCTU     O08447         
 Q27470         CPT7_ONCMY     O44658         CPCM_RAT       
 O16156         CPT7_CHICK     CP3T_PIG       O45659         
 THAS_PIG       O16482         O44655         CPT7_SQUAC     
 CPCT_MOUSE     CPN1_HUMAN     O45317         O16670         
 CPT7_ORYLA     O86330         CPN1_PAPHA     CP36_RABIT     
 P95099         CPN2_MESAU     CPCB_RAT       Q27482         
 CPCU_RABIT     O16672         CPN2_HUMAN     CP10_LYMST     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 CPM1_CAPHI     CPM1_SHEEP     CPM1_BOVIN     Q16874         
 Q16749         Q16742         Q16741         CPS3_PIG       
 CPS1_PIG       CPS1_HUMAN     CPS1_BOVIN     CP27_RAT       
 Q64639         Q64615         CPM1_PIG       CPXU_BRAJA     
 CP51_PENIT     CP51_USTMA     CPM1_ONCMY     CP27_HUMAN     
 P96813         CPC2_RABIT     O23397         CPCD_RAT       
 CPT7_ICTPU     YDAK_CAEEL     CPN1_CAVPO     CP51_CANGA     
 O02641         CP51_CANAL     ERG5_YEAST     CPXN_ANASP     
 Q59163         Q64530         CP51_UNCNE     CPDA_MOUSE     
 Q27506         CP51_SCHPO     O22188         O61935         
 CPCG_RABIT     CP74_ARATH     O62377         STCL_EMENI     
 CP27_RABIT     CPP1_DROAC     O16673         Q92088         
 CPT7_RANDY     O62378         CPCN_RAT       CPD5_RAT       
 CPD9_MOUSE     O16362         O76800         O23387         
 CPC6_RAT       CPD1_RAT       CPZ6_CANFA     CPDF_CANFA     
 O44659         CPDI_RAT       Q64529         CPD3_RAT       
 CPD4_RAT       CPN1_MESAU     CPDH_MACFA     C7E1_SORBI     
 C2F2_MOUSE     STCF_EMENI     Q29454         CPDG_CAVPO     
 Q16753         CPD6_HUMAN     C823_SOYBN     CPDJ_CALJA     
 O22185         TR11_FUSSP     C932_SOYBN     CPCP_MESAU     
 CPCQ_MESAU     C2F1_HUMAN     O16671         O23389         
 O44656         C931_SOYBN     Q27471         CPC4_RABIT     
 CPC5_RABIT     C824_SOYBN     CPC8_HUMAN     CPJ1_RABIT     
 O93297         Q92129         O46051         O64989         
 CP74_LINUS     CP3E_CAVPO     C933_SOYBN     CP18_DROME     
 CPK1_ONCMY     O93304         C861_ARATH     O22744         
 CPJ2_HUMAN     O33959         P95746         O88037         
 C772_SOLME     CPA6_HUMAN     CPA7_HUMAN     C892_ARATH     
 CPAB_RABIT     O23154         P77900         O61204         
 CP3C_CANFA     THAS_MOUSE     C4D2_DROME     O46053         
 CP39_RAT       CPE1_HUMAN     CPE1_MOUSE     CPE1_MESAU     
 CPE1_BOVIN     THAS_HUMAN     O45605         O58111         
 CPE1_RABIT     Q29508         CP3O_SHEEP     CPBB_CANFA     
 CPE1_RAT       O44704         Q64590         CPBA_MOUSE     
 CPC3_RABIT     C757_EUSGR     Q54296         CP3D_MOUSE     
 CPE1_PIG       O44657         CP3R_ONCMY     Q43071         
 O48786         Q08078         HNF4_DROME     CP31_RAT       
 Q06884         O44652         C755_EUSGR     CP33_HUMAN     
 CP34_HUMAN     CPB9_MOUSE     Q64463         O26651         
 Q64460         O76345         Q42959         CPA4_MOUSE     
 CPA5_MOUSE     CPA3_RAT       C718_MENPI     CP3A_MESAU     
 C4D1_DROME     C4D1_DROSI     P70983         O64853         
 C756_CAMME     O52819         


  PROTEIN TITLES
   Q59523           CYTOCHROME P450-LIKE PROTEIN (EC 1.14.14.1) - MICROMONOSPORA
   O32460           ORF 10 - ACTINOMADURA HIBISCA.
   O87605           CYTOCHROME P450 MONOOXYGENASE - STREPTOMYCES VIOLACEUS (STRE
   CPXF_STRGO       CYTOCHROME P450-SU2 (EC 1.14.-.-) (P450-CVB1) (CYP105B1) - S
   CPXE_STRGO       CYTOCHROME P450-SU1 (EC 1.14.-.-) (P450-CVA1) (CYP105A1) - S
   Q59831           CYTOCHROME P450 SCA-2 (EC 1.14.14.1) - STREPTOMYCES CARBOPHI
   CPXK_SACER       CYTOCHROME P450 107B1 (EC 1.14.-.-) (P450CVIIB1) - SACCHAROP
   Q59819           CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES ANTIBIOTICUS.
   Q59910           CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES FRADIAE.
   O31785           HYDROXYLASE OF THE POLYKETIDE PRODUCED BY THE PKS CLUSTER - 
   CPXJ_SACER       6-DEOXYERYTHRONOLIDE B HYDROXYLASE (EC 1.-.-.-) (6-DEB HYDOX
   O34374           P450 HEME-THIOLATE PROTEIN - BACILLUS SUBTILIS.
   O85697           PUTATIVE CYTOCHROME P450 OXIDOREDUCTASE - STREPTOMYCES LIVID
   CPXY_BACSU       CYTOCHROME P450 (EC 1.14.-.-) - BACILLUS SUBTILIS.
   CPXM_BACSU       CYTOCHROME P450 109 (EC 1.14.-.-) (ORF405) - BACILLUS SUBTIL
   CPXQ_SACER       CYTOCHROME P450 113A1 (ERYTHROMYCIN B/D C-12 HYDROXYLASE) - 
   CPXH_STRGR       CYTOCHROME P450-SOY (EC 1.14.-.-) - STREPTOMYCES GRISEUS.
   CPXR_BRAJA       CYTOCHROME P450 BJ-3 (EC 1.14.14.-) (CYTOCHROME P450 114) - 
   O87674           OXYGENASE B - AMYCOLATOPSIS MEDITERRANEI.
   YP22_MYCTU       PUTATIVE CYTOCHROME P450 CY369.22 (EC 1.14.-.-) - MYCOBACTER
   O52544           CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI.
   BIOI_BACSU       BIOTIN BIOSYNTHESIS; CYTOCHROME P450-LIKE ENZYME (EC 1.14.-.
   CPXM_BACME       CYTOCHROME P450(MEG) (EC 1.14.99.-) (STEROID 15-BETA-HYDROXY
   FAS1_RHOFA       CYTOCHROME P450 FAS1 (EC 1.14.-.-) - RHODOCOCCUS FASCIANS.
   Q54302           CYTOCHROME P450 - STREPTOMYCES HYGROSCOPICUS.
   O52823           PCZA363.7 - AMYCOLATOPSIS ORIENTALIS.
   O53563           PUTATIVE CYTOCHROME P450 MONOXYGENASE - MYCOBACTERIUM TUBERC
   CPXR_RHISN       CYTOCHROME P450 BJ-3 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. 
   O08464           CYTOCHROME P450 (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS.
   P77902           PROBABLE CYTOCHROME P450 CY369.11C (EC 1.14.14.1) - MYCOBACT
   NOR2_CYLTO       CYTOCHROME P450 55A3 (EC 1.14.-.-) (CYTOCHROME P450NOR2) - C
   CPXI_BACME       CYTOCHROME P450(BM-1) (EC 1.14.14.1) - BACILLUS MEGATERIUM.
   O87192           ORF-2 PROTEIN - STREPTOMYCES GRISEUS.
   O52561           CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI.
   YU44_MYCTU       PUTATIVE CYTOCHROME P450 CY339.44C (EC 1.14.-.-) - MYCOBACTE
   Q60005           PUTATIVE CYTOCHROME P-450 PROTEIN (EC 1.14.14.1) (UNSPECIFIC
   NOR_FUSOX        CYTOCHROME P450 55A1 (EC 1.14.-.-) (CYPLVA1) (P450 DNIR) (NI
   O87675           OXYGENASE C - AMYCOLATOPSIS MEDITERRANEI.
   CPXL_PSESP       CYTOCHROME P450-TERP (EC 1.14.-.-) (CYTOCHROME P450 108) - P
   CPXP_RHISN       CYTOCHROME P450 BJ-1 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. 
   NOR1_CYLTO       CYTOCHROME P450 55A2 (EC 1.14.-.-) (CYTOCHROME P450NOR1) - C
   CPXP_BRAJA       CYTOCHROME P450 BJ-1 (EC 1.14.14.-) (CYTOCHROME P450 112) - 
   P71856           HYPOTHETICAL 48.4 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   Q59723           CYTOCHROME P450 LIN (EC 1.14.14.1) - PSEUDOMONAS INCOGNITA.
   O33180           PROBABLE CYTOCHROME P450 - MYCOBACTERIUM TUBERCULOSIS.
 
   CPXG_STRSQ       CYTOCHROME P450 105C1 (EC 1.14.-.-) - STREPTOMYCES SP.
   CPXW_SULSO       PROBABLE CYTOCHROME P450 119 (EC 1.14.14.-) - SULFOLOBUS SOL
   THCB_RHOSO       CYTOCHROME P450 116 (EC 1.14.-.-) - RHODOCOCCUS SP. (STRAIN 
   Y08Q_MYCTU       PUTATIVE CYTOCHROME P450 CY50.26 (EC 1.14.-.-) - MYCOBACTERI
   CPXC_AGRT6       CYTOCHROME P450-PINF1, PLANT-INDUCIBLE (EC 1.14.-.-) - AGROB
   Q59921           CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES HYGROSCOPICUS.
   YU42_MYCTU       PUTATIVE CYTOCHROME P450 CY339.42 (EC 1.14.-.-) - MYCOBACTER
   O24727           HYPOTHETICAL 43.4 KD PROTEIN - NOCARDIOIDES SP. (STRAIN KP7)
   O52560           CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI.
 
   O52802           PCZA361.17 - AMYCOLATOPSIS ORIENTALIS.
   O52572           CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI.
   P77977           CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES SP.
   O50242           P-450 MONOOXYGENASE - AGROBACTERIUM TUMEFACIENS.
   CPXA_PSEPU       CYTOCHROME P450-CAM (EC 1.14.15.1) (CAMPHOR 5-MONOOXYGENASE)
   Q59971           CYTOCHROME P450 (DAUNOMYCIN C-14 HYDROXYLASE) (EC 1.14.14.1)
 
   Q59079           VITAMIN D3 25-HYDROXYLASE (EC 1.14.-.-) - AMYCOLATA AUTOTROP
   O53936           PUTATIVE CYTOCHROME P450 - MYCOBACTERIUM TUBERCULOSIS.
   O08362           HYPOTHETICAL 43.7 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM 
   O50243           P-450 MONOXYGENASE - AGROBACTERIUM TUMEFACIENS.
   Y4VG_RHISN       PROBABLE CYTOCHROME P450 Y4VG (EC 1.14.14.-) - RHIZOBIUM SP.
 
   O87673           OXYGENASE A - AMYCOLATOPSIS MEDITERRANEI.
   CPXD_AGRT6       CYTOCHROME P450-PINF2, PLANT-INDUCIBLE (EC 1.14.-.-) - AGROB
   O52822           PCZA363.6 - AMYCOLATOPSIS ORIENTALIS.
   O34926           CYPB - BACILLUS SUBTILIS.
   C883_ARATH       CYTOCHROME P450 88A3 (EC 1.14.-.-) - ARABIDOPSIS THALIANA (M
 
   YU34_MYCTU       PUTATIVE CYTOCHROME P450 CY339.34C (EC 1.14.-.-) - MYCOBACTE
   Q54823           DNRP - STREPTOMYCES PEUCETIUS.
   CPN2_MOUSE       CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P45
   C881_MAIZE       CYTOCHROME P450 88A1 (EC 1.14.-.-) (DWARF3 PROTEIN) - ZEA MA
   Q64539           CYTOCHROME P450 11-BETA (EC 1.14.14.1) - RATTUS NORVEGICUS (
   Q64546           CYTOCHROME P450 C11B3 (EC 1.14.14.1) - RATTUS NORVEGICUS (RA
   Q64586           CYTOCHROME P450 (STEROID 11-BETA-HYDROXYLASE) (EC 1.14.14.1)
   CPN1_PIG         CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
 
   CP2B_HUMAN       25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECU
   O13254           CYTOCHROME P450 SCC (EC 1.14.14.1) - GALLUS GALLUS (CHICKEN)
   O54225           DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE - SACCHAROPOLYSPORA
   O33934           ERYCII - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEU
   CP2B_MOUSE       25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECU
   CP2B_RAT         25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECU
   CPM1_RAT         CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   O46515           CYTOCHROME P450 CHOLESTEROL SIDE-CHAIN CLEAVAGE - EQUUS CABA
   Q27465           SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS E
   CPN1_RAT         CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
   CPN3_RAT         CYTOCHROME P450 11B3 PRECURSOR (EC 1.14.15.4) (CYPXIB3) (P45
   CPN2_RAT         CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P45
   CPXU_RHISN       CYTOCHROME P450 BJ-4 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. 
   CPM1_HUMAN       CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   O13820           PUTATIVE CYTOCHROME P450 C19A8.04 IN CHROMOSOME I (EC 1.14.-
   AVNA_ASPPA       AVERANTIN OXIDOREDUCTASE (EC 1.14.-.-) (CYTOCHROME P450 60A1
   O17655           C41G6.1 PROTEIN - CAENORHABDITIS ELEGANS.
   O87829           CYTOCHROME P450 MONOOXYGENASE - STREPTOMYCES ANTIBIOTICUS.
   O69653           PUTATIVE CYTOCHROME P-450 - MYCOBACTERIUM TUBERCULOSIS.
   O65624           CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   THAS_RAT         THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - 
   O81077           PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
   CP09_MYCTU       CYTOCHROME P450 51-LIKE RV3059 (EC 1.14.-.-) - MYCOBACTERIUM
   O08447           PUTATIVE CYTOCHROME P450 MONOXYGENASE (EC 1.14.14.1) - MYCOB
   Q27470           SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS E
   CPT7_ONCMY       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   O44658           B0213.14 PROTEIN - CAENORHABDITIS ELEGANS.
   CPCM_RAT         CYTOCHROME P450 2C22 (EC 1.14.14.1) (CYPIIC22) (P450 MD) (P4
   O16156           CYTOCHROME P450 30 - MERCENARIA MERCENARIA (NORTHERN QUAHOG)
   CPT7_CHICK       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   CP3T_PIG         CYTOCHROME P450 3A29 (EC 1.14.14.1) (CYPIIIA29) - SUS SCROFA
   O45659           K05D4.4 PROTEIN - CAENORHABDITIS ELEGANS.
   THAS_PIG         THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - 
   O16482           SIMILAR TO CYTOCHROME P450 - CAENORHABDITIS ELEGANS.
   O44655           B0213.10 PROTEIN - CAENORHABDITIS ELEGANS.
   CPT7_SQUAC       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   CPCT_MOUSE       CYTOCHROME P450 2C29 (EC 1.14.14.1) (CYPIIC29) (P-450 MUT-2)
   CPN1_HUMAN       CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
   O45317           Y17D7A.4 PROTEIN - CAENORHABDITIS ELEGANS.
   O16670           F41B5.4 PROTEIN - CAENORHABDITIS ELEGANS.
   CPT7_ORYLA       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   O86330           HYPOTHETICAL 47.9 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   CPN1_PAPHA       CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
   CP36_RABIT       CYTOCHROME P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C) - OR
   P95099           HYPOTHETICAL 56.2 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM 
   CPN2_MESAU       CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (C450XIB2) (AL
   CPCB_RAT         CYTOCHROME P450 2C11 (EC 1.14.14.1) (CYPIIC11) (P-450(M-1)) 
   Q27482           SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS E
   CPCU_RABIT       CYTOCHROME P450 2C30 (EC 1.14.14.1) (CYPIIC30) - ORYCTOLAGUS
   O16672           F41B5.7 PROTEIN - CAENORHABDITIS ELEGANS.
   CPN2_HUMAN       CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P-4
   CP10_LYMST       CYTOCHROME P450 10 (EC 1.14.-.-) (CYPX) - LYMNAEA STAGNALIS 
 
   CPM1_CAPHI       CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   CPM1_SHEEP       CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   CPM1_BOVIN       CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   Q16874           CYTOCHROME P450 21-HYDROXYLASE (STEROID 21-MONOOXYGENASE) (E
   Q16749           CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) - H
   Q16742           CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) - H
   Q16741           CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE). (E
   CPS3_PIG         CYTOCHROME P450 XXIA3 (EC 1.14.99.10) (STEROID 21-HYDROXYLAS
   CPS1_PIG         CYTOCHROME P450 XXIA1 (EC 1.14.99.10) (STEROID 21-HYDROXYLAS
   CPS1_HUMAN       CYTOCHROME P450 XXIB (EC 1.14.99.10) (STEROID 21-HYDROXYLASE
   CPS1_BOVIN       CYTOCHROME P450 XXIA1 (EC 1.14.99.10) (STEROID 21-HYDROXYLAS
   CP27_RAT         STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-)
   Q64639           CYTOCHROME P450 C27/25 (EC 1.14.14.1) - RATTUS NORVEGICUS (R
   Q64615           CYTOCHROME P450 C27/25 (EC 1.14.14.1) - RATTUS NORVEGICUS (R
   CPM1_PIG         CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   CPXU_BRAJA       CYTOCHROME P450 BJ-4 (EC 1.14.14.-) (CYTOCHROME P450 117) - 
   CP51_PENIT       CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STERO
   CP51_USTMA       CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STERO
   CPM1_ONCMY       CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6)
   CP27_HUMAN       STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-)
   P96813           HYPOTHETICAL 49.3 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM 
   CPC2_RABIT       CYTOCHROME P450 2C2 (EC 1.14.14.1) (CYPIIC2) (P450 PBC2) (PH
   O23397           ALLENE OXIDE SYNTHASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRES
   CPCD_RAT         CYTOCHROME P450 2C13, MALE-SPECIFIC (EC 1.14.14.1) (CYPIIC13
   CPT7_ICTPU       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   YDAK_CAEEL       PUTATIVE CYTOCHROME P450 C34B7.3 IN CHROMOSOME I (EC 1.14.-.
   CPN1_CAVPO       CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
   CP51_CANGA       CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STERO
   O02641           PUTATIVE CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELE
   CP51_CANAL       CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STERO
   ERG5_YEAST       CYTOCHROME P450 61 (EC 1.14.14.-) (C-22 STEROL DESATURASE) -
   CPXN_ANASP       PROBABLE CYTOCHROME P450 110 (EC 1.14.-.-) (ORF3) - ANABAENA
   Q59163           CYTOCHROME P450 (EC 1.14.14.1) - ANABAENA VARIABILIS.
   Q64530           CYTOCHROME P450 16A-MS2 (EC 1.14.14.1) - MUS SPRETUS (WESTER
   CP51_UNCNE       CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STERO
   CPDA_MOUSE       CYTOCHROME P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-16-ALPH
   Q27506           K09A11.2 PROTEIN - CAENORHABDITIS ELEGANS.
   CP51_SCHPO       PROBABLE CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A
   O22188           PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
   O61935           COSMID T09H2 - CAENORHABDITIS ELEGANS.
   CPCG_RABIT       CYTOCHROME P450 2C16 (EC 1.14.14.1) (CYPIIC16) - ORYCTOLAGUS
   CP74_ARATH       ALLENE OXIDE SYNTHASE PRECURSOR (EC 4.2.1.92) (HYDROPEROXIDE
   O62377           T10H4.11 PROTEIN - CAENORHABDITIS ELEGANS.
   STCL_EMENI       PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE ST
   CP27_RABIT       STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-)
   CPP1_DROAC       CYTOCHROME P450 12B1 PRECURSOR (EC 1.14.-.-) (CYPXIIB1) - DR
   O16673           F41B5.2 PROTEIN - CAENORHABDITIS ELEGANS.
   Q92088           CYTOCHROME P450 2M1 (EC 1.14.14.1) (CYPIIM1) (AURIC ACID OME
   CPT7_RANDY       CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STER
   O62378           T10H4.10 PROTEIN - CAENORHABDITIS ELEGANS.
   CPCN_RAT         CYTOCHROME P450 2C23 (EC 1.14.14.1) (CYPIIC23) (ARACHIDONIC 
   CPD5_RAT         CYTOCHROME P450 2D5 (EC 1.14.14.1) (CYPIID5) (P450-DB5) (P45
   CPD9_MOUSE       CYTOCHROME P450 2D9 (EC 1.14.14.1) (CYPIID9) (P450-16-ALPHA)
   O16362           F44C8.1 PROTEIN - CAENORHABDITIS ELEGANS.
   O76800           CYP6-LIKE MICROSOMAL CYTOCHROME P450 - DROSOPHILA MELANOGAST
   O23387           SIMILARITY TO CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-
   CPC6_RAT         CYTOCHROME P450 2C6 (EC 1.14.14.1) (CYPIIC6) (P450 PB1) (PTF
   CPD1_RAT         CYTOCHROME P450 2D1 (EC 1.14.14.1) (CYPIID1) (P450-DB1) (P45
   CPZ6_CANFA       CYTOCHROME P450 2C41 (EC 1.14.14.1) (CYPIIC41) - CANIS FAMIL
   CPDF_CANFA       CYTOCHROME P450 2D15 (EC 1.14.14.1) (CYPIID15) (P450 DUT2) -
   O44659           B0213.15 PROTEIN - CAENORHABDITIS ELEGANS.
   CPDI_RAT         CYTOCHROME P450 2D18 (EC 1.14.14.1) (CYPIID18) (P450 2D-29/2
   Q64529           CYTOCHROME P450 16A-MS1 (EC 1.14.14.1) - MUS SPRETUS (WESTER
   CPD3_RAT         CYTOCHROME P450 2D3 (EC 1.14.14.1) (CYPIID3) (P450-DB3) (DEB
   CPD4_RAT         CYTOCHROME P450 2D4 (EC 1.14.14.1) (CYPIID4) (P450-DB4) (P45
   CPN1_MESAU       CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P45
   CPDH_MACFA       CYTOCHROME P450 2D17 (EC 1.14.14.1) (CYPIID17) - MACACA FASC
   C7E1_SORBI       CYTOCHROME P450 71E1 (EC 1.14.-.-) - SORGHUM BICOLOR MILO (S
   C2F2_MOUSE       CYTOCHROME P450 2F2 (EC 1.14.14.-) (CYPIIF2) (NAPHTHALENE DE
   STCF_EMENI       PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE ST
   Q29454           CYTOCHROME P450 IID (EC 1.14.14.1) - BOS TAURUS (BOVINE).
   CPDG_CAVPO       CYTOCHROME P450 2D16 (EC 1.14.14.1) (CYPIID16) - CAVIA PORCE
   Q16753           DEBRISOQUINE 4-HYDROXYLASE MUTANT ALLELE (EC 1.14.14.1) - HO
   CPD6_HUMAN       CYTOCHROME P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1) (DEB
   C823_SOYBN       CYTOCHROME P450 82A3 (EC 1.14.-.-) (P450 CP6) - GLYCINE MAX 
   CPDJ_CALJA       CYTOCHROME P450 2D19 (EC 1.14.14.1) (CYPIID19) (P450 CM2D-1)
   O22185           PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
   TR11_FUSSP       ISOTRICHODERMIN C-15 HYDROXYLASE (EC 1.14.-.-) (CYTOCHROME P
   C932_SOYBN       CYTOCHROME P450 93A2 (EC 1.14.-.-) - GLYCINE MAX (SOYBEAN).
   CPCP_MESAU       CYTOCHROME P450 2C26 (EC 1.14.14.1) (CYPIIC26) (P450 HSM2) -
   CPCQ_MESAU       CYTOCHROME P450 2C27 (EC 1.14.14.1) (CYPIIC27) (P450 HSM3) -
   C2F1_HUMAN       CYTOCHROME P450 2F1 (EC 1.14.14.1) (CYPIIF1) - HOMO SAPIENS 
   O16671           F41B5.3 PROTEIN - CAENORHABDITIS ELEGANS.
   O23389           SIMILARITY TO CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-
   O44656           B0213.11 PROTEIN - CAENORHABDITIS ELEGANS.
   C931_SOYBN       CYTOCHROME P450 93A1 (EC 1.14.-.-) - GLYCINE MAX (SOYBEAN).
   Q27471           SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS E
   CPC4_RABIT       CYTOCHROME P450 2C4 (EC 1.14.14.1) (CYPIIC4) (PROGESTERONE 2
   CPC5_RABIT       CYTOCHROME P450 2C5 (EC 1.14.14.1) (CYPIIC5) (P450 1) (PROGE
   C824_SOYBN       CYTOCHROME P450 82A4 (EC 1.14.-.-) (P450 CP9) - GLYCINE MAX 
   CPC8_HUMAN       CYTOCHROME P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 FORM 1) (
   CPJ1_RABIT       CYTOCHROME P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (P-450IB) - ORY
   O93297           CYTOCHROME P450 2K4 (EC 1.14.14.1) (CYPIIK4) - ONCORHYNCHUS 
   Q92129           CYTOCHROME P-450 (EC 1.14.14.1) - XENOPUS LAEVIS (AFRICAN CL
   O46051           EG:152A3.2 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
   O64989           STEROID 22-ALPHA-HYDROXYLASE - ARABIDOPSIS THALIANA (MOUSE-E
   CP74_LINUS       ALLENE OXIDE SYNTHASE PRECURSOR (EC 4.2.1.92) (HYDROPEROXIDE
   CP3E_CAVPO       CYTOCHROME P450 3A14 (EC 1.14.14.1) (CYPIIIA14) - CAVIA PORC
   C933_SOYBN       CYTOCHROME P450 93A3 (EC 1.14.-.-) (P450 CP5) - GLYCINE MAX 
   CP18_DROME       CYTOCHROME P450 18 (EC 1.14.14.-) (CYPXVIII) - DROSOPHILA ME
   CPK1_ONCMY       CYTOCHROME P450 2K1 (EC 1.14.14.1) (CYPIIK1) (P450 LMC2) - O
   O93304           CYTOCHROME P450 2K1 (EC 1.14.14.1) (CYPIIK1) (P450 LMC2) - O
   C861_ARATH       CYTOCHROME P450 86A1 (EC 1.14.-.-) (CYPLXXXVI) - ARABIDOPSIS
   O22744           PUTATIVE OBTUSIFOLIOL 14-ALPHA DEMETHYLASE - ARABIDOPSIS THA
   CPJ2_HUMAN       CYTOCHROME P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (ARACHIDONIC AC
   O33959           TYL ORFX - STREPTOMYCES FRADIAE.
   P95746           HYPOTHETICAL 44.1 KD PROTEIN - STREPTOMYCES FRADIAE.
   O88037           HYPOTHETICAL 100.1 KD PROTEIN - STREPTOMYCES COELICOLOR.
   C772_SOLME       CYTOCHROME P450 77A2 (EC 1.14.-.-) (CYPLXXVIIA2) (P-450EG5) 
   CPA6_HUMAN       CYTOCHROME P450 2A6 (EC 1.14.14.1) (CYPIIA6) (COUMARIN 7-HYD
   CPA7_HUMAN       CYTOCHROME P450 2A7 (EC 1.14.14.1) (CYPIIA7) (P450-IIA4) - H
   C892_ARATH       CYTOCHROME P450 89A2 (EC 1.14.-.-) (CYPLXXXIX) (ATH 6-1) - A
   CPAB_RABIT       CYTOCHROME P450 2A11 (EC 1.14.14.1) (CYPIIA11) (P450-IIA11) 
   O23154           CYTOCHROME P450-LIKE PROTEIN - ARABIDOPSIS THALIANA (MOUSE-E
   P77900           HYPOTHETICAL 52.2 KD PROTEIN CY21B4.11C (EC 1.14.14.1) - MYC
   O61204           B0213.16 PROTEIN - CAENORHABDITIS ELEGANS.
   CP3C_CANFA       CYTOCHROME P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (P450-PBD-1)
   THAS_MOUSE       THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) (T
   C4D2_DROME       CYTOCHROME P450 4D2 (EC 1.14.14.1) (CYPIVD2) - DROSOPHILA ME
   O46053           COSMID 152A3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
   CP39_RAT         CYTOCHROME P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3) (O
   CPE1_HUMAN       CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) - HOMO
   CPE1_MOUSE       CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450-
   CPE1_MESAU       CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) - MESO
   CPE1_BOVIN       CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) - BOS TAURUS (B
   THAS_HUMAN       THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - 
   O45605           H02I12.8 PROTEIN - CAENORHABDITIS ELEGANS.
   O58111           230AA LONG HYPOTHETICAL COBALAMIN SYNTHASE - PYROCOCCUS HORI
   CPE1_RABIT       CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (ISOZYME 3A) (P
   Q29508           CYTOCHROME P450 (P450IIE2) (EC 1.14.14.1) - ORYCTOLAGUS CUNI
   CP3O_SHEEP       CYTOCHROME P450 3A24 (EC 1.14.14.1) (CYPIIIA24) - OVIS ARIES
   CPBB_CANFA       CYTOCHROME P450 2B11 (EC 1.14.14.1) (CYPIIB11) (P450 PBD-2) 
   CPE1_RAT         CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450R
   O44704           C45H4.2 PROTEIN - CAENORHABDITIS ELEGANS.
   Q64590           CYTOCHROME P450 (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT).
   CPBA_MOUSE       CYTOCHROME P450 2B10 (EC 1.14.14.1) (CYPIIB10) (TESTOSTERONE
   CPC3_RABIT       CYTOCHROME P450 2C3 (EC 1.14.14.1) (CYPIIC3) (P450 PBC3) (P4
   C757_EUSGR       FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHRO
   Q54296           POLYKETIDE SYNTHASE - STREPTOMYCES HYGROSCOPICUS.
   CP3D_MOUSE       CYTOCHROME P450 3A13 (EC 1.14.14.1) (CYPIIIA13) - MUS MUSCUL
   CPE1_PIG         CYTOCHROME P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P-450
   O44657           B0213.12 PROTEIN - CAENORHABDITIS ELEGANS.
   CP3R_ONCMY       CYTOCHROME P450 3A27 (EC 1.14.14.1) (CYPIIIA27) - ONCORHYNCH
   Q43071           CYTOCHROME P450 (EC 1.14.14.1) - PHALAENOPSIS SP.
   O48786           PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
   Q08078           CYTOCHROME P450 2C25 (EC 1.14.14.1) (CYPIIC25) (P450 HSM1) -
   HNF4_DROME       TRANSCRIPTION FACTOR HNF-4 HOMOLOG (DHNF4) - DROSOPHILA MELA
   CP31_RAT         CYTOCHROME P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1) - 
   Q06884           CYTOCHROME P450 IIIA (EC 1.14.14.1) (STEROID INDUCIBLE) - RA
   O44652           K07C6.2 PROTEIN - CAENORHABDITIS ELEGANS.
   C755_EUSGR       FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHRO
   CP33_HUMAN       CYTOCHROME P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLP) - HOMO S
   CP34_HUMAN       CYTOCHROME P450 3A4 (EC 1.14.14.1) (CYPIIIA4) (NIFEDIPINE OX
   CPB9_MOUSE       CYTOCHROME P450 2B9 (EC 1.14.14.1) (CYPIIB9) (TESTOSTERONE 1
   Q64463           CYTOCHROME P450 (TESTOSTERONE 16-ALPHA HYDROXYLASE TYPE A) (
   O26651           DNA HELICASE II RELATED PROTEIN - METHANOBACTERIUM THERMOAUT
   Q64460           CYTOCHROME P450 (TESTOSTERONE 16-ALPHA HYDROXYLASE TYPE B) (
   O76345           CYTOCHROME P450 - HOMARUS AMERICANUS (AMERICAN LOBSTER).
   Q42959           CYTOCHROME P450 (EC 1.14.14.1) - NICOTIANA TABACUM (COMMON T
   CPA4_MOUSE       CYTOCHROME P450 2A4 (EC 1.14.14.1) (CYPIIA4) (TESTOSTERONE 1
   CPA5_MOUSE       CYTOCHROME P450 2A5 (EC 1.14.14.1) (CYPIIA5) (COUMARIN 7-HYD
   CPA3_RAT         CYTOCHROME P450 2A3 (EC 1.14.14.1) (CYPIIA3) (COUMARIN 7-HYD
   C718_MENPI       CYTOCHROME P450 71A8 (EC 1.14.-.-) - MENTHA PIPERITA (PEPPER
   CP3A_MESAU       CYTOCHROME P450 3A10 (EC 1.14.14.1) (CYPIIIA10) (6 BETA-HYDR
   C4D1_DROME       CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA ME
   C4D1_DROSI       CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA SI
   P70983           ALKALINE AMYLOPULLULANASE - BACILLUS SP.
   O64853           PUTATIVE THROMBOXANE-A SYNTHASE - ARABIDOPSIS THALIANA (MOUS
   C756_CAMME       FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHRO
   O52819           PCZA363.3 - AMYCOLATOPSIS ORIENTALIS.

SCAN HISTORY OWL25_3 2 1000 NSINGLE SPTR37_9f 3 300 NSINGLE INITIAL MOTIF SETS BP4501 Length of motif = 12 Motif number = 1 B-class P450 motif I - 1 PCODE ST INT MDPPEQRQFRAL CPXA_PSEPU 103 103 SNGETHGKRRSG CPXC_AGRT6 106 106 KDGTEHARERMA CPXD_AGRT6 96 96 LDPPEHGTRRRM CPXE_STRGO 97 97 MDDPEHARLRRM CPXF_STRGO 97 97 AATLEDERCRRL CPXG_STRSQ 75 75 VDDPEHNTQRRM CPXH_STRGR 105 105 MDPPEHMHQRSM CP55_FUSOX 88 88 LDPPDHRKARSL CPXI_BACME 92 92 SDPPTHTRLRKL CPXJ_SACER 93 93 TDPPDHTRLRKL CPXK_SACER 96 96 MDPPTHTAYRGL CPXL_PSESP 105 105 MDPPKHTKLRAL CPXM_BACSU 86 86 LDPPDHTRLRHI S42052 93 93 QDGPGHLRLRRL STMCARAA 97 97 IDPPEHRALRKV B40634 90 90 LDPPVHTQYRKV A48495 94 94 EDEPIHTERRRL RSU171302 110 110 HEGREHARLRAI BJU126781 88 88 KDPPTHTRLRRL BJU126782 50 50 BP4502 Length of motif = 17 Motif number = 2 B-class P450 motif II - 1 PCODE ST INT NFTEDYAEPFPIRIFML CPXA_PSEPU 149 34 NFTEMYASQLPALTIAS CPXC_AGRT6 152 34 DTVDLFAEICGPVAARI CPXD_AGRT6 140 32 DLVSQFALPVPSMVICR CPXE_STRGO 144 35 DLVTEFALPLPSLVICL CPXF_STRGO 144 35 DLVEHFALPVPSLVIAE CPXG_STRSQ 122 35 ELVSAFALPVPSMVICA CPXH_STRGR 152 35 DLVKEFALPVPSYIIYT CP55_FUSOX 138 38 NIVDDLSSPFPSLVIAD CPXI_BACME 138 34 DIVDRFAHPLPIKVICE CPXJ_SACER 139 34 DLIDEFAFPLPITVISE CPXK_SACER 142 34 DFMTDCALYYPLHVVMT CPXL_PSESP 152 35 DIIEDFAGPLPVIIIAE CPXM_BACSU 132 34 DLMDRYALPVSLLVLCE S42052 140 35 DVLEDFSYPLSIDVICE STMCARAA 146 37 DLVDVLAFPLPVTIVAE B40634 134 32 DLVPLLSAPLPLLTLAE A48495 140 34 DLIGDLLYEVPCIVALI RSU171302 156 34 DLRRHLSFPLPAMVISA BJU126781 135 35 DLHREFALALPMLVFAE BJU126782 100 38 BP4503 Length of motif = 16 Motif number = 3 B-class P450 motif III - 1 PCODE ST INT LAGLPEEDIPHLKYLT CPXA_PSEPU 166 0 VLGLPSEDTPFFTRLV CPXC_AGRT6 169 0 ILGICEASDVEIIRWS CPXD_AGRT6 160 3 LLGVPYADHEFFQDAS CPXE_STRGO 161 0 LLGVPYEDHAFFQERS CPXF_STRGO 161 0 LLGVPPPDREHFQHDT CPXG_STRSQ 139 0 LLGVPYADHAFFEERS CPXH_STRGR 169 0 LLGVPFNDLEYLTQQN CP55_FUSOX 155 0 LFGVPVKDRYQFKKWV CPXI_BACME 155 0 LLGVDEKYRGEFGRWS CPXJ_SACER 156 0 LMGVEDSRRDDFRSWT CPXK_SACER 159 0 ALGVPEDDEPLMLKLT CPXL_PSESP 169 0 MLGAPIEDRHLIKTYS CPXM_BACSU 149 0 LLGVPYADRDELRDRT S42052 157 0 IVGIPEEAREQWHTWG STMCARAA 163 0 LLGLPPMDHEQFGDWS B40634 151 0 LLGLDPDCWYELYNWT A48495 157 0 FLGVPDEDIETCRQYG RSU171302 173 0 LMGVLYEDHAFFAGLS BJU126781 152 0 LFGMPQDDMFELAAGI BJU126782 117 0 BP4504 Length of motif = 23 Motif number = 4 B-class P450 motif IV - 1 PCODE ST INT DYLIPIIEQRRQKPGTDAISIVA CPXA_PSEPU 202 20 DYVRSVIADSGRRMRDDFLSRYL CPXC_AGRT6 212 27 CLFNDLVKKHRSAPNPSAFATML CPXD_AGRT6 204 28 GYLDGLITQFQTEPGAGLVGALV CPXE_STRGO 197 20 EYLARLARTKRERPDDAIISRLV CPXF_STRGO 198 21 GQLQRLVRLKRTEPGDDLLSGLI CPXG_STRSQ 176 21 EYLGALIDRKRAEPGDGLLDELI CPXH_STRGR 205 20 DYLAILVEQRLVEPKDDIISKLC CP55_FUSOX 192 21 QYLYPIVIEKRSNLSDDIISDLI CPXI_BACME 198 27 NFILDLVERRRTEPGDDLLSALI CPXJ_SACER 194 22 EYLTELIAKKRTEPGDDLLTALL CPXK_SACER 195 20 DYFNGFTVDRRSCPKDDVMSLLA CPXL_PSESP 221 36 DYFRDILSKRRAEPKEDLMTMLL CPXM_BACSU 195 30 RYMATLVTRAQEQPGDDLLGILA S42052 194 21 DHLHLLIEQRRATPTGDLLTGLV STMCARAA 198 19 AYLKARCAERRADPGDDLISRLV B40634 195 28 GFCQELFESRRANPGPDIATLLA A48495 199 26 EFAGGLVDKLKADPNAKGWIPHA RSU171302 216 27 AYIRGKMRDKRQDPDDNLLTDLL BJU126781 192 24 AYFGDLIQRKRTDPRRDIVSMLV BJU126782 160 27 BP4505 Length of motif = 12 Motif number = 5 B-class P450 motif V - 1 PCODE ST INT AACEELLRRFSL CPXA_PSEPU 283 58 AAVEEGLRFEPP CPXC_AGRT6 293 58 QAFEEGLRWVAP CPXD_AGRT6 281 54 GAVEELLRYLAI CPXE_STRGO 278 58 GAVEELLRYLTI CPXF_STRGO 275 54 SAVEELLRHLSV CPXG_STRSQ 254 55 VVVEELLRFLSI CPXH_STRGR 286 58 QFVEELCRYHTA CP55_FUSOX 273 58 KAVEEMLRYRFH CPXI_BACME 280 59 NAVEEILRYIAP CPXJ_SACER 276 59 GAIEETLRYESP CPXK_SACER 276 58 RLVDEAVRWTAP CPXL_PSESP 302 58 NVIEETLRYYSP CPXM_BACSU 276 58 SGIEELLRWLSV S42052 273 56 QAVDELMRWCTP STMCARAA 280 59 AIVEEVLRYRPP B40634 276 58 TATAEMVRHASP A48495 280 58 KAIEECLRYSGS RSU171302 299 60 KAVQEILRMYPP BJU126781 272 57 AFVEEVLRCDAP BJU126782 242 59 BP4506 Length of motif = 28 Motif number = 6 B-class P450 motif VI - 1 PCODE ST INT RILTSDYEFHGVQLKKGDQILLPQMLSG CPXA_PSEPU 299 4 RLALKDIDLDGYVLPKGSLLALSVMSGL CPXC_AGRT6 310 5 RLVREDTEIRGFIVPKGDIVMTIQASAN CPXD_AGRT6 298 5 RVATADIEVEGHLIRAGEGVIVVNSIAN CPXE_STRGO 296 6 RIATEDVLIGGRTIAAGEGVLCMISSAN CPXF_STRGO 293 6 RAALQDADIEGTPVKAGEVVVVSLGAAN CPXG_STRSQ 272 6 RLATEDMEVDGATIRKGEGVVFSTSLIN CPXH_STRGR 303 5 RTAKEDVMIGDKLVRANEGIIASNQSAN CP55_FUSOX 291 6 RTVKQDNELLGVKLKKGDVVIAWMSACN CPXI_BACME 297 5 RFAAEEVEIGGVAIPQYSTVLVANGAAN CPXJ_SACER 293 5 RHTAEAVRFGDVVIPEGELVWVALGAAN CPXK_SACER 294 6 RTALADTEVRGQNIKRGDRIMLSYPSAN CPXL_PSESP 319 5 RVATEDTELGGVFIKKGSSVISWIASAN CPXM_BACSU 293 5 RMAVTEVQIAGVTIPAGSFVIPSLLAAN S42052 291 6 RYATEDLDVGGVTVRKGEQVVAVIGAAG STMCARAA 298 6 RTTTKATEVAGVPIPADVMVNTWVLSAN B40634 293 5 RTAMEDTEIGGQAIAKGDKVVLWYASGN A48495 297 5 RKAVVDTTVGEVDIPAGGRLLIVMASAN RSU171302 316 5 RYPRTDVTIAGEHIPAESKVLVGLPATS BJU126781 292 8 RIAQRDIELGGVVIPKNADVRVLIASGN BJU126782 261 7 BP4507 Length of motif = 16 Motif number = 7 B-class P450 motif VII - 1 PCODE ST INT LDERENACPMHVDFSR CPXA_PSEPU 327 0 RDEKHYEHPQLFDVGR CPXC_AGRT6 338 0 RDEDVFEDGESFNVFR CPXD_AGRT6 326 0 RDGTVYEDPDALDIHR CPXE_STRGO 324 0 RDAEVFPGGDDLDVAR CPXF_STRGO 321 0 RDPARFERPDAVDVTR CPXG_STRSQ 300 0 RDADVFPRAETLDWDR CPXH_STRGR 331 0 RDEEVFENPDEFNMNR CP55_FUSOX 319 0 MDETMFENPFSVDIHR CPXI_BACME 325 0 RDPKQFPDPHRFDVTR CPXJ_SACER 321 0 RDGERFEDPDRFDITR CPXK_SACER 322 0 RDEEVFSNPDEFDITR CPXL_PSESP 347 0 RDEDKFCKPDCFKIDR CPXM_BACSU 321 0 RDSNLTDRPDDLDITR S42052 319 0 HDPDRFPDPERFDITR STMCARAA 326 0 RDSDAHDDPDRFDPSA B40634 321 0 RDESVFSDADRFDVTR A48495 325 0 RDDSMFPEPDDFDIHR RSU171302 344 0 FDPHHFDDPEIFDIER BJU126781 320 0 RDPDAFADPDRFDPAR BJU126782 289 0 BP4508 Length of motif = 10 Motif number = 8 B-class P450 motif VIII - 1 PCODE ST INT TTFGHGSHLC CPXA_PSEPU 348 5 LGFGAGVHRC CPXC_AGRT6 360 6 QSFGSGPHHC CPXD_AGRT6 347 5 LAFGFGVHQC CPXE_STRGO 345 5 VAFGFGVHQC CPXF_STRGO 342 5 LAFGHGMHQC CPXG_STRSQ 321 5 LAFGFGVHQC CPXH_STRGR 352 5 LGFGFGDHRC CP55_FUSOX 342 7 LTFGNGPHFC CPXI_BACME 347 6 LSFGQGIHFC CPXJ_SACER 342 5 VAFGHGIHFC CPXK_SACER 343 5 LGFGWGAHMC CPXL_PSESP 368 5 LSFGFGIHFC CPXM_BACSU 342 5 LAFGHGVHFC S42052 340 5 VGFGFGPHYC STMCARAA 351 9 SSFGHGVHFC B40634 345 8 VGFGSGQHVC A48495 346 5 LTFGIGSHTC RSU171302 366 6 LAFSYGPHAC BJU126781 341 5 LSFGHGIHFC BJU126782 320 15 BP4509 Length of motif = 12 Motif number = 9 B-class P450 motif IX - 1 PCODE ST INT CLGQHLARREII CPXA_PSEPU 357 -1 CLGETLARIELQ CPXC_AGRT6 369 -1 CPGAQISRQTVG CPXD_AGRT6 356 -1 CLGQNLARLELE CPXE_STRGO 354 -1 CLGQPLARVELQ CPXF_STRGO 351 -1 CLGRQLARIELR CPXG_STRSQ 330 -1 CLGQNLARAELD CPXH_STRGR 361 -1 CIAEHLAKAELT CP55_FUSOX 351 -1 CLGAPLARLEMK CPXI_BACME 356 -1 CMGRPLAKLEGE CPXJ_SACER 351 -1 CVGAALARLEAQ CPXK_SACER 352 -1 CLGQHLAKLEMK CPXL_PSESP 377 -1 CLGAPLARLEAN CPXM_BACSU 351 -1 CLGHSLARMTLR S42052 349 -1 CLGAALAHQETA STMCARAA 360 -1 CLAAPLARLENR B40634 354 -1 CVGSRLAEMQLR A48495 355 -1 CLGATLARLEMK RSU171302 375 -1 CIGVALARLELK BJU126781 350 -1 CLGAQLARVQLA BJU126782 329 -1 FINAL MOTIF SETS BP4501 Length of motif = 12 Motif number = 1 B-class P450 motif I - 3 PCODE ST INT MDPPEHSRLRRL Q59523 86 86 MDPPEHTRMRKI O32460 98 98 SDPPRHTRLRKL O87605 95 95 MDDPEHARLRRM CPXF_STRGO 97 97 LDPPEHGTRRRM CPXE_STRGO 97 97 MDPPEHGTRRRM Q59831 102 102 TDPPDHTRLRKL CPXK_SACER 96 96 QDPPDHTRLRRL Q59819 96 96 IDPPRHGPLRKL Q59910 101 101 KDTPDHTRLRSL O31785 96 96 SDPPTHTRLRKL CPXJ_SACER 93 93 MDPPKHTKIRSV O34374 84 84 VDDPEHRAQRRM O85697 99 99 SDPPDHNRLRTL CPXY_BACSU 99 99 MDPPKHTKLRAL CPXM_BACSU 86 86 IDPPEHRALRKV CPXQ_SACER 76 76 VDDPEHNTQRRM CPXH_STRGR 105 105 KDPPTHTRLRRL CPXR_BRAJA 97 97 YDPPEHTRLRQK O87674 91 91 MDDPRHTRIRRL YP22_MYCTU 98 98 MDPPEHTRYRKL O52544 92 92 QNQPDHRRLRTL BIOI_BACSU 84 84 SDPPDHRKRRSL CPXM_BACME 91 91 LDPPDHTRLRHI FAS1_RHOFA 93 93 MDPPEHTRLRRV Q54302 93 93 YDPPEHTRLRQK O52823 99 99 MDDPAHLLRRKL O53563 78 78 KEPPTHTRLRRL CPXR_RHISN 97 97 VEPPDHTRYRKT O08464 114 114 MDDPAHLRMRTL P77902 89 89 MDAPAHMNQRSM NOR2_CYLTO 95 95 LDPPDHRKARSL CPXI_BACME 92 92 MDPPASSRLRGL O87192 95 95 SDGEEHARLRKL O52561 103 103 LDDPRHQRLRSI YU44_MYCTU 113 113 QDGPGHLRLRRL Q60005 97 97 MDPPEHMHQRSM NOR_FUSOX 88 88 YDPPEHTRLRKM O87675 100 100 MDPPTHTAYRGL CPXL_PSESP 105 105 HEGGEHARLRTI CPXP_RHISN 87 87 MDAPDHMNQRGM NOR1_CYLTO 89 89 HEGREHARLRAI CPXP_BRAJA 88 88 MDAPHHTRLRKI P71856 119 119 LDPPVHTQYRKV Q59723 94 94 ADDPAHAVHRKL O33180 123 123 BP4502 Length of motif = 17 Motif number = 2 B-class P450 motif II - 3 PCODE ST INT DLVAMFARQLPVRVICE Q59523 133 35 DLIAHLALPLPVTVICE O32460 145 35 DLMESLAWPLPITVISE O87605 143 36 DLVTEFALPLPSLVICL CPXF_STRGO 144 35 DLVSQFALPVPSMVICR CPXE_STRGO 144 35 DLVSQFALPVPSMVICH Q59831 149 35 DLIDEFAFPLPITVISE CPXK_SACER 142 34 DLVEFLAVPFPVAVICE Q59819 143 35 DVVSDLAYPLPVIVIAE Q59910 147 34 DIMKSFASPLPFIVISE O31785 142 34 DIVDRFAHPLPIKVICE CPXJ_SACER 139 34 DLVHDFSYPLPVIVISE O34374 130 34 DLVTAFALPVPSMVICA O85697 146 35 NLVDDYAFPLPIIVISE CPXY_BACSU 145 34 DIIEDFAGPLPVIIIAE CPXM_BACSU 132 34 DLVDVLAFPLPVTIVAE CPXQ_SACER 120 32 ELVSAFALPVPSMVICA CPXH_STRGR 152 35 DLHREFALALPMLVFAE CPXR_BRAJA 147 38 DLVAFVADKVPGAVLCE O87674 138 35 DFVVEIAAELPMQMICI YP22_MYCTU 144 34 DVVMDFAKPLVLRMLGE O52544 139 35 EVISDFAFPLASFVIAN BIOI_BACSU 130 34 DIVASLASPLPIIVMAD CPXM_BACME 137 34 DLMDRYALPVSLLVLCE FAS1_RHOFA 140 35 DLMEDFALPLPIIMICE Q54302 140 35 DLIEFVADEVPGAVLCE O52823 146 35 DFVRDLAAPLPMAVIGD O53563 124 34 DLHRQFALALPMLVFAE CPXR_RHISN 147 38 DVVGRYCSQLPIVVISE O08464 161 35 DFVAEFAGKLPMDVISE P77902 135 34 DLIEKFALPVPSYIIYT NOR2_CYLTO 144 37 NIVDDLSSPFPSLVIAD CPXI_BACME 138 34 DFVARVSAPLPLITICE O87192 142 35 DLVESFCYPLPVTVICE O52561 153 38 DLVSELAGPLPLQIICD YU44_MYCTU 162 37 DVLEDFSYPLSIDVICE Q60005 146 37 DLVKEFALPVPSYIIYT NOR_FUSOX 138 38 DLQALFADPVGALALCE O87675 147 35 DFMTDCALYYPLHVVMT CPXL_PSESP 152 35 DLRRHLSFPLPAMVISA CPXP_RHISN 134 35 DLVKEFALPVPSYIIYT NOR1_CYLTO 139 38 DLRRHLSFPLPAMVISA CPXP_BRAJA 135 35 DFVEQVSCELPLQAIAG P71856 165 34 DLVPLLSAPLPLLTLAE Q59723 140 34 EWMGAMANRLPMMVVAE O33180 169 34 BP4503 Length of motif = 16 Motif number = 3 B-class P450 motif III - 3 PCODE ST INT LLGVPSADHDRFTRWS Q59523 150 0 MLGVPPEDRPRFQDWT O32460 162 0 LLGVPEPDRAAFRVWT O87605 160 0 LLGVPYEDHAFFQERS CPXF_STRGO 161 0 LLGVPYADHEFFQDAS CPXE_STRGO 161 0 MLGVPYADHEFFQDAS Q59831 166 0 LMGVEDSRRDDFRSWT CPXK_SACER 159 0 LLGVPLEDRDLFRTFS Q59819 160 0 LLGIPAEDRDLFREWV Q59910 164 0 LMGIPKEDRSQFQIWT O31785 159 0 LLGVDEKYRGEFGRWS CPXJ_SACER 156 0 LLGVPSAHMEQFKAWS O34374 147 0 LLGVPYADHEFFEEQS O85697 163 0 MLGIPLEDRQKFRVWS CPXY_BACSU 162 0 MLGAPIEDRHLIKTYS CPXM_BACSU 149 0 LLGLPPMDHEQFGDWS CPXQ_SACER 137 0 LLGVPYADHAFFEERS CPXH_STRGR 169 0 LFGMPQDDMFELAAGI CPXR_BRAJA 164 0 LIGVPRDDRATFMQLC O87674 155 0 LLGVPETDRHWLFEAV YP22_MYCTU 161 0 LVGLPYEERDRYVPAV O52544 156 0 IIGVPEEDREQLKEWA BIOI_BACSU 147 0 LMGVPSKDRLLFKKWV CPXM_BACME 154 0 LLGVPYADRDELRDRT FAS1_RHOFA 157 0 LLGVPIEDQTKFRTWS Q54302 157 0 LIGVPRDDRAMFMQLC O52823 163 0 MLGVRPEQRDMFLRWS O53563 141 0 LFGMPQDDMFGLAAGI CPXR_RHISN 164 0 ILGVPEHDRPRVLEFG O08464 178 0 LIGVPDTDRARIRALA P77902 152 0 ILGVPFEDLEYLTEQN NOR2_CYLTO 161 0 LFGVPVKDRYQFKKWV CPXI_BACME 155 0 ALDIPEADRPWLRAHA O87192 159 0 LVGVDHEDRPQWRAWS O52561 170 0 MMGIPKADHQRIFHWT YU44_MYCTU 179 0 IVGIPEEAREQWHTWG Q60005 163 0 LLGVPFNDLEYLTQQN NOR_FUSOX 155 0 LLGIPRDDQREFVRRI O87675 164 0 ALGVPEDDEPLMLKLT CPXL_PSESP 169 0 LMGVLYEDHAFFAGLS CPXP_RHISN 151 0 ILGVPFNDLDHLTNQN NOR1_CYLTO 156 0 LMGVLYEDHAFFAGLS CPXP_BRAJA 152 0 LLGVPQEDRGKLFHWS P71856 182 0 LLGLDPDCWYELYNWT Q59723 157 0 LIGLPDPDIAQLVKWG O33180 186 0 BP4504 Length of motif = 23 Motif number = 4 B-class P450 motif IV - 3 PCODE ST INT AYMGDLIDRRRKEPTDDLVSALV Q59523 188 22 GYLAELIDAKTAAPADDLLSLLS O32460 203 25 GYLSRLIDSKRGQDGEDLLSALV O87605 196 20 EYLARLARTKRERPDDAIISRLV CPXF_STRGO 198 21 GYLDGLITQFQTEPGAGLVGALV CPXE_STRGO 197 20 RYLDGLITKLESEPGTGLLGKLV Q59831 202 20 EYLTELIAKKRTEPGDDLLTALL CPXK_SACER 195 20 VYMDGLVAQRRDAPTEDLLGALA Q59819 198 22 DYLYRRIALKRETPTDDLMSGLI Q59910 210 30 DYIAKLIHDRRIKPKDDLISKLV O31785 197 22 NFILDLVERRRTEPGDDLLSALI CPXJ_SACER 194 22 AFFAGIIEEKRNKPEQDIISILV O34374 193 30 AYLGELIDRKRRAPGEGLLDDLV O85697 199 20 EYLESLVRKKRREPAGDLISALI CPXY_BACSU 202 24 DYFRDILSKRRAEPKEDLMTMLL CPXM_BACSU 195 30 AYLKARCAERRADPGDDLISRLV CPXQ_SACER 181 28 EYLGALIDRKRAEPGDGLLDELI CPXH_STRGR 205 20 AYFGDLIQRKRTDPRRDIVSMLV CPXR_BRAJA 207 27 RYLLAMIARERKDPGEGLIGAVV O87674 192 21 TYALELIAGKRAEPADDMLSVVA YP22_MYCTU 204 27 KFFDEVIERRRQRPQDDLISSLV O52544 193 21 AYFKELIQKRKRHPQQDMISMLL BIOI_BACSU 190 27 QYLYPIVVQKRLNPADDIISDLL CPXM_BACME 197 27 RYMATLVTRAQEQPGDDLLGILA FAS1_RHOFA 194 21 LYLSELIAERRKQDTNDLLGSLV Q54302 195 22 RYLLAMIARERKDPGEGLIGAVI O52823 200 21 DFTRATIAARRADPTDDLVSVLV O53563 184 27 AYFGDLIQRKCIDPRHDIVATLV CPXR_RHISN 207 27 CWLEGHLQQLRHAPGDDLMSQLI O08464 221 27 RYYADLIAEFRRRPANNLTSALL P77902 193 25 KYLAKLVDQRLQEPKDDLIGRLV NOR2_CYLTO 198 21 QYLYPIVIEKRSNLSDDIISDLI CPXI_BACME 198 27 GYFQELTADRRRSPGEDLISTLA O87192 197 22 AAARGMIERRRAEPKDDMVTALV O52561 205 19 AYATALAEDRRVNHHDDLTSSLV YU44_MYCTU 221 26 DHLHLLIEQRRATPTGDLLTGLV Q60005 198 19 DYLAILVEQRLVEPKDDIISKLC NOR_FUSOX 192 21 RYLDNLIARQRRDADDGFLGMIV O87675 201 21 DYFNGFTVDRRSCPKDDVMSLLA CPXL_PSESP 221 36 AYIRGKMRDKRQDPGDNLLTDLL CPXP_RHISN 191 24 DYLASLVEKRLEEPKDDLISKLC NOR1_CYLTO 193 21 AYIRGKMRDKRQDPDDNLLTDLL CPXP_BRAJA 192 24 GYAMKMAEEKAKNPADDIVTQLI P71856 222 24 GFCQELFESRRANPGPDIATLLA Q59723 199 26 GYIFEQFDRAAADPRDNLLGELA O33180 229 27 BP4505 Length of motif = 12 Motif number = 5 B-class P450 motif V - 3 PCODE ST INT SAVEELTRWVPL Q59523 269 58 AAVEELLRYGQI O32460 283 57 GAVEEMLRYEGP O87605 278 59 GAVEELLRYLTI CPXF_STRGO 275 54 GAVEELLRYLAI CPXE_STRGO 278 58 GAVEELLRVLAI Q59831 283 58 GAIEETLRYESP CPXK_SACER 276 58 AAVEEMLRYTPL Q59819 279 58 GAIEETLRYRSP Q59910 291 58 TAVEELLRYTSP O31785 278 58 NAVEEILRYIAP CPXJ_SACER 276 59 QAVEEALRFRAP O34374 274 58 GAVEELMRVLSI O85697 280 58 SAIEEALRFHSP CPXY_BACSU 283 58 NVIEETLRYYSP CPXM_BACSU 276 58 AIVEEVLRYRPP CPXQ_SACER 262 58 VVVEELLRFLSI CPXH_STRGR 286 58 AFVEEVLRCDAP CPXR_BRAJA 289 59 RAVDELIRYLTV O87674 271 56 TAIEEIVRWTSP YP22_MYCTU 288 61 AAIEELLRYLTV O52544 269 53 TAVEECLRYESP BIOI_BACSU 270 57 QAVEEMLRFRFN CPXM_BACME 279 59 SGIEELLRWLSV FAS1_RHOFA 273 56 KAVDELLRIIPI Q54302 276 58 RAVDELIRYLTV O52823 279 56 GAIEEMLRWTAP O53563 265 58 AFVEEVLRCDAP CPXR_RHISN 289 59 NTVEEILRLDSP O08464 305 61 MWVEETLRYDTS P77902 274 58 GFVEELCRYHTG NOR2_CYLTO 279 58 KAVEEMLRYRFH CPXI_BACME 280 59 RTLEELLRHIPF O87192 278 58 QAVRELQRLGPI O52561 287 59 TAVEEIVRWASP YU44_MYCTU 303 59 QAVDELMRWCTP Q60005 280 59 QFVEELCRYHTA NOR_FUSOX 273 58 RVVNELLRYLSP O87675 280 56 RLVDEAVRWTAP CPXL_PSESP 302 58 KAVEEILRMYPP CPXP_RHISN 271 57 QFVEELCRYHTA NOR1_CYLTO 274 58 KAVQEILRMYPP CPXP_BRAJA 272 57 TAADEIVRWATP P71856 301 56 TATAEMVRHASP Q59723 280 58 AFIEETLRYEPP O33180 309 57 BP4506 Length of motif = 28 Motif number = 6 B-class P450 motif VI - 3 PCODE ST INT RYAVEDVTLRGVTIRAGEPVLASTGAAN Q59523 288 7 RIAVEDVEVGGTLVRAGEAVIPLFNAAN O32460 302 7 RFPVEPVDLDGTVIPAGDTVLVVLADAH O87605 296 6 RIATEDVLIGGRTIAAGEGVLCMISSAN CPXF_STRGO 293 6 RVATADIEVEGHLIRAGEGVIVVNSIAN CPXE_STRGO 296 6 RIATADIEIDGQLIRAGEGVIVTNSIAN Q59831 301 6 RHTAEAVRFGDVVIPEGELVWVALGAAN CPXK_SACER 294 6 RVATEDVELSTVTVRAGEPCVVHFASAN Q59819 298 7 RLLKEDTDILGHPMKAGQMVVAWIASAN Q59910 308 5 RWAIEDFTYKGHSIKRGDMIFIGIGSAN O31785 296 6 RFAAEEVEIGGVAIPQYSTVLVANGAAN CPXJ_SACER 293 5 RIAKRDTEIGGHLIKEGDMVLAFVASAN O34374 291 5 RMATEDIDVDGQTIRAGDGVVFSTSVIN O85697 297 5 RWTAEPFILHGQEIKRKDVIIISLASAN CPXY_BACSU 301 6 RVATEDTELGGVFIKKGSSVISWIASAN CPXM_BACSU 293 5 RTTTKATEVAGVPIPADVMVNTWVLSAN CPXQ_SACER 279 5 RLATEDMEVDGATIRKGEGVVFSTSLIN CPXH_STRGR 303 5 RIAQRDIELGGVVIPKNADVRVLIASGN CPXR_BRAJA 308 7 RIAKQDVTVGDQVIKAGESVICSLPAAN O87674 289 6 RTASRAVSLGGQPIEAGQKVVVWEGSAN YP22_MYCTU 305 5 RTALEDVKLEGELIKKGDTVTVSLPAAN O52544 287 6 RVASEDIDICGVTIRQGEQVYLLLGAAN BIOI_BACSU 287 5 RTVKEDNDLLGVELKEGDSVVVWMSAAN CPXM_BACME 296 5 RMAVTEVQIAGVTIPAGSFVIPSLLAAN FAS1_RHOFA 291 6 RMAVEDVELSGTIVKAGEAVAIQTHSAN Q54302 295 7 RIAMQDVIVASQMIKKGESVICSLPAAN O52823 297 6 RVLTADTEFHGTALCAGEKMMLLFESAN O53563 282 5 RIAQSDIELSGVVIPKNADVRVLIAAGN CPXR_RHISN 308 7 RVACRDVEVAGVRIKRGEVVVIYLAAAN O08464 322 5 RTVAHDLTLYDTTIPEGEVLLLLPGSAN P77902 291 5 RVAKEDMELGGKLIRAGEGIIASNQSAN NOR2_CYLTO 297 6 RTVKQDNELLGVKLKKGDVVIAWMSACN CPXI_BACME 297 5 RIALEDVELSGVLIKAGDVVHVSYLTAN O87192 297 7 RFATEDIEVGGTVIPRGMPVVPLIMAAN O52561 304 5 RTLTQDIELRGTKMAAGDKVSLWYCSAN YU44_MYCTU 320 5 RYATEDLDVGGVTVRKGEQVVAVIGAAG Q60005 298 6 RTAKEDVMIGDKLVRANEGIIASNQSAN NOR_FUSOX 291 6 SLAVKDVIIDGQLIKAGDYVLCSVLMAN O87675 298 6 RTALADTEVRGQNIKRGDRIMLSYPSAN CPXL_PSESP 319 5 RYPRTDVTIAGVHIPAESKVLVGLPATS CPXP_RHISN 291 8 RTAKVDLEIGGKHIKANEGIIASNQSAN NOR1_CYLTO 292 6 RYPRTDVTIAGEHIPAESKVLVGLPATS CPXP_BRAJA 292 8 RTALRDYELSGVQIKKGQRVVMFYRSAN P71856 318 5 RTAMEDTEIGGQAIAKGDKVVLWYASGN Q59723 297 5 RHVRNATTLDGTELPADSHLLLLWGAAN O33180 326 5 BP4507 Length of motif = 16 Motif number = 7 B-class P450 motif VII - 3 PCODE ST INT RDQAQFPDADRIDVDR Q59523 316 0 RDPEVFADPEELDLGR O32460 330 0 RTPERFPDPHRFDIRR O87605 324 0 RDAEVFPGGDDLDVAR CPXF_STRGO 321 0 RDGTVYEDPDALDIHR CPXE_STRGO 324 0 RDSSVFENPDRLDVHR Q59831 329 0 RDGERFEDPDRFDITR CPXK_SACER 322 0 RDEEVFDHADELDFHR Q59819 326 0 RDSAHFSDPDTFDVRR Q59910 336 0 RDPNFFENPEILNINR O31785 324 0 RDPKQFPDPHRFDVTR CPXJ_SACER 321 0 RDEAKFDRPHMFDIRR O34374 319 0 RDESVYPEPDALDWHR O85697 325 0 RDEKIFPNADIFDIER CPXY_BACSU 329 0 RDEDKFCKPDCFKIDR CPXM_BACSU 321 0 RDSDAHDDPDRFDPSR CPXQ_SACER 307 0 RDADVFPRAETLDWDR CPXH_STRGR 331 0 RDPDAFADPDRFDPAR CPXR_BRAJA 336 0 RDPALVPDADRLDVTR O87674 317 0 RDPSVFDRADEFDITR YP22_MYCTU 333 0 RDPAKFGCPAELDIER O52544 315 0 RDPSIFTNPDVFDITR BIOI_BACSU 315 0 MDEEMFEDPFTLNIHR CPXM_BACME 324 0 RDSNLTDRPDDLDITR FAS1_RHOFA 319 0 TDPKVYDHPEEIDFHR Q54302 323 0 RDPALVPDPNRLDVTR O52823 325 0 FDEAVFCEPEKFDVQR O53563 310 0 RDPDAFADPDRFDPAR CPXR_RHISN 336 0 RDPAVFPDPHRFDIER O08464 350 0 RDDRVFDDPDDYRIGR P77902 319 0 RDEDVFPNPDVFDMHR NOR2_CYLTO 325 0 MDETMFENPFSVDIHR CPXI_BACME 325 0 RDSAKFDRPDELDPDR O87192 325 0 SDPRKFPEPEKLQIDR O52561 332 0 RDESKFADPWTFDLAR YU44_MYCTU 348 0 HDPDRFPDPERFDITR Q60005 326 0 RDEEVFENPDEFNMNR NOR_FUSOX 319 0 RDEALTPNPNVFDANR O87675 326 0 RDEEVFSNPDEFDITR CPXL_PSESP 347 0 FDPRHFEDPEIFDIGR CPXP_RHISN 319 0 RDADIFENPDEFNMNR NOR1_CYLTO 320 0 FDPHHFDDPEIFDIER CPXP_BRAJA 320 0 FDEEVFQDPFTFNILR P71856 346 0 RDESVFSDADRFDVTR Q59723 325 0 RDPAQFEAPGEFRLDR O33180 354 0 BP4508 Length of motif = 10 Motif number = 8 B-class P450 motif VIII - 3 PCODE ST INT LGFGHGVHHC Q59523 337 5 IALGHGIHYC O32460 351 5 LAFGHGIHFC O87605 345 5 VAFGFGVHQC CPXF_STRGO 342 5 LAFGFGVHQC CPXE_STRGO 345 5 LSFGYGVHQC Q59831 350 5 VAFGHGIHFC CPXK_SACER 343 5 IAFGHGAHHC Q59819 347 5 MSFGHGIHHC Q59910 357 5 ISFGFGIHFC O31785 345 5 LSFGQGIHFC CPXJ_SACER 342 5 IAFGHGIHFC O34374 340 5 VAFGFGIHQC O85697 346 5 IAFGHGNHFC CPXY_BACSU 350 5 LSFGFGIHFC CPXM_BACSU 342 5 FSFGHGVHFC CPXQ_SACER 330 7 LAFGFGVHQC CPXH_STRGR 352 5 LSFGHGIHFC CPXR_BRAJA 367 15 VAFGHGIHHC O87674 338 5 LGFGQGVHYC YP22_MYCTU 354 5 VAFGFGIHQC O52544 336 5 LSFGHGHHVC BIOI_BACSU 336 5 LTFGNGPHFC CPXM_BACME 346 6 LAFGHGVHFC FAS1_RHOFA 340 5 MSLGHGAHHC Q54302 344 5 VAFGHGVHHC O52823 346 5 LAFGFGTHFC O53563 331 5 LSFGHGIHFC CPXR_RHISN 367 15 LAFSTGRHFC O08464 372 6 VSFGSGAHFC P77902 341 6 LGFGFGPHRC NOR2_CYLTO 348 7 LTFGNGPHFC CPXI_BACME 347 6 MTFGWGAHHC O87192 346 5 LGFGKGIHRC O52561 356 8 GFGGGGAHFC YU44_MYCTU 370 6 VGFGFGPHYC Q60005 351 9 LGFGFGDHRC NOR_FUSOX 342 7 VGFGHGIHYC O87675 347 5 LGFGWGAHMC CPXL_PSESP 368 5 LAFSYGPHYC CPXP_RHISN 340 5 LGYGFGPHRC NOR1_CYLTO 343 7 LAFSYGPHAC CPXP_BRAJA 341 5 GFGGTGAHYC P71856 368 6 VGFGSGQHVC Q59723 346 5 ISFGKGAHFC O33180 376 6 BP4509 Length of motif = 12 Motif number = 9 B-class P450 motif IX - 3 PCODE ST INT CLGAPLARVELQ Q59523 346 -1 CLGAPLARLELQ O32460 360 -1 CIGAPLARLEAR O87605 354 -1 CLGQPLARVELQ CPXF_STRGO 351 -1 CLGQNLARLELE CPXE_STRGO 354 -1 CLGQNLARLELE Q59831 359 -1 CVGAALARLEAQ CPXK_SACER 352 -1 CIGAQLGRLELQ Q59819 356 -1 CLGSFLARLEAK Q59910 366 -1 CLGAPLARLEGH O31785 354 -1 CMGRPLAKLEGE CPXJ_SACER 351 -1 CLGAPLARLEAN O34374 349 -1 CLGQNLARAELE O85697 355 -1 CLGAQLARLEAK CPXY_BACSU 359 -1 CLGAPLARLEAN CPXM_BACSU 351 -1 CLGAPLARLENR CPXQ_SACER 339 -1 CLGQNLARAELD CPXH_STRGR 361 -1 CLGAQLARVQLA CPXR_BRAJA 376 -1 CLGAALARLELR O87674 347 -1 CLGANLARLELR YP22_MYCTU 363 -1 CLGQNLARIELR O52544 345 -1 CLGSSLARLEAQ BIOI_BACSU 345 -1 CLGAPLARLEAK CPXM_BACME 355 -1 CLGHSLARMTLR FAS1_RHOFA 349 -1 CMGAQLVRVEMQ Q54302 353 -1 CLGAALSRLELR O52823 355 -1 CLGNQLARLELS O53563 340 -1 CLGAQLARVQLA CPXR_RHISN 376 -1 CLGAALARAEGE O08464 381 -1 CLGAHLARMEAR P77902 350 -1 CIAELLAKAELE NOR2_CYLTO 357 -1 CLGAPLARLEMK CPXI_BACME 356 -1 CLGAPLATMELE O87192 355 -1 CLGQHVAYLEAE O52561 365 -1 CLGANLARREIR YU44_MYCTU 379 -1 CLGAALAHQETA Q60005 360 -1 CIAEHLAKAELT NOR_FUSOX 351 -1 CVGAALARSMLR O87675 356 -1 CLGQHLAKLEMK CPXL_PSESP 377 -1 CIGMALARLELK CPXP_RHISN 349 -1 CIAEHLAKAELT NOR1_CYLTO 352 -1 CIGVALARLELK CPXP_BRAJA 350 -1 CIGANLARMTIN P71856 377 -1 CVGSRLAEMQLR Q59723 355 -1 CVGAALARLEAR O33180 385 -1

User query: Display/Full Code "BP450"