WORKLIST ENTRIES (1):
BCL2FAMILY View alignment Bcl-2 apoptosis regulator protein family signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR01863 APOPREGBCL2; PR01864 APOPREGBCLX; PR01865 APOPREGBCLW
PRINTS; PR01866 APOPREGMCL1; PR01867 BCL2RLATEDA1
PROSITE; PS50062; BCL2_FAMILY
PFAM; PF00452 Bcl-2
INTERPRO; IPR002475
MIM; 151430
Creation date 04-MAY-2005
1. HUNOT, S. AND FLAVELL, R.A.
Apoptosis: death of a monopoly?
SCIENCE 292 865-866 (2001).
2. GERMAIN, M. AND SHORE, G.C.
Cellular distribution of Bcl-2 family proteins.
SCI.STKE 173 PE10 (2003).
3. ADAMS, J.M. AND CORY, S.
The Bcl-2 protein family: arbiters of cell survival.
SCIENCE 281 1322-1326 (1998).
Apoptosis, or programmed cell death (PCD), is a common and evolutionarily
conserved property of all metazoans [1]. In many biological processes,
apoptosis is required to eliminate supernumerary or dangerous (e.g., pre-
cancerous) cells and to promote normal development. Thus, dysregulation
of apoptosis can contribute to the development of many major diseases,
including cancer, autoimmunity and neurodegenerative disorders. In most
cases, proteins of the caspase family execute the genetic programme that
leads to cell death. Bcl-2 proteins are central regulators of caspase
activation, and play a key role in cell death by regulating the integrity
of the mitochondrial and endoplasmic reticulum (ER) membranes [2]. At
least 20 Bcl-2 proteins have been reported in mammals, and several
others have been identified in viruses.
Bcl-2 family proteins fall roughly into three subtypes, which either promote
cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All
members contain at least one of four conserved motifs, termed Bcl-2 Homology
(BH) domains. Bcl-2 subfamily proteins, which contain at least BH1 and BH2,
promote cell survival by inhibiting the adapters needed for the activation
of caspases. Pro-apoptotic members potentially exert their effects by dis-
placing the adapters from the pro-survival proteins; these proteins belong
either to the Bax subfamily, which contain BH1-BH3, or to the BH3 subfamily,
which mostly only feature BH3 [3]. Thus, the balance between antagonistic
family members is believed to play a role in determining cell fate.
Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and
Mcl-1, are described by their similarity to Bcl-2 protein, a member of
the pro-survival Bcl-2 subfamily [3].
BCL2FAMILY is a 3-element fingerprint that provides a signature for the
Bcl-2 apoptosis regulator protein family. The fingerprint was derived
from an initial alignment of 21 sequences: the motifs were drawn from
conserved regions spanning the C-terminal half of the alignment - motif 1
includes the N-terminus of BH1; motif 2 includes the C-terminus of BH1; and
motif 3 includes the N-terminus of BH2. Four iterations on SPTR44_27f were
required to reach convergence, at which point a true set comprising 83
sequences was identified. Numerous partial matches were also found, most of
which appear to be related members of the Bcl-2 family that fail to make
a significant match with motif 1.
SUMMARY INFORMATION
83 codes involving 3 elements
20 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 83 83 83
2| 2 20 18
--+----------------
| 1 2 3
True positives..
Q923R6 Q8BQK4 Q7TSN8 Q75SV7
Q6R755 BCL2_RAT BCL2_MOUSE BCL2_HUMAN
BCL2_CRILO BCLX_MOUSE BCLX_RAT BCL2_BOVIN
Q9MYW4 Q9N1A2 Q9MZS7 Q8SQ42
Q76LT7 BCLX_HUMAN Q8I008 Q6NTH7
Q7TS62 O35843 BCL2_CHICK BCLX_PIG
Q8C5P0 BCLX_CHICK Q90Z98 Q90ZH2
AR11_XENLA Q6GLI5 BAXA_BOVIN Q8HYU5
Q8SQ43 Q6GP82 BAXA_HUMAN BAXD_HUMAN
Q8WZ49 Q9NR76 BAXA_RAT Q9JKL3
O88996 Q7TS60 BAXB_HUMAN Q9NYG7
BCLW_HUMAN BCLW_MOUSE Q9CYW5 Q8CFR2
BAXA_MOUSE Q8K3J2 Q8CGL4 Q6P4Y4
Q98U13 Q9I9N4 Q925A9 O55179
O55177 Q8K164 BFL1_MOUSE BFL1_HUMAN
Q86W13 Q6AYY5 Q9Z1P3 P97287
Q9W6F2 Q7YRZ9 MCL1_HUMAN Q9UNJ1
Q8HYS5 Q8UWD6 Q8UWD5 Q95KR3
O35425 Q792S6 Q9UL32 Q9UMX3
Q9DGJ5 Q9I8I2 EAR_ASFE4 EAR_ASFB7
EAR_ASFM2 Q8BEN2 Q967D2
Subfamily: Codes involving 2 elements
Subfamily True positives..
O55178 Q9UQD6 Q7T381 Q6DC66
O88857 Q9I9N3 Q9N754 NR13_COTJA
Q90ZN1 Q8T8Y5 Q9E1F2 Q9N9X1
Q9DH00 Q7KM33 Q677S5 Q804D0
Q9V9C8 BCLB_HUMAN Q7KJ42 Q99M66
PROTEIN TITLES
Q923R6 B-cell lymphoma protein 2 - Cricetulus longicaudatus (Long-t
Q8BQK4 Mus musculus 7 days embryo whole body cDNA, RIKEN full-lengt
Q7TSN8 Bcl2-like protein - Rattus norvegicus (Rat).
Q75SV7 Bcl-2 protein - Canis familiaris (Dog).
Q6R755 Bcl-2 - Canis familiaris (Dog).
BCL2_RAT Apoptosis regulator Bcl-2 - Rattus norvegicus (Rat).
BCL2_MOUSE Apoptosis regulator Bcl-2 - Mus musculus (Mouse).
BCL2_HUMAN Apoptosis regulator Bcl-2 - Homo sapiens (Human).
BCL2_CRILO Apoptosis regulator Bcl-2 - Cricetulus longicaudatus (Long-t
BCLX_MOUSE Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) - Mus muscu
BCLX_RAT Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) - Rattus no
BCL2_BOVIN Apoptosis regulator Bcl-2 - Bos taurus (Bovine).
Q9MYW4 Bcl-X - Oryctolagus cuniculus (Rabbit).
Q9N1A2 Anti-apoptotic regulator Bcl-xL - Sus scrofa (Pig).
Q9MZS7 Bcl-x long protein - Ovis aries (Sheep).
Q8SQ42 Bcl-xl protein - Felis silvestris catus (Cat).
Q76LT7 Bcl-xL - Canis familiaris (Dog).
BCLX_HUMAN Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) - Homo sapi
Q8I008 Bcl-2 protein - Felis silvestris catus (Cat).
Q6NTH7 B-cell leukemia/lymphoma 2 - Mus musculus (Mouse).
Q7TS62 Bcl-xbeta - Rattus norvegicus (Rat).
O35843 Bcl-x-gamma - Mus musculus (Mouse).
BCL2_CHICK Apoptosis regulator Bcl-2 - Gallus gallus (Chicken).
BCLX_PIG Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) - Sus scrof
Q8C5P0 Mus musculus 13 days embryo male testis cDNA, RIKEN full-len
BCLX_CHICK Apoptosis regulator Bcl-X (Bcl-2-like 1 protein) - Gallus ga
Q90Z98 Bcl-XL-like protein 1 (Bcl2l protein) - Brachydanio rerio (Z
Q90ZH2 Bcl-XL - Xenopus laevis (African clawed frog).
AR11_XENLA Apoptosis regulator R11 (XR11) - Xenopus laevis (African cla
Q6GLI5 Bcl2l1-prov protein - Xenopus tropicalis (Western clawed fro
BAXA_BOVIN Apoptosis regulator BAX, membrane isoform alpha - Bos taurus
Q8HYU5 Bax - Canis familiaris (Dog).
Q8SQ43 Bax-protein - Felis silvestris catus (Cat).
Q6GP82 MGC80617 protein - Xenopus laevis (African clawed frog).
BAXA_HUMAN Apoptosis regulator BAX, membrane isoform alpha - Homo sapie
BAXD_HUMAN BAX protein, cytoplasmic isoform delta - Homo sapiens (Human
Q8WZ49 Bax isoform psi - Homo sapiens (Human).
Q9NR76 Bax zeta - Homo sapiens (Human).
BAXA_RAT Apoptosis regulator BAX, membrane isoform alpha - Rattus nor
Q9JKL3 Bax protein splice variant k - Rattus norvegicus (Rat).
O88996 Bcl-w (Hypothetical protein) - Rattus norvegicus (Rat).
Q7TS60 BCL-WEL - Rattus norvegicus (Rat).
BAXB_HUMAN Apoptosis regulator BAX, cytoplasmic isoform beta - Homo sap
Q9NYG7 Bax-sigma - Homo sapiens (Human).
BCLW_HUMAN Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) - Homo sapi
BCLW_MOUSE Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) - Mus muscu
Q9CYW5 Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-
Q8CFR2 Bcl2l2 protein - Mus musculus (Mouse).
BAXA_MOUSE Apoptosis regulator BAX, membrane isoform alpha - Mus muscul
Q8K3J2 Bcl2-associated X protein kappa isoform - Mus musculus (Mous
Q8CGL4 Bcl2-like protein 2 - Mus musculus (Mouse).
Q6P4Y4 Hypothetical protein MGC76049 - Xenopus tropicalis (Western
Q98U13 Bax - Xenopus laevis (African clawed frog).
Q9I9N4 Bax (Bcl2-associated X protein) - Brachydanio rerio (Zebrafi
Q925A9 BCL2-related protein A1 - Rattus norvegicus (Rat).
O55179 B-cell leukemia/lymphoma 2 related protein A1d - Mus musculu
O55177 A1-b protein - Mus musculus (Mouse).
Q8K164 Bcl2a1a protein - Mus musculus (Mouse).
BFL1_MOUSE Bcl-2-related protein A1 (BFL-1 protein) (Hemopoietic-specif
BFL1_HUMAN Bcl-2-related protein A1 (BFL-1 protein) (Hemopoietic-specif
Q86W13 A1 splice variant - Homo sapiens (Human).
Q6AYY5 Myeloid cell leukemia sequence 1 - Rattus norvegicus (Rat).
Q9Z1P3 Mcl-1 protein - Rattus norvegicus (Rat).
P97287 EAT/MCL-1 protein (Myeloid cell leukemia sequence 1) - Mus m
Q9W6F2 Protein A1 - Gallus gallus (Chicken).
Q7YRZ9 Mcl-1 - Felis silvestris catus (Cat).
MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1
Q9UNJ1 Myeloid cell leukemia sequence 1, isoform 1 (Myeloid cell di
Q8HYS5 Mcl-1 - Canis familiaris (Dog).
Q8UWD6 Mcl1b - Brachydanio rerio (Zebrafish) (Danio rerio).
Q8UWD5 Nr13 - Brachydanio rerio (Zebrafish) (Danio rerio).
Q95KR3 Myeloid cell leukemia protein 1 - Sus scrofa (Pig).
O35425 Bcl-2-related ovarian killer protein-like (Apoptosis activat
Q792S6 Bcl-2-related ovarian killer protein - Rattus norvegicus (Ra
Q9UL32 Bcl-2 related ovarian killer - Homo sapiens (Human).
Q9UMX3 BCL-2-related ovarian killer protein (BOK protein) - Homo sa
Q9DGJ5 Bcl-2-related ovarian killer protein - Gallus gallus (Chicke
Q9I8I2 Bcl-2-related ovarian killer protein - Gallus gallus (Chicke
EAR_ASFE4 Apoptosis regulator Bcl-2 homolog precursor (LMH-5W) - Afric
EAR_ASFB7 Apoptosis regulator Bcl-2 homolog precursor - African swine
EAR_ASFM2 Apoptosis regulator Bcl-2 homolog precursor (LMH-5W) - Afric
Q8BEN2 ORF64 - Callitrichine herpesvirus 3.
Q967D2 Bcl-x homologous protein, BHP2 - Geodia cydonium (Sponge).
O55178 A1-c protein - Mus musculus (Mouse).
Q9UQD6 Bax epsilon - Homo sapiens (Human).
Q7T381 Similar to BCL2-related ovarian killer - Brachydanio rerio (
Q6DC66 Zgc:100979 protein - Brachydanio rerio (Zebrafish) (Danio re
O88857 Bcl-2-related ovarian killer protein - Rattus norvegicus (Ra
Q9I9N3 Cell death regulator Mcl-1a - Brachydanio rerio (Zebrafish)
Q9N754 BHP1 protein - Suberites domuncula (Sponge).
NR13_COTJA Apoptosis regulator NR-13 - Coturnix coturnix japonica (Japa
Q90ZN1 Anti-apoptotic NR13 - Gallus gallus (Chicken).
Q8T8Y5 AT16536p (CG8238-PA) - Drosophila melanogaster (Fruit fly).
Q9E1F2 RSORF1 N13-like protein - Meleagrid herpesvirus 1 (herpesvir
Q9N9X1 BHP1 protein (BHP1g protein) - Geodia cydonium (Sponge).
Q9DH00 Similar to Apoptosis inhibitor, Bcl2 family proteins (Apopto
Q7KM33 Bcl-2 family member protein - Drosophila melanogaster (Fruit
Q677S5 Hypothetical protein - Lymphocystis disease virus - isolate
Q804D0 Bcl-2 related anti-apoptotic protein - Gallus gallus (Chicke
Q9V9C8 Drob-1 (BG1) (Bcl-2 ortholog dBorg-1) (CG33134-PA) (Proapopt
BCLB_HUMAN Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Anti-apop
Q7KJ42 Pro-apoptotic Bcl-2/Bax-like protein - Drosophila melanogast
Q99M66 BCL2L10 - Rattus norvegicus (Rat).
SCAN HISTORY
SPTR44_27f 4 400 NSINGLE
INITIAL MOTIF SETS
BCL2FAMILY1 Length of motif = 13 Motif number = 1
Bcl-2 apoptosis regulator protein family motif I - 1
PCODE ST INT
FATVVEELFRDGV BCL2_BOVIN 120 120
FATVVEELFRDGV BCL2_CRILO 127 127
FATVVEELFRDGV BCL2_HUMAN 130 130
FATVVEELFRDGV BCL2_MOUSE 127 127
FATVVEELFRDGV BCL2_RAT 127 127
FVAVVEELFRDGV BCL2_CHICK 124 124
FTQVSDELFQGGP BCLW_HUMAN 79 79
FTQVSDELFQGGP BCLW_MOUSE 79 79
FTQVSDELFQGGP O88996 79 79
FEQVVNELFRDGV Q9N1A2 123 123
FEQVVNELFRDGV Q8SQ42 123 123
FQQVMGELFRDGT Q90ZH2 95 95
FESVMDEVFRDGV Q90Z98 126 126
FNQVMEKEFEDGI Q925A9 71 71
FNQVMEKEFEDGI O55177 71 71
FNQVMEKEFEDGI BFL1_MOUSE 71 71
FNQVMEKEFEDGI O55179 71 71
FNQVMEKEFEDGI BFL1_HUMAN 71 71
LSRVMIHVFSDGV MCL1_HUMAN 246 246
FSRVMVHVFKDGV P97287 227 227
FSRVMTHVFKDGV Q9Z1P3 226 226
BCL2FAMILY2 Length of motif = 29 Motif number = 2
Bcl-2 apoptosis regulator protein family motif II - 1
PCODE ST INT
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_BOVIN 133 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CRILO 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_HUMAN 143 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_MOUSE 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_RAT 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CHICK 137 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_HUMAN 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_MOUSE 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG O88996 92 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9N1A2 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q8SQ42 136 0
NWGRIVAFFSFGRALCVESANKEMTDLLP Q90ZH2 108 0
NWGRIVGLFAFGGALCVECVEKEMSPLVG Q90Z98 139 0
NWGRIVTIFAFGGVLLKKLPQEQIGLDVD Q925A9 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55177 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVC BFL1_MOUSE 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55179 85 1
NWGRIVTIFAFEGILIKKLLRQQIAPDVD BFL1_HUMAN 85 1
NWGRIVTLISFGAFVAKHLKTINQESCIE MCL1_HUMAN 260 1
NWGRIVTLISFGAFVAKHLKSVNQESFIE P97287 241 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q9Z1P3 240 1
BCL2FAMILY3 Length of motif = 25 Motif number = 3
Bcl-2 apoptosis regulator protein family motif III - 1
PCODE ST INT
SIALWMTEYLNRHLHTWIQDNGGWD BCL2_BOVIN 162 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_CRILO 169 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_HUMAN 172 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_MOUSE 169 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_RAT 169 0
NIATWMTEYLNRHLHNWIQDNGGWD BCL2_CHICK 166 0
QVQEWMVAYLETRLADWIHSSGGWA BCLW_HUMAN 121 0
QVQDWMVAYLETRLADWIHSSGGWA BCLW_MOUSE 121 0
QVQDWMVTYLETRLADWIHSSGGWA O88996 121 0
RIATWMATYLNDHLEPWIQENGGWD Q9N1A2 165 0
RIAAWMATYLNDHLEPWIQENGGWD Q8SQ42 165 0
RIVQWMVNYLEHTLQPWMQENGGWE Q90ZH2 137 0
RIAEWMTVYLDNHIQPWIQSQGGWE Q90Z98 168 0
QVSSFVAEFIMNNTGEWIQQNGGWE Q925A9 117 3
QVSSFVAEFIINNTGEWIRRNGGWE O55177 117 3
QVSSFVAEFIMNNTGEWIRQNGGWE BFL1_MOUSE 117 3
QVSSFVAEFIMNNTGEWIRRNGGWE O55179 117 3
EISYFVAEFIMNNTGEWIRQNGGWE BFL1_HUMAN 117 3
PLAESITDVLVRTKRDWLVKQRGWD MCL1_HUMAN 289 0
PLAETITDVLVRTKRDWLVKQRGWD P97287 270 0
PLAESITDVLVRTKRDWLVKQRGWD Q9Z1P3 269 0
FINAL MOTIF SETS
BCL2FAMILY1 Length of motif = 13 Motif number = 1
Bcl-2 apoptosis regulator protein family motif I - 4
PCODE ST INT
FATVVEELFRDGV BCL2_CRILO 127 127
FATVVEELFRDGV BCL2_HUMAN 130 130
FATVVEELFRDGV BCL2_MOUSE 127 127
FATVVEELFRDGV BCL2_RAT 127 127
FATVVEELFRDGV Q6R755 127 127
FATVVEELFRDGV Q75SV7 130 130
FATVVEELFRDGV Q7TSN8 127 127
FATVVEELFRDGV Q8BQK4 127 127
FATVVEELFRDGV Q923R6 127 127
FEQVVNELFRDGV BCLX_MOUSE 123 123
FEQVVNELFRDGV BCLX_RAT 123 123
FATVVEELFRDGV BCL2_BOVIN 120 120
FEQVVNELFRDGV Q9MYW4 123 123
FEQVVNELFRDGV Q9MZS7 123 123
FEQVVNELFRDGV Q9N1A2 123 123
FEQVVNELFRDGV BCLX_HUMAN 123 123
FEQVVNELFRDGV Q76LT7 123 123
FEQVVNELFRDGV Q8SQ42 123 123
FATVVEELFRDGV Q8I008 126 126
FATVVEELFRDGV Q6NTH7 127 127
FEQVVNELFRDGV Q7TS62 123 123
FEQVVNELFRDGV O35843 123 123
FVAVVEELFRDGV BCL2_CHICK 124 124
FEQVLNELFRDGV BCLX_PIG 123 123
FATVVEELFRDGV Q8C5P0 127 127
FEQVVNELFHDGV BCLX_CHICK 119 119
FESVMDEVFRDGV Q90Z98 126 126
FQQVMGELFRDGT AR11_XENLA 95 95
FQQVMGELFRDGT Q90ZH2 95 95
FQQVVGELFRDGT Q6GLI5 91 91
FFRVAAEMFSDGN BAXA_BOVIN 92 92
FFRVAAEMFSDGN Q8HYU5 92 92
FFRVAAEMFSDGN Q8SQ43 92 92
FAEVAGSLFQGGV Q6GP82 74 74
FFRVAADMFSDGN BAXA_HUMAN 92 92
FFRVAADMFSDGN BAXD_HUMAN 43 43
FFRVAADMFSDGN Q8WZ49 73 73
FFRVAADMFSDGN Q9NR76 14 14
FFRVAADMFADGN BAXA_RAT 92 92
FFRVAADMFADGN Q9JKL3 73 73
FTQVSDELFQGGP O88996 79 79
FTQVSDELFQGGP Q7TS60 105 105
FFRVAADMFSDGN BAXB_HUMAN 92 92
FFRVAADMFSDGN Q9NYG7 92 92
FTQVSDELFQGGP BCLW_HUMAN 79 79
FTQVSDELFQGGP BCLW_MOUSE 79 79
FTQVSDELFQGGP Q8CFR2 79 79
FTQVSDELFQGGP Q9CYW5 79 79
FFRVAADMFADGN BAXA_MOUSE 92 92
FFRVAADMFADGN Q8K3J2 73 73
FTQVSDELFQGGP Q8CGL4 79 79
FFHVAKELFADGV Q6P4Y4 122 122
FFHVAKELFADGV Q98U13 122 122
FIRVAREIFSDGK Q9I9N4 94 94
FNQVMEKEFEDGI Q925A9 71 71
FNQVMEKEFEDGI O55179 71 71
FNQVMEKEFEDGI O55177 71 71
FNQVMEKEFEDGI Q8K164 71 71
FNQVMEKEFEDGI BFL1_MOUSE 71 71
FNQVMEKEFEDGI BFL1_HUMAN 71 71
FNQVMEKEFEDGI Q86W13 71 71
FSRVMTHVFKDGV Q6AYY5 226 226
FSRVMTHVFKDGV Q9Z1P3 226 226
FSRVMVHVFKDGV P97287 227 227
FNGVMEEKFADGN Q9W6F2 71 71
LSRVMVHVFSDGV Q7YRZ9 246 246
LSRVMIHVFSDGV MCL1_HUMAN 246 246
LSRVMIHVFSDGV Q9UNJ1 246 246
LSRVIVHVFSDGV Q8HYS5 246 246
IKQVATELFSDGT Q8UWD6 124 124
LQSVMRELVGDGK Q8UWD5 69 69
LSRVMVHVLSDGV Q95KR3 48 48
FLAVAGHIFSAGI O35425 107 107
FLAVAGHIFSAGI Q792S6 107 107
FLAVAGHIFSAGI Q9UL32 107 107
FLAVAGHIFSAGI Q9UMX3 106 106
FLAVAAQIFTAGI Q9DGJ5 107 107
FLAVAAQIFTAGI Q9I8I2 107 107
FTGVVTELFRDLI EAR_ASFE4 70 70
FTGVVTELFKDLI EAR_ASFB7 70 70
FTGVVTELFKDLI EAR_ASFM2 70 70
IWGVQEELFGDGC Q8BEN2 79 79
FREVERRTFSDGV Q967D2 119 119
BCL2FAMILY2 Length of motif = 29 Motif number = 2
Bcl-2 apoptosis regulator protein family motif II - 4
PCODE ST INT
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CRILO 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_HUMAN 143 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_MOUSE 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_RAT 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q6R755 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q75SV7 143 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q7TSN8 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q8BQK4 140 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q923R6 140 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_MOUSE 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_RAT 136 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_BOVIN 133 0
NWGRIVAFFSFGGALCVESVDKEMEVLVS Q9MYW4 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9MZS7 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9N1A2 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_HUMAN 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q76LT7 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q8SQ42 136 0
NWGRIVAFFEFGGVMCVEGVNREMSPLVD Q8I008 139 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q6NTH7 140 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q7TS62 136 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS O35843 136 0
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CHICK 137 0
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_PIG 136 0
NWGRIVAFLEFGGVMCVESVNREMSPLVD Q8C5P0 140 0
NWGRIVAFFSFGGALCVESVDKEMRVLVG BCLX_CHICK 132 0
NWGRIVGLFAFGGALCVECVEKEMSPLVG Q90Z98 139 0
NWGRIVAFFSFGRALCVESANKEMTDLLP AR11_XENLA 108 0
NWGRIVAFFSFGRALCVESANKEMTDLLP Q90ZH2 108 0
NWGRIVAFFSFGRALCVESANKEMTELLP Q6GLI5 104 0
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_BOVIN 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q8HYU5 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q8SQ43 106 1
NWGRIVAFFVFGAALCAESVNKEMSPLLP Q6GP82 87 0
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_HUMAN 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR BAXD_HUMAN 57 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q8WZ49 87 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q9NR76 28 1
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_RAT 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q9JKL3 87 1
NWGRLVAFFVFGAALCAESVNKEMEPLVG O88996 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q7TS60 118 0
NWGRVVALFYFASKLVLKALCTKVPELIR BAXB_HUMAN 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q9NYG7 106 1
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_HUMAN 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_MOUSE 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q8CFR2 92 0
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q9CYW5 92 0
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_MOUSE 106 1
NWGRVVALFYFASKLVLKALCTKVPELIR Q8K3J2 87 1
NWGRLVAFFVFGAALCAESVNKHMEPLVG Q8CGL4 92 0
NWGRVVALFYFACKLVVKALCTKVPEMIR Q6P4Y4 136 1
NWGRVVALFYFACKLVVKALCTKVPEMIR Q98U13 136 1
NWGRVVALFYFACRLVIKAISTRVPDIIR Q9I9N4 108 1
NWGRIVTIFAFGGVLLKKLPQEQIGLDVD Q925A9 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55179 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55177 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVG Q8K164 85 1
NWGRIVTIFAFGGVLLKKLPQEQIALDVC BFL1_MOUSE 85 1
NWGRIVTIFAFEGILIKKLLRQQIAPDVD BFL1_HUMAN 85 1
NWGRIVTIFAFEGILIKKLLRQQIAPDVD Q86W13 85 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q6AYY5 240 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q9Z1P3 240 1
NWGRIVTLISFGAFVAKHLKSVNQESFIE P97287 241 1
NWGRIMTIFTFGGLLTKKLQEHGVQLTGE Q9W6F2 85 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q7YRZ9 260 1
NWGRIVTLISFGAFVAKHLKTINQESCIE MCL1_HUMAN 260 1
NWGRIVTLISFGAFVAKHLKTINQESCIE Q9UNJ1 260 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q8HYS5 260 1
NWGRIASLLTFGAMLCKYQNDRGHSKYVR Q8UWD6 138 1
NWGRVVSIFTFTGVLASELLSRGENSEGS Q8UWD5 83 1
NWGRIVTLISFGAFVAKHLKSINQESCIE Q95KR3 62 1
TWGKVVSLYSVAAGLAVDCVRQAQPAMVH O35425 120 0
TWGKVVSLYSVAAGLAVDCVRQAQPAMVH Q792S6 120 0
TWGKVVSLYSAAAGLAVDCVRQAQPAMVH Q9UL32 120 0
TWGKVVSLYAVAAGLAVDCVRQAQPAMVH Q9UMX3 119 0
TWGKVVSLYAVAAGLAVDCVRHAQPAMVH Q9DGJ5 120 0
TWGKVVSLYAVAAGLAVDCVRHAQPAMVH Q9I8I2 120 0
NWGRICGFIVFSARMAKYCKDANNHLEST EAR_ASFE4 83 0
NWGRICGFIVFSAKMAKYCKDANNHLEST EAR_ASFB7 83 0
NWGRICGFIVFSARMAKYCKDANNHLEST EAR_ASFM2 83 0
NWGRIVVWLAWCCFMCRCTRCCEDYNLVD Q8BEN2 92 0
HWGRVIAFLAFSMSFAAYVNSRGIDGGAY Q967D2 132 0
BCL2FAMILY3 Length of motif = 25 Motif number = 3
Bcl-2 apoptosis regulator protein family motif III - 4
PCODE ST INT
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_CRILO 169 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_HUMAN 172 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_MOUSE 169 0
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_RAT 169 0
NIALWMTEYLNRHLHTWIQDNGGWD Q6R755 169 0
NIALWMTEYLNRHLHTWIQDNGGWD Q75SV7 172 0
NIALWMTEYLNRHLHTWIQDNGGWD Q7TSN8 169 0
NIALWMTEYLNRHLHTWIQDNGGWD Q8BQK4 169 0
NIALWMTEYLNRHLHTWIQDNGGWD Q923R6 169 0
RIASWMATYLNDHLEPWIQENGGWD BCLX_MOUSE 165 0
RIASWMATYLNDHLEPWIQENGGWD BCLX_RAT 165 0
SIALWMTEYLNRHLHTWIQDNGGWD BCL2_BOVIN 162 0
RIAAWMATYLNDHLEPWIQENGGWD Q9MYW4 165 0
RIATWMATYLNDHLEPWIQENGGWD Q9MZS7 165 0
RIATWMATYLNDHLEPWIQENGGWD Q9N1A2 165 0
RIAAWMATYLNDHLEPWIQENGGWD BCLX_HUMAN 165 0
RIAAWMATYLNDHLEPWIQENGGWD Q76LT7 165 0
RIAAWMATYLNDHLEPWIQENGGWD Q8SQ42 165 0
NIALWMTEYLNRHLHTWIQDNGGWD Q8I008 168 0
NIALWMTEYLNRHLHTWIQDNGGWV Q6NTH7 169 0
RIASWMATYLNDHLEPWIQENGGWV Q7TS62 165 0
RIASWMATYLNDHLEPWIQENGGWG O35843 165 0
NIATWMTEYLNRHLHNWIQDNGGWD BCL2_CHICK 166 0
RIATWMATYLNDHLEPWIQENGGWD BCLX_PIG 165 0
NIALWMTEYLNRHLHTWIQDNGGWV Q8C5P0 169 0
RIVSWMTTYLTDHLDPWIQENGGWE BCLX_CHICK 161 0
RIAEWMTVYLDNHIQPWIQSQGGWE Q90Z98 168 0
RIVQWMVNYLEHTLQPWMQENGGWE AR11_XENLA 137 0
RIVQWMVNYLEHTLQPWMQENGGWE Q90ZH2 137 0
RIVQWMVQYLEHTLQPWMLENGGWE Q6GLI5 133 0
TIMGWTLDFLRERLLGWIQDQGGWD BAXA_BOVIN 135 0
TIMGWTLDFLRERLLGWIQDQGGWD Q8HYU5 135 0
TIMGWTLDFLRERLLGWIQDQGGWD Q8SQ43 135 0
RIQDWMVTYLETNLRGWIQSNGGWN Q6GP82 116 0
TIMGWTLDFLRERLLGWIQDQGGWD BAXA_HUMAN 135 0
TIMGWTLDFLRERLLGWIQDQGGWD BAXD_HUMAN 86 0
TIMGWTLDFLRERLLGWIQDQGGWD Q8WZ49 116 0
TIMGWTLDFLRERLLGWIQDQGGWD Q9NR76 57 0
TIMGWTLDFLRERLLVWIQDQGGWD BAXA_RAT 135 0
TIMGWTLDFLRERLLVWIQDQGGWD Q9JKL3 116 0
QVQDWMVTYLETRLADWIHSSGGWA O88996 121 0
QVQDWMVTYLETRLADWIHSSGGWA Q7TS60 147 0
TIMGWTLDFLRERLLGWIQDQGGWV BAXB_HUMAN 135 0
TIMGWTLDFLRERLLGWIQDQGGWT Q9NYG7 135 0
QVQEWMVAYLETRLADWIHSSGGWA BCLW_HUMAN 121 0
QVQDWMVAYLETRLADWIHSSGGWA BCLW_MOUSE 121 0
QVQDWMVAYLETRLADWIHSSGGWV Q8CFR2 121 0
QVQDWMVAYLETRLADWIHSSGGWV Q9CYW5 121 0
TIMGWTLDFLRERLLVWIQDQGGWE BAXA_MOUSE 135 0
TIMGWTLDFLRERLLVWIQDQGGWE Q8K3J2 116 0
QVQDWMVAYLETRLAYWIHSSGGWA Q8CGL4 121 0
TIINWTMEYLREYVVQWIRDQGGWE Q6P4Y4 165 0
TIINWTMDYLRDYVVQWIRDQGGWE Q98U13 165 0
TIISWTMSYIQEHVINWIREQGGWD Q9I9N4 137 0
QVSSFVAEFIMNNTGEWIQQNGGWE Q925A9 117 3
QVSSFVAEFIMNNTGEWIRRNGGWE O55179 117 3
QVSSFVAEFIINNTGEWIRRNGGWE O55177 117 3
QVSSFVAEFIINNTGEWIRRNGGWE Q8K164 117 3
QVSSFVAEFIMNNTGEWIRQNGGWE BFL1_MOUSE 117 3
EISYFVAEFIMNNTGEWIRQNGGWE BFL1_HUMAN 117 3
EISYFVAEFIMNNTGEWIRQNGGWG Q86W13 117 3
PLAESITDVLVRTKRDWLVKQRGWD Q6AYY5 269 0
PLAESITDVLVRTKRDWLVKQRGWD Q9Z1P3 269 0
PLAETITDVLVRTKRDWLVKQRGWD P97287 270 0
KISYFITEYIINNKAAWIDANGGWE Q9W6F2 117 3
PLAESITDVLVRTKRDWLVKQRGWD Q7YRZ9 289 0
PLAESITDVLVRTKRDWLVKQRGWD MCL1_HUMAN 289 0
PLAESITDVLVRTKRDWLVKQRGWD Q9UNJ1 289 0
PLAESITDVLVRTKRDWLVKQRGWD Q8HYS5 289 0
LVGEEISSYLLTEQRDWILRNKAWD Q8UWD6 167 0
RLAETIADYLGGEKQDWLVENGGWE Q8UWD5 113 1
PLAESITDVLVRTKRDWLVKQRGWD Q95KR3 91 0
ALVDCLGEFVRKTLATWLRRRGGWT O35425 149 0
ALVDCLGEFVRKTLATWLRRRGGWT Q792S6 149 0
ALVDCLGEFVRKTLATWLRRRGGWT Q9UL32 149 0
ALVDCLGEFVRKTLATWLRRRGGWT Q9UMX3 148 0
TIVDCLGEFVRKTLVTWLKRRGGWA Q9DGJ5 149 0
TIVDCLGEFVRKTLVTWLKRRGGWA Q9I8I2 149 0
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFE4 111 -1
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFB7 111 -1
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFM2 111 -1
DAVFRGVLESTEGIDGWIHSHGGWD Q8BEN2 120 -1
SVFNWTLRVLNDSLADFIQRENGWR Q967D2 161 0
User query: Display/Full Code "BCL2FAMILY"