WORKLIST ENTRIES (1):
ADENOSINER View alignment View Structure Adenosine receptor signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00249 GPCRSECRETIN; PR00250 GPCRSTE2; PR00899 GPCRSTE3
PRINTS; PR00251 BACTRLOPSIN
PRINTS; PR00552 ADENOSINEA1R; PR00553 ADENOSINA2AR; PR00554 ADENOSINA2BR
PRINTS; PR00555 ADENOSINEA3R; PR00594 P2UPURNOCPTR; PR00595 P2YPURNOCPTR
INTERPRO; IPR001634
Creation date 16-DEC-1995; UPDATE 06-JUN-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ATTWOOD, T.K. AND FINDLAY, J.B.C.
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
5. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
6. WATSON, S. AND ARKINSTALL, S.
Adenosine and adenine nucleotides.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.19-31.
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1,2]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The rhodopsin-like GPCRs themselves represent a widespread protein family
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary
widely in structure and character, the amino acid sequences of the
receptors are very similar and are believed to adopt a common structural
framework comprising 7 transmembrane (TM) helices [3-5].
In addition to their role in energy metabolism, purines (especially
adenosine and adenine nucleotides) produce a wide range of pharmacological
effects mediated by activation of cell surface receptors [6]. Distinct
receptors exist for adenosine. In the periphery, the main effects of
adenosine include vasodilation, bronchoconstriction, immunosuppresion,
inhibition of platelet aggregation, cardiac depression, stimulation of
nociceptive afferents, inhibition of neurotransmitter release and
inhibition of the release of other factors, e.g. hormones [6]. In the CNS,
adenosine exerts a pre- and post-synaptic depressant action, reducing motor
activity, depressing respiration, inducing sleep and relieving anxiety. The
physiological role of adenosine is thought to be to adjust energy demands
in line with oxygen supply. Many of the clinical actions of methylxanthines
are thought to be mediated through antagonism of adenosine receptors. Four
subtypes of receptor have been identified, designated A1, A2A, A2B and A3.
ADENOSINER is a 6-element fingerprint that provides a signature for the
adenosine receptors. The fingerprint was derived from an initial alignment
of 7 sequences: the motifs were drawn from conserved sections either within
loop or TM regions, focusing on those areas of the alignment that
characterise the adenosine receptors but distinguish them from the rest of
the rhodopsin-like superfamily - motif 1 lies at the N-terminus of the first
TM domain; motif 2 spans part of the first external loop and the N-terminus
of the third TM domain; motif 3 lies at the C-terminus of TM domain 4,
leading into the second external loop; motif 4 spans part of the second
external loop and the N-terminus of TM domain 5; motif 5 spans part of the
third cytoplasmic loop and the N-terminus of TM domain 6; and motif 6 lies
at the N-terminus of TM domain 7. Three iterations on OWL26.3 were required
to reach convergence, at which point a true set comprising 21 sequences was
identified. Four partial matches were also found, all of which are adenosine
receptor fragments.
An update on SPTR37_9f identified a true set of 22 sequences.
SUMMARY INFORMATION
22 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 22 22 22 22 22 22
5| 0 0 0 0 0 0
4| 0 0 0 0 0 0
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
AA1R_BOVIN AA1R_CAVPO AA1R_HUMAN AA1R_RAT
O08766 AA1R_CANFA AA1R_RABIT AA1R_CHICK
AA2A_HUMAN AA2A_CAVPO AA2A_MOUSE AA2A_RAT
AA2A_CANFA AA2B_CHICK AA2B_MOUSE AA2B_RAT
AA2B_HUMAN AA3R_CANFA AA3R_SHEEP AA3R_HUMAN
AA3R_RAT AA3R_RABIT
PROTEIN TITLES
AA1R_BOVIN ADENOSINE A1 RECEPTOR - BOS TAURUS (BOVINE).
AA1R_CAVPO ADENOSINE A1 RECEPTOR - CAVIA PORCELLUS (GUINEA PIG).
AA1R_HUMAN ADENOSINE A1 RECEPTOR - HOMO SAPIENS (HUMAN).
AA1R_RAT ADENOSINE A1 RECEPTOR - RATTUS NORVEGICUS (RAT).
O08766 A1 RECEPTOR 326 AS - RATTUS NORVEGICUS (RAT).
AA1R_CANFA ADENOSINE A1 RECEPTOR - CANIS FAMILIARIS (DOG).
AA1R_RABIT ADENOSINE A1 RECEPTOR - ORYCTOLAGUS CUNICULUS (RABBIT).
AA1R_CHICK ADENOSINE A1 RECEPTOR - GALLUS GALLUS (CHICKEN).
AA2A_HUMAN ADENOSINE A2A RECEPTOR - HOMO SAPIENS (HUMAN).
AA2A_CAVPO ADENOSINE A2A RECEPTOR - CAVIA PORCELLUS (GUINEA PIG).
AA2A_MOUSE ADENOSINE A2A RECEPTOR - MUS MUSCULUS (MOUSE).
AA2A_RAT ADENOSINE A2A RECEPTOR - RATTUS NORVEGICUS (RAT).
AA2A_CANFA ADENOSINE A2A RECEPTOR - CANIS FAMILIARIS (DOG).
AA2B_CHICK ADENOSINE A2B RECEPTOR - GALLUS GALLUS (CHICKEN).
AA2B_MOUSE ADENOSINE A2B RECEPTOR - MUS MUSCULUS (MOUSE).
AA2B_RAT ADENOSINE A2B RECEPTOR - RATTUS NORVEGICUS (RAT).
AA2B_HUMAN ADENOSINE A2B RECEPTOR - HOMO SAPIENS (HUMAN).
AA3R_CANFA ADENOSINE A3 RECEPTOR - CANIS FAMILIARIS (DOG).
AA3R_SHEEP ADENOSINE A3 RECEPTOR - OVIS ARIES (SHEEP).
AA3R_HUMAN ADENOSINE A3 RECEPTOR - HOMO SAPIENS (HUMAN).
AA3R_RAT ADENOSINE A3 RECEPTOR (TGPCR1) - RATTUS NORVEGICUS (RAT).
AA3R_RABIT ADENOSINE A3 RECEPTOR - ORYCTOLAGUS CUNICULUS (RABBIT).
SCAN HISTORY
OWL26_3 3 100 NSINGLE
SPTR37_9f 2 23 NSINGLE
INITIAL MOTIF SETS
ADENOSINER1 Length of motif = 10 Motif number = 1
Adenosine receptor motif I - 1
PCODE ST INT
AAYIGIEVLI AA1R_BOVIN 10 10
SVYITVELAI AA2A_HUMAN 7 7
SVYITVELAI AA2A_RAT 4 4
SVYITVELAI A48974 4 4
ITYITMEAAI RNGPCR 15 15
ALYVALELVI AA2B_HUMAN 8 8
ITYVTMEAAI AA3R_RAT 15 15
ADENOSINER2 Length of motif = 13 Motif number = 2
Adenosine receptor motif II - 1
PCODE ST INT
TCLKVACPVLILT AA1R_BOVIN 79 59
GCLFIACFVLVLT AA2A_HUMAN 76 59
GCLFFACFVLVLT AA2A_RAT 73 59
GCLFFACFVLVLT A48974 73 59
ACLFMSCVLLVFT RNGPCR 84 59
GCLFLACFVLVLT AA2B_HUMAN 77 59
ACLFMSCVLLVFT AA3R_RAT 84 59
ADENOSINER3 Length of motif = 11 Motif number = 3
Adenosine receptor motif III - 1
PCODE ST INT
VGLTPMFGWNN AA1R_BOVIN 138 46
IGLTPMLGWNN AA2A_HUMAN 135 46
IGLTPMLGWNN AA2A_RAT 132 46
IGLTPMLGWNN A48974 132 46
VGLTPMFGWNR RNGPCR 143 46
IGLTPFLGWNS AA2B_HUMAN 136 46
VGLTPMFGWNR AA3R_RAT 143 46
ADENOSINER4 Length of motif = 20 Motif number = 4
Adenosine receptor motif IV - 1
PCODE ST INT
CQFEKVISMEYMVYFNFFVW AA1R_BOVIN 169 20
CLFEDVVPMNYMVYFNFFAC AA2A_HUMAN 166 20
CLFEDVVPMNYMVYYNFFAF AA2A_RAT 161 18
CLFEDVVPMNYMVYYNFFAF A48974 161 18
CHFRSVVGLDYMVFFSFITW RNGPCR 168 14
CLFENVVPMSYMVYFNFFGC AA2B_HUMAN 171 24
CHFRFVVGLDYMVFFSFITW AA3R_RAT 168 14
ADENOSINER5 Length of motif = 14 Motif number = 5
Adenosine receptor motif V - 1
PCODE ST INT
QKYYGKELKIAKSL AA1R_BOVIN 223 34
RSTLQKEVHAAKSL AA2A_HUMAN 222 36
RSTLQKEVHAAKSL AA2A_RAT 217 36
RSTLQKEVHAAKSL A48974 217 36
RAFYGREFKTAKSL RNGPCR 221 33
RTTLQREIHAAKSL AA2B_HUMAN 223 32
RAFYGREFKTAKSL AA3R_RAT 221 33
ADENOSINER6 Length of motif = 11 Motif number = 6
Adenosine receptor motif VI - 1
PCODE ST INT
IYIAIFLSHGN AA1R_BOVIN 270 33
MYLAIVLSHTN AA2A_HUMAN 270 34
MYLTIILSHSN AA2A_RAT 265 34
MYLAIILSHSN A48974 265 34
MCLGILLSHAN RNGPCR 266 31
MNMAILLSHAN AA2B_HUMAN 272 35
MCLGILLSHAN AA3R_RAT 266 31
FINAL MOTIF SETS
ADENOSINER1 Length of motif = 10 Motif number = 1
Adenosine receptor motif I - 2
PCODE ST INT
AAYIGIEVLI AA1R_BOVIN 10 10
AAYIGIEVLI AA1R_CAVPO 10 10
AAYIGIEVLI AA1R_HUMAN 10 10
AAYIGIEVLI AA1R_RAT 10 10
AAYIGIEVLI O08766 10 10
AAYIGIEVLI AA1R_CANFA 10 10
AAYIGIEVLI AA1R_RABIT 10 10
AAYISIEVLI AA1R_CHICK 10 10
SVYITVELAI AA2A_HUMAN 7 7
SVYITVELVI AA2A_CAVPO 4 4
SVYIMVELAI AA2A_MOUSE 4 4
SVYITVELAI AA2A_RAT 4 4
WVYITVELAI AA2A_CANFA 7 7
TTYIVLELII AA2B_CHICK 6 6
ALYVALELVI AA2B_MOUSE 8 8
ALYVALELVI AA2B_RAT 8 8
ALYVALELVI AA2B_HUMAN 8 8
VTYITVEILI AA3R_CANFA 13 13
VTYITVEILI AA3R_SHEEP 13 13
VTYITMEIFI AA3R_HUMAN 13 13
ITYITMEAAI AA3R_RAT 15 15
ASYIVFEIVI AA3R_RABIT 14 14
ADENOSINER2 Length of motif = 13 Motif number = 2
Adenosine receptor motif II - 2
PCODE ST INT
TCLKVACPVLILT AA1R_BOVIN 79 59
TCLMVACPVLILT AA1R_CAVPO 79 59
TCLMVACPVLILT AA1R_HUMAN 79 59
TCLMVACPVLILT AA1R_RAT 79 59
TCLMVACPVLILT O08766 79 59
TCLMVACPVLILT AA1R_CANFA 79 59
TCLMVACPVLILT AA1R_RABIT 79 59
SCLMMACPVLILT AA1R_CHICK 79 59
GCLFIACFVLVLT AA2A_HUMAN 76 59
GCLFFACFVLVLT AA2A_CAVPO 73 59
GCLFIACFVLVLT AA2A_MOUSE 73 59
GCLFFACFVLVLT AA2A_RAT 73 59
NCLFFACFVLVLT AA2A_CANFA 76 59
SCLFFACFVLVLT AA2B_CHICK 75 59
GCLFLACFVLVLT AA2B_MOUSE 77 59
SCLFLACFVLVLT AA2B_RAT 77 59
GCLFLACFVLVLT AA2B_HUMAN 77 59
NCLFMTCLLLIFT AA3R_CANFA 82 59
SCLFMTCLMLIFT AA3R_SHEEP 82 59
SCLFMTCLLLIFT AA3R_HUMAN 82 59
ACLFMSCVLLVFT AA3R_RAT 84 59
SCLVMSCLLLVFT AA3R_RABIT 83 59
ADENOSINER3 Length of motif = 11 Motif number = 3
Adenosine receptor motif III - 2
PCODE ST INT
VGLTPMFGWNN AA1R_BOVIN 138 46
VGLTPMFGWNN AA1R_CAVPO 138 46
VGLTPMFGWNN AA1R_HUMAN 138 46
VGLTPMFGWNN AA1R_RAT 138 46
VGLTPMFGWNN O08766 138 46
VGLTPLFGWNR AA1R_CANFA 138 46
VGLTPMFGWNN AA1R_RABIT 138 46
VGLTPMFGWNN AA1R_CHICK 138 46
IGLTPMLGWNN AA2A_HUMAN 135 46
IGLTPMLGWNN AA2A_CAVPO 132 46
IGLTPMLGWNN AA2A_MOUSE 132 46
IGLTPMLGWNN AA2A_RAT 132 46
IGLTPMLGWNN AA2A_CANFA 135 46
IGLTPLMGWNK AA2B_CHICK 134 46
IGLTPFLGWNS AA2B_MOUSE 136 46
IGLTPFLGWNS AA2B_RAT 136 46
IGLTPFLGWNS AA2B_HUMAN 136 46
VGLTPMFGWNM AA3R_CANFA 141 46
VGLTPMFGWNM AA3R_SHEEP 141 46
VGLTPMFGWNM AA3R_HUMAN 141 46
VGLTPMFGWNR AA3R_RAT 143 46
VGFTPMFGWNM AA3R_RABIT 142 46
ADENOSINER4 Length of motif = 20 Motif number = 4
Adenosine receptor motif IV - 2
PCODE ST INT
CQFEKVISMEYMVYFNFFVW AA1R_BOVIN 169 20
CEFEKVISMEYMVYFNFFVW AA1R_CAVPO 169 20
CEFEKVISMEYMVYFNFFVW AA1R_HUMAN 169 20
CEFEKVISMEYMVYFNFFVW AA1R_RAT 169 20
CEFEKVISMEYMVYFNFFVW O08766 169 20
CEFEKVISMEYMVYFNFFVW AA1R_CANFA 169 20
CEFEKVISMEYMVYFNFFVW AA1R_RABIT 169 20
CQFETVISMEYMVYFNFFVW AA1R_CHICK 169 20
CLFEDVVPMNYMVYFNFFAC AA2A_HUMAN 166 20
CLFEDVVPMNYMVYYNFFAF AA2A_CAVPO 163 20
CLFEDVVPMNYMVYYNFFAF AA2A_MOUSE 161 18
CLFEDVVPMNYMVYYNFFAF AA2A_RAT 161 18
CLFEDVVPMNYMVYYNFFAF AA2A_CANFA 166 20
CLFENVVTMSYMVYFNFFGC AA2B_CHICK 171 26
CLFENVVPMSYMVYFNFFGC AA2B_MOUSE 171 24
CLFENVVPMSYMVYFNFFGC AA2B_RAT 171 24
CLFENVVPMSYMVYFNFFGC AA2B_HUMAN 171 24
CQFSSVMRMDYMVYFSFFTW AA3R_CANFA 166 14
CRFRSVMRMDYMVYFSFFLW AA3R_SHEEP 165 13
CQFVSVMRMDYMVYFSFLTW AA3R_HUMAN 166 14
CHFRSVVGLDYMVFFSFITW AA3R_RAT 168 14
CKFDSVIPMEYMVFFSFFTW AA3R_RABIT 167 14
ADENOSINER5 Length of motif = 14 Motif number = 5
Adenosine receptor motif V - 2
PCODE ST INT
QKYYGKELKIAKSL AA1R_BOVIN 223 34
QKYYGKELKIAKSL AA1R_CAVPO 223 34
QKYYGKELKIAKSL AA1R_HUMAN 223 34
QKYYGKELKIAKSL AA1R_RAT 223 34
QKYYGKELKIAKSL O08766 223 34
QKYYGKELKIAKSL AA1R_CANFA 223 34
HKYYGKELKIAKSL AA1R_RABIT 223 34
QKYYGKELKIAKSL AA1R_CHICK 223 34
RSTLQKEVHAAKSL AA2A_HUMAN 222 36
RSTLQKEVHPAKSL AA2A_CAVPO 219 36
RSTLQKEVHAAKSL AA2A_MOUSE 217 36
RSTLQKEVHAAKSL AA2A_RAT 217 36
RSTLQKEVHAAKSL AA2A_CANFA 222 36
RTTLQKEVHAAKSL AA2B_CHICK 223 32
RTTLQREIHAAKSL AA2B_MOUSE 223 32
RTTLQREIHAAKSL AA2B_RAT 223 32
RTTLQREIHAAKSL AA2B_HUMAN 223 32
GAFYGREFKTAKSL AA3R_CANFA 219 33
GAFYGREFKTAKSL AA3R_SHEEP 218 33
GAFYGREFKTAKSL AA3R_HUMAN 219 33
RAFYGREFKTAKSL AA3R_RAT 221 33
GAFYRREFKTAKSL AA3R_RABIT 220 33
ADENOSINER6 Length of motif = 11 Motif number = 6
Adenosine receptor motif VI - 2
PCODE ST INT
IYIAIFLSHGN AA1R_BOVIN 270 33
TYIAIFLTHGN AA1R_CAVPO 270 33
TYIAIFLTHGN AA1R_HUMAN 270 33
IYIAIFLTHGN AA1R_RAT 270 33
IYIAIFLTHGN O08766 270 33
MYIAIFLTHGN AA1R_CANFA 270 33
VYTAIFLTHGN AA1R_RABIT 270 33
TYIAIFLTHGN AA1R_CHICK 270 33
MYLAIVLSHTN AA2A_HUMAN 270 34
MYLTIILSHGN AA2A_CAVPO 267 34
MYLAIILSHSN AA2A_MOUSE 265 34
MYLTIILSHSN AA2A_RAT 265 34
MYLTIVLSHTN AA2A_CANFA 270 34
MYVAIILSHAN AA2B_CHICK 272 35
MNVAILLSHAN AA2B_MOUSE 272 35
MNVAILLSHAN AA2B_RAT 272 35
MNMAILLSHAN AA2B_HUMAN 272 35
LYLGILLSHAN AA3R_CANFA 264 31
LYLGILLSHAN AA3R_SHEEP 263 31
LYMGILLSHAN AA3R_HUMAN 264 31
MCLGILLSHAN AA3R_RAT 266 31
LLVGILLSHAN AA3R_RABIT 265 31
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