WORKLIST ENTRIES (1):

ACOABINDINGP View alignment View Structure    Acyl-coA-binding protein signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   INTERPRO; IPR000582
   PROSITE; PS00880 ACBP 
   PFAM; PF00887 ACBP
   PDB; 2ABD 3Dinfo
   SCOP; 2ABD
   CATH; 2ABD

 Creation date 10-APR-1997; UPDATE 07-JUN-1999

   1. MARQUARDT, H., TODARO, G.J. AND SHOYAB, M.
   Complete amino acid sequences of bovine and human endozepines. Homology 
   with rat diazepam binding inhibitor. 
   J.BIOL.CHEM. 261(21) 9727-9731 (1986).

   2. ANDERSEN, K.V. AND POULSEN, F.M.
   Three-dimensional structure in solution of acyl-coenzyme A binding protein
   from bovine liver.
   J.MOL.BIOL. 226(4) 1131-1141 (1992).

   Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium-
   and long-chain acyl-CoA esters with high affinity, and may act as an intra-
   cellular carrier of acyl-CoA esters. ACBP has a number of important
   physiological and biochemical functions: it is known as a diazepam binding
   inhibitor, as a putative neurotransmitter, as a regulator of insulin
   release from pancreatic cells, and as a mediator in corticotropin-dependent
   adrenal steroidogenesis [1,2]. It is possible that the protein acts as a
   neuropeptide that takes part in the modulation of gamma-aminobutyric
   acid-ergic transmission [1].
  
   The structure of ACBP has been deduced by NMR spectroscopy and has been
   shown to be a mainly-alpha protein, consisting of 5 short alpha-helices
   and 3 connecting beta-strands [2].
  
   ACOABINDINGP is a 4-element fingerprint that provides a signature for
   acyl-CoA-binding proteins. The fingerprint was derived from an initial
   alignment of 15 sequences: the motifs were drawn from conserved regions
   spanning the full alignment length - motif spans helix 1 and most of the
   first loop; motif 2 encodes helix 2 and corresponds to the region
   encoded by PROSITE pattern ACBP (PS00880); motif 3 spans part of the 
   second loop, helix 3 and the N-terminal portion of helix 4; and motif 4
   spans helix 5. Two iterations on OWL29.2 were required to reach convergence,
   at which point a true set comprising 22 sequences was identified.
  
   An update on SPTR37_9f identified a true set of 21 sequences, and 3
   partial matches.

  SUMMARY INFORMATION
     21 codes involving  4 elements
      2 codes involving  3 elements
      1 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  21   21   21   21  
    3|   0    2    2    2  
    2|   1    1    0    0  
   --+---------------------
     |   1    2    3    4  

True positives..
 ACBP_PIG       ACBP_BOVIN     ACBP_HUMAN     ACBP_RAT       
 ACBP_MOUSE     ACBP_GOSHI     ACBP_ANAPL     ACBP_RANRI     
 Q39315         ACBP_RICCO     ACBP_YEAST     Q96496         
 Q92272         O22643         ACBP_MANSE     O01805         
 ACBP_DROME     Q09603         O42310         ENDR_BOVIN     
 Q20507         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 O75521         O09035         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 Q20862         


  PROTEIN TITLES
   ACBP_PIG         ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_BOVIN       ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_HUMAN       ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_RAT         ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_MOUSE       ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_GOSHI       ACYL-COA-BINDING PROTEIN (ACBP) - GOSSYPIUM HIRSUTUM (UPLAND
   ACBP_ANAPL       ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
   ACBP_RANRI       ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
   Q39315           ACYL-COA BINDING PROTEIN - BRASSICA NAPUS (RAPE).
   ACBP_RICCO       ACYL-COA-BINDING PROTEIN (ACBP) - RICINUS COMMUNIS (CASTOR B
   ACBP_YEAST       ACYL-COA-BINDING PROTEIN (ACBP) - SACCHAROMYCES CEREVISIAE (
   Q96496           ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCE
   Q92272           ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCE
   O22643           ACYL-COA-BINDING PROTEIN - FRITILLARIA AGRESTIS.
   ACBP_MANSE       ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
   O01805           SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS
   ACBP_DROME       ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
   Q09603           HYPOTHETICAL 42.1 KD PROTEIN R06F6.9 IN CHROMOSOME II - CAEN
   O42310           ACBP/ECHM - CYPRINUS CARPIO (COMMON CARP).
   ENDR_BOVIN       ENDOZEPINE-RELATED PROTEIN PRECURSOR (MEMBRANE-ASSOCIATED DI
   Q20507           F47B10.7 PROTEIN - CAENORHABDITIS ELEGANS.
 
   O75521           DBI-RELATED PROTEIN - HOMO SAPIENS (HUMAN).
   O09035           DIAZEPAM BINDING INHIBITOR-LIKE 5 (ENDOZEPINE-LIKE PEPTIDE) 
 
   Q20862           SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS

SCAN HISTORY OWL29_2 2 100 NSINGLE SPTR37_9f 2 160 NSINGLE INITIAL MOTIF SETS ACOABINDINGP1 Length of motif = 16 Motif number = 1 Acyl-coA-binding protein motif I - 1 PCODE ST INT QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2 QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2 QAEFEKAAEEVKNLKT ACBP_PIG 2 2 QADFDKAAEEVKRLKT ACBP_RAT 2 2 QADFDEAAEEVKKLKT ACBP_ANAPL 19 19 EAEFDKAAEDVKHLKT A60212 2 2 QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2 KEEFEEHAEKVKTLPA GHU35015 4 4 SEQFNAAAEKVKSLTK ACBP_DROME 3 3 QADFEKAQKNLKTLKE CER06F69 26 26 KEDFEEHAEKVKKLTA S48040 4 4 QEKFDAAVEIIQKLPK CEF47B106 4 4 QEQFDQAASNVRNLKS ACBP_MANSE 4 4 ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43 ETRFEAAVKVIQSLPK S80107 62 62 ACOABINDINGP2 Length of motif = 19 Motif number = 2 Acyl-coA-binding protein motif II - 1 PCODE ST INT PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1 PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1 PADDEMLFIYSHYKQATVG ACBP_PIG 19 1 PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1 PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1 PADDEMLYIYSHYKQATVG A60212 19 1 PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1 PSNDDMLILYGLYKQATVG GHU35015 21 1 PSDDEFLQLYALFKQASVG ACBP_DROME 20 1 PDNDVKLQLYGLFKQATAG CER06F69 43 1 PSNEDLLILYGLYKQATVG S48040 21 1 TSNDQKLTFYSLFKQASIG CEF47B106 25 5 PSDNDLLELYALFKQASAG ACBP_MANSE 21 1 PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5 PTNEMMLKFYSFYKQATEG S80107 83 5 ACOABINDINGP3 Length of motif = 16 Motif number = 3 Acyl-coA-binding protein motif III - 1 PCODE ST INT ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4 DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4 ERPGILDLKGKAKWDA ACBP_PIG 42 4 DRPGLLDLKGKAKWDS ACBP_RAT 42 4 ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4 ERPGLLDLRGKXXRDA A60212 42 4 ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4 SRPGMFNMREKYKWDA GHU35015 44 4 AKPGLLDLKGKAKWEA ACBP_DROME 43 4 KRPGMMDFVGRAKYDA CER06F69 66 4 SRPGMFSMKERAKWDA S48040 44 4 DRPGIFSIIERKKWDS CEF47B106 48 4 NRPGLLDLKGKAKFDA ACBP_MANSE 45 5 SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4 SKPGFWDPVGRYKWDA S80107 106 4 ACOABINDINGP4 Length of motif = 18 Motif number = 4 Acyl-coA-binding protein motif IV - 1 PCODE ST INT GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5 GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5 GTSKEDAMKAYINKVEEL ACBP_PIG 63 5 GTSKENAMKTYVEKVEEL ACBP_RAT 63 5 GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5 KPSDDLDMKAYVNKVEDL A60212 86 28 GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5 GKSKEEAMGDYITKVKQL GHU35015 65 5 GKSSEAAQQEYITFVEGL ACBP_DROME 64 5 GQTQDEARANYAKLVGGL CER06F69 87 5 GKSTDEAMSDYITKVKQL S48040 65 5 GVSQDEAKERYIKALNDM CEF47B106 69 5 GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5 DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5 DMTKEEAMIAYVEEMKKI S80107 127 5 FINAL MOTIF SETS ACOABINDINGP1 Length of motif = 16 Motif number = 1 Acyl-coA-binding protein motif I - 2 PCODE ST INT QAEFEKAAEEVKNLKT ACBP_PIG 2 2 QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2 QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2 QADFDKAAEEVKRLKT ACBP_RAT 2 2 QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2 KEEFEEHAEKVKTLPA ACBP_GOSHI 4 4 QADFDEAAEEVKKLKT ACBP_ANAPL 19 19 QADFDKAAGDVKKLKT ACBP_RANRI 3 3 KEDFEEHAEKVKKLTA Q39315 4 4 KEDFEEHAEKAKTLPE ACBP_RICCO 4 4 SQLFEEKAKAVNELPT ACBP_YEAST 3 3 SQLFEEKAKAVNELPT Q96496 3 3 SQLFEEKAKAVNELPT Q92272 3 3 KEEFEEHAVKAKTLPE O22643 4 4 QEQFDQAASNVRNLKS ACBP_MANSE 4 4 TLSFDDAAATVKTLKT O01805 2 2 SEQFNAAAEKVKSLTK ACBP_DROME 3 3 QADFEKAQKNLKTLKE Q09603 26 26 VEEFNAAKEKLGALKK O42310 5 5 ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43 QEKFDAAVEIIQKLPK Q20507 4 4 ACOABINDINGP2 Length of motif = 19 Motif number = 2 Acyl-coA-binding protein motif II - 2 PCODE ST INT PADDEMLFIYSHYKQATVG ACBP_PIG 19 1 PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1 PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1 PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1 PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1 PSNDDMLILYGLYKQATVG ACBP_GOSHI 21 1 PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1 PTDDELKELYGLYKQSTVG ACBP_RANRI 20 1 PSNEDLLILYGLYKQATVG Q39315 21 1 TTNENKLILYGLYKQATVG ACBP_RICCO 21 1 PSTDELLELYALYKQATVG ACBP_YEAST 20 1 PSTDELLELYGLYKQATVG Q96496 20 1 PSTDELLELYGLYKQATVG Q92272 20 1 TSNENKLILYGLYKQSTVG O22643 21 1 PSDNDLLELYALFKQASAG ACBP_MANSE 21 1 PSNDELLKLYALFKQGTVG O01805 19 1 PSDDEFLQLYALFKQASVG ACBP_DROME 20 1 PDNDVKLQLYGLFKQATAG Q09603 43 1 PGNEVKLKVYALFKQATQG O42310 22 1 PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5 TSNDQKLTFYSLFKQASIG Q20507 25 5 ACOABINDINGP3 Length of motif = 16 Motif number = 3 Acyl-coA-binding protein motif III - 2 PCODE ST INT ERPGILDLKGKAKWDA ACBP_PIG 42 4 ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4 ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4 DRPGLLDLKGKAKWDS ACBP_RAT 42 4 DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4 SRPGMFNMREKYKWDA ACBP_GOSHI 44 4 ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4 ECPGMLDLKGKAKWDA ACBP_RANRI 43 4 SRPGMFSMKERAKWDA Q39315 44 4 SRPGMFNMRDRAKWDA ACBP_RICCO 44 4 EKPGIFNMKDRYKWEA ACBP_YEAST 43 4 EKPGIFNMKDRYKWEA Q96496 43 4 EKPGIFNMKDRYKWEA Q92272 43 4 GRPGMFSPRERAKWDA O22643 44 4 NRPGLLDLKGKAKFDA ACBP_MANSE 45 5 DKPGMFDLKGKAKWSA O01805 42 4 AKPGLLDLKGKAKWEA ACBP_DROME 43 4 KRPGMMDFVGRAKYDA Q09603 66 4 PKPSMLDFVNKAKWDA O42310 45 4 SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4 DRPGIFSIIERKKWDS Q20507 48 4 ACOABINDINGP4 Length of motif = 18 Motif number = 4 Acyl-coA-binding protein motif IV - 2 PCODE ST INT GTSKEDAMKAYINKVEEL ACBP_PIG 63 5 GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5 GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5 GTSKENAMKTYVEKVEEL ACBP_RAT 63 5 GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5 GKSKEEAMGDYITKVKQL ACBP_GOSHI 65 5 GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5 GLSKEDAMSAYVSKAHEL ACBP_RANRI 64 5 GKSTDEAMSDYITKVKQL Q39315 65 5 GKSTEEAMSDYITKVKQL ACBP_RICCO 65 5 GKSQEDAEKEYIALVDQL ACBP_YEAST 64 5 GKSQEDAEKEYIAYVDNL Q96496 64 5 GKSQEDAEKEYIAYVDNL Q92272 64 5 GKSKEEAMGDYITKVKQL O22643 65 5 GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5 GLAKDDAQKAYVALVEEL O01805 63 5 GKSSEAAQQEYITFVEGL ACBP_DROME 64 5 GQTQDEARANYAKLVGGL Q09603 87 5 SVSQEEARQQYVDLISSL O42310 66 5 DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5 GVSQDEAKERYIKALNDM Q20507 69 5

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