WORKLIST ENTRIES (1):
ACOABINDINGP View alignment View Structure Acyl-coA-binding protein signature
Type of fingerprint: COMPOUND with 4 elements
Links:
INTERPRO; IPR000582
PROSITE; PS00880 ACBP
PFAM; PF00887 ACBP
PDB; 2ABD 3Dinfo
SCOP; 2ABD
CATH; 2ABD
Creation date 10-APR-1997; UPDATE 07-JUN-1999
1. MARQUARDT, H., TODARO, G.J. AND SHOYAB, M.
Complete amino acid sequences of bovine and human endozepines. Homology
with rat diazepam binding inhibitor.
J.BIOL.CHEM. 261(21) 9727-9731 (1986).
2. ANDERSEN, K.V. AND POULSEN, F.M.
Three-dimensional structure in solution of acyl-coenzyme A binding protein
from bovine liver.
J.MOL.BIOL. 226(4) 1131-1141 (1992).
Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium-
and long-chain acyl-CoA esters with high affinity, and may act as an intra-
cellular carrier of acyl-CoA esters. ACBP has a number of important
physiological and biochemical functions: it is known as a diazepam binding
inhibitor, as a putative neurotransmitter, as a regulator of insulin
release from pancreatic cells, and as a mediator in corticotropin-dependent
adrenal steroidogenesis [1,2]. It is possible that the protein acts as a
neuropeptide that takes part in the modulation of gamma-aminobutyric
acid-ergic transmission [1].
The structure of ACBP has been deduced by NMR spectroscopy and has been
shown to be a mainly-alpha protein, consisting of 5 short alpha-helices
and 3 connecting beta-strands [2].
ACOABINDINGP is a 4-element fingerprint that provides a signature for
acyl-CoA-binding proteins. The fingerprint was derived from an initial
alignment of 15 sequences: the motifs were drawn from conserved regions
spanning the full alignment length - motif spans helix 1 and most of the
first loop; motif 2 encodes helix 2 and corresponds to the region
encoded by PROSITE pattern ACBP (PS00880); motif 3 spans part of the
second loop, helix 3 and the N-terminal portion of helix 4; and motif 4
spans helix 5. Two iterations on OWL29.2 were required to reach convergence,
at which point a true set comprising 22 sequences was identified.
An update on SPTR37_9f identified a true set of 21 sequences, and 3
partial matches.
SUMMARY INFORMATION
21 codes involving 4 elements
2 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 21 21 21 21
3| 0 2 2 2
2| 1 1 0 0
--+---------------------
| 1 2 3 4
True positives..
ACBP_PIG ACBP_BOVIN ACBP_HUMAN ACBP_RAT
ACBP_MOUSE ACBP_GOSHI ACBP_ANAPL ACBP_RANRI
Q39315 ACBP_RICCO ACBP_YEAST Q96496
Q92272 O22643 ACBP_MANSE O01805
ACBP_DROME Q09603 O42310 ENDR_BOVIN
Q20507
Subfamily: Codes involving 3 elements
Subfamily True positives..
O75521 O09035
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q20862
PROTEIN TITLES
ACBP_PIG ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_BOVIN ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_HUMAN ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_RAT ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_MOUSE ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_GOSHI ACYL-COA-BINDING PROTEIN (ACBP) - GOSSYPIUM HIRSUTUM (UPLAND
ACBP_ANAPL ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR)
ACBP_RANRI ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
Q39315 ACYL-COA BINDING PROTEIN - BRASSICA NAPUS (RAPE).
ACBP_RICCO ACYL-COA-BINDING PROTEIN (ACBP) - RICINUS COMMUNIS (CASTOR B
ACBP_YEAST ACYL-COA-BINDING PROTEIN (ACBP) - SACCHAROMYCES CEREVISIAE (
Q96496 ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCE
Q92272 ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCE
O22643 ACYL-COA-BINDING PROTEIN - FRITILLARIA AGRESTIS.
ACBP_MANSE ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
O01805 SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS
ACBP_DROME ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING IN
Q09603 HYPOTHETICAL 42.1 KD PROTEIN R06F6.9 IN CHROMOSOME II - CAEN
O42310 ACBP/ECHM - CYPRINUS CARPIO (COMMON CARP).
ENDR_BOVIN ENDOZEPINE-RELATED PROTEIN PRECURSOR (MEMBRANE-ASSOCIATED DI
Q20507 F47B10.7 PROTEIN - CAENORHABDITIS ELEGANS.
O75521 DBI-RELATED PROTEIN - HOMO SAPIENS (HUMAN).
O09035 DIAZEPAM BINDING INHIBITOR-LIKE 5 (ENDOZEPINE-LIKE PEPTIDE)
Q20862 SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS
SCAN HISTORY
OWL29_2 2 100 NSINGLE
SPTR37_9f 2 160 NSINGLE
INITIAL MOTIF SETS
ACOABINDINGP1 Length of motif = 16 Motif number = 1
Acyl-coA-binding protein motif I - 1
PCODE ST INT
QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2
QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2
QAEFEKAAEEVKNLKT ACBP_PIG 2 2
QADFDKAAEEVKRLKT ACBP_RAT 2 2
QADFDEAAEEVKKLKT ACBP_ANAPL 19 19
EAEFDKAAEDVKHLKT A60212 2 2
QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2
KEEFEEHAEKVKTLPA GHU35015 4 4
SEQFNAAAEKVKSLTK ACBP_DROME 3 3
QADFEKAQKNLKTLKE CER06F69 26 26
KEDFEEHAEKVKKLTA S48040 4 4
QEKFDAAVEIIQKLPK CEF47B106 4 4
QEQFDQAASNVRNLKS ACBP_MANSE 4 4
ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43
ETRFEAAVKVIQSLPK S80107 62 62
ACOABINDINGP2 Length of motif = 19 Motif number = 2
Acyl-coA-binding protein motif II - 1
PCODE ST INT
PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1
PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1
PADDEMLFIYSHYKQATVG ACBP_PIG 19 1
PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1
PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1
PADDEMLYIYSHYKQATVG A60212 19 1
PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1
PSNDDMLILYGLYKQATVG GHU35015 21 1
PSDDEFLQLYALFKQASVG ACBP_DROME 20 1
PDNDVKLQLYGLFKQATAG CER06F69 43 1
PSNEDLLILYGLYKQATVG S48040 21 1
TSNDQKLTFYSLFKQASIG CEF47B106 25 5
PSDNDLLELYALFKQASAG ACBP_MANSE 21 1
PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5
PTNEMMLKFYSFYKQATEG S80107 83 5
ACOABINDINGP3 Length of motif = 16 Motif number = 3
Acyl-coA-binding protein motif III - 1
PCODE ST INT
ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4
DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4
ERPGILDLKGKAKWDA ACBP_PIG 42 4
DRPGLLDLKGKAKWDS ACBP_RAT 42 4
ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4
ERPGLLDLRGKXXRDA A60212 42 4
ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4
SRPGMFNMREKYKWDA GHU35015 44 4
AKPGLLDLKGKAKWEA ACBP_DROME 43 4
KRPGMMDFVGRAKYDA CER06F69 66 4
SRPGMFSMKERAKWDA S48040 44 4
DRPGIFSIIERKKWDS CEF47B106 48 4
NRPGLLDLKGKAKFDA ACBP_MANSE 45 5
SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4
SKPGFWDPVGRYKWDA S80107 106 4
ACOABINDINGP4 Length of motif = 18 Motif number = 4
Acyl-coA-binding protein motif IV - 1
PCODE ST INT
GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5
GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5
GTSKEDAMKAYINKVEEL ACBP_PIG 63 5
GTSKENAMKTYVEKVEEL ACBP_RAT 63 5
GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5
KPSDDLDMKAYVNKVEDL A60212 86 28
GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5
GKSKEEAMGDYITKVKQL GHU35015 65 5
GKSSEAAQQEYITFVEGL ACBP_DROME 64 5
GQTQDEARANYAKLVGGL CER06F69 87 5
GKSTDEAMSDYITKVKQL S48040 65 5
GVSQDEAKERYIKALNDM CEF47B106 69 5
GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5
DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5
DMTKEEAMIAYVEEMKKI S80107 127 5
FINAL MOTIF SETS
ACOABINDINGP1 Length of motif = 16 Motif number = 1
Acyl-coA-binding protein motif I - 2
PCODE ST INT
QAEFEKAAEEVKNLKT ACBP_PIG 2 2
QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2
QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2
QADFDKAAEEVKRLKT ACBP_RAT 2 2
QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2
KEEFEEHAEKVKTLPA ACBP_GOSHI 4 4
QADFDEAAEEVKKLKT ACBP_ANAPL 19 19
QADFDKAAGDVKKLKT ACBP_RANRI 3 3
KEDFEEHAEKVKKLTA Q39315 4 4
KEDFEEHAEKAKTLPE ACBP_RICCO 4 4
SQLFEEKAKAVNELPT ACBP_YEAST 3 3
SQLFEEKAKAVNELPT Q96496 3 3
SQLFEEKAKAVNELPT Q92272 3 3
KEEFEEHAVKAKTLPE O22643 4 4
QEQFDQAASNVRNLKS ACBP_MANSE 4 4
TLSFDDAAATVKTLKT O01805 2 2
SEQFNAAAEKVKSLTK ACBP_DROME 3 3
QADFEKAQKNLKTLKE Q09603 26 26
VEEFNAAKEKLGALKK O42310 5 5
ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43
QEKFDAAVEIIQKLPK Q20507 4 4
ACOABINDINGP2 Length of motif = 19 Motif number = 2
Acyl-coA-binding protein motif II - 2
PCODE ST INT
PADDEMLFIYSHYKQATVG ACBP_PIG 19 1
PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1
PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1
PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1
PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1
PSNDDMLILYGLYKQATVG ACBP_GOSHI 21 1
PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1
PTDDELKELYGLYKQSTVG ACBP_RANRI 20 1
PSNEDLLILYGLYKQATVG Q39315 21 1
TTNENKLILYGLYKQATVG ACBP_RICCO 21 1
PSTDELLELYALYKQATVG ACBP_YEAST 20 1
PSTDELLELYGLYKQATVG Q96496 20 1
PSTDELLELYGLYKQATVG Q92272 20 1
TSNENKLILYGLYKQSTVG O22643 21 1
PSDNDLLELYALFKQASAG ACBP_MANSE 21 1
PSNDELLKLYALFKQGTVG O01805 19 1
PSDDEFLQLYALFKQASVG ACBP_DROME 20 1
PDNDVKLQLYGLFKQATAG Q09603 43 1
PGNEVKLKVYALFKQATQG O42310 22 1
PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5
TSNDQKLTFYSLFKQASIG Q20507 25 5
ACOABINDINGP3 Length of motif = 16 Motif number = 3
Acyl-coA-binding protein motif III - 2
PCODE ST INT
ERPGILDLKGKAKWDA ACBP_PIG 42 4
ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4
ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4
DRPGLLDLKGKAKWDS ACBP_RAT 42 4
DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4
SRPGMFNMREKYKWDA ACBP_GOSHI 44 4
ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4
ECPGMLDLKGKAKWDA ACBP_RANRI 43 4
SRPGMFSMKERAKWDA Q39315 44 4
SRPGMFNMRDRAKWDA ACBP_RICCO 44 4
EKPGIFNMKDRYKWEA ACBP_YEAST 43 4
EKPGIFNMKDRYKWEA Q96496 43 4
EKPGIFNMKDRYKWEA Q92272 43 4
GRPGMFSPRERAKWDA O22643 44 4
NRPGLLDLKGKAKFDA ACBP_MANSE 45 5
DKPGMFDLKGKAKWSA O01805 42 4
AKPGLLDLKGKAKWEA ACBP_DROME 43 4
KRPGMMDFVGRAKYDA Q09603 66 4
PKPSMLDFVNKAKWDA O42310 45 4
SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4
DRPGIFSIIERKKWDS Q20507 48 4
ACOABINDINGP4 Length of motif = 18 Motif number = 4
Acyl-coA-binding protein motif IV - 2
PCODE ST INT
GTSKEDAMKAYINKVEEL ACBP_PIG 63 5
GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5
GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5
GTSKENAMKTYVEKVEEL ACBP_RAT 63 5
GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5
GKSKEEAMGDYITKVKQL ACBP_GOSHI 65 5
GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5
GLSKEDAMSAYVSKAHEL ACBP_RANRI 64 5
GKSTDEAMSDYITKVKQL Q39315 65 5
GKSTEEAMSDYITKVKQL ACBP_RICCO 65 5
GKSQEDAEKEYIALVDQL ACBP_YEAST 64 5
GKSQEDAEKEYIAYVDNL Q96496 64 5
GKSQEDAEKEYIAYVDNL Q92272 64 5
GKSKEEAMGDYITKVKQL O22643 65 5
GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5
GLAKDDAQKAYVALVEEL O01805 63 5
GKSSEAAQQEYITFVEGL ACBP_DROME 64 5
GQTQDEARANYAKLVGGL Q09603 87 5
SVSQEEARQQYVDLISSL O42310 66 5
DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5
GVSQDEAKERYIKALNDM Q20507 69 5
User query: Display/Full Code "ACOABINDINGP"