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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|--
 P2Y6_RAT              ------------------------MERDNGTIQAPGLPPTTCVY-REDFKRLLLPPVYSVVLVVGLPLNVCVIAQIC-ASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATG-IQRNRTVCYDLSPPI----------LSTR-YLPYGMALTVIGFLLPFTALLACYCRMARRLCRQDGPAGPVA-QERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTPGVS--CPV-----------LETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV  
 O57466                ---------MDAPVRMFSLAPWTPTPTPWLGGNTTAAAEAKCVF-NEEFKFILLPISYGIVFVVGLPLNSWAMWIFV-SRMRPWNATTTYMFNLAISDTLYVFSLPTLVYYYADRNNWPFGKVFCKIVRFLFYANLYSSILFLTCISVHRYMGICHPIR-SLKWVKTKHARLICVGVWLVVTICLIPNLIFVTTSS-KDNSTLCHDTTKPE----------EFDH-YVHYSSSIMALLFGIPFLVIVVCYCLMAKRLCKRSFPSPSPRVPSYKKRSIKMIIIVLTVFAICFVPFHITRTLYYTSRYFQAD---CQT-----------LNIINFTYKITRPLASINSCLDPILYFMAGDKYRGRLRRGAAQRPRPVPTSLLALVSPSVDSSVVGSCCNSESRGMGTVWSRGGQ  
 Q9CPV9                -------------------MDVPGVNTTSANTTFSPGTSTLCVR-DYKITQVLFPLLYTVLFFAGLITNSLAMRIF--FQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGPLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFK-TSSPSNLLGAKILSVVIWAFMFLISLPNMILTNRRPKDKDVTKCSFL-KSE----------FGLV-WHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSA-KVPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFD--CSA-----------ENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLTSMLRCSNSTSTSGT-NKKKGQEGGEPSEETPM  
 P2YR_MOUSE            MTEVPWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFV-FHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLK-SLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGTRKNKTVTCYDTTSND----------YLRS-YFIYSMCTTVAMFCIPLVLILGCYGLIVKALIYNDLDNSP-----LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDF-----------NDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL  
 P2YR_HUMAN            MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFV-FHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLK-SLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDE----------YLRS-YFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSP-----LRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAF-----------NDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL  
 Q9H244                -------------------MQAVD-NLTSA-----PGNTSLCTR-DYKITQVLFPLLYTVLFFVGLITNGLAMRIF--FQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFK-TSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFL-KSE----------FGLV-WHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVG-KVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFD--CTA-----------ENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM  
 Q9EPX4                -------------------MEVPGANATSANTTSIPGTSTLCSR-DYKITQVLFPLLYTVLFFAGLITNSLAMRIF--FQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFK-TSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFL-KSE----------FGLV-WHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSA-KAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFD--CNA-----------ENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSG-----ANKKKGQEGGDPSEETPM  
 P2Y3_MELGA            -----------------------------MSMANFTAGRNSCTF-QEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIW-LARKALTRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-TQRNRTVCYDLSPPD----------RSAS-YFPYGITLTITGFLLPFAAILACYCSMARILCQKDELIGLAV-HKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSPTLP--CPT-----------LQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRHDHCITYGS  
 P2UR_RAT              -----------------MAAGLDSWNSTINGTWEGDELGYKCRF-NEDFKYVLLPVSYGVVCVLGLCLNVVALYIFL-CRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRSLGVLRPLH-SLRWGHARYARRVAAVVWVLVLACQTPVLYFVTTS-VRGTRITCHDTSDRE----------LFSH-FVAYSSVMLGLLFAVPFSIILVCYVLMARRLLKPAYGTTG--LPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLS---CHT-----------LNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPATEPTPSPQARRKLGLHRPNRTD-TVRKDLSISSDDSRRTESTPAGSE-TKDIRL  
 P2YR_CHICK            MTEALISAALNGTQPELLAG---GWAAGNATT--------KCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFV-FHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLK-SLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADE----------YLRS-YFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSP-----LRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAF-----------NDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL  
 Q9JJS7                -------------------MTSADSLLFTSLGPSPSSGDGDCKF-NEEFKFILLPLSYAVVFVLGLALNAPTLWLFL-FRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLR-AIRWGRPRFAGLLCLGVWLVVAGCLVPNLFFVTTN-ANGTTILCHDTTLPE----------EFDH-YVYFSSTIMVLLFGFPFLITLVCYGLMARRLYRPLPGAGQSS---SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLNAE---CRV-----------LNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSTPKRRTTASSLALVTLHEESISRWADIHQDSIFPAYEGDRL  
 P2Y6_HUMAN            ------------------------MEWDNGTGQALGLPPTTCVY-RENFKQLLLPPVYSAVLAAGLPLNICVITQIC-TSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATG-IQRNRTVCYDLSPPA----------LATH-YMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVA-QERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVP--CTV-----------LEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR  
 P2Y3_CHICK            -----------------------------MSMANFTGGRNSCTF-HEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIW-LARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-TQRNRTVCYDLSPPD----------RSTS-YFPYGITLTITGFLLPFAAILACYCSMARILCQKDELIGLAV-HKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSASLP--CPT-----------LQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRQDHCISYGS  
 Q9BYU4                ----------------------MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVV-EFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFF-ARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCS-VARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVA-----EKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTR--CPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ  
 P2Y8_XENLA            -------MTEDIMATSYPTFLTTPYLPMKLLMNLTNDTEDICVF-DEGFKFLLLPVSYSAVFMVGLPLNIAAMWIFI-AKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPFGEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPIT-SLRRMNAKHAYVICALVWLSVTLCLVPNLIFVTVSP-KVKNTICHDTTRPE----------DFAR-YVEYSTAIMCLLFGIPCLIIAGCYGLMTRELMKPIVSGNQQTLPSYKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLLGIK---CYA-----------LNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRRRSSVPNRRCMHTNHPQTEPHMTAGPLPVISAEEIPSNGSMVRDENGEGSREHRVEWTDTKEINQMMNRRSTIKRNSTDKNDMKENRHGENYLPYVEVVEKEDYETKRENRKTTEQSSKTNAEQDELQTQIDSRLKRGKWQLSSKKGAAQENEKGHMEPSFEGEGTSTWNLLTPKMYGKKDRLAKNVEEVGYGKEKELQNFPKA  
 P2UR_HUMAN            -----------------MAADLGPWNDTINGTWDGDELGYRCRF-NEDFKYVLLPVSYGVVCVLGLCLNAVALYIFL-CRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLR-SLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTS-ARGGRVTCHDTSAPE----------LFSR-FVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGG-LPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLS---CHT-----------LNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIGDVLGSSEDFRRTESTPAGSENTKDIRL  
 P2Y4_HUMAN            ---------------MASTESSLLRSLGLSPGPGSSEVELDCWF-DEDFKFILLPVSYAVVFVLGLGLNAPTLWLFI-FRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLR-ALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTS-NKGTTVLCHDTTRPE----------EFDH-YVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSS---SRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEAD---CRV-----------LNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL  
 P2UR_MOUSE            -----------------MAADLEPWNSTINGTWEGDELGYKCRF-NEDFKYVLLPVSYGVVCVLGLCLNVVALYIFL-CRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLH-SLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTS-VRGTRITCHDTSARE----------LFSH-FVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKPAYGTTGG-LPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLS---CHT-----------LNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKLGLHRPNRT---VRKDLSVSSDDSRRTESTPAGSE-TKDIRL