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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|--
 Q6F3Q9_DANRE          ---MFLLRLRTLLCLYSLAVGSIQTSESFWKLKPNVLVVDVD-VKGVNRVEVPVIC----------GEAYEGH-NITWTKNKDKH----LEAQGNRITVTVEGWK-GANYSCF-DNEGSYLNHTLVL-------AQWSFRKII---RNTPEKGYIHCATNNYGGLFQCSWSWGENRHGHITHIEAIR-PDGGSNISCSLDPEGK--------------------SITCLDQDY-CPYAEELERINLTVYFRSS-FVVESYNAKFYIMNI----VKPDM---VAISRINHT---CVEVGYPDSWNTPSSYFPLIFQVKEIRCRKRKKCD--CSQLSS---------IETYHTQSLQL----PVSKGK-MVCVRAKDEFCNSSWSEWSQYKCKKN---------RKQRKPKLKML  
 Q70M89_CHICK          ----MSHLLFALLSLLSFA----ALLEAQWKLRENVYVIESEWNDETPAKKVKLTC-----------DTSDEALPVYWKKGTELK------GTGKTLTTEVKEFPDAGNYTCLSAKTHEIISYSFFLITKVDSNGQMI-RSILKSYKEP-SKTFLKCEAKNYSGIFTCSWMTENESPSVKFTIRSLKGSQG--DVTCSSPVARTDKSV-------------TEYTAQCQKENY-CPFAEEHQPTEMFLEVIDE-VEYENYTSSS-SSE-----ISKARPTSMSVCKHNGT----VTWTYPKTWSTPKSYFPLTFRVKVESTKKYKSK------------------VYDADEQSIQI----PKTGPKDKISVQARDRYYNSSWSEWSTL-CR  
 Q5DVP7_ONCMY          ------MTVVPWLIMLLCV---ILPTVNGLTSFHELYMVDKG------DSLVTLTC-----------PTAFSG-AMTWKYEGETEDLDKTLVQGRNLILNEVDWY--GEYSC--WDGDKKLGSIYLL-------------EEL---KNPDDDDLISCRAKSYGCTFNCSWTHSEFTAVRL-----------GLGNDCTDSQESCTWV--------YPTTSLQDGGLEFELTHSLSPYTEEAAPLVVTVEAITR-QDYLRKTKRFYLHDI----VQPDSPAGMKCQVMDQR--LKVKVEPPATWNCPPSYFPLEHQIGYIFKDNGKEE----------------------HSTNPLI-----PRGVS-KLRARSRDPLVPSPWSQWTPWKNVTN  
 Q6UAP1_TETNG          --MGIKCFIFTVVCMFFSG--SNQNPLGIWSLRPHILVVEVD---GTWG-QLPLSCLTSSS------EKQEEE-GIFWMNNRVME-----KQKGNLYVVHLEESLGGGNYTCH-SKSGSLLNYTVVLI---KE-VKLR-RKIL---LKNDQGEYLSCSAKNFDGEFVCSWSWHTRRAGRVALVTAHR-AEDNSLPVCSVDASGRHWSCSSGRSEVTCSVDDGDGGIWCRVEQH-CPYAEESQPVQITIHVSSKHFLVENYSRHFFLSDI----VKPDK---VTIRKVNAT---MVAWSYPSSWNSPSSYFPLTFQIARLKK-TCKACEEPCAHSRA---------TKTLTVSCPEICQHEVKKRTK-GVCVRAKDALCDSQWGEWSFLSLREEKYRTRTIIARTRRIQQLNLFF  
 Q9ET05_MARMO          --MCLQQLVISWVSLVWLA----SPLLAIWELEKNVYVVELDWHPDTPGETVVLTC-----------DTPEED-GITWTSEQSSE----VLGSGKTLTILVKEFEDAGHYTC--HRGGEVLSQMLLLLHK-NEDGIWS-TDILKK-KEPENKNLVTCEAKNYSGRFTCWWL-TAISTDVKFSVKSHRGSSDPQGVTCGEATLSAERVK-------IEQREYKKYSVQCQEDNA-CPTAEETLPITVVVDAVHK-LKYENYISSFFIRDI----IKPDPPKNLKMKPSKTPQQVEVTWEYPDSWSTPHSYFSLTFSVQVQGKKKKRSN------------------TLHVDKTSVTV----TCQKGA-KVSVQARDRYYNSSWSEWATMSCP  
 IL12B_CAPHI           --MHPQQLVVSWFSLVLLA----SPIVAIWELEKNVYVVELDWYPNAPGETVVLTC-----------DTPEED-GITWTSDQSSE----VLGSGKTLTIQVKEFGDAGQYTC--HKGGEVLSRSLLLLHK-KEDGIWS-TDILKDQKEPKAKSFLKCEAKDYSGHFTCSWL-TAISTNLKFSVKSSRGSSDPRGVTCGAASLSAEKVS-------MDHREYNKYTVECQEGSA-CPAAEESLPIEVVMEAVHK-LKYENYTSSFFIRDI----IKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKK-------------------LFTDQTSAKV----TCHKDA-NIRVQARDRYYSSFWSEWASVSCS  
 IL12B_HUMAN           --MCHQQLVISWFSLVFLA----SPLVAIWELKKDVYVVELDWYPDAPGEMVVLTC-----------DTPEED-GITWTLDQSSE----VLGSGKTLTIQVKEFGDAGQYTC--HKGGEVLSHSLLLLHK-KEDGIWS-TDILKDQKEPKNKTFLRCEAKNYSGRFTCWWL-TTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVR-------GDNKEY-EYSVECQEDSA-CPAAEESLPIEVMVDAVHK-LKYENYTSSFFIRDI----IKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKD-----------------RVFTDKTSATV----ICRKNA-SISVRAQDRYYSSSWSEWASVPCS  
 Q924K7_MERUN          --MCHQKLTISWFAVVLLA----SPLMAIWELEKNVYVVEMDWRSGANE-SVVLTC-----------DTSEEG-DITWTKDQTTK----VEQSGKTVTIEVKDFNEAGQYTC--HKGDQTLSHFRLLLHK-KKNGYWS-NEILKQDKNSENQTFLKCEAANYSGRFTCSWL--VERTDLKFSIKNSSSSPDSRAVTCGAVSLTAEKVKGD-----EKDGKLKQYSVTCQEDIT-CPTAEETVPIGLVLEAQEQ-NKYENYSTSFFIRDI----ITPDPPKNLKVKPLKND-KVEVSWEYPDSWSTPHSYFALKFYVWTESNKENKMRNTNSNKENKMRNACIQNGTWLVDTTSTKV----RC-KDG-RVCVEAQDRYYNSLYSKHACVPCK  
 Q5DVP6_ONCMY          ------MTVVPWLIMLLCV---ILPTVNGLTSFHELYMVDKG------DSLVTLTC-----------PTAFSG-AMTWKYEGETEDLDKTLVQGRNLILNEVDWY--GEYSC--WDGDKKLGSIYLL-------------EEL---KNPDDDDLISCRAKSYGCTFNCSWTHSEFTAVRL-----------GLGNDCTDSQESCTWV--------YPTTSLQDGGLEFELTHSLSPYTEEAAPLVVTVEAITR-QDYLRKTKRFYLHDI----VQPDSPAGMKCQVMDQR--LKVKVEPPATWNCPPSYFPLEHQIGYIFKDNGKEE----------------------HSTNPLI-----PRGVS-KLRARSRDPLVPSPWSQWTPWKNVVTGGKKEEKCKEKRKGKDSICCKTGEKKRTKTKSRSAFTANE  
 Q800F2_FUGRU          ---MPGLCCHTLLNTFSLR----------WVLLP-VLVVQTD---GSSG-QLLLSCLTSTPEEEHVGGSPEDV-DIFWKNNGVME-----TQRGNLYVVDLEESLGGGNYTCH-SQTGSLLNYTVVLI---KEDNDTR-KKIL---LKNDQGQYLSCSANNFNGDFRCSWSWHAILVGKVAFITAQRQDSPMISIFCSAADGSLPACS-------VDAMDDGDGGMWCKDEQH-CPYAEESQPIHIDVHVSSKHFLMQTYSSRFFLSDIGGRFLGPVKPDKVIIRKVNAT---MVAWSYPSSWNTPFSYFPLTFQIRQLRK-SCRTC----------------------DHPCTQT----RVTKVG-LTAIERLDK--------WQKVTRI  
 IL12B_SIGHI           --MCHQKLTISWFAMVLLV----SPLMAIWELEKDVYVVEVDWSPGAPGERVVLTC-----------DTSEED-DIIWTSDQSSE----VVGSGKTLIVQVKEFSDAGQYTC--HKGGETLSHSRLLLHK-KEDGIWS-TDILKDQKDPKNKTFLKCEAANYSGRFTCWWL-TAVSTDLKFSLKSSSSSSDSRSVTCGAASLSTEKVT-------VDQRDYNKYSVACQEDIT-CPTAEETLPIELVMEAQHK-YKYENYSTGFFIRDI----IKPDPPKNLQLKPLKSS-QVEVSWEYPDSWSTPHSYFSLKFFVQVYRKKEKKGE------------------SLLVDKPSAKI----RCSKGG-EVRVRAQDHYYNSSWSEWASVSCN  
 IL12B_BUBCA           --MHPQQLVVSWFSLVLLA----SPIVAIWELEKNVYIVELDWYPDAPGETVVLTC-----------DTPEED-GITWTSDQSSE----VLGSGKTLTIQVKEFGDAGQYTC--HKGGEALSRSLLLLHK-KEDGIWS-TDILKDQKEPKAKSFLKCEAKDYSGHFTCWWL-TAISTDLKFSVKSSRGSSDPRGVTCGAASLSAEKVS-------VDHREYNKYTVECQEGST-CPAAEESLLIEVVVEAVHK-LKYENYTSSFFIRDI----IKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKK-------------------LFMDQTSAKV----TCHKDA-NVRVQARDRYYSSFWSEWASVSCS  
 Q7SX69_FUGRU          MGNHNKLLIFTIICIFLRG--TNQNSIDAWTLLPHILVVQTD---GSSG-QLLLSCLTSTPEEEHVGGSPEDV-DIFWKNNGVME-----TQRGNLYVVDLEESLGGGNYTCH-SQTGSLLNYTVVLI---KEDNDTR-KKIL---LKNDQGQYLSCSANNFNGDFRCSWSWHAILVGKVAFITAQR-AADGSLPACSVDASGRHWSCSSGQRKVTCSVDDGDGGMWCKDEQH-CPYAEESQPIHIDVHVSSKHFLMQTYSSRFFLSDI----VKPDK---VIIRKVNAT---MVAWSYPSSWNTPFSYFPLTFQIRQLRK-SCRTCDHPCTQTRV---------TKTLTVSSPEIYQHQVKRRIM-VVCVRAKDALCISQWGEWSFLRLRSGK--------RSRKTTKA