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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|------
 AAD21871              MAMVPEITCDEVDFYRDDDDRQFYEADGPNQKKGYFQYPDLC-SKESLLEEDGIQL--KFTTQPHQFHQTVMVIVAIE---KMKHLNGLSSQFFQDNDLMNIFTNIFQEEPITFKNC----DIYESDSSFRLVSSQDCTIQDINQKCLALSK-----ASELRALHLNGRN-ISQQVIFSMKYLLGDIGS----QKTHVVLCIKKNNLYLSCVRRGEK---PILQLEQIAN------FPSINVEKRFIFNKVEINN----TTEFESAEYPNWYISTS--QMDEQPVFLGNIRGGKDITDFILADF  
 IL1B_PIG              MAIVPEPAKEVMANYGDNNNDLLFEADGPKEMKCCTQNLDLG-----SLRNGSIQLQISHQLWNKSIRQMVSVIVAVE---KPMK--NPSSQAFCDDDQKSIFSFIFEEEPIILET------CNDDFVCDANVQSMECKLQDKDHKSLVLAG-----PHMLKALHLLTGD-LKREVVFCMSFVQGDDSN----NKIPVTLGIKGKNLYLSCVMKDNT---PTLQLEDIDPKR----YPKRDMEKRFVFYKTEIKN----RVEFESALYPNWYISTS--QAEQKPVFLGNSKGRQDITDFTMEVLSP  
 IL1B_HUMAN            MAEVPKLASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDL------CPLDGGIQLRISDHHYSKGFRQAASVVVAMD---KLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTW-----DNEAYVHDAPVRSLNCTLRDSQQKSLVMSG-----PYELKALHLQGQD-MEQQVVFSMSFVQGEESN----DKIPVALGLKEKNLYLSCVLKDDK---PTLQLESVDPKN----YPKKKMEKRFVFNKIEINN----KLEFESAQFPNWYISTS--QAENMPVFLGGTKGGQDITDFTMQFVSS  
 IL1A_CERTO            MAKVPDMFEDLKNCYSENEEDSSSIDHLFLNQKSFYDVSYGPLHESCMDQSVSLSISEISKTSKLSFKQSMVVVSTNG---KVLKKRRLSLSQSIADDNLEAIANDSEEEIIKPRSA-PFSFLSNMTYHIIRIIKHESILNDTLNQTIIR-----ANDQYLTAAAIHN--LDEAVKFDMGAYTSSKDDT-----KVPVILRISKTQLYVSAQDEDQ----PVLL-KEMPEIPKTTT----GGETNSLSSWETRGT----KNYFISVAHPNLFIAT------KHDNWVCLAKGLPSITDFQILENQA  
 IL1B_FELCA            MAPVPELTSEMMAYYS-DENDLFFEADGPEKMKGSLQNLSHS-----FLGDEGIQLQISHQPDNKSLRHAVSVIVAME---KLKKISFACSQPLQDEDLKSLFCCIFEEEPIICDTW------DDGFVCDAAIQSQDYTFRDISQKSLVLSG-----SYELRALHLNGQN-MNQQVVFRMSFVHGEENS----KKIPVVLCIKKNNLYLSCVMKDGK---PTLQLEMLDPKV----YPKKKMEKRFVFNKTEIKG----NVEFESSQFPNWYISTS--QAEEMPVFLGNTKGGQDITDFIMESAS-  
 IL1B_MACNE            MAEVPELASEMMAYYSGNEDDLFFEVDGPKQMKCSFQDLDL------CPLDGGIQLQISHEHYNKGFRQAVSVVVAME---KLRKMLVPCPQIFQDNDLSTLIPFIFEEEPVFLDTR-----NNDACVHDAPVRSLHCTLRDAQLKSLVMSG-----PYELKALHLQGQD-LEQQVVFFMSFVQGEESN----DKIPVALGLKAKNLYLSCVLKDDK---PTLQLESVDPKN----YPKKKMEKRFVFNKIEINN----KLEFESAQFPNWYISTS--QAENMPVFLGGTRGGQDITDFTMQFVSS  
 IL1A_BOVIN            MAKVPDLFEDLKNCYSENEDYSSEIDHLSLNQKSFYDASYEPLREDQMNKFMSLDTSETSKTSKLSFKENVVMVAASG---KILKKRRLSLNQFITDDDLEAIANNTEEEIIKPRSA-HYSFQSNVKYNFMRVIHQECILNDALNQSIIR----DMSGPYLTATTLNN--LEEAVKFDMVAYVSEEDS------QLPVTLRISKTQLFVSAQNEDE----PVLL-KEMPETPKIIK-----DETNLLFFWEKHGS----MDYFKSVAHPKLFIAT------KQEKLVHMASGPPSITDFQILEK  
 IL1A_PIG              MAKVPDLFEDLKNCYSENEEYSSDIDHLSLNQKSFYDASYEPLPGDGMDKFMPLSTSKTSKTSRLNFKDSVVMAAANG---KILKKRRLSLNQFITDDDLEAIANDTEEEIIKPRSA-TYSFQSNMKYNFMRVINHQCILNDARNQSIIR----DPSGQYLMAAVLNN--LDEAVKFDMAAYTSNDDS------QLPVTLRISETRLFVSAQNEDE----PVLL-KELPETPKTIK-----DETSLLFFWEKHGN----MDYFKSAAHPKLFIAT------RQEKLVHMAPGLPSVTDFQILENQS  
 IL1B_MACFA            MAEVPELASEMMAYYSGNEDDLFFDVDGPKQMKCSFQDLDL------CPLDGGIQLQISHEHYNEGFRQAVSVVVAME---KLRKMLVPCPQIFQDNDLSTLIPFIFEEEPVFLDTR-----NNDACVHDAPVRSLHCTLRDAQLKSLVMSG-----PYELKALHLQGQD-LEQQVVFSMSFVQGEESN----DKIPVALGLKAKNLYLSCVLKDDK---PTLQLESVDPKN----YPKKKMEKRFVFNKIEINN----KLEFESAQFPNWYISTS--QAESMPVFLGGTRGGQDITDFTMQFVS  
 CAA38566              MATVPEPINEVMACYS-DENELLFEVDGPKQMKSCTQHLDLG-----SMGDGNIQLQISHKLYNKSFRQAVSVIVAME---KLRS--RAYEHVFRDDDLRSILSFIFEEEPVIFET------SSDELLCDAAVQSVKCKLQDREQKSLVLDS-----PCVLKALHLLSQE-MSREVVFCMSFVQGEERD----NKIPVALGIRDKNLYLSCVKKGDT---PTLQLEEVDPKV----YPKRNMEKRFVFYKTEIKN----TVEFESVLYPNWYISTS--QIEEKPVFLGRFRGGQDITDFRMETLSP  
 O73909                MAFVPDLDVLESSSLS-EET--FYGPSCLCLQKKPRLDSE--------HTTVDVQVTVRKGRGARSFRRAAVLVVAMT---KLLRR--PRSRDFADSDLSALLEEVF--EPVTFQRLES---SYAGAPAFRYTRSQSFDIFDINQKCFVLES-----PTQLVALHLQGPSSSQKVRLNIALYRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTE---PTLQLEEADVMRDI----DSVELTRFIFYRLDSPTE--GTTRFESAAFPGWFICTS--LQPRQPVGITNQPDQVNIATYKLSGR  
 IL1B_BOVIN            MATVPEPINEMMAYYS-DENELLFEADDPKQMKSCIQHLDLG-----SMGDGNIQLQISHQFYNKSFRQVVSVIVAME---KLRN--SAYAHVFHDDDLRSILSFIFEEEPVIFET------SSDEFLCDAPVQSIKCKLQDREQKSLVLAS-----PCVLKALHLLSQE-MNREVVFCMSFVQGEERD----NKIPVALGIKDKNLYLSCVKKGDT---PTLQLEEVDPKV----YPKRNMEKRFVFYKTEIKN----TVEFESVLYPNWYISTS--QIEERPVFLGHFRAGQDITDFRMETLSP  
 AF1196221             MAAVPELSSEVTAYHS-DENELFFEVDGPNKMQYCFQDRDLC-----SL-DEGIKLQISHQHFNKSFRQTVSLIVAVE---KLRKKLAPCTWAFQDDDLRPLLPFIFEEEPIVCDTW------DEEYESDTPVPSRNCTLHDIQHKRLVLSD-----PCELKALHLNGDN-LNRQVVFSMSFVQGERSD----NKMPVALGLKGKNLYLSCVMKDGK---PVLQLESVDGKQ----YPKKKMEKRFVFNKITSKS----TVEFESAQFPNWYISTS--QAEHKPVFLGNNNG-QDIIDFKLELVSS  
 ICBO1B                MATVPEPINEMMAYYS-DENELLFEADDPKQMKSCIQHLDLG-----SMGDGNIQLQISHQFYNKSFRQVVSVIVAME---KLRN--SAYAHVFHDDDLRSILSFIFEEEPVIFET------SSDEFLCDAPVQSIKCKLQDREQKSLVLAS-----PCVLKALHLLSQE-MNREVVFCMSFVQGEERD----NKIPVALGIKDKNLYLSCVKKGDT---PTLQLEEVDPKV----YPKRNMEKRFVFYKTEIKN----TVEFESVLYPNWYISTS--QIEERPVFLGHFRGGQDITDFRMETLSP  
 IL1B_CERTO            MAEVPELASEMMAYYSSNEDDLFFEVDGPKQMKCSFQDLDL------CPLDGGIQLQISHEHYNKGFRQAVSVVVAME---KLRKMLVPCPQTFQDNDLSTLIPFIFEEEPVFLDTC-----NNDACVHDAPVRSLHCTLRDAQLKSLVMSG-----PYELKALHLQGQD-VEQQVVFSMSFVQGEESN----DKVPVALGLKAKNLYLSCVLKDDK---PTLQLESVDPKN----YPKKKMEKRFVFNKIEINN----KLECESAQFPNWYISTS--QAENMPVFLGGTRGGQDITDFTMQFVSS  
 CAB53541              --------------------MEFESNCSLM---------KNTSASVAWSSKLPQGLDVEISHHPITLRCVANLIIAME---RLNGGKGFTLGR---DEGLLNFLLESAVE---VLELESARTEASSRAAFSSKGEYECSVTDSENKCWVLNE----GSMELHAIMLQGGSSYHKVHLNLSTYITPVPSE---TKARPVALGIKGSNLYLSCITSEGT---PTLHLEEVADKEQLKSINHESDMVRFLFYKQDTGVD---ISTLESAHYRNWFISTALQQDNTKMVNMCQRATLNRNTTFTI--QRHN  
 IL1B_RAT              MATVPELNCEIAAFDS-EENDLFFEADRPQKIKDCFQALDLG-----CP-DESIQLQISQQHLDKSFRKAVSLIVAVE---KLWQLPMSCPWSFQDEDPSTFFSFIFEEEPVLCDSW----DDDDLLVCDVPIRQLHCRLRDEQQKCLVLSD-----PCELKALHLNGQN-ISQQVVFSMSFVQGETSN----DKIPVALGLKGLNLYLSCVMKDGT---PTLQLESVDPKQ----YPKKKMEKRFVFNKIEVKT----KVEFESAQFPNWYISTS--QAEHRPVFLGNSNGR-DIVDFTMEPVSS  
 IL1A_RABIT            MAKVPDLFEDLKNCFSENEEYSSAIDHLSLNQKSFYDASYEPLHEDCMNKVVSLSTSETSVSPNLTFQENVVAVTASG---KILKKRRLSLNQPITDVDLETNVSDPEEGIIKPRSV-PYTFQRNMRYKYLRIIKQEFTLNDALNQSLVR----DTSDQYLRAAPLQN--LGDAVKFDMGVYMTSEDS------ILPVTLRISQTPLFVSAQNEDE----PVLL-KEMPETPRIIT----DSESDILFFWETQGN----KNYFKSAANPQLFIAT------KPEHLVHMARGLPSMTDFQIS  
 IL1B_CEREL            MAPVPEPINEMMAYYS-DENELLFEADGPKQMKSCIQHLDLG-----SVEVGNIQLQISHQLYNKSFRQVVSVIVAME---KLRN--SAYAHVFHDDDLRNVLSFIFEEEPVIFET------SSDEFLCDAAVQSVNCKLQDREQNSLVLAS-----PCVLKALHLLSQE-MSREVVFCMSFVQAEERD----NKIPVALGIRDKNQYLSCVKKGDT---PTLQLEEVDPKV----YPKRNMEKRFVFYKTEIKD----TVEFESVLYPNWYISTS--HPEEKPVFLGHFRGGQDITDFRMETLSP  
 IL1X_RABIT            -----------------------------------------------------------MRPSRSTRRHLIS-LLLFL----------------------------------------FHSETACRPSGKRPCRMQAFRIWDVNQKTFYLRN------NQLVAGYLQGPNAKLEERIDVVPLEP-----------QLLFLGIQRGKLCLSCVKSGDK---MKLHLEAVNITD---LGKNKEQDKRFTFIRSNSGP----TTTFESASCPGWFLCTA--LEADQPVSLTNTPDDSIVVTKFYFQEDQ  
 O57398                -------MACHEYVHQLDLSEAFETDSAIYSDSADSDELDCPDPQSMSCQCDMHDIKLELSSHPHSMRQVVNIIIAVE---RL-KHIKNMSSGKFCDEELLGFILENVIEERLV------KPLNETPIYSKTSLTLQCTICDKYKKTMVQSNKLSDEPLHLKAVTLSAGAMQYKVQFSMSTFVSSATQK----EAQPVCLGISNSNLYLACTQLDGSS--PVLILKEASGSVNTIKA--GDPNDSLLFFRKETGTR---YNTFESVKYPGWFISTA--FDDWEKVEMNQM-PTTRTTNFTLEDQKRI  
 IL1B_RABIT            MATVPELTSEMMAYHSGNENDLFFEADGPNYMKSCFQDLDLC-----CP-DEGIQLRISCQPYNKSFRQVLSVVVALE---KLRQKAVPCPQAFQDDGLRTFFSLIFEEEPVLCNTW-----DDYSLECDA-VRSLHCRLQDAQQKSLVLSG-----TYELKALHLNAEN-LNQQVVFSMSFVQGEESN----DKIPVALGLRGKNLYLSCVMKDDK---PTLQLESVDPNR----YPKKKMEKRFVFNKIEIKD----KLEFESAQFPNWYISTS--QTEYMPVFLGNNSGGQDLIDFSMEFVSS  
 CAA06157              --------------------MDFESNYSLI---------KNTSESAAWSSKLPQGLDLEVSHHPITMRHIANLIIAME---RLKGGEGVTMGTEFKDKDLLNFLLESAVEEHIVLELESAPPASRRAAGFSSTSQYECSVTDSENKCWVLMN----EAMELHAMMLQGGSSYHKVHLNLSSYVTPVPIE---TEARPVALGIKGSNLYLSCSKSGGR---PTLHLEEVADKDQLKSISQQSDMVRFLFYRRNTGVD---ISTLESASFRNWFISTDMQQDYTKPVDMCQKAAPNRLTTFTI--QRHN  
 IL1B_MOUSE            MATVPELNCEMPPFDS-DENDLFFEVDGPQKMKGCFQTFDLG-----CP-DESIQLQISQQHINKSFRQAVSLIVAVE---KLWQLPVSFPWTFQDEDMSTFFSFIFEEEPILCDSW---DDDDNLLVCDVPIRQLHYRLRDEQQKSLVLSD-----PYELKALHLNGQN-INQQVIFSMSFVQGEPSN----DKIPVALGLKGKNLYLSCVMKDGT---PTLQLESVDPKQ----YPKKKMEKRFVFNKIEVKS----KVEFESAEFPNWYISTS--QAEHKPVFLGNNS-GQDIIDFTMESVSS  
 IL1B_SHEEP            MATVPEPINEVMAYYS-DENELLFEVDGPKQMKSCTQHLDLG-----SMGDGNIQLQISHQLYNKSFRQVVSVIVAME---KLRS--RAYEHVFRDDDLRSILSFIFEEEPVIFET------SSDELLCDAAVQSVKCKLQDREQKSLVLDS-----PCVLKALHLPSQE-MSREVVFCMSFVQGEERD----NKIPVALGIRDKNLYLSCVKKGDT---PTLQLEEVDPKV----YPKRNMEKRFVFYKTEIKN----TVEFESVLYPNWYISTS--QIEEKPVFLGRFRGGQDITDFRMETLSP  
 IL1A_MACMU            MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYDVSYGPLHEGCMDQSVSLSISEISKTSKLTFKQSMVVVSTNG---KVLKKRRLSLSQSITDNNLEAIANDSEEEIIKPRSA-PFSFLSNMTYHFIRIIKHEFILNDTLNQTIIR-----ANDQHLTAAAIHN--LDEAVKFDMGAYTSSKDDT-----KVPVILRISKTQLYVSAQDEDQ----PVLL-KEMPEINKTIT----GSETNFLFFWETHGT----KNYFISVAHPNLFIAT------KHDNWVCLAKGLPSITDFQILENQA  
 IL1X_RAT              -----------------------------------------------------------MEICRGPYSHLISLLLILL----------------------------------------FRSESAGHPAGKRPCKMQAFRIWDTNQKTFYLRN------NQLIAGYLQGPNTKLEEKIDMVPIDF-----------RNVFLGIHGGKLCLSCVKSGDD---TKLQLEEVNITD---LNKNKEEDKRFTFIRSETGP----TTSFESLACPGWFLCTT--LEADHPVSLTNTPKEPCTVTKFYFQEDQ  
 IL1A_SHEEP            MAKVPDLFEDLKNCYSENEDYSSEIDHLSLNQKSFYDASYEPLREDHMNKFMSLDTSETSKTSRLSFKENVVMVTANG---KILKKRRLSLNQFITDDDLEAIANDTEEEIIKPRSA-HYSFQSNVKYNFMRVIHQECILNDALNQSIIR----DMSGPYMTAATLNN--LEEAVKFDMVAYVSEEDS------QLPVTLRISKTQLFVSAQNEDE----PVLH-KEMPETPKIIK-----DETNLLFFWEKHGS----MDYFKSVAHPKLFIAT------KQEKLVHMASGPPSITDFLILEK  
 IL1A_MOUSE            MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNQKSFYDASYGSLHETCTDQFVSLRTSETSKMSNFTFKESRVTVSATSSNGKILKKRRLSFSETFTEDDLQSITHDL-EETIQPRSA-PYTYQSDLRYKLMKLVRQKFVMNDSLNQTIYQ----DVDKHYLSTTWLND--LQQEVKFDMYAYSSGGDDS-----KYPVTLKISDSQLFVSAQGEDQ----PVLL-KELPETPKLIT----GSETDLIFFWKSINS----KNYFTSAAYPELFIAT------KEQSRVHLARGLPSMTDFQIS  
 CAB52366              -------MAYHKYVHPLDLSEAFETDSAIYSDSADSDELDCPDPQSMSCQCDMHDIKLELSSHPHSMRQVVNIIIAVE---RL-KHIKNMSSGKFCDEELLGFILENVIEERLV------KPLNETPIYSKTSLTLQCTICDKYKKTMVQSNKLSDEPLHLKAVTLSAGAMQYKVQFSMSTFVSSATQK----EAQPVCLGISNSNLYLACTQLDGSS--PVLILKEASGSVNTIKA--GDPNDSLLFFRKETGTR---YNTFESVKYPGWFISTA--FDDWEKVEMNQM-PTTRTTNFTLEDQKRI  
 CAB53499              MALVPDLSSIPMEGYS-GDDEMFYSDSPSGMKDDMGDAAQWQSSTSHCSLDIHVQIT-HGKGSLHSFRKAVVLVVAVE---KLKRG---KERFFGDEDLLGLLDSIFVEEEIGFSQA---KETYASASTYRYQRATTCRIKDTSNKCFVMQK--FHENAQLVALQLQGANIQREEKVSMAFYATQPHQG---GSKRPVALGLAGKNLYLSCRATEDGQDSPKLYLEEISNIKDV----KGEDLNRFIFMKSQDGLNETSTNSFESVAFPGWYISTS--QRENELVQMVHQKNQEAIKDFNLFSVI  
 IL1A_RAT              MAKVPDLFEDLKNCYSENEEYSSAIDHLSLNQKSFYDASYGSLHENCTDKFVSLRTSETSKMSTFTFKESRVVVSATSNKGKILKKRRLSFNQPFTEDDLEAIAHDL-EETIQPRSA-PHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYV----DMDRIHLKAASLND--LQLEVKFDMYAYSSGGDDS-----KYPVTLKVSNTQLFVSAQGEDK----PVLL-KEIPETPKLIT----GSETDLIFFWEKINS----KNYFTSAAFPELLIAT------KEQSQVHLARGLPSMIDFQIS  
 IL1A_HUMAN            MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNG---KVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSA-PFSFLSNVKYNFMRIIKYEFILNDALNQSIIR-----ANDQYLTAAALHN--LDEAVKFDMGAYKSSKDDA-----KITVILRISKTQLYVTAQDEDQ----PVLL-KEMPEIPKTIT----GSETNLLFFWETHGT----KNYFTSVAHPNLFIAT------KQDYWVCLAGGPPSITDFQILENQA  
 IL1X_HUMAN            -----------------------------------------------------------MEICRGLRSHLIT-LLLFL----------------------------------------FHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRN------NQLVAGYLQGPNVNLEEKIDVVPIEP-----------HALFLGIHGGKMCLSCVKSGDE---TRLQLEAVNITD---LSENRKQDKRFAFIRSDSGP----TTSFESAACPGWFLCTA--MEADQPVSLTNMPDEGVMVTKFYFQEDE  
 IL1X_MOUSE            -----------------------------------------------------------MEICWGPYSHLISLLLILL----------------------------------------FHSEAACRPSGKRPCKMQAFRIWDTNQKTFYLRN------NQLIAGYLQGPNIKLEEKIDMVPIDL-----------HSVFLGIHGGKLCLSCAKSGDD---IKLQLEEVNITD---LSKNKEEDKRFTFIRSEKGP----TTSFESAACPGWFLCTT--LEADRPVSLTNTPEEPLIVTKFYFQEDQ  
 IL1B_MACMU            MAEVPELASEMMAYYSGNEDDLFFDVDGPKQMKCSFQDLDL------CPLGGGIQLQISHEHYNEGFRQAVSVVVAME---KLRKMLVPCPQIFQDNDLSTLIPFIFEEEPVFLDTR-----NNDACVHDAPVRSLHCTLRDAQLKSLVMSG-----PYELKALHLQGQD-LEQQVVFSMSFVQGEESN----DKIPVALGLKAKNLYLSCVLKDDK---PTLQLESVDPKN----YPKKKMEKRFVFNKIEINN----KLEFESAQFPNWYISTS--QAENMPVFLGGTRGGQDITDFTMQFVSS  
 IL1A_MACFA            MAKVPDMFEDLKNCYSENEEVSSSIDHLSLNQKSFYDVSYGPLHEGCMDQSVSLSISEISKTSKLTFKQSMVVVSTNG---KVLKKRRLSLSQSITDNNLEAIANDSEEEIIKPRSA-PFSFLSNMTYHFIRIIKHEFILNDTLNQTIIR-----ANDQYLTAAAIHN--LDEAVKFDMGAYTSSKDDT-----KVPVILRISKTQLYVSAQDEDQ----PVLL-KEMPEIPKTIT----GSETNFLFFWETHGT----KNYFISVAHPNLFIAT------KHDNWVCLAKGLPSITDFQILENQA