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 CADD_HUMAN            ------MQPRTPL----------VLCVLLS--------Q--VLLLTSAEDLDCTPGFQ--QKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSS-PYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAEDMAELVIVG-------------------------GKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDS-DRPER-SKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTD-VNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADD-PATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAG-LDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEG--AVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVEN-EDPLVPDVSYGPS---STATVHITVLDVNEGPVFYPDPMMVTRQEDLSVG----SVLLTVNATDPDSLQHQT-IRYSVYKDPAGWLNINPIN-GTVDTTAVLDRE-SPFVDNSVYTALFLAIDSGNPP----ATGTGTLLITLEDVND---------NAPFIY-PTVAEVCDDAK----------------------------------------NLSVVILGASDKDL-------HPN----------------------------------TDPFKFEIH-K-QAVPDKVWKISKINNTHALVSL------LQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRN---SK--------VDCN------------AAGALRFSLPSV----------------LLLSLFSLAC  
 CADB_XENLA            MGGTDKFRYPSVWL-------CGLLCLLQVVP------S----INVDVSG--CQPGFS-SANYTFSVNRRELERGRKLGKVNLVDCTTRKHGLYDVGD-SRFRVLPDGTVLVKRHVKLHSKDTRFTISTWDARGIKHSTNISVVNKRHRSGEEARSR------------SSELP----VLTFPEKHTGLKRKKRDWVIPPIKVSENERGPFPKRLVQIKSNKEKLSK-VFYSITGQGADTPPEGIFRIEKETGWMQVTRPLDREEYEKYVLLSHAVS-ENGASVEEPMEITVTVIDQNDNRPKFTQPVFRGSVREGVQPGTKVMSVSATDDDDSIDSLNGVIAYSILKQDPEEPIPNLFTINRETGVISLIGTG--LDREKFP--EYTLTVQAADLDG---AGLTAEGKAVIEITDANDNAPIFDPKTYTALVPENE-VGFEVQRLSVTDLDMPGTAAWQAVYKIRVNE-GGFFNITTDPESNQGILTTAKGLDFEVRKQYVIQITVEN-AVPFSVPLPT------STATVTVTVEDVNEAPVFVPVVSRVDVSEDLTRG----EKIVSLVAQDPDKQQIQK-LSYFIGNDPARWLTINKDN-GIVTGNGNLDRESE-YVKNNTYTVIMLVTDDGVPV----GTGTGTLILHVLDIND---------NGPVPS-PRVFTMCDQN------------------------------------------PEPQVLTITDADI-------PPN----------------------------------TYPYSVSLSH----GSELTWKAELDSK-GTSMRLS--P--TQQLKKGDYSIYVLLADAQA--NRQLTVVNATVCICEGKAIK---------CQEK------------LVAGFDLPIILV----------------ILGSILALLILSLLLLLFLK-------------------RK---KVVKEPLLLPEDDTR---DNIFYYGEEG----GGEEDQ---------DYDLSQLHR---------GLDARPD--IMRNDVVPTL---------MSVPHYRPRP--------------------------------------SNPDE--IGNFIDENLDAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSEAASLSSLNSSNSNNEHDYNYLNDWGPRFRKLADMYGGDDDDDEE  
 CAD4_HUMAN            ------MTAGAGV----------LLLLLSLSG------ALRAHNEDLTTRETCKAGFS--EDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNS-MDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIP-IRYSITGVGADQPPMEVFSINSMSGRMYVTRPMDREEHASYHLRAHAVD-MNGNKVENPIDLYIYVIDMNDNHPEFINQVYNCSVDEGSKPGTYVMTITANDADD-STTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAG--WDREKVQ--QYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPSEFTASTFAGEVPENS-VETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSN-QAPLASGIQMSFQ---STAGVTISIMDINEAPYFPSNHKLIRLEEGVPPG----TVLTTFSAVDPDRFMQQA-VRYSKLSDPASWLHINATN-GQITTVAVLDRE-SLYTKNNVYEATFLAADNGIPP----ASGTGTLQIYLIDIND---------NAPELL-PKEAQICERP-----------------------------------------NLNAINITAADADV-------HPN----------------------------------IGPYVFELPFV-PAAVRKNWTITRLNGDYAQLSLR-----ILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTT-------IGAV------------AAAGLGTGAIVA----------------ILICILILLTMVLLFVMWMK-------------------RREKERHTKQLLIDPEDDVR---EKILKYDEEG----GGEEDQ---------DYDLSQLQQP----EAMGHVPSKAPG-VRRVDERP-V---------GPEPQYPIRP--------------------------------------MVPHPGDIGDFINEGLRAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSVSSLNSSSSG-DQDYDYLNDWGPRFKKLADMYGGGE  
 CAD8_HUMAN            -------------------------------------------------------MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSP--------------------------------------LELNSL----------------------------------------GEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAIIKTALPN--MDREAKE--EYLVVIQAKDMGG-HSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFK---DTATVKIVVEDADEPPVFSSPTYLLEVHENAALN----SVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADD-GKITLATPLDRE-----LSVWHNITIIATEIRNHS----QISRVPVAIKVLDVND---------NAPEFASEYEAFLCEN---------------------------------------GKPGQVIQTVSAMDKDD-------PKN----------------------------------GHYFLYSLLP--EMVNNPNFTIKKNEDNSLSILAK--HNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNV----EAYV------------LPIGLSMGALIA----------------ILACIILLLVIVVLFVTLRR-------------------HK----NEP-LIIKDDEDVR---ENIIRYDDEG----GGEEDTE--------AFDIATLQNP----DGINGFLPR-------KDIKP-------------DLQFMPRQGLA-----------------------------------PVPNGVDVDEFINVRLHEADN-------------------------------DPTAPP-YDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET  
 CAD1_HUMAN            ------MGPWSRS-------LSALLLLLQVSS------W----LCQEPEP--CHPGFD-AESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLD-TRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA------------SVSGIQAELLTFPNSSPG-LRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGK-VFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVS-SNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTG--LDRESFP--TYTLVVQAADLQG---EGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENE-ANVVITTLKVTDADAPNTPAWEAVYTILN-DDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTN-VVPFEVSLTT------STATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVG----QEITSYTAQEPDTFMEQK-ITYRIWRDTANWLEINPDT-GAISTRAELDREDFEHVKNSTYTALIIATDNGSPV----ATGTGTLLLILSDVND---------NAPIPE-PRTIFFCERN------------------------------------------PKPQVINIIDADL-------PPN----------------------------------TSPFTAELTH----GASANWTIQYNDPTQESIILK--P--KMALEVGDYKINLKLMDNQN--KDQVTTLEVSVCDCEGAAGVCR-------KAQP------------VEAGLQIPAILG----------------ILGGILALLILILLLLLFLR-------------------RR---AVVKEPLLPPEDDTR---DNVYYYDEEG----GGEEDQ---------DFDLSQLHR---------GLDARPE--VTRNDVAPTL---------MSVPRYLPRP--------------------------------------ANPDE--IGNFIDENLKAADT-------------------------------DPTAPP-YDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGE  
 CADN_XENLA            ------MCRKQ------------PFLLPTLLGILAALMLQQGPVEAFGGSRLCKTGFL--EDVYHASVYRSVHEGQPLLNVMFTDCGTDRRIQYETSNPTDFRIDGDGIVFASRTFDISPEQAEFLVYAQDEDTRELWHVTVKITLRPPHEHHSHQG------------FHKVREIKFSTQRNSNG--LQRQKRDWVIPPINVPENARGTFPQELVRIRSDRDKNLS-LRYSVTGPGADQPPIGVFIINPIGGQLSVTKPLDREQIANFHLRAHAVD-VNGNQVENPIDIVINVIDMNDNRPEFLHQIWNGSIPEGSKPGTYVMTVTAIDGDD-PKQPNGMLRYKILSQTPAISSPNMFTINNETGDIITLAAG--LDREKVQ--RYTLIIQATDMEGNPTYGLSNTATAVIAVTDVNDNPPEFTAMTFYGEVPENR-VDVVVANLTVTDKDQPHTPAWNAVYRIVGGDGTGRFAIKTDANSNDGLVTVVKPIDYETKSTYILTVVAEN-QVDLIRGIQFKPE---STATVSVTVIDVNENPYFTPNPKLIRQEEGLFAS----KMLTTFSAQDPDRYMQQT-IRYSKLSDPANWLKIDPVN-GLITTTAVLDRE-SMYVKNNMYNATFLATDSGIPP----MSGTGTLQIYLLDIND---------NAPYVY-PQEVEICERP-----------------------------------------DPNAINITALDADI-------NPN----------------------------------SGPFIFELPYS-PMDIKN-WTVTRLSGDHAQLSLK-----IGSLDYGIYNIPIHITDSGNPAMSNTSYLRVKVCSCEH-EYCST-------TAPI------------IGTGLGTGAIIA----------------ILLCIIILLTLVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTMEPDTIKPVG-IRRMDERP-I---------HAEPQYPIRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGG  
 CAD5_PIG              ---------------------------------------------------------------MQVLVMLLAAAGTYLGLLT------APTAASN-----------------------------------------PGRQDT----------------------------------------PSTLPLHRRQKRDWIWNQMHIDEEKNGSLPHYVGKIKSSVNHKN--TKYQLKGESAG----KVFRVDENTGDVYAFERLDREKIPEYQLVALVVDKNTEKNLESPSSFTIKVHDINDNWPVFTQLVFNASVPEMSVIGTSVIQLTAVDADDPTVADHASVIYRLKEGEE------HFRIR-GPGLIETASKN--LDRETVP--MYKIVVETQDAQG--LRGDSGTATVFITLQDVNDNFPVFTQTRYTFSVPEDIRVGSPLGSLFVKDPDEPQNR--KTKYSIVQGEYRDTFTIEPDPTRNEGIIKPMKPLDYERIQQYSFTIEATDPTIDLRYLSGTSTK---NIARVIINVTDVDEPPNFKQPFYHFQLRENEKK-----PWIGSVLAVDPDAAQRSIGYSIRRTSDKGQFFGINKH--GNIYNVKELDRE-----VYPWYNLTVEAKELDSRGTPTGKESIVQVHIEVLDEND---------NAPEFAKPYEAKVCED---------------------------------------APQGKLVVQISAIDKDV-------TPR----------------------------------DVKFKFSLST--EDS---NFTLTDNHDNTANITVK--HGYFDRERAKVHHLPILISDNGRPSLTGTSTLHVTVCKCNERGEFTLC------EEMG------------AQVGVSIQALVA----------------IFLCILTIAVISLLVYLRRR-------------------LR----KQARAHGKSVPEIH---EQLVTYDEEG----GGEMDTT--------SYDVSVLNSV----RHGGAKPPRPA-----LDARPSL---------YAQVQKPPRHAPG-----------------------------------AH-APGEMAAMIEVKKDEADH-------------------------------DGGGPP-YDTLHIFGYEGAESIAESLSSLGTDSSDSDIDYDFLNDWGPRFKMLAELYGSDPREELLY  
 CAD5_HUMAN            ---------------------------------------------------------------MQRLMMLLATSGACLGLLA------VAAVAAAGAN--------------------------------------PAQRDT----------------------------------------HSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKN--AKYLLKGEYVG----KVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE------YFAID-NSGRIITITKS--LDREKQA--RYEIVVEARDAQG--LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNR--MTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAG---NRAQVIINITDVDEPPIFQQPFYHFQLKENQKK-----PLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKK--GDIYNEKELDRE-----VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDEND---------NAPEFAKPYQPKVCEN---------------------------------------AVHGQLVLQISAIDKDI-------TPR----------------------------------NVKFKFTLNT--EN----NFTLTDNHDNTANITVK--YGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFC------EDMA------------AQVGVSIQAVVA----------------ILLCILTITVITLLIFLRRR-------------------LR----KQARAHGKSVPEIH---EQLVTYDEEG----GGEMDTT--------SYDVSVLNSV----RRGGAKPPRPA-----LDARPSL---------YAQVQKPPRHAPG-----------------------------------AHGGPGEMAAMIEVKKDEADH-------------------------------DGDGPP-YDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY  
 CAD2_MOUSE            ------MCRIAGG----------RGTLLP-----LLAALLQASVEASGEIALCKTGFP--EDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKE------------PHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLS-LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVD-INGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADD-PNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAG--LDREKVQ--QYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENR-VDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAEN-QVPLAKGIQHPPQ---STATVSVTVIDVNENPYFAPNPKIIRQEEGLHAG----TMLTTLTAQDPDRYMQQN-IRYTKLSDPANWLKIDPVN-GQITTIAVLDRE-SPYVQNNIYNATFLASDNGIPP----MSGTGTLQIYLLDIND---------NAPQVL-PQEAETCETP-----------------------------------------EPNSINIAALDYDI-------DPN----------------------------------AGPFAFDLPLS-PVTIKRNWTINRLNGDFAQLNLK-----IKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTD-------VDRI------------VGAGLGTGAIIA----------------ILLCIIILLILVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTVEPDAIKPVG-IRRLDERP-I---------HAEPQYPVRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGG  
 CADF_XENLA            -MGSTRLRNASVWL-------CGLLCLLQVVP------S----INADVSG--CKPGFS-SAEYIFSVNRRELERGRKLGKVNFSDCTTRKHGLYDVGD-SRFRVLPDGTVLVKRHVKLH-KDTKFTISTWDARGIKHSTNIAVASKRHRSGEEAHSR------------SSKLP----VLTFPETHTGLKRKKRDWVIPPIKVSENERGPFPKRLVQIKSNKDRFNK-VYYSITGQGADNPPQGVFRIEWETGWMLVTRPLDREEYDKYVLSSHAVS-ENGSPVEEPMEITINVIDQNDNRPKFTQDVFRGSVREGVQPGTQVMAVSATDEDDNIDSLNGVLSYSILKQDPEEPIPNLFTINRETGVISLIGTG--LDREKFP--EYTLTVQATDLEG---AGLSVEGKAIIQITDANDNAPIFDPKTYTALVPENE-IGFEVQRLSVTDLDMPGTPAWQAVYKIRVNE-GGFFNITTDPESNQGILTTAKGLDFELRKQYVLQITVEN-AEPFSVPLPT------STATVTVTVEDVNEAPFFVPAVSRVDVSEDLSRG----EKIISLVAQDPDKQQIQK-LSYFIGNDPARWLTVNKDN-GIVTGNGNLDRESE-YVKNNTYTVIMLVTDDGVSV----GTGTGTLILHVLDVND---------NGPVPS-PRVFTMCDQN------------------------------------------PEPQVLTISDADI-------PPN----------------------------------TYPYKVSLSH----GSDLTWKAELDSK-GTSMLLS--P--TQQLKKGDYSIYVLLSDAQN--NPQLTVVNATVCSCEGKAIK---------CQEK------------LVGGFDLPIILV----------------ILGSVLALLILFLLLLLFLK-------------------RK---KVVKEPLLLPEDDTR---DNIFYYGEEG----GGEEDQ---------DYDLSQLHR---------GLDSRPD--IMRNDVVPTL---------MPAPHYRPRP--------------------------------------SNPDE--IGNFIDENLDAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSEAASLSSLNSSNSNDEHDYNYLSDWGSRFRKLADMYGGDDDEE  
 CAD4_MOUSE            ------MTTGSVL----------PLLLLGLSG------ALRAHREDLTVREACKAGFS--EEGYTALISPNVLEGEKLLKVEFSSCVGTKGMQYETNS-LDFKVGADGTVFATRELKIPSEQVAFTVTARERQSAEQWAAMVRLLVAQTSSAHSEHK--KGQ-TVALDPSQPPNDTLLPWPQHQSSGGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIP-IRYSITGVGADQPPMEVFNIDSMSGRMYVTRPMDREERASYHLRAHAVD-MNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADD-STTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAG--LDREKVQ--QYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTSTFAGEVPENR-IETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSN-QAPLASGIQMSFQ---STAGVTISVTDVNEAPYFPSNHKLIRLEEGVPAG----TALTTFSAVDPDRFMQQA-VRYSKLSDPANWLHINTSN-GQITTAAILDRE-SLYTKNNVYEATFLAADNGIPP----ASGTGTLQIYLIDIND---------NAPQLL-PKEAQICERP-----------------------------------------GLNAINITAADADM-------DPN----------------------------------IGPYVFELPFI-PTTVRKNWTITRLNGDYAQLSLR-----ILYLEAGVYDVPIIVTDSGNPPLSNTSVIKVKVCPCDENGDCTT-------VGAV------------AAAGLGTGAIVA----------------ILICIVILLIMVLLFVVWMK-------------------RREKERHTKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----EAMEHVLSKTPG-VRRVDERP-V---------GAEPQYPVRP--------------------------------------VVPHPGDIGDFINEGLRAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSVSSLNSSSSG-DQDYDYLNDWGPRFKKLADMYGGGE  
 DSG1_HUMAN            --------------------------------------------------------------MDWSFFRVVAVLFIFLVVVEVNSEFRIQVRDYNTKN-----------------------------------------------------------------------------------GTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQ-VTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADE-PNNLNSKIAFKIIRQEPS--DSPMFIINRNTGEIRTMNNF--LDREQYG--QYALAVRGSDRDGGA-DGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRN-KAEFHHSIMSQYK--LKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS----NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRT-GKLTLKNKVTKE-QYNMLGGKYQGTILSIDDNLQR-----TCTGTININIQSFGN---------DDRTNTEPNTKITTNTGR------------------------------------QESTSSTNYDTSTTSTDSSQVYSSEPGN-----------------------GAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRS--AAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYG---------GREMQDLGGGERMTG----------FELTEGVKTSGMPEICQEY-SGTLRR-----NSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEG---VGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK  
 CAD1_MOUSE            ------MGARCRS-------FSALLLLLQVSS------W----LCQELEPESCSPGFS-SEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSED-SRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRD------------PASESNPELLMFPSVYPG-LRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETK-VFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVS-SNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSG--LDRESYP--TYTLVVQAADLQG---EGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENE-VNARIATLKVTDDDAPNTPAWKAVYTVVN-DPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVEN-EEPFEGSLVP------STATVTVDVVDVNEAPIFMPAERRVEVPEDFGVG----QEITSYTAREPDTFMDQK-ITYRIWRDTANWLEINPET-GAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPI----ATGTGTLLLVLLDVND---------NAPIPE-PRNMQFCQRN------------------------------------------PQPHIITILDPDL-------PPN----------------------------------TSPFTAELTH----GASVNWTIEYNDAAQESLILQ--P--RKDLEIGEYKIHLKLADNQN--KDQVTTLDVHVCDCEGTVNNCM-------KAGI------------VAAGLQVPAILG----------------ILGGILALLILILLLLLFLR-------------------RR---TVVKEPLLPPDDDTR---DNVYYYDEEG----GGEEDQ---------DFDLSQLHR---------GLDARPE--VTRNDVAPTL---------MSVPQYRPRP--------------------------------------ANPDE--IGNFIDENLKAADS-------------------------------DPTAPP-YDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGE  
 CAD1_CHICK            ------MGRRWGSPALQRFPVLVLLLLLQVCG------R----RCDEAAP--CQPGFA-AETFSFSVPQDSVAAGRELGRVSFAACSGRPWAVYVPTD-TRFKVNGDGVVSTKRPLTLYGRKISFTIYAQDAMGKRHSARVTVG--RHRHRRHHHNH------------HLQDTTPAVLTFPKHDPGFLRRQKRDWVIPPISCLENHRGPYPMRLVQIKSNKDKESK-VYYSITGQGADSPPVGIFIIERETGWLEVTEQLDREKIDRYTLLSHAVS-ASGQPVEDPMEIIITVMDQNDNKPVFIKEVFVGYIEENAKPGTSVMTVNATDADDAVNTDNGIVSYSIVSQQPPRPHPQMFTIDPAKGIISVLGTG--LDRETTP--NYTLIVQATDQEG---KGLSNTATAIIEVTDANDNIPIFNPTMYEGVVEENK-PGTEVARLTVTDQDAPGSPAWQAVYHIKSGNLDGAFSIITDPSTNNGILKTAKGLDYETKSRYDLVVTVEN-KVPLSVPITL------STASVLVTVLDVNEPPVFVPPIKRVGVPEDLPVG----QQVTSYTAQDPDRDMRQK-ITYRMGSDPAGWLYIHPEN-GIVTATQPLDRE-SVHAINSTYKAIILAVDNGIPD----TTGTGTLLLLLQDVND---------NGPTPE-PRSFEICSRQ------------------------------------------PEKQILSIVDKDL-------PPH----------------------------------TYPFKAALEH----GSSNNWTVEIRG--QDELAMG--L--KKELEPGEYNIFVKLTDSQG--KAQVTQVKAQVCECEGTAKNCE-------RRSY------------IVGGLGVPAILG----------------ILGGILALLILLLLLLLFAR-------------------RR---KVEKEPLLPPEDDMR---DNVYNYDEEG----GGEEDQ---------DYDLSQLHR---------GLDARPE--VIRNDVAPPL---------MAAPQYRPRP--------------------------------------ANPDE--IGNFIDENLKAADT-------------------------------DPTAPP-YDSLLVFDYEGGGSEATSLSSLNSSASDQDQDYDYLNEWGNRFKKLAELYGGGEDDE  
 CADB_CHICK            -------------------------------------------------------MKE-----DNCLHAALICLGMLYYSHAITTEK-LNHVRPSLHG--------------------------------------HHEK------------------------------------------GKEGQVLHRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAG----IIFVIDDKSGNIHATKTLDREERAQYTLTAQAVDRNTNRPLEPPSEFIVKVQDINDNPPEFLHENYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP------YFSVEAQTGIIRTALPN--MDREAKE--EYHVVIQAKDMGG-HMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENG--LVAYSIIDGDGMDMFEITTDYETQEGVVKLKKVLDFETKKSYSLKVEAANVHIDPKFISNGPFK---DTVTVKITVEDADEPPVFLKPSYIFEVQENAASG----TVVGKVHAKDPDAANSAIRYSIDRHTDLERYFTINADD-GNIKTIKALDRE-----EIAWHNISVFAVEVHKQH----QEAKVPVAIKVVDVND---------NAPKFAAAYEAFVCEN---------------------------------------ARSNQQFITISADDKDD-------SAN----------------------------------GPRFIFSLPP--EIIHNPNFSLRDNRDNTASVLVR--REGFSRQKQDLYLLPIVISDGGLPPMSSTNTLTIRVCGCDSNGSLLSCNA----EAYI------------LNAGLSTGALIA----------------ILACIVILLVIVVLFVTLKR-------------------QK----KEP-LIVFEEEDVR---ENIITYDDEG----GGEEDTE--------AFDIATLQNP----DGINGFIPR-------KDIKP-------------EYQYMPRPGLR-----------------------------------PAPNSVDVDDFINTRIQEADN-------------------------------DPTAPP-YDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS  
 DSC3_HUMAN            ------------------------MAAAGPRR-----SVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDP--DFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSK----------------------------TRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYT-VFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYAST-ADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDE-PDTMHTRLKYSILQQTPR--SPGLFSVHPSTGVITTVSHY--LDREVVD--KYSLIMKVQDMDG-QFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNN-EAPFARDIP-RVT-ALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG----SKINGYKAYDPENRNGNG-LRYKKLHDPKGWITIDEIS-GSIITSKILDREVET-PKNELYNITVLAIDKDDRS------CTGTLAVNIEDVND---------NPPEIL-QEYVVICKPK------------------------------------------MGYTDILAVDPDE-------PVH----------------------------------GAPFYFSLPNT-SPEISRLWSLTKVNDTAARLSYQ------KNAGFQEYTIPITVKDRAG--QAATKLLRVNLCECTHPTQCRATSR----S---------------TGVILGKWAILA----------------ILLGIALLFSVLLTLVCGVF-------------------GAT------KGKRFPEDLAQ---QNLIISNTEA----PGDDRVC--------SANGFMTQTTNNSSQGFCGTMGSGMK-NGGQETIEMM---------KGGNQTLESCRGAG-HHHTLDSCR------------GGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQ-------------------------------NEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEE--DGLDFLNNLEPKFITLAEACTK  
 CAD2_HUMAN            ------MCRIAGA----------LRTLLP-----LLLALLQASVEASGEIALCKTGFP--EDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKE------------SAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLS-LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVD-INGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADD-PNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAG--LDREKVQ--QYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENR-VDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAEN-QVPLAKGIQHPPQ---STATVSVTVIDVNENPYFAPNPKIIRQEEGLHAG----TMLTTFTAQDPDRYMQQN-IRYTKLSDPANWLKIDPVN-GQITTIAVLDRE-SPNVKNNIYNATFLASDNGIPP----MSGTGTLQIYLLDIND---------NAPQVL-PQEAETCETP-----------------------------------------DPNSINITALDYDI-------DPN----------------------------------AGPFAFDLPLS-PVTIKRNWTITRLNGDFAQLNLK-----IKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTD-------VDRI------------VGAGLGTGAIIA----------------ILLCIIILLILVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTVEPDAIKPVG-IRRMDERP-I---------HAEPQYPVRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGG  
 CAD4_CHICK            ------MRTGSRL----------LLVLLVWG-------SAAALNGDLTVRPTCKPGFS--EEDYTAFVSQNIMEGQKLLKVKFNNCAGNKGVRYETNS-LDFKVRADGTMYAVHQVQMASKQLILMVTAWDPQTLGRWEAIVRFLVGEK-LQHNGHKP-KGRKSGPVDLAQQQSDTLLPWRQHQSAKGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDKEIH-IRYSITGVGADQPPMEVFSIDPVSGRMYVTRPMDREERASYHLRAHAVD-MNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADD-STTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAG--LDREKVQ--QYMVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTSTYSGEVPENR-VEVVVANLTVMDRDQPHSPNWNAIYRIISGDPSGHFTIRTDPVTNEGMVTVVKAVDYEMNRAFMLTVMVSN-QAPLASGIQMSFQ---STAGVTISVTDVNEAPYFPTNHKLIRLEEGVPTG----TVLTTFSAVDPDRFMQQA-VRYSKLSDPANWLNINATN-GQITTAAVLDRE-SDYIKNNVYEATFLAADNGIPP----ASGTGTLQIYLIDIND---------NAPELL-PKEAQICEKP-----------------------------------------NLNVINITAADADI-------DPN----------------------------------VGPFVFELPSV-PSAVRKNWTITRLNGDYAQLSLR-----IMYLEAGVYDVPIIVTDSGNPPLYNTSIIKVKVCPCDENGDCTT-------IGAV------------AAAGLGTGAIIA----------------ILICIIILLTMVLLFVVWMK-------------------RREKERHTKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----ETMDHVLNKAPG-VRRVDERP-I---------GAEPQYPIRP--------------------------------------VIPHPGDIGDFINEGLRAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSVSSLNSSSSG-DQDYDYLNDWGPRFKKLADMYGGGE  
 CAD1_XENLA            ------MGLKRPW-------LLGAVVLLTLIQ------V----QGGLAEWTQCRMGFS-KEKYSFLVPKN-LETDKALGRVIFNSCEGPVRIQFASKD-PNFEIHKDGTVYIKNPAKMKDNRKTFRVLAWETKGHVYSTNITLKREGHRHRQDLFSG------------KHS-------HHPKSETG-LKRQKRDWVIPPIIVSENEKGPFPKRIVQIKSSYAKEVK-VYYSITGQGADTPPEGVFAIGREDGWLNVTRPLDREAIDNYVLFSHAVS-SNGANVEDPMEIIIKVQDQNDNDPVFTQSVFEGSVPEGSKPGTAVMTVSATDADDSVDMYNGVITYSILNQEPKEPTNKMFTIHSESGLISVLTTG--LDREKNP--VYTLTIQAADGEFG--KDRTTTATALIVVMDTNDNPPVFDPTQYTAKVPENE-VGYEVARLTVTDEDIEGTDAWNAVYKIIKGNEANYFSIQTDTG-NIGLLKTVKGLDYELKKQYILSVIVTN-KANFSVPLQT------STATVTVSVEDVNEAPIFLPPVKEVSVSEDLPSG----QVVATYTAQDPDKEQNQK-ITYVIGNDPAGWVSVNKDN-GIVTGNGNLDRE-SKFVLNNTYKVIILAADSGSPS----ATGTGTLVLNLLDVND---------NGPFLE-PQQESFCQKD------------------------------------------PGFRVFTIIDRDL-------SPN----------------------------------TYPYKAELTG----ESNENWTAIVTG--QSILELR--P--KKELEIGQYDVMITLLDSFG--LSNVTKLHITICQCDGDKMQCE-------EKAA------------IAGGLGISAIVG----------------ILGGILALLLLLLLLLLFVR-------------------RK---KVVKEPLLPPEDETR---DNVFSYDEEG----GGEEDQ---------DFDLSQLHR---------GLDARPD--VIRNDVAP-V---------LAAPQYRPRP--------------------------------------ANPDE--IGNFIDENLNAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSEAASLSSLNSPNSDLDQDYSALNDWGPRFTKLADMYGG  
 CAD8_MOUSE            -------------------------------------------------------MPERLAETLMDLWTPLIILWITLPSCVYTAPMNQAHVLTTGSP--------------------------------------LELSRQ----------------------------------------SEDMRILSRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAIIKTALPN--MDREAKE--EYLVVIQAIDMGG-HSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFK---DTATVKIVVEDADEPPVFSSPTYLLEVHENAALN----SVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADD-GKITLATPLDRE-----LSVWHNITIIATEIRNHS----QISRVPVAIKVLDVND---------NAPEFASEYEAFLCEN---------------------------------------GKPGQVIQTVSAMDKDD-------PKN----------------------------------GHFFLYSLLP--EMVNNPNFTIKKNEDNSLSILAK--HNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNV----EAYV------------LPIGLSMGALIA----------------ILACIILLLVIVVLFVTLRR-------------------HK----NEP-LIIKDDEDVR---ENIIRYDDEG----GGEEDTE--------AFDIATLQNP----DGINGFLPR-------KDIKP-------------DLQFMPRQGLA-----------------------------------PVPNGVDVDEFINVRLHEADN-------------------------------DPTAPP-YDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET  
 CAD3_MOUSE            ------MELLSGPH-------AFLLLLLQVCW------L----RSVVSEP--YRAGFIGEAGVTLEVEGTDLEPSQVLGKVALAGQG-----------------------------------------------MHHADNGDIIMLTRGTVQGGKDA------------MHS----------PPTRI-LRRRKREWVMPPIFVPENGKGPFPQRLNQLKSNKDRGTK-IFYSITGPGADSPPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVS-ENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLEGVMPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSG--LDREKVP--EYRLTVQATDMDG---EGSTTTAEAVVQILDANDNAPEFEPQKYEAWVPENE-VGHEVQRLTVTDLDVPNWPAWRATYHIVGGDDGDHFTITTHPETNQGVLTTKKGLDFEAQDQHTLYVEVTN-EAPFAVKLPT------ATATVVVHVKDVNEAPVFVPPSKVIEAQEGISIG----ELVCIYTAQDPDKE-DQK-ISYTISRDPANWLAVDPDS-GQITAAGILDREDEQFVKNNVYEVMVLATDSGNPP----TTGTGTLLLTLTDIND---------HGPIPE-PRQIIICNQS------------------------------------------PVPQVLNITDKDL-------SPN----------------------------------SSPFQAQLTH----DSDIYWMAEVSEK-GDTVALS--L--KKFLKQDTYDLHLSLSDHGN--REQLTMIRATVCDCHGQVFND--------CPRP------------WKGGFILP--------------------ILGAVLALLTLLLALLLLVR-------------------KK---RKVKEPLLLPEDDTR---DNVFYYGEEG----GGEEDQ---------DYDITQLHR---------GLEARPEV-VLRNDVVPTF---------IPTPMYRPRP--------------------------------------ANPDE--IGNFIIENLKPANT-------------------------------DPTAPP-YDSLMVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYGGGE  
 DSC3_BOVIN            ------------------------MAAPGSG------APCAELCRQLLLTLVVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSVDRIQSSDP--DFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTEKRTQKEILVLLEYQKKVLK----------------------------KRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYT-IFYSISGRGVDKEPLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYAST-ADGYSADFPLPLPIRVEDENDNHPIFTEAVYNFEVPESSRVGTTVGVVCATDRDE-PDTMHTRLKYSILEQTPR--SPGLFSVHPSTGVITTVSHY--LDREVAD--KYSLIMKVQDMDG-QFFGLMSTATCIITVKDSNDNLPTFRQNAYEASVEENT-VNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVKPLDYEESHQVVLEIGVAN-EAPFTRDVALRMT-TMNRAVVTVHVKDQDEGPECSPEVQYIRIKENSAVG----SKISGYKAYDPETKSSSG-LRYKILHDPKEWITVNEGS-GSLETYKTLDREVIT-PKNDLYNITVLAIDQDGRS------CTGTLAVSIEDVND---------NPPEIL-QDYLVICKGN------------------------------------------MDYVDISAIDHDS-------SIN----------------------------------GAPFYFSLANT-SPEINRLWTITRVNDTAARLAYQ------KNAQFQEYFIPVAVKDRAG--LSATKTLRVNLCDCTNPVQCRAARR----S---------------ADVILGKWAILA----------------ILLGIALLFSILLTLVCGIV-------------------SAR------NKKAFPDDLAQ---QNLIISNTEA----PGDDKVC--------SANGFMTQTVNNANQGFCGTMGSGVK-NGGQESIEMV---------KGGQQTLESCRGAG-HHHTLDSCR------------GGTIEVENSRYTYSEWQNFTQPRLGEKLHLCNQ-------------------------------DEEHMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEE--DGLDFLNNLEAKFAALAKTCTK  
 CAD6_MOUSE            -------------------------------------------------------------MRTYRYFLLLFWVGQPYPTFS--NPLSKRTSGFPAKR--------------------------------------KALELS----------------------------------------ADSRNELSRSKRGWMWNQFFLLEGYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLFIINEHTGDIQATKRLDREEKPVYILRAQAVNRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIKTALLN--MDRENRE--QYQVVIQAKDMGG-QMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGHEMFDVITDQETQEGIITVKKLLDFEKKKVYTLRWKASNPHVEPRFLYLGPFK---DSATVRIVVDDVDEPPVFSKLAYILQIREDARIN----TTIVSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGN-GSIFTSKLLDRE-----TLLWHNITVIATEIKNPK----QSSRVPLYIKVLDVND---------NAPEFAEFYETFVCEK---------------------------------------AKADQLIQTLRAVDKDD-------PYS----------------------------------GHQFSFSLAP--EAASSSNFTIQDNKDNTAGILTR--KNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNIESCHA----EALI------------HPTGLSSGALVA----------------ILLCIVILLVTVVLFAALRR-------------------QE----KKE-PLIISKEDIR---DNIVSYNDEG----GGEEDTQ--------AFDIGTLRNP----EAMEDSKSR-------RDIVP-------------EALFLPRR-TP-----------------------------------TARDNTDVRDFINQRLKENDT-------------------------------DPTAPP-YDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKVADMYGGMDSDKDS  
 DSG3_HUMAN            --------------------------------------------------------------MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEE-----------------------------------------------------------------------------------EMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQK-ITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALN-AQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADE-PNHLNSKIAFKIVSQEPA--GTPMFLLSRNTGEVRTLTNS--LDREQAS--SYRLVVSGADKDG---EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENI-LSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKN-KAEFHQSVISRYR--VQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKT-AEIKFVKNMNRD-STFIVNKTITAEVLAIDEYTGK-----TSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNIC--VPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVD--GEGKEVQPPS------KDSGYGIESCGHPIEVQQTGFVKCQTLSGS-QG--------------------ASALSASGSVQPAVSIPDP-----------------------------LQHG-NYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI-  
 CADF_HUMAN            --------------------------------------------------------------MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYP---------------------------------------------------------------------------------------WRRAPALSRVRRAWVIPPISVSENHKR-LPYPLVQIKSDKQQLGS-VIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALD-LGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADD-PETDNAALRFSILQQGS----PELFSIDELTGEIRTVQVG--LDREVVA--VYNLTLQVADMSG---DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV-SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQN-EAPLQAAALRAER---GQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPG----TLVATFSARDPDTEQLQR-LSYSKDYDPEDWLQVDAAT-GRIQTQHVLSPA-SPFLKGGWYRAIVLAQDDASQP----RTATGTLSIEILEVND---------HAPVLAPPPPGSLCSEPH----------------------------------------QGPGLLLGATDEDL-------PPH----------------------------------GAPFHFQLSPR-LPELGRNWSLSQVNVSHARLRPR------HQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAA----ALLA------------GGTGLSLGALVI----------------VLASALLLLVLVLLVALRAR-------------------FWK-QSRGKGLLHGPQDDLR---DNVLNYDEQG----GGEEDQD--------AYDISQLRH----PTALSLPLGPPP---LRRDAPQGR---------LHPQPPRVLP--------------------------------------TSPLD--IADFINDGLEAADS-------------------------------DPSVPP-YDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA  
 CAD2_CHICK            ------MCRIAGT----------PPRILPPLALMLLAALQQAPIKATCEDMLCKMGFP--EDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPEDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKETQEEWQMKVKLTPEPAFTGASEKD------------QKKIEDIIFPWQQYKDSSHLKRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKSLS-LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIASFHLRAHAVD-VNGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADD-PNAQNGMLRYRILSQAPSSPSPNMFTINNETGDIITVAAG--LDREKVQ--QYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENR-VDVIVANLTVTDKDQPHTPAWNARYQMTGGDPTGQFTILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAEN-QVPLAKGIQHPPQ---STATVSITVIDVNESPYFVPNPKLVRQEEGLLAG----SMLTTFTARDPDRYMQQTSLRYSKLSDPANWLKIDPVN-GQITTTAVLDRE-SIYVQNNMYNATFLASDNGIPP----MSGTGTLQIYLLDIND---------NAPQVN-PKEATTCETL-----------------------------------------QPNAINITAVDPDI-------DPN----------------------------------AGPFAFELPDS-PPSIKRNWTIVRISGDHAQLSLR-----IRFLEAGIYDVPIVITDSGNPHASSTSVLKVKVCQCDINGDCTD-------VDRI------------VGAGLGTGAIIA----------------ILLCIIILLILVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTVEPDAIKPVG-IRRLDERP-I---------HAEPQYPVRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGG  
 CADF_MOUSE            --------------------------------------------------------------MGSALLLALGLLAQSLGLSWAVP-EPEPSTLYP---------------------------------------------------------------------------------------WRRASAPGRVRRAWVIPPISVSENHKR-LPYPLVQIKSDKQQLGS-VIYSIQGPGVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALD-LGGSTLEDPTDLEIVVVDQNDNRPAFLQDVFRGHILEGAIPGTFVTRAEATDADD-PETDNAALRFSILEQGS----PEFFSIDEHTGEIRTVQVG--LDREVVA--VYNLTLQVADMSG---DGLTATASAIISIDDINDNAPEFTKDEFFMEAAEAV-SGVDVGRLEVEDKDLPGSPNWVARFTILEGDPDGQFKIYTDPKTNEGVLSVVKPLDYESREQYELRVSVQN-EAPLQAAAPRARR---GQTRVSVWVQDTNEAPVFPENPLRTSIAEGAPPG----TSVATFSARDPDTEQLQR-ISYSKDYDPEDWLQVDGAT-GRIQTQRVLSPA-SPFLKDGWYRAIILALDNAIPP----STATGTLSIEILEVND---------HAPALALPPSGSLCSEPD----------------------------------------QGPGLLLGATDEDL-------PPH----------------------------------GAPFHFQLNPR-VPDLGRNWSVSQINVSHARLRLR------HQVSEGLHRLSLLLQDSGEPPQQREQTLNVTVCRCGSDGTCLPGAA----ALRG------------GGVGVSLGALVI----------------VLASTVVLLVLILFAALRTR-------------------FRG-HSRGKSLLHGLQEDLR---DNILNYDEQG----GGEEDQD--------AYDINQLRHPVE-PRATSRSLGRPP---LRRDAPFS----------YVPQPHRVLP--------------------------------------TSPSD--IANFISDGLEAADS-------------------------------DPSVPP-YDTALIYDYEGDGSVAGTLSSILSSLGDEDQDYDYLRDWGPRFARLADMYGH  
 CAD3_HUMAN            ------MGLPRGP--------LASLLLLQVCW------L----QCAASEP--CRAVFR-EAEVTLEAGGAEQEPGQALGKVFMGCPGQEPA-------------------------------------------LFSTDNDDFTVRNGETVQERRSL------------KERNP----LKIFPSKRI-LRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTK-IFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVS-ENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSG--LDREKVP--EYTLTIQATDMDG---DGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENA-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTN-EAPFVLKLPT------STATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTG----EPVCVYTAEDPDKE-NQK-ISYRILRDPAGWLAMDPDS-GQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPP----TTGTGTLLLTLIDVND---------HGPVPE-PRQITICNQS------------------------------------------PVRHVLNITDKDL-------SPH----------------------------------TSPFQAQLTD----DSDIYWTAEVNEE-GDTVVLS--L--KKFLKQDTYDVHLSLSDHGN--KEQLTVIRATVCDCHGHVET---------CPGP------------WKGGFILP--------------------VLGAVLALLFLLLVLLLLVR-------------------KK---RKIKEPLLLPEDDTR---DNVFYYGEEG----GGEEDQ---------DYDITQLHR---------GLEARPEV-VLRNDVAPTI---------IPTPMYRPRP--------------------------------------ANPDE--IGNFIIENLKAANT-------------------------------DPTAPP-YDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGE  
 CADB_MOUSE            -------------------------------------------------------MKE-----NYCLQAALVCLSMLYHSQAFALER-RSHLHPSFHG--------------------------------------HHEK------------------------------------------GKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAG----TIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHEIYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP------YFSVEAQTGIIRTALPN--MDREAKE--EYHVVIQAKDMGG-HMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENG--LVTYNIVDGDGIELFEITTDYETQDGVVKLKKPVDFETKRAYSLKIEAANVHIDPKFISNGPFK---DTVTVKISVEDADEPPMFLAPSYIHEVQENAAAG----TVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPED-GFIKTTKPLDRE-----ETAWLNISVFAAEIHNRH----QETKVPVAIRVLDVND---------NAPKFAAPYEGFICESDHP-----------------------------------KALSNQPIVTVSADDQDD-------TAN----------------------------------GPRFIFSLPP--EIMHNPNFTVRDNRDNTAGVYAR--RGGFSRQKQDFYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNA----EAYI------------LNAGLSTGALIA----------------ILACIVILLVIVVLFVTLRR-------------------QK----KEP-LIVFEEEDVR---ENIITYDDEG----GGEEDTE--------AFDIATLQNP----DGINGFIPR-------KDIKP-------------EYQYMPRPGLR-----------------------------------PAPNSVDVDDFINTRIQEADN-------------------------------DPTAPP-YDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS  
 DSC1_BOVIN            --------------------------MAVASA-----APGSIFWKQLLFSLLVLILFCDACQKISLQVPSHLRAEALVGKVNLKECLQSASLILSSDP--DFRILEDGSIYTTHDLVLSS-GKSFSILLSDSQGQGQKEIEIILEAGGKKVP----------------------------KRHMKDAVLRRTKRRWAPIPCSLMENSLGPFPQHVQQVQSDAAQNYT-IFYSISGPGVDKEPFNLFFIEKDTGDIFCTRSIDREQYQEFPIYAYATT-ADGYAPEYPLPLVFKVEDDNDNAPYFENKLTVFTVPENCRTGTSVGKVTAIDLDE-PDTLHTRLKYKILQQIPN--NPRHFTVHPDTGVITTTTPL--LDREKCD--TYKLIMEVRDMGG-QPFGLFNTGTITISLEDENDNAPYFTETSYTVEVEENR-IDVEILRMAVHDHDLPNTPHSRAVYQILQGNENGTFKISTDPNTNEAVLCVVKPLNYEVNRQVVLQIGVLN-EAQFAKAVNSKTTTTMCTTVVTVKVKDHDEGPECQPPVKVIQSEDCLPTG----TELLGYKAVDPERGTGEG-LRYKKIQDEDNWFEINEYT-GDLKTVKVLDRESTF-VKNNQYNVSVIAFDADGRS------CTGTLVVFLEDKND---------HPPQIK-QEELTICRHD------------------------------------------KDYVVLEPTDQDG-------PDN----------------------------------GPPFQFILDNS----ASKLWTVETRDGKTAILRGR------QDLDYDYYTVPIQIKDRHG--ASATHILPVRVCDCTIPSECRMPSK----LSREA---------ALANVFLGKWAILA----------------MVLGSVLLLCILFTCFCVT---------------------VKK----TVKKCFPEDVAQ---QNLIVSNTEG----PGEEVMD--------ANIRLPTQTSNVCDTSISVGTLGGQG-VKTQQSFEMV---------KGG-YTLDANKGGG--HQTLESVKGVTD---------------TGRYTYSDWHNFTQPRLGEKVYLCGQ-------------------------------DEEHKLCEDYVRSYSYEGKGSVAGSVGCCSDRQEE--EGLDFLDHLEPKFRTLAKTCVK  
 DSC1_HUMAN            --------------------------MALASA-----APGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDP--AFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK---------------------------KRHTKDTALKRTKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYT-IFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDE-PDTLHTRLKYKILQQIPD--HPKHFSIHPDTGVITTTTPF--LDREKCD--TYQLIMEVRDMGG-QPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVIN-EAQFSKAASSQTP-TMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAG----QELLGYKALDPEISSGEG-LRYQKLGDEDNWFEINQHT-GDLRTLKVLDRESKF-VKNNQYNISVVAVDAVGRS------CTGTLVVHLDDYND---------HAPQID-K-EVTICQNN------------------------------------------EDFAVLKPVDPDG-------PEN----------------------------------GPPFQFFLDNS----ASKNWNIEEKDGKTAILRQR------QNLDYNYYSVPIQIKDRHG--LVATHMLTVRVCDCSTPSECRMKDK----STRD----------VRPNVILGRWAILA----------------MVLGSVLLLCILFTCFCVT---------------------AKR----TVKKCFPEDIAQ---QNLIVSNTEG----PGEEVTE--------ANIRLPMQTSNICDTSMSVGTVGGQG-IKTQQSFEMV---------KGG-YTLDSNKGGG--HQTLESVKGVGQG------------D-TGRYAYTDWQSFTQPRLGEKVYLCGQ-------------------------------DEEHKHCEDYVFSYNYEGKGSLAGSVGCCSDRQEE--EGLEFLDHLEPKFRTLAKTCIK  
 CAD5_MOUSE            ---------------------------------------------------------------MQRLTELATALGAFLGLLA------VAAMAGPN----------------------------------------FPQIDT----------------------------------------PNMLPAHHRQKRDWIWNQMHIDEEKNESLPHYVK-DQSNVNRQN--AKYVLQGEFAG----KIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVKGNE------YFSID-NSGLIFTKIKN--LDREKQA--EYKIVVETQDALG--LRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKPLGFLTVVDPDEPQNR--MTKYSIMQGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGK---NKAMVTINVLDVDEPPVFQRHFYHFKLPENQKK-----PLIGTVVAKDPDKAQRSIGYSIRKTSDRGQFFRITKQ--GNIYNEKELDRE-----TYAWYNLTVEANELDSRGNPVGKESIVQVYIEVLDEND---------NPPEFAQPYEPKVCEN---------------------------------------AAQGKLVVQISATDKDV-------VPV----------------------------------NPKFKFALKN--EDS---NFTLINNHDNTANITVK--YGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNEQGEFTFC------EEMA------------AQAGVSIQALVA----------------IFLCILTITVITLLIILRRR-------------------IR----KQAHAHSKSALEIH---EQLVTYDEEG----GGEMDTT--------SYDVSVLNSV----RGGSTKPLRST-----MDARPAV---------YTQVQKPPRLAPG-----------------------------------LHGGPREMATMIDVKKEEADN-------------------------------DGGGPP-YDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII  
 CAD6_RAT              -------------------------------------------------------------MRTYRYFLLLFWVGQPYPTFS--NPLSKRTSGFPAKR--------------------------------------RALELS----------------------------------------ANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIKTALLN--MDRENRE--QYQVVIQAKDMGG-QMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGHDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFK---DSATVRIVVDDVDEPPVFSKPAYILQIREDAQIN----TTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGN-GSIFTSKLLDRE-----TLLWHNITVIATEINNPK----QSSRVPLYIKVLDVND---------NAPEFAEFYETFVCEK---------------------------------------AKADQLIQTLHAVDKDD-------PYS----------------------------------GHQFSFSLAP--EAASGSNFTIQDNKDNTAGILTR--KNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHA----EALI------------HPTGLSTGALVA----------------ILLCIVILLVTVVLFAALRR-------------------QR----KKE-PLIISKEDIR---DNIVSYNDEG----GGEEDTQ--------AFDIGTLRNP----KPWR-QQSR-------RDMVP-------------EALFLPRR-TP-----------------------------------TARDNTDVRDFISQRLRKMNT-------------------------------DPTAPP-YDSLATYAYEGTGSVADSLSSLESVTTDGDQDYGYLSDWGPRFKKLADMYGGMDSDKDS  
 DSC2_HUMAN            ------------------------MEAARPSG-----SWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDP--DFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLK----------------------------KRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYT-IYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATT-PDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDE-PDTMHTRLKYSIIGQVPP--SPTLFSMHPTTGVITTTSSQ--LDRELID--KYQLKIKVQDMDG-QYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENT-VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVN-EAPFSREAS-PRS-AMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVG----TTSNGYKAYDPETRSSSG-IRYKKLTDPTGWVTIDENT-GSIKVFRSLDREAET-IKNGIYNITVLASDQGGRT------CTGTLGIILQDVND---------NSPFIP-KKTVIICKPT------------------------------------------MSSAEIVAVDPDE-------PIH----------------------------------GPPFDFSLESS-TSEVQRMWRLKAINDTAARLSYQ------NDPPFGSYVVPITVRDRLG--MSSVTSLDVTLCDCITENDCTHRVD----PRIG-----------GGGVQLGKWAILA----------------ILLGIALLFCILFTLVCGAS-------------------GTS-----KQPKVIPDDLAQ---QNLIVSNTEA----PGDDKVY--------SANGFTTQTVGASAQGVCGTVGSGIK-NGGQETIEMV---------KGGHQTSESCRGAG-HHHTLDSCR------------GGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQ-------------------------------DENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEE--DGLEFLDNLEPKFRTLAEACMK  
 CADC_HUMAN            -------------------------------------------------------------MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRE--------------------------------------NVIHLP----------------------------------------GQ-RSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP------YFSIDPKTGVIRTALPN--MDREVKE--QYQVLIQAKDMGG-QLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNA--EIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFK---DTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVG----TIIGAVTAQDLDVGSGAVRYFIDWKSDGDSYFTID-GNEGTIATNELLDRE-----STAQYNFSIIASKVSNPL----LTSKVNILINVLDVNE---------FPPEISVPYETAVCEN---------------------------------------AKPGQIIQIVSAADRDL-------SPA----------------------------------GQQFSFRLSP--EAAIKPNFTVRDFRNNTAGIETR--RNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNV----EAIF------------LPVGLSTGALIA----------------ILLCIVILLAIVVLYVALRR-------------------QK----KKH-TLMTSKEDIR---DNVIHYDDEG----GGEEDTQ--------AFDIGALRNP----KVIEENKIR-------RDIKP-------------DSLCLPRQ-RP-----------------------------------PMEDNTDIRDFIHQRLQENDV-------------------------------DPTAPP-IDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT  
 CAD2_BOVIN            --------------------------------------------------SLCKTGFP--EDVYSAVLSRDVLEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHSKFLIYAQDKETQEKWQVAVKLSLKPALPEDSVKE------------SREIEEIVFPRQVTKHNGYLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLS-LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVD-INGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADD-PNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAG--LDREKVQ--QYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENR-VDVIVANLTVTDKDQPHTPAWNAIYRISGGDPAGRFAIQTDPNSNDGLVTVVKPIDFETNRMYVLTVAAEN-QVPLAKGIQHPPQ---STATVSVTVIDVNENPYFAPNPKIIRQEEGLHAG----TVLTTFTAQDPDRYMQQN-IRYTKLSDPANWLKIDSVN-GQITTIAVLDRE-SPNVKANIYNATFLASDNGIPP----MSGTGTLQIYLLDIND---------NAPQVL-PQEAEICETP-----------------------------------------DPNSINITALDYDI-------DPN----------------------------------AGPFAFDLPLS-PVTIKRNWTITRLNGDFAQLNLK-----IKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTD-------VDRI------------VGAGLGTGAIIA----------------ILLCIIILLILVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTVEPDAIKPVG-IRRLDERP-I---------HAEPQYPVRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGG  
 DSC2_MOUSE            ------------------------MAAVGSMR-----SGSPAFGLGHLLTLAILALASDACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIVHLSDP--DFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISVHLEGPVEVLN----------------------------KRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQSDTAQNYT-IYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATT-PDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDE-PDTMHTRLRYSILEQSPS--PPMLFTMHPSTGVITTTSAQ--LDRELID--KYQLLIKVQDMDG-QYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENT-VNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVN-EAPYTREAS-SKS-PMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVG----TRNDGYKAYDPETRSSSG-IRYRKLSDPRGWVTVNEDS-GSITIFRALDREAET-VRNGIYNITVLALDADGRS------CTGTLGIILEDVND---------NGPFIP-KQTVVICKAT------------------------------------------MSSAEIVAVDLDD-------PVN----------------------------------GPPFDFSLESS-DSEVQRMWRLTRINDTAARLSYQ------NDPSFGSYAVPIRVTDRLG--LSSVTTLNVLVCDCITESDCTLRSG----ERTG-----------YADVRLGPWAILA----------------ILLGIALLFCILFTLVCSVS-------------------RAS-----KQQKILPDDLAQ---QNLIVSNTEA----PGDDKVY--------STNGLTTQTMGASGQTAFTTMGTGVK-SGGQETIEMV---------KGGQQTLDSRRGAGYHHHTLDPCR------------GGHVEVDNYRHTYSEWYNFIQPRLGDKVQFCHT-------------------------------DDNQKLAQDYVLTYNYEGKGSAAGSVGCCSDLQEE--DGLEFLDHLEPKFRTLAEVCAK  
 CAD6_HUMAN            -------------------------------------------------------------MRTYRYFLLLFWVGQPYPTLS--TPLSKRTSGFPAKK--------------------------------------RALELS----------------------------------------GNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIKTALLN--MDRENRE--QYQVVIQAKDMGG-QMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFK---DSATVRIVVEDVDEPPVFSKLAYILQIREDAQIN----TTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGN-GSIFTSKLLDRE-----TLLWHNITVIATEINNPK----QSSRVPLYIKVLDVND---------NAPEFAEFYETFVCEK---------------------------------------AKADQLIQTLHAVDKDD-------PYS----------------------------------GHQFSFSLAP--EAASGSNFTIQDNKDNTAGILTR--KNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHA----EALI------------HPTGLSTGALVA----------------ILLCIVILLVTVVLFAALRR-------------------QR----KKE-PLIISKEDIR---DNIVSYNDEG----GGEEDTQ--------AFDIGTLRNP----EAIEDNKLR-------RDIVP-------------EALFLPRR-TP-----------------------------------TARDNTDVRDFINQRLKENDT-------------------------------DPTAPP-YDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSDKDS  
 CADB_HUMAN            -------------------------------------------------------MKE-----NYCLQAALVCLGMLCHSHAFAPER-RGHLRPSFHG--------------------------------------HHEK------------------------------------------GKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAG----TIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP------YFSVEAQTGIIRTALPN--MDREAKE--EYHVVIQAKDMGG-HMGGLSGTTKVTITLTDVNDNPPKFPQRLYQMSVSEAAVPGEEVGRVKAKDPDIGENG--LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETERAYSLKVEAANVHIDPKFISNGPFK---DTVTVKISVEDADEPPMFLAPSYIHEVQENAAAG----TVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPED-GFIKTTKPLDRE-----ETAWLNITVFAAEIHNRH----QEAQVPVAIRVLDVND---------NAPKFAAPYEGFICESDQT-----------------------------------KPLSNQPIVTISADDKDD-------TAN----------------------------------GPRFIFSLPP--EIIHNPNFTVRDNRDNTAGVYAR--RGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNA----EAYI------------LNAGLSTGALIA----------------ILACIVILLVIVVLFVTLRR-------------------QK----KEP-LIVFEEEDVR---ENIITYDDEG----GGEEDTE--------AFDIATLQNP----DGINGFIPR-------KDIKP-------------EYQYMPRPGLR-----------------------------------PAPNSVDVDDFINTRIQEADN-------------------------------DPTAPP-YDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS  
 CADD_CHICK            ------MQHKTQL----------TLSFLLS--------Q--VLLLACAEDLECTPGFQ--QKVFYIEQPFEFTEDQPILNLVFDDCKGNNKLNFEVSN-PDFKVEHDGSLVALKNVSEAGR--ALFVHARSEHAEDMAEILIVG-------------------------ADEKHDALKEIFKIEGNLGIPRQKRAILATPILIPENQRPPFPRSVGKVIRS-EGTEG-AKFRLSGKGVDQDPKGIFRINEISGDVSVTRPLDREAIANYELEVEVTD-LSGKIIDGPVRLDISVIDQNDNRPMFKEGPYVGHVMEGSPTGTTVMRMTAFDADD-PSTDNALLRYNILKQTPTKPSPNMFYIDPEKGDIVTVVSPVLLDRETMETPKYELVIEAKDMGG-HDVGLTGTATATILIDDKNDHPPEFTKKEFQATVKEG--VTGVIVNLTVGDRDDPATGAWRAVYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVEN-EDPLIPDIAYGPS---STATVQITVEDVNEGPVFHPNPMTVTKQENIPIG----SIVLTVNATDPDTLQHQT-IRYSVYKDPASWLEINPTN-GTVATTAVLDRE-SPHVQDNKYTALFLAIDSGNPP----ATGTGTLHITLEDVND---------NVPSLY-PTLAKVCDDAK----------------------------------------DLRVVVLGASDKDL-------HPN----------------------------------TDPFKFELS-K-QSGPEKLWRINKLNNTHAQVVL------LQNLKKANYNIPISVTDSGKPPLTNNTELKLQVCSCKK---SR--------MDCS------------ASDALHISMT-L----------------ILLSLFSLFC  
 DSC1_MOUSE            --------------------------MAVACA-----APGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDP--AFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFR---------------------------KRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYT-IFYSISGPGDDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATT-ADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDE-PGTLHTRLKYKILQQIPD--QPKHFSIHPDTGVITTTTPL--LDREKCD--TYKLVMEVRDMGG-QPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENR-IDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLN-EAQFTNAANAQPP-TMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAG----QELLGYKAVDPETSSGEG-LRYEMVGDEDNWFEINKIT-GDLRTVKVLDRESKF-VKNNQYNISVVATDTAGRS------CTGTLVVLLEDFND---------HPPQID-K-EVTICQQE------------------------------------------KDFAVLEPIDLDG-------PDN----------------------------------GPPFQFLLDNS----SSKLWTLESQDGKRAILRQR------HNLNYNYYSVPIQIQDRHG--FSAKHVLSVRVCDCTTPTECRMAVK----EERD----------AKPNIILGKWAILA----------------MVLGSALLLCILFTCFCVTT--------------------TKR----TVKKCFPDDVAQ---QNLIVSNTEG----PGEEVTE--------ANIRLPTQTANICDTSMSVGTLGGQG-IKTQQSFEMV---------KGG-HTLESHKGG---------VLGAAE---------------PGRYAYTDWQTFTQPRLGEKVYLCGQ-------------------------------AEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEE--EGLEFLDQLEPKFRTLAKTCVK  
 DSC2_BOVIN            ---------------------------------------------------------------------------KFIGRVNLKECFKSATLIHSSDP--DFQILEDGSVYTTHAILLSSEKSSFTILLSNTETQEEKEILVLLEHQTKVLK----------------------------KRHSQEKVLRRAKRRWAPIPCSVPENSLGPFPLFLQQIQSDTAQNYT-IYYSISGPGVDKEPRNLFYVERDTGNLFCTASIDRETYPLFELVAFATT-PDGYTPEYPLTLVIRIEDENDNAPIFTETSYSFEVFENSKVGTTVGQVCATDQDE-PDTLHTRLKYSIIEQFPA--LPTLFSMHPTTGVITTSSSK--LDRELID--KYQLKIKVQDMDG-QYFGLQTTAICIINIEDVNDNLPTFTRSSYVASVEENR-IDVEILRVAVRDKDLINTANWRANYTILKGNEDGNFKIVTDSQTNEGVLCVVKPLNYEEKQQVTLEIGVVN-EAPYTGTS---RS-TTNMATVTVNVQNQDEGPECDPRVQTVRIKENVPVG----TKTIGYKAYDPETGSSSG-IRYKKSSDPEGWVDVDKNS-GVITILKRLDREAR----SGVYNISIIASDKDGRT------CNGVLGIVLEDVND---------NGPVIP-QRTVVICKTV------------------------------------------MSSAEIVAVDPDE-------PIH----------------------------------GPPFDFSLEGVSDSEVLRMWRLTKVNDTAARLSYL------NDLRFGKYTVPVRVTDRLG--QSLVTQLVVILCDCVTPNDCSFRPV----SRTG-----------NREVILGKWAILA----------------ILLGIALLFCILFTLVCGAT-------------------TGAD----KKPKVFPDDLAQ---QNLIVSNTEA----PGDDKVY--------STNDFTTHAVGGSAHGIGGTLGSRVK-NGGQETIEMV---------KGGHQTMESCQETG-HDHTLERCKEGGQHTLDSCR-GGPVATDNCKYTYSEWYTYTQPRLGEKVQQCDQ-------------------------------DNTHMQAQDYVLTYNYEGRGSAAGSVGCCSERQEE--DGLEFLDHLGPKFRTLAETCMK  
 CADO_XENLA            ------MCRKE------------PFLLPTALCILAALVLHQGPVEALGGSRLCKTGFL--EDVYHASVYRSVHEGQPLLNVKFTDCGADRRIHYETSNPTDFRIDGDGIVCASRTFDISPEQAEFLVYAQDEDTRELWHVTVKITLRPRHVQDLHQG------------FHKVREIKFSTQRKHNG--LQRQKRDWVIPPINVPENARGTFPQELVGIRSDRDKSLS-LRYSVTGPGADQPPLGVFIINPISGQLSVTKPLDREQIATFHLRAHAVD-VNGNQVENPIDIVINVIDMNDNRPEFLHQIWNGTIPEGSKPGTYVMTVTAIDGDD-PKQPNGMLRYKILSQTPASSSPNMFTINNETGDIITLAAG--LDREKVQ--RYTLIIQATDMEGNPTYGLSNTATAVIAVTDVNDNPPEFTAMTFYGEVPENR-VDVVVANLTVTDKDQPHTPAWNAVYRIVGGDGTGRFAIKTDANSNDGLVTVVKPIDYETKSTYILTVVAEN-QVELIRGIQYKPE---STATVSVTIIDVNENPYFTPNPKLIRQEEGLFAG----KLLTTFSAQDPDRYMQQT-IRYSKLSDPANWLKIDPVN-GFITTTAVLDRE-SIYVKNNMYNATFLATDSGIPP----MSGTGTLQIYLLDIND---------NAPYVY-PQEVEICDRP-----------------------------------------DPNAINITALDADI-------NPN----------------------------------AGPFIFELPYS-PMDIKKNWTVTRLSGDHAQLSLK-----IGSLDYGIYNIPIQITDSGNPAMSNTSYLRVKVCSCEH-GYCST-------TAPI------------IGTGLGTGAIIA----------------ILLCIIILLTLVLMFVVWMK-------------------RRDKERQAKQLLIDPEDDVR---DNILKYDEEG----GGEEDQ---------DYDLSQLQQP----DTVEPDTIKPVG-IRRMDERP-I---------HAEPQYPIRS--------------------------------------AAPHPGDIGDFINEGLKAADN-------------------------------DPTAPP-YDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGG  
 CADA_CHICK            ------------------------------------------------------------MTIQQVLLLLLLWMWLLHPCRT--EMLFRRTPDLRPKG--------------------------------------FVGRTS----------------------------------------GSDGKALHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAG----TLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARIIYSILQGQP------YFSVEPETGIIRTALPN--MNRENRE--QYQVVIQAKDMGG-QMGGLSGTTTVNITLTDVNDNPPRFPQSTIHLRIPESSPVGTPIGSIKATDADTGKNA--EVEYRIIDGDGTDMFDIVTQRDTQEGIITVRKPLDYETRRLYTLKVEAENTHVDPRFYYLGPFK---DTTIVKISVEDVDEPPVFSRSSYLFEVHEDIELG----TIIGTVMARDPDSASSPIRFSLDRHTDLDRIFNIHSGN-GSIYTSKPLDRE-----ISQWHNLSVIAAEINNLK----DTTRVPVYVRILDVND---------NAPQFAVFYDTFVCEN---------------------------------------ARAGQLIQTISAVDKDD-------PLG----------------------------------GQKFFFSLAA--VNP---NFTVQDNEDNTARILTR--RNGFSRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSRGNMQSCNA----EALL------------LPAGLSTGALIA----------------ILLCIIILLVIVVLFAALKR-------------------QR----KKE-PLILSKEDIR---DNIVSYNDEG----GGEEDTQ--------AFDIGTLRNP----AAIEDKKLR-------RDIIP-------------ETLFVPRR-TP-----------------------------------SAPDNTDVRDFINQRLKEHDS-------------------------------DPSAPP-YDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDAS