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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-----
 Q8SQ42                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKG-YSWSRFSDVEEN--RTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSS-SLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPG-TAYQSFEQVVNELFRDGV-NWGRIVAFFSFGGALCVESVDKEMQVLVS---RIAAWMATYLNDHLEPWIQENGGWD-TFVELYGNNAAAESRKGQER---SNRWFLTG-MTVAGVVLLGSLFSRK--  
 P97287                MFGLRRNAVIGLNLYCGGASLGAGGG---SPAG-ARLVAEEAKARRE-GGGEAALL--------------PGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPE----AIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETL------------------------------------------------------RRVGDGVQRNHETAFQGMLRKLDIKNE-GDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIE---PLAETITDVLVRTKRDWLVKQRGWD-GFVEFFHVQDLEGGI--------RNVLLAF--AGVAGVGAGLAYLIR---  
 BCLW_HUMAN            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATPASA-PDTRALVADFVGYKLRQKG-YVCGAGPGEG----------------------------------------------------PAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPG-SAQQRFTQVSDELFQGGP-NWGRLVAFFVFGAALCAESVNKEMEPLVG---QVQEWMVAYLETRLADWIHSSGGWA-EFTALYGDGALEEARRLREGNWASVRTVLTG-AVALGALVTVGAFFASK-  
 BFL1_MOUSE            -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAESELMHIHSLAEHYLQYVLQVPAFE-----------------------------------------------------SAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEP---------------KSGWLTF--LQMTGQIWEMLFLLK---  
 BCL2_CRILO            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAQAGRTGYDNREIVMKYIHYKLSQRG-YEWDVGDVDAAP--LGAAPTPGIFSFQPESNPTPAVHRDMAARTSPLR---PIVATTGPTLSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPF-TARGRFATVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWD-AFVELYGP----SVRPLFDFSWLSLKTLLS--LALVGACITLGTYLGHK-  
 Q9Z1P3                MFGLRRNAVIGLNLYCGGASLGAGGG---SPAG-TRLAAEEAKARRE-GGGEAALL--------------PGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASAAAIMS-PEEELDGCEPE----VLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYHQSLEIISRYLREQATGSKDAKPLGEAGAAGRRALETL------------------------------------------------------RRVGDGVQRNHETAFQGMLRKLDIKNE-DDVKSFSRVMTHVFKDGVTNWGRIVTLISFGAFVAKHLKSINQESCIE---PLAESITDVLVRTKRDWLVKQRGWD-GFVEFFHVQDLEGGI--------RNVLLAF--AGVAGVGAGLAYLIR---  
 BCL2_BOVIN            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHAGGTGYDNREIVMKYIHYKLSQRG-YEWDAGDAGAAP--PGAAPAPGILSSQPGRTPAPS-------RTSPPP---PPAAAAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPF-TARERFATVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---SIALWMTEYLNRHLHTWIQDNGGWD-AFVELYGP----SMRPLFDFSWLSLKALLS--LALVGACITLGAYLGHK-  
 O55179                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEYEFMYIHSLAEHYLQYVLQVPAFE-----------------------------------------------------SAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVGAYKQVSSFVAEFIMNNTGEWIRRNGGWEDGFIKKFEP---------------KSGWLTF--LQMTGQIWEMLFLLK---  
 Q9I9N3                ---------------------------------------------------------------------------------------------MALSLDFRRTATMSFFAQGVQTPTLKTCVEDELDGYTEEEEAPLKRLRPGTNGLKGLQLDGRFVSATDGSLPTTPDPEELDYAELERDTRQLLLDFYRTHTGMCPVDRKLHHAI-------------------------------------------------------------PTMKRVVDNILVKHQIAYKGMIQRLQLDSQPASLDFIRCIASTMFKDGVTNWGRIASLVAFGAVVCSRLKELQQDQCVE---RVAEQISSYLTSEQQDWILKNKSWH-GFVEFFHQEDVESVV--------RHGLLAL--VGCAGIGAGLAFLIR---  
 O55177                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEYEFMYIHSLAEHYLQYVLQVPAFE-----------------------------------------------------SAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVGAYKQVSSFVAEFIINNTGEWIRRNGGWEDGFIKKFEP---------------KSGWLTF--LQMTGQFWEMLFLLK---  
 Q90ZH2                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGSSRDLVEKFVSKKLSQN--EACRKFSNNPQ-----------------PNAIS-------------NGTSTSERPGEGATQGIVEEEVLQALLEATEEFELRYQRAFSDLTSQLHITQD-TAQQSFQQVMGELFRDGT-NWGRIVAFFSFGRALCVESANKEMTDLLP---RIVQWMVNYLEHTLQPWMQENGGWE-AFVGLYGKNAAAQSRESQER---FGR-LLT-IVMLTGVFALVCYMRRR--  
 BCL2_CHICK            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHPGRRGYDNREIVLKYIHYKLSQRG-YDWAAGE-DRPP--VPPAPAPAAAPAAVAAAGASS-----HHRPEPPGSAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTPF-TAHGRFVAVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---NIATWMTEYLNRHLHNWIQDNGGWD-AFVELYGN----SMRPLFDFSWISLKTILS--LVLVGACITLGAYLGHK-  
 BCL2_HUMAN            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHAGRTGYDNREIVMKYIHYKLSQRG-YEWDAGDVGAAP--PGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPF-TARGRFATVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWD-AFVELYGP----SMRPLFDFSWLSLKTLLS--LALVGACITLGAYLGHK-  
 O88996                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATPAST-PDTRALVADFVGYKLRQKG-YVCGAGPGEG----------------------------------------------------PAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPG-SAQQRFTQVSDELFQGGP-NWGRLVAFFVFGAALCAESVNKEMEPLVG---QVQDWMVTYLETRLADWIHSSGGWA-EFTALYGDGALEEARRLREGNWASVRTVLTG-AVALGALVTVGAFFASK-  
 O35844                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKG-YSWSQFSDVEEN--RTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSS-SLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPG-TAYQSFEQVVNELFRDGV-NWGRIVAFFSFGGALCVESVDKEMQVLVS---RIASWMATYLNDHLEPWIQENGGWD-TFVDLYGNNAAAESRKGKEG---FNRWFLTG-MTVAGVVLLGSLFSRK--  
 MCL1_HUMAN            MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEP----LGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDDLYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETL------------------------------------------------------RRVGDGVQRNHETAFQGMLRKLDIKNE-DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIE---PLAESITDVLVRTKRDWLVKQRGWD-GFVEFFHVEDLEGGI--------RNVLLAF--AGVAGVGAGLAYLIR---  
 Q90Z98                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSYYNRELVVFFIKYKLSQRN-YPCNHIGLTEDTNRTDGAEENGEGAAGATTLVNGTMNRTNASSTGTPPQSPASSPQRQTNGSGGLDAVKEALRDSANEFELRYSRAFNDLSSQLHITPA-TAYQSFESVMDEVFRDGV-NWGRIVGLFAFGGALCVECVEKEMSPLVG---RIAEWMTVYLDNHIQPWIQSQGGWE-RFAEIFGKDAAAESRKSQES---FKKWLFAGMTLLTGVVVGGLIAQKRL-  
 Q925A9                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDCEFMYIHSLAENYLQYVLQVPAFE-----------------------------------------------------SAPSKTSRVLQRVAFSVQKEVEKNLKPYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIGLDVDTYKQVSSFVAEFIMNNTGEWIQQNGGWEDGFTKKFEP---------------KSGWLTF--LQMTGKIWEMLFLLKQHY  
 BCLW_MOUSE            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATPAST-PDTRALVADFVGYKLRQKG-YVCGAGPGEG----------------------------------------------------PAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPG-SAQQRFTQVSDELFQGGP-NWGRLVAFFVFGAALCAESVNKEMEPLVG---QVQDWMVAYLETRLADWIHSSGGWA-EFTALYGDGALEEARRLREGNWASVRTVLTG-AVALGALVTVGAFFASK-  
 BCL2_MOUSE            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAQAGRTGYDNREIVMKYIHYKLSQRG-YEWDAGDADAAP--LGAAPTPGIFSFQPESNPMPAVHREMAARTSPLR---PLVATAGPALSPVPPCVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPF-TARGRFATVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWD-AFVELYGP----SMRPLFDFSWLSLKTLLS--LALVGACITLGAYLGHK-  
 O55178                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEYELMHIHSLAEHYLQYVLQVPAFE-----------------------------------------------------SAPSQAFRVLQRVAFSVQKEVGKNLKSYLDDFHVESIDTTRIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKTSTRADCPGCTC-----------LQTSFQFWGRIHNE-----------------------------------------------------  
 BFL1_HUMAN            -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDCEFGYIYRLAQDYLQCVLQIPQPG-----------------------------------------------------SGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEP---------------KSGWMTF--LEVTGKICEMLSLLKQYC  
 Q9N1A2                ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQSNRELVVDFLSYKLSQKG-YSWSQFTDVEEN--RTEAPEGTESEAETPSAINGNPSWHLADSPAVNGATGHSS-SLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPG-TAYQSFEQVVNELFRDGV-NWGRIVAFFSFGGALCVESVDKEMQVLVS---RIATWMATYLNDHLEPWIQENGGWD-TFVELYGNNAAAESRKGQER---FNRWFLTG-MTLAGVVLLGSLFSRK--  
 BCL2_RAT              ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAQAGRTGYDNREIVMKYIHYKLSQRG-YEWDTGDEDSAP--LRAAPTPGIFSFQPESNRTPAVHRDTAARTSPLR---PLVANAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPF-TARGRFATVVEELFRDGV-NWGRIVAFFEFGGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWD-AFVELYGP----SMRPLFDFSWLSLKTLLS--LALVGACITLGAYLGHK-