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 AP2B_MOUSE            ---------------------MLWKLVENVKYED---------------------------------IYEDRHDGVPSHS--SRLSQLGSVSQG--PYSSAPPLSHTPS-SDFQ-PPYFPPPYQPLPYHQSQDPYS-HVN-------DPYS--LNPLH------QPQQHPWGQ------------------RQRQ------EVGSEAGSLLP-----QPRAALPQLSGLDP-----RRDYHSVRR-PDVLLHSAHHGLDAGM-GDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQS-------VIKKVPVP-PK----SVT----------------------------------------SLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHT--DPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPI--LEPGIQSCLTHF-SLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNT--------TNRHTSGEGP----GSKTGDKEEKHRK  
 O93346                ---------------------MLWKLVENVKYED---------------------------------IYEDRHDGVPSHS--SRLSQLGSVSQ--GPYSSAPPLSHTPS-SDFQ-PPYFPPPYQPLPYHQSQDPYS-HVN-------DPYS--LNPLH------QPQQHPWGQ------------------RQRQ------EVGSDTGSLLP-----QPRAALPQLSGLDP-----RRDYHSVRRPDVLLHSA-HHGLDSGM-GDSLSLHGIGHPGMEEVQSVEDANNSGMNLLDQS-------VIKKVPVP-PK----SVT----------------------------------------SLMMNKDGFLGGISVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHT--DPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPTPI--LEPGIQSCLTHF-SLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNNT-------ANRHTSGEGPG----SKTGDKEEKHRK  
 AP2C_MOUSE            ---------------------MLWKITDNVKYEE---------------------------------DCEDRHDSSSNGN--PRIPHLSSPGQH--LYSPAPPLSHTGV-AEYQPPPYFPPPYQQVVYSQSADHYS-HLG-------EAYAAAMNPLHQPAATGS-QQQAWPG------------------RQSQ------EGS-SLASHHSRSASLIPH-----ISGLEGGSVSARREVY---RRSDLLLPHA-HALEAGLA-ENLGLHEMAHP-IEEVQNVDDAHLLLHDQT----------VIRKGPISMTKNPLGLP--------------------------------------------CQKDL-VGVVMNPS-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKAVADYLTRPHLG-GRNEMATRKSMLLAAQQVCKEFTDLLHQDRTPNGNNRPAQV--LEPNIQNCLSHF-SLITHGFGSQAICAAVSAVQNYIKEALIAIDKSYMNPG--------DQSPA--DSS------KTMEKMEKHRK  
 Q8UVE5                ----------------------MYHIQKEETRMSLMGKMG---------------------------DWQDRHDGTSNGT--ARLPQLGSVGQ--SPYTSAPPLSHTPN-SDFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--INSLH---AQSQPQHPGWPG-----------------QRQSQ------ESS-LLHQHRG-----LPH----QLC----------REY----RREVLLPSG--HGIDTGLT-DSIPIHGIPHS-LEDVQQVEDQGIHIPDQT----------VIKKGPVSISKNNSN-IS----------------------------------------AIPINKDGLVGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAIAEYMNRQHS--DPNEQVQRKNMLLATKQICKEFTDLLSQDRSPLGNSRPQPI--LEPGIQSCLTHF-SLISHGFGTPAVCAALTALQNYLTEAIKAMDKMYLNNN--------PNSHS--ETG-----SKAGDKDEKHRK  
 Q96SH0                -------------------MKMLWKLTDNIKYE----------------------------------DCEDRHDGTSNGT--ARLPQLGTVGQ--SPYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ESG-LLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HALSSGL-GD-LSIHSLPHA-IEEVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------AIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGKRIHLLTRRNFLLG-KWIIFSGQMF--------GRILCQLGSFIFAENIARC-EWNYFMA-KRNI------------------CMYSYTSILLPSFPLP  
 AP2B_HUMAN            ---------------------MLWKLVENVKYED---------------------------------IYEDRHDGVPSHS--SRLSQLGSVSQG--PYSSAPPLSHTPS-SDFQ-PPYFPPPYQPLPYHQSQDPYS-HVN-------DPYS--LNPLH------QPQQHPWGQ------------------RQRQ------EVGSEAGSLLP-----QPRAALPQLSGLDP-----RRDY-HSVRRPDVLLHSAHHGLDAGM-GDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQS-------VIKKVPVP-PK----SVT----------------------------------------SLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHT--DPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPI--LEPGIQSCLTHF-SLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTT-------TNRHTSGEGPG----SKTGDKEEKHRK  
 Q99L72                ---------------------MLWKITDNVKYEE---------------------------------DCEDRHDSSSNGN--PRIPHLSSPGQH--LYSPAPPLSHTGV-AEYQPPPYFPPPYQQLAYSQSADHYS-HLG-------EAYAAAMNPLHQPAATGS-QQQAWPG------------------RQSQ------EGS-SLASHHSRSASLIPH-----ISGLEGGSVSARREVY---RRSDLLLPHA-HALEAGLA-ENLGLHEMAHP-IEEVQNVDDAHLLLHDQT----------VIRKGPISMTKNPLGLP--------------------------------------------CQKDL-VGVVMNPS-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKAVADYLTRPHLG-GRNEMATRKSMLLAAQQVCKEFTDLLHQDRTPNGNNRPAQV--LEPNIQNCLSHF-SLITHGFGSQAICAAVSAVQNYIKEALIAIDKSYMNPG--------DQSPA--DSS------KTMEKMEKHRK  
 O96378                -------------------MHILHRTND-HQFEDQKFMMERLS------------GHGSLGLSSGSAAYTTHSGGHTGRS----GPATGHSGHSSTH-GSAATMHHQSLQSDFQ-PPYFPPPFHH---STQSPPQQQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAG--------------------LRSTQ------DQLGIHRTHREAE--LQGHVTQLSHGFPYTDR---RSDYG-----SAISAGAA-HGTRLGHEHESLALHQALQ------NAVDDVQAPALDDN----------VAFMSDLPLIKSMKSGKE-----------------------------------------------AGNIGSGSPS-EVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQT--EPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHL--LEPSMQRHLTHF-SLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKI--DN-------------EKK  
 AP2A_RAT              ---------------------MLWKLTDNIKYE----------------------------------DCEDRHDGTSNGT--ARLPQLGTVGQ--SPYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ESG-LLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HGLGSGL-GD-LPIHSLPHA-IEDVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------AIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSSPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNS-----AKSSDKEEKHRK  
 Q96SH1                -------------------MKMLWKLTDNIKYE----------------------------------DCEDRHDGTSNGT--ARLPQLGTVGQ--SPYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ESG-LLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HALSSGL-GD-LSIHSLPHA-IEEVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------AIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNN-----AKSSDKEEKHRK  
 AP2A_MOUSE            ---------------------MLWKLTDNIKYE----------------------------------DCEDRHDGTSNGT--ARLPQLGTVGQS--PYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ESG-LLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HALGSGL-GD-LPIHSLPHA-IEDVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------AIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNS-----AKSSDKEEKHRK  
 AP2A_HUMAN            ---------------------MLWKLTDNIKYE----------------------------------DCEDRHDGTSNGT--ARLPQLGTVGQS--PYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ES-GLLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HALSSGL-GD-LSIHSLPHA-IEEVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------AIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNN-----AKSSDKEEKHRK  
 Q09585                ----------------------MFNRKLMECSDDEFVRGS---------------------------QCDEEDEEEQQRQSSQRPPFVGSA-----LFI---PLQYILF-LQYENMRTFAPSHMHIS-CHYDIPYPPHLIQPPVCGVSTFT---------------------------------------------------------------------------------------------------------------------------------------------------------YAREFPVSNSQQFF-NVTPPQQQQQQGTGGSGEEDYCIPKSEDRDHSSNYSQVATKQDRPFVFFASDCQSPLEIVGEVYCTVPGRTSLLSSTTKYRVTVAEIQRRISPPECLNASLLGGILRKAKSKDGGKTLRDSLKKLGLTLPAGRRKQANVTAWTALVEEEAIHMAKEFALVCEKEFHSREIGIYLTKTSLAIDP-DVVKRRTALEMSRKVVGELAELLSCDRTPLTPYFPRNMLPIDPSVQQHLSHF-TLMTHGFGNVAMSAVLESVKLMIDESIKYIDR-CCSQNVWR  
 O76923                -------------------MTLAYVDMPAVI-----QVQERLS------------GHGSLGLSSGSAAYTTHSGGHTGRS----GPATGHSGHSSTH-GSAATMHHQSLQSDFQ-PPYFPPPFHH---STQSPPQQQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAG--------------------LRSTQ------DQLGIHRTHREAE--LQGHVTQLSHGFPYTDR---RSDYG-----SAISAGAA-HGTRLGHEHESLALHQALQ------NAVDDVQAPALDDN----------VAFMSDLPLIKSMKSGKE-----------------------------------------------AGNIGSGSPS-EVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQT--EPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHL--LEPSMQRHLTHF-SLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKI--DN-------------EKK  
 AP2A_SHEEP            -MPPRLASVKIPYDWGRKGPFRFWRIFCQSRAVGWFLAAACGRAGRFRTQPAEWPTPDAVFSPLGLALFQDRHDGASNGT--ARLPQLGTVGQS--PYTSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNPLH---AQPQPQHPGWPG-----------------QRQSQ------ES-GLLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HGLGSGL-GD-LPIHSLPHA-IEDVPHVEDPGINIPDQT----------VIKKGPVSLSKSNSNAVS----------------------------------------SIPINKDNLFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNS-----AKSSDKEEKHRK  
 Q91ZK0                -------------------MSTTFP--GLVH------------------------------------DAEIRHDGSNSYR-LMQLGCLESVANSTVAYSSSSPLTYSTTGTEFA-SPYFSTNHQYTPLHHQSFHYEFQHSHPAVTP-DAYS--LNSLH-------HSQQYYQQIHHGEPTDFINLHNARALKSSCLDEQRRELGCLDAYRRHD----LSLM---SHGSQYG------------MHPDQRLLPG---PS-LGLAA--AGA--------------DDLQGSV-EAQCGIVLNGQGGVIRRGGTC--------------------------------------------------------------VVNPT-DLFCSVPGRLSLLSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNLPAGRRKAANVTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHM--EQKEQTARKKMILATKQICKEFQDLLSQDRSPLGSSRPTPI--LDLDIQRHLTHF-SLITHGFGTPAICAALSTFQTVLSEMLNYLEKHTTHKNGG--AADSGQGHANSEKAPLRKASEAAVKEGKTEKTD  
 Q8UVE6                ---------------------MLWKLTDNIKYE----------------------------------DFEDRHDGTSNGT--ARLPQLGSVGQ--SPYTSAPPLSHTPN-SDFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--INSLH---AQSQPQHPGWPG-----------------QRQSQ------ESS-LLHQHRG-----LPH----QLC----------REY----RREVLLPSG--HGIDTGLT-DSIPIHGIPHS-LEDVQQVEDQGIHIPDQT----------VIKKGPVSISKNNSN-IS----------------------------------------AIPINKDGLVGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAIAEYMNRQHS--DPNEQVQRKNMLLATKQICKEFTDLLSQDRSPLGNSRPQPI--LEPGIQSCLTHF-SLISHGFGTPAVCAALTALQNYLTEAIKAMDKMYLNNN--------PNSHS--ETG-----SKAGDKDEKHRK  
 Q91867                --------------------MGEWQ---------------------------------------------DRHDG-SNGT--GRLPQLGSVGQS--PYASAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNSLH---AQPQPQHPGWPG-----------------QRQSQ------ETS-LLHTHRG-----LPH----QLSGLDP-----RRDY---RRHEDLLHGP--HGLSSGL-GD-LPLHSIPH-VIEDVSHVEDPSINIPDQT----------VIKKGPVSFSKSNNNAVS----------------------------------------SLSLNKDNLFGGVLNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEFVNRQHS--DPNEQVTRKNMLLATKQICKEFTDLLSQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAITALQNYLTEALKAMDKMYLNNN--------PNSHT--DNS------KGGDKDEKHRK  
 O13111                ---------------------MLWKLTDNIKYE----------------------------------ECEERHDSASNGT--ARLPQLGAVGQS--PYSSAPPLSHTPN-ADFQ-PPYFPPPYQPI-YPQSQDPYS-HVN-------DPYS--LNSLH---TQPQPQHPAWPG-----------------QRQSQ------EP-SLLHAHRG-----LPH----QLGGLDP-----RRDY---RRHDDLLHGP--HGLGAGLA-D-LPLHSIPHA-IEDVPHVDDPGINIPDQT----------VIKKGPVSLSKSNNNAVS----------------------------------------SIPINKDALFGGVVNPN-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHS--DPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPI--LEPGIQSCLTHF-NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNN--------PNSHT--DNS-----TKSSDKEEKHRK  
 AP2C_HUMAN            ---------------------MLWKITDNVKYEE---------------------------------DCEDRHDGSSNGN--PRVPHLSSAGQ--HLYSPAPPLSHTGV-AEYQPPPYFPPPYQQLAYSQSADPYS-HLG-------EAYAAAINPLHQPAPTGS-QQQAWPG------------------RQSQ------EGA-GLPSHHGRPAGLLPH-----LSGLEAGAVSARRDAY---RRSDLLLPH-AHALDAAGLAENLGLHDMPHQ-MDEVQNVDDQHLLLHDQT----------VIRKGPISMTKNPL--------------------------------------------NLPCQKE-LVGAVMNPT-EVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLG-GRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPV--LETNIQNCLSHF-SLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPG--------DQSPA--DSN------KTLEKMEKHRK