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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---
 AP2A_HUMAN            --------------------MLWKL-----------------------------TDNIKYE----------DCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGD-LSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK  
 Q96SH1                ------------------MKMLWKL-----------------------------TDNIKYE----------DCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGD-LSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK  
 AP2A_MOUSE            --------------------MLWKL-----------------------------TDNIKYE----------DCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALGSGLGD-LPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK  
 O13111                --------------------MLWKL-----------------------------TDNIKYE----------ECEERHDSASNGTARLPQLGAVGQSPYSSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNSLHTQPQPQHPAWPGQRQSQEPSLLHAHRGLPHQLGGLDPRRDYRRHDDLLHGPHGLGAGLAD-LPLHSIPHAIEDVPHVDDPGINIPDQTVIKKGPVSLSKSNNNAVSSIPINKDALFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSTKSSDKEEKHRK  
 Q8UVE5                ---------------------MYHI--------------------------------QKEETRMSLMGKMGDWQDRHDGTSNGTARLPQLGSVGQSPYTSAPPLSHTPNSDFQPPYFPPPYQPIYPQSQDPYSHVNDPYSINSLHAQSQPQHPGWPGQRQSQESSLLHQHRGLPHQLC-----REY-RREVLLPSGHGIDTGLTDSIPIHGIPHSLEDVQQVEDQGIHIPDQTVIKKGPVSISKNNSN-ISAIPINKDGLVGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAIAEYMNRQHSDPNEQVQRKNMLL------------------------------------ATKQICKE-FTDLLSQDRSPLGNSRPQPILEPGIQSCLTHFSLISHGFGTPAVCAALTALQNYLTEAIKAMDKMYLNNNPNSHSETGSKAGDKDEKHRK  
 AP2A_SHEEP            MPPRLASVKIPYDWGRKGPFRFWRIFCQSRAVGWFLAAACGRAGRFRTQPAEWPTPDAVFSP-----LGLALFQDRHDGASNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGD-LPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSSIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK  
 Q96SH0                ------------------MKMLWKL-----------------------------TDNIKYE----------DCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGD-LSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGKRIHL-------------------------------LTRRNFLLGKWIIFSGQMFGRILCQLGSFIFAENIARCEWNYFMAKRNICMYSYTSILL-PSFPLP  
 Q8UVE6                --------------------MLWKL-----------------------------TDNIKYE----------DFEDRHDGTSNGTARLPQLGSVGQSPYTSAPPLSHTPNSDFQPPYFPPPYQPIYPQSQDPYSHVNDPYSINSLHAQSQPQHPGWPGQRQSQESSLLHQHRGLPHQLC-----REY-RREVLLPSGHGIDTGLTDSIPIHGIPHSLEDVQQVEDQGIHIPDQTVIKKGPVSISKNNSN-ISAIPINKDGLVGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAIAEYMNRQHSDPNEQVQRKNMLL------------------------------------ATKQICKE-FTDLLSQDRSPLGNSRPQPILEPGIQSCLTHFSLISHGFGTPAVCAALTALQNYLTEAIKAMDKMYLNNNPNSHSETGSKAGDKDEKHRK  
 Q91867                ---------------------------------------------------------------------MGEWQDRHDG-SNGTGRLPQLGSVGQSPYASAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNSLHAQPQPQHPGWPGQRQSQETSLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLSSGLGD-LPLHSIPHVIEDVSHVEDPSINIPDQTVIKKGPVSFSKSNNNAVSSLSLNKDNLFGGVLNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEFVNRQHSDPNEQVTRKNMLL------------------------------------ATKQICKE-FTDLLSQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAITALQNYLTEALKAMDKMYLNNNPNSHTDNS-KGGDKDEKHRK  
 AP2A_RAT              --------------------MLWKL-----------------------------TDNIKYE----------DCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGD-LPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSSPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLL------------------------------------ATKQICKE-FTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK